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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

(Rule 13d-102)

Under the Securities Exchange Act of 1934
(Amendment No. )*

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO
RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED
PURSUANT TO RULE 13d-2(b)

Dor Biopharma, Inc.
(Name of Issuer)
Common Shares, par value $0.001
(Title of Class of Securities)
258094101
(CUSIP Number)
February 7, 2007
(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

     o Rule 13d-1(b)

     þ Rule 13d-1(c)

     o Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

 
 


TABLE OF CONTENTS

Item 1(a) Name of Issuer
Item 1(b) Address of Issuer’s Principal Executive Offices
Item 2(a) Name of Person Filing
Item 2(b) Address of Principal Business Office, or, if none, Residence
Item 2(c) Citizenship or Place of Organization
Item 2(d) Title of Class of Securities
Item 2(e) CUSIP Number
Item 3 If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
Item 4 Ownership
Item 5 Ownership of Five Percent or Less of a Class
Item 6 Ownership of More Than Five Percent on Behalf of Another Person
Item 7 Identification and Classification of the Subsidiary which Acquired the Security Being Reported On by the Parent Holding Company
Item 8 Identification and Classification of Members of the Group
Item 9 Notice of Dissolution of Group
Item 10 Certification
SIGNATURE
Joint Filing Agreement


Table of Contents

                     
CUSIP No.
 
258094101 
  Page  
  of   
11 

 

           
1   NAMES OF REPORTING PERSONS:
Southpoint Capital Advisors LP
   
  I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY): 
    20-0975910
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS):

  (a)   o
  (b)   o
     
3   SEC USE ONLY:
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION:
   
  Delaware
       
  5   SOLE VOTING POWER:
     
NUMBER OF   8,510,638**
       
SHARES 6   SHARED VOTING POWER:
BENEFICIALLY    
OWNED BY   0
       
EACH 7   SOLE DISPOSITIVE POWER:
REPORTING    
PERSON   8,510,638**
       
WITH: 8   SHARED DISPOSITIVE POWER:
     
    0
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
   
  8,510,638**
     
10   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS):
   
  o
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
   
  9.94%**
     
12   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS):
   
  PN
** SEE ITEM 4.


Table of Contents

                     
CUSIP No.
 
258094101 
  Page  
3  
  of   
11 

 

           
1   NAMES OF REPORTING PERSONS:
Southpoint GP, LP
   
  I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY): 
    20-1095514
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS):

  (a)   o
  (b)   o
     
3   SEC USE ONLY:
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION:
   
  Delaware
       
  5   SOLE VOTING POWER:
     
NUMBER OF   8,510,638**
       
SHARES 6   SHARED VOTING POWER:
BENEFICIALLY    
OWNED BY   0
       
EACH 7   SOLE DISPOSITIVE POWER:
REPORTING    
PERSON   8,510,638**
       
WITH: 8   SHARED DISPOSITIVE POWER:
     
    0
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
   
  8,510,638**
     
10   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS):
   
  o
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
   
  9.94%**
     
12   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS):
   
  PN
** SEE ITEM 4.


Table of Contents

                     
CUSIP No.
 
258094101 
  Page  
  of   
11 

 

           
1   NAMES OF REPORTING PERSONS:
Southpoint Capital Advisors LLC
   
  I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY): 
    20-0975900
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS):

  (a)   o
  (b)   o
     
3   SEC USE ONLY:
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION:
   
  Delaware
       
  5   SOLE VOTING POWER:
     
NUMBER OF   8,510,638**
       
SHARES 6   SHARED VOTING POWER:
BENEFICIALLY    
OWNED BY   0
       
EACH 7   SOLE DISPOSITIVE POWER:
REPORTING    
PERSON   8,510,638**
       
WITH: 8   SHARED DISPOSITIVE POWER:
     
    0
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
   
  8,510,638**
     
10   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS):
   
  o
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
   
  9.94%**
     
12   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS):
   
  OO
** SEE ITEM 4.


Table of Contents

                     
CUSIP No.
 
