Filed by Atrix Laboratories, Inc.
                           Pursuant to Rule 425 under the Securities Act of 1933
                              and deemed filed pursuant to Rule 14a-12 under the
                                                 Securities Exchange Act of 1934

                                       Subject Company: Atrix Laboratories, Inc.
                                                   Commission File No. 000-18231


On June 14, 2004, Atrix Laboratories, Inc., a Delaware corporation (the
"Company") entered into an Agreement and Plan of Merger (the "Merger Agreement")
with QLT Inc., a company incorporated under the laws of the Province of British
Columbia ("QLT"), and Aspen Acquisition Corp., a Delaware corporation and a
wholly owned subsidiary of QLT ("Merger Sub"). Pursuant to, and subject to the
terms and conditions contained in, the Merger Agreement, QLT would acquire the
Company through the merger of Merger Sub with and into the Company, with the
Company continuing as the surviving corporation, immediately followed by the
merger of the Company into a Delaware corporation that is a wholly owned
subsidiary of QLT. A copy of the Merger Agreement is set forth below.

------------------------------------------------------------------------


                          AGREEMENT AND PLAN OF MERGER

                                  BY AND AMONG

                                    QLT INC.

                             ASPEN ACQUISITION CORP.

                                       AND

                            ATRIX LABORATORIES, INC.

                            DATED AS OF JUNE 14, 2004







                                TABLE OF CONTENTS

ARTICLE 1. The Merger 1

      Section 1.1      The Merger..............................................1
      Section 1.2      Closing.................................................1
      Section 1.3      Effect of the Merger....................................2
      Section 1.4      Certificate of Incorporation; Bylaws....................2
      Section 1.5      Directors and Officers of the Surviving Corporation.....2
      Section 1.6      Second Step Merger......................................2

ARTICLE 2. Conversion of Securities; Exchange of Certificates..................2

      Section 2.1      Conversion of Securities................................2
      Section 2.2      Exchange of Certificates................................6
      Section 2.3      Stock Transfer Books....................................9
      Section 2.4      Stock Options...........................................9
      Section 2.5      Warrant................................................10

ARTICLE 3. Representations and Warranties of the Company......................10

      Section 3.1      Organization, Standing and Corporate Power.............10
      Section 3.2      Subsidiaries...........................................10
      Section 3.3      Capital Structure......................................11
      Section 3.4      Authority; Noncontravention............................13
      Section 3.5      Company SEC Filings....................................14
      Section 3.6      Absence of Certain Changes or Events...................16
      Section 3.7      Litigation.............................................16
      Section 3.8      Contracts..............................................17
      Section 3.9      Compliance with Laws; Permits..........................18
      Section 3.10     Employee Benefit Plans.................................18
      Section 3.11     Labor and Other Employment Matters.....................21
      Section 3.12     Taxes..................................................22
      Section 3.13     Environmental Matters..................................24
      Section 3.14     Title to Properties....................................25
      Section 3.15     Intellectual Property..................................26
      Section 3.16     Development, Distribution, Marketing, Supply
                       and Manufacturing Agreements...........................28
      Section 3.17     Regulatory Compliance..................................28
      Section 3.18     Corporate Governance Matters...........................31
      Section 3.19     Insurance..............................................32
      Section 3.20     Voting Requirements....................................32
      Section 3.21     State Takeover Statutes; Self-Dealing..................33
      Section 3.22     Brokers; Advisory Fees.................................33
      Section 3.23     Opinion of Financial Advisor...........................33
      Section 3.24     Company Rights Plan....................................33

ARTICLE 4. Representations and Warranties of Parent and Merger Sub............33

      Section 4.1      Organization, Standing and Corporate Power.............33
      Section 4.2      Subsidiaries...........................................34



