Genprex (NASDAQ: GNPX) chief medical officer Dr. Mark Berger is spotlighted in the latest episode of the Bell2Bell podcast (https://ibn.fm/M3OqD). During the episode, hosted by IBN’s Jonathan Keim, the executive talks about the clinical-stage gene therapy company, which develops potentially life-changing therapies for patients with cancer and diabetes who have limited treatment options. Recorded live at the 2023 American Society of Clinical Oncology (“ASCO”) Annual Meeting, the interview included an overview of the company and why this year has been so successful. Berger specifically talked about progress made on the company’s Acclaim 1 study, which will be moving into phase 2 clinical study, and the announcement earlier this year that Genprex research collaborators had presented positive preclinical date for the NPRL2 gene. Bell2Bell is committed to being a primary destination for informative updates and exclusive interviews with executives operating in fast-moving industries.
To hear the full podcast, visit https://ibn.fm/BFkvm
About Genprex Inc.
Genprex is a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes. Genprex’s technologies are designed to administer disease-fighting genes to provide new therapies for large patient populations with cancer and diabetes, which currently have limited treatment options. Genprex works with world-class institutions and collaborators to develop drug candidates to further its pipeline of gene therapies in order to provide novel treatment approaches. Genprex’s oncology program utilizes its proprietary, nonviral ONCOPREX(R) Nanoparticle Delivery System, which encapsulates the gene-expressing plasmids using lipid nanoparticles. The resultant product is then administered intravenously, where it is then taken up by tumor cells that express tumor suppressor proteins that are deficient in the tumor. The company’s lead product candidate, REQORSA (quaratusugene ozeplasmid), is being evaluated in three clinical trials as a treatment for non-small cell lung cancer (“NSCLC”) and small cell lung cancer (“SCLC”). Both NSCLC clinical programs received a fast-track designation from the Food and Drug Administration. Genprex’s diabetes gene therapy approach is comprised of a novel infusion process that uses an endoscope and an adeno-associated virus (“AAV”) vector to deliver Pdx1 (“Pdx1”) and MafA (“MafA”) genes to the pancreas. In models of type a diabetes, GPX-002 transforms alpha cells in the pancreas into functional beta-like cells, which can produce insulin but are distinct enough from beta cells to evade the body’s immune system. In a similar approach, GPX-003 for type w diabetes, where autoimmunity is not at play, is believed to rejuvenate and replenish exhausted beta cells. For more information, please visit the company’s website at www.Genprex.com.
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