258094101 
  Page  
  of   
11 

 

           
1   NAMES OF REPORTING PERSONS:
Southpoint GP, LLC
   
  I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY): 
    20-1064783
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS):

  (a)   o
  (b)   o
     
3   SEC USE ONLY:
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION:
   
  Delaware
       
  5   SOLE VOTING POWER:
     
NUMBER OF   8,510,638**
       
SHARES 6   SHARED VOTING POWER:
BENEFICIALLY    
OWNED BY   0
       
EACH 7   SOLE DISPOSITIVE POWER:
REPORTING    
PERSON   8,510,638**
       
WITH: 8   SHARED DISPOSITIVE POWER:
     
    0
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
   
  8,510,638**
     
10   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS):
   
  o
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
   
  9.94%**
     
12   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS):
   
  OO
** SEE ITEM 4.


Table of Contents

                     
CUSIP No.
 
258094101 
  Page  
  of   
11 

 

           
1   NAMES OF REPORTING PERSONS:
Robert W. Butts
   
  I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY): 
   
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS):

  (a)   o
  (b)   o
     
3   SEC USE ONLY:
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION:
   
  United States
       
  5   SOLE VOTING POWER:
     
NUMBER OF   8,510,638**
       
SHARES 6   SHARED VOTING POWER:
BENEFICIALLY    
OWNED BY   0
       
EACH 7   SOLE DISPOSITIVE POWER:
REPORTING    
PERSON   8,510,638**
       
WITH: 8   SHARED DISPOSITIVE POWER:
     
    0
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
   
  8,510,638**
     
10   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS):
   
  o
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
   
  9.94%**
     
12   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS):
   
  IN
** SEE ITEM 4.


Table of Contents

                     
CUSIP No.
 
258094101 
  Page  
  of   
11 

 

           
1   NAMES OF REPORTING PERSONS:
John S. Clark II
   
  I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY): 
   
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS):

  (a)   o
  (b)   o
     
3   SEC USE ONLY:
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION:
   
  United States
       
  5   SOLE VOTING POWER:
     
NUMBER OF   8,510,638**
       
SHARES 6   SHARED VOTING POWER:
BENEFICIALLY    
OWNED BY   0
       
EACH 7   SOLE DISPOSITIVE POWER:
REPORTING    
PERSON   8,510,638**
       
WITH: 8   SHARED DISPOSITIVE POWER:
     
    0
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
   
  8,510,638**
     
10   CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS):
   
  o
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9):
   
  9.94%**
     
12   TYPE OF REPORTING PERSON (SEE INSTRUCTIONS):
   
  IN
** SEE ITEM 4.


Table of Contents

SCHEDULE 13G
     This Schedule 13G (the “Schedule 13G”) is being filed on behalf of Southpoint Capital Advisors LLC, a Delaware limited liability company (“Southpoint CA LLC”), Southpoint GP, LLC, a Delaware limited liability company (“Southpoint GP LLC”), Southpoint Capital Advisors LP, a Delaware limited partnership (“Southpoint Advisors”), Southpoint GP, LP, a Delaware limited partnership (“Southpoint GP”), Robert W. Butts and John S. Clark II. Southpoint CA LLC is the general partner of Southpoint Advisors. Southpoint GP LLC is the general partner of Southpoint GP. Southpoint GP is the general partner of Southpoint Fund LP, a Delaware limited partnership (the “Fund”), Southpoint Qualified Fund LP, a Delaware limited partnership (the “Qualified Fund”), and Southpoint Master Fund, LP, a Cayman Islands exempted limited partnership (the “Master Fund”). Southpoint Offshore Fund, Ltd., a Cayman Island exempted company (the “Offshore Fund”), is also a general partner of the Master Fund. This Schedule 13G relates to shares of Common Stock of Dor Biopharma, Inc., a Delaware corporation (the “Issuer”), purchased by the Fund, the Qualified Fund and the Master Fund.
Item 1(a)   Name of Issuer.
 
    Dor Biopharma, Inc.
Item 1(b)   Address of Issuer’s Principal Executive Offices.
 
    1101 Brickell Avenue
Suite 701-S
Miami, Florida 33131
United States
Item 2(a)   Name of Person Filing.
  (1)   Southpoint Capital Advisors, LP
 
  (2)   Southpoint GP, LP
 
  (3)   Southpoint Capital Advisors, LLC
 
  (4)   Southpoint GP, LLC
 
  (5)   Robert W. Butts
 
  (6)   John S. Clark II
Item 2(b)   Address of Principal Business Office, or, if none, Residence.
  (1)   For all Filers:
623 Fifth Avenue, Suite 2503
New York, NY 10022
(212) 692-6350


Table of Contents

Item 2(c)   Citizenship or Place of Organization.
  (1)   Southpoint Capital Advisors LP is a Delaware limited partnership.
 