                                       i



      Section 4.3      Capital Structure......................................34
      Section 4.4      Authority; Noncontravention............................36
      Section 4.5      Parent SEC Filings.....................................38
      Section 4.6      Absence of Certain Changes or Events...................39
      Section 4.7      Litigation.............................................39
      Section 4.8      Contracts..............................................40
      Section 4.9      Compliance with Laws; Permits..........................40
      Section 4.10     Intellectual Property..................................41
      Section 4.11     Taxes..................................................41
      Section 4.12     Regulatory Compliance..................................42
      Section 4.13     Corporate Governance Matters...........................43
      Section 4.14     Interim Operations of Merger Sub.......................44
      Section 4.15     Parent Shareholder Approval............................44
      Section 4.16     Brokers................................................44
      Section 4.17     Opinion of Financial Advisor...........................45
      Section 4.18     Sufficient Funds.......................................45

ARTICLE 5. Covenants  45

      Section 5.1      Conduct of Business by the Company.....................45
      Section 5.2      Conduct of Business by Parent Pending the Closing......50
      Section 5.3      Tax-Free Reorganization Treatment......................51
      Section 5.4      Control of Other Party's Business......................52

ARTICLE 6. Additional Agreements..............................................52

      Section 6.1      Registration Statement; Proxy Statement................52
      Section 6.2      Shareholders' Meetings.................................54
      Section 6.3      Access to Information; Parent Takeover Proposal;
                       Confidentiality........................................55
      Section 6.4      No Solicitation of Transactions........................56
      Section 6.5      Appropriate Action; Consents; Filings..................58
      Section 6.6      Certain Notices........................................60
      Section 6.7      Public Announcements...................................61
      Section 6.8      Nasdaq and Toronto Stock Exchange Listings.............61
      Section 6.9      Indemnification of Directors and Officers..............61
      Section 6.10     Plan of Reorganization.................................63
      Section 6.11     Affiliate Letters......................................63
      Section 6.12     Section 16 Matters.....................................63
      Section 6.13     Stock Award Matters....................................63
      Section 6.14     Company ESPP...........................................64
      Section 6.15     Board of Directors of Parent; Vice Chairman............64
      Section 6.16     Benefit Matters........................................64

ARTICLE 7. Closing Conditions.................................................66

      Section 7.1      Conditions to Each Party's Obligation to
                       Effect the Merger......................................66
      Section 7.2      Conditions to Obligations of Parent and Merger Sub.....67
      Section 7.3      Conditions to Obligation of the Company................68


                                       ii



ARTICLE 8. Termination, Amendment and Waiver..................................69

      Section 8.1      Termination............................................69
      Section 8.2      Effect of Termination..................................70
      Section 8.3      Amendment..............................................72
      Section 8.4      Waiver.................................................72
      Section 8.5      Fees and Expenses......................................72

ARTICLE 9. General Provisions.................................................72

      Section 9.1      Non-Survival of Representations and Warranties.........72
      Section 9.2      Notices................................................73
      Section 9.3      Certain Definitions....................................74
      Section 9.4      Terms Defined Elsewhere................................79
      Section 9.5      Interpretation.........................................81
      Section 9.6      Severability...........................................82
      Section 9.7      Entire Agreement.......................................82
      Section 9.8      Assignment.............................................82
      Section 9.9      Parties in Interest....................................82
      Section 9.10     Mutual Drafting........................................82
      Section 9.11     Governing Law..........................................82
      Section 9.12     Enforcement............................................82
      Section 9.13     Disclosure.............................................83
      Section 9.14     Counterparts...........................................83


Exhibit 6.11                     Form of Affiliate Letter

Exhibit 7.2(c)(i)                Parent Tax Matters Certificate

Exhibit 7.2(c)(ii)               Company Tax Matters Certificate



                                      iii






      AGREEMENT AND PLAN OF MERGER, dated as of June 14, 2004 (this
"Agreement"), by and among QLT Inc., a company incorporated under the laws of
the Province of British Columbia ("Parent"), Aspen Acquisition Corp., a Delaware
corporation and a wholly-owned subsidiary of Parent ("Merger Sub"), and Atrix
Laboratories, Inc., a Delaware corporation (the "Company").

