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Coya Therapeutics Strengthens Scientific Advisory Board (SAB) with the Addition of Neuroimmunology Pioneer, Dr. Guillaume Dorothée, an Expert on the Role of the Immune System and Regulatory T Cells (Tregs) in Alzheimer’s Disease (AD)

  • Dr. Guillaume Dorothée, Ph.D., is a tenured research director and team head in neuroimmunology at the French National Institute of Health and Medical Research (INSERM) in Paris
  • He is one of the world’s leading experts on the role that the immune system and peripheral-central immune crosstalk play in the pathophysiology of AD
  • His team was the first to illustrate the beneficial role of Regulatory T cells (Tregs) in AD and the therapeutic effects of low dose Interleukin-2 (low dose IL-2) in modifying AD pathology and restoring cognitive function
  • Dr. Dorothée joins an SAB with leading Treg experts including Dr. Shimon Sakaguchi, the discoverer of Tregs, and the chair of Coya’s SAB, Dr. Stanley Appel, who elucidated the role of Tregs in Amyotrophic Lateral Sclerosis (ALS)
  • Dr. Dorothée will play an integral role in guiding Coya on its scientific and clinical strategy in AD and other neurodegenerative diseases


Coya Therapeutics, Inc. (NASDAQ: COYA) (“Coya” or the “Company”), a clinical-stage biotechnology company developing biologics intended to enhance Treg function, today announced the appointment of Dr. Guillaume Dorothée, Ph.D., to Coya’s SAB, joining a roster of scientific luminaries. Dr. Dorothée will provide insight and perspective into Coya’s clinical programs in ALS and AD, and other indications that Coya is evaluating.

Dr. Dorothée’s seminal work has focused on the role of the immune system and peripheral-central immune crosstalk in the pathophysiology of AD and other neurodegenerative diseases, with a particular interest in neuroinflammation and its effects on beta Amyloid, Tau, and other AD pathology. He has pioneered research into understanding how Tregs critically control immune responses to Beta Amyloid (Toly-Ndour et al, J Immunol, 2011), and how enhancing Tregs with low dose IL-2 plays a beneficial role in the pathophysiology of AD-like amyloid pathology while restoring cognitive function (Dansokho et al, Brain, 2016).

“Coya could not be prouder in having Dr. Dorothée join its SAB. The fact that he discovered the therapeutic role of low dose IL-2 in AD dovetails with Coya’s low dose IL-2 asset, COYA 301, and its highly promising proof of concept clinical data showing cognitive improvement and halting of cognitive decline. He continues to publish on the mechanism of how Tregs are working in AD and we look forward to his active participation in guiding our path forward,” stated, Howard H. Berman, Ph.D., CEO of Coya Therapeutics.

Dr. Dorothée commented: “I am glad and honored to join such eminent scientists on the prestigious SAB of Coya Therapeutics. I am fully convinced that innovative Treg-based immunomodulatory approaches, as developed by Coya, are highly promising therapeutic strategies for the treatment of neurodegenerative disorders and other neuroinflammatory conditions. I will be happy to help Coya Therapeutics in this exciting endeavor.”

About Coya Therapeutics, Inc.

Headquartered in Houston, TX, Coya Therapeutics, Inc. (Nasdaq: COYA) is a clinical-stage biotechnology company developing proprietary treatments focused on the biology and potential therapeutic advantages of regulatory T cells (“Tregs”) to target systemic inflammation and neuroinflammation. Dysfunctional Tregs underlie numerous conditions including neurodegenerative, metabolic, and autoimmune diseases, and this cellular dysfunction may lead to a sustained inflammation and oxidative stress resulting in lack of homeostasis of the immune system. Coya’s investigational product candidate pipeline leverages multiple therapeutic modalities aimed at restoring the anti-inflammatory and immunomodulatory functions of Tregs. Coya’s lead therapeutic programs includes Treg-enhancing biologics (COYA 300 Series product candidates) COYA 301 and COYA 302, which are intended to enhance Treg function and expand Treg numbers. COYA 301 is a cytokine biologic for subcutaneous administration intended to enhance Treg function and expand Treg numbers in vivo, and COYA 302 is a biologic combination for subcutaneous and/or intravenous administration intended to enhance Treg function while depleting T effector function and activated macrophages. These two mechanisms may be additive or synergistic in suppressing inflammation. For more information about Coya, please visit

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