  (2)   Southpoint GP, LP is a Delaware limited partnership.
 
  (3)   Southpoint Capital Advisors LLC is a Delaware limited liability company.
 
  (4)   Southpoint GP, LLC is a Delaware limited liability company.
 
  (5)   Robert W. Butts is a U.S. citizen.
 
  (6)   John S. Clark II is a U.S. citizen.
Item 2(d)   Title of Class of Securities.
 
    Common Shares (the “Common Shares”), par value $0.001.
Item 2(e)   CUSIP Number.
 
    258094101
Item 3   If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
 
    Not Applicable.
Item 4   Ownership.
  (a)   Southpoint CA LLC, Southpoint GP LLC, Southpoint GP, Southpoint Advisors, Robert W. Butts and John S. Clark II may be deemed the beneficial owners of 8,510,638 shares of Common Stock.
 
  (b)   As of February 16, 2007, Southpoint CA LLC, Southpoint GP LLC, Southpoint GP, Southpoint Advisors, Robert W. Butts and John S. Clark II may be deemed the beneficial owners of 9.94% of the outstanding shares of Common Stock. This percentage was determined by dividing 8,510,638 by 85,597,631, the total number of Common Shares, par value $0.001, issued and outstanding, which is equal to 73,916,781 Common Shares outstanding as of December 31, 2006, based on information received from the Issuer, plus the 11,680,850 shares issued by pursuant to a private placement on February 7, 2007, as reported in the Issuer’s Form 8-K filed with the Securities and Exchange Commission February 12, 2007.
 
  (c)   Southpoint CA LLC, Southpoint GP LLC, Southpoint GP, Southpoint Advisors, Robert W. Butts and John S. Clark II have the sole power to vote and dispose of the 8,510,638 shares of Common Stock beneficially owned.
Item 5   Ownership of Five Percent or Less of a Class.
 
    Not Applicable.

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Item 6   Ownership of More Than Five Percent on Behalf of Another Person.
 
    All securities reported in this schedule are owned by clients of the Investment Manager. To the knowledge of the Investment Manager, no one client owns more than 5% of the Common Stock.
Item 7   Identification and Classification of the Subsidiary which Acquired the Security Being Reported On by the Parent Holding Company.
 
    Not Applicable.
Item 8   Identification and Classification of Members of the Group.
 
    Not Applicable.
Item 9   Notice of Dissolution of Group.
 
    Not Applicable.
Item 10   Certification.
 
    By signing below each of the Reporting Persons certifies that, to the best of such person’s knowledge and belief, the securities referred to above were acquired and held in the ordinary course of business and were not acquired and were not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.
 
Exhibits   Exhibit 1
 
    Joint Filing Agreement dated February 16, 2007, between Southpoint CA LLC, Southpoint GP LLC, Southpoint GP, Southpoint Advisors, Robert W. Butts and John S. Clark II.

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SIGNATURE
     After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
     Date: February 16, 2007
                 
    SOUTHPOINT CAPITAL ADVISORS, LP    
 
               
    By:   Southpoint Capital Advisors LLC
its general partner
   
 
               
 
      By:   /s/ Robert W. Butts    
 
      Name:  
 
Robert W. Butts
   
 
      Title:   Manager    
 
               
    SOUTHPOINT GP, LP    
 
               
    By:   Southpoint GP, LLC
its general partner
   
 
               
 
      By:   /s/ Robert W. Butts    
 
      Name:  
 
Robert W. Butts
   
 
      Title:   Manager    
 
               
    SOUTHPOINT CAPITAL ADVISORS, LLC    
 
               
    By:   /s/ Robert W. Butts    
             
    Name:   Robert W. Butts    
    Title:   Manager    
 
               
    SOUTHPOINT GP, LLC    
 
               
    By:   /s/ Robert W. Butts    
             
    Name:   Robert W. Butts    
    Title:   Manager    
 
               
              /s/ Robert W. Butts    
         
              Robert W. Butts    
 
               
              /s/ John S. Clark II    
         
              John S. Clark II    

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