      WHEREAS, the respective Boards of Directors of Parent, Merger Sub and the
Company have approved the merger of Merger Sub with and into the Company (the
"First Step Merger" or the "Merger") upon the terms and subject to the
conditions of this Agreement and in accordance with the Delaware General
Corporation Law (the "DGCL");

      WHEREAS, the respective Boards of Directors of Parent and the Company have
determined that the Merger is advisable, the Board of Directors of Parent has
determined that the Merger is in the best interest of its shareholders, the
Board of Directors of the Company has determined that the Merger is in the best
interests of its stockholders, and Parent has approved this Agreement and the
Merger as the sole stockholder of Merger Sub;

      WHEREAS, for federal income tax purposes, Parent, Merger Sub and the
Company intend that the First Step Merger and the Second Step Merger shall be
treated as a single integrated transaction (together, the "Transaction") and
shall qualify as a "reorganization" under Sections 367 and 368(a) of the
Internal Revenue Code of 1986, as amended (the "Code") and the regulations
promulgated thereunder.

      NOW, THEREFORE, in consideration of the foregoing and the respective
representations, warranties, covenants and agreements set forth in this
Agreement and intending to be legally bound hereby, the parties hereto agree as
follows:

                                   ARTICLE 1.
                                   THE MERGER

      Section 1.1 The Merger. Upon the terms and subject to satisfaction or
waiver of the conditions set forth in this Agreement, and in accordance with the
DGCL, at the Effective Time, Merger Sub shall be merged with and into the
Company. As a result of the Merger, the separate corporate existence of Merger
Sub shall cease and the Company shall continue as the surviving corporation
following the Merger (the "Surviving Corporation").

      Section 1.2 Closing. The closing of the Merger (the "Closing") shall take
place on the first Business Day after the satisfaction or waiver (subject to
applicable Law) of the conditions (excluding conditions that, by their nature,
cannot be satisfied until the Closing Date) set forth in Article 7, unless this
Agreement has been theretofore terminated pursuant to its terms or unless
another time or date is agreed to in writing by the parties hereto (the actual
date of the Closing being referred to herein as the "Closing Date"). The Closing
shall be held at the offices of Latham & Watkins LLP, 135 Commonwealth Drive,
Menlo Park, California 94025, unless another place is agreed to in writing by
the parties hereto. As soon as practicable after the Closing, the parties hereto
shall cause the Merger to be consummated by filing a certificate of merger
relating to the Merger (the "Certificate of Merger") with the Secretary of State
of the State of Delaware, in such form as required by, and executed in
accordance with the relevant





provisions of, the DGCL (the date and time of such filing, or if another date
and time is specified in such filing, such specified date and time, being the
"Effective Time").

      Section 1.3 Effect of the Merger. At the Effective Time, the effect of the
Merger shall be as provided in the applicable provisions of the DGCL. Without
limiting the generality of the foregoing, at the Effective Time, except as
otherwise provided herein, all the property, rights, privileges, powers and
franchises of the Company and Merger Sub shall vest in the Surviving
Corporation, and all debts, liabilities and duties of the Company and Merger Sub
shall become the debts, liabilities and duties of the Surviving Corporation.

      Section 1.4 Certificate of Incorporation; Bylaws.

      (a) Certificate of Incorporation. At the Effective Time, the Certificate
of Incorporation of the Surviving Corporation shall be amended in its entirety
to read as the Certificate of Incorporation of Merger Sub, until thereafter
changed or amended as provided therein or by applicable Law, except that Article
1 thereof shall be amended to read as follows: "The name of the Corporation is
Atrix Laboratories, Inc."

      (b) Bylaws. At the Effective Time, the Bylaws of Merger Sub, as in effect
immediately prior to the Effective Time, shall be the Bylaws of the Surviving
Corporation, until thereafter changed or amended as provided therein or by
applicable Law.

      Section 1.5 Directors and Officers of the Surviving Corporation. The
directors of Merger Sub immediately prior to the Effective Time shall be the
initial directors of the Surviving Corporation, each to hold office in
accordance with the Certificate of Incorporation and Bylaws of the Surviving
Corporation. The President and Chief Executive Officer of Parent immediately
prior to the Effective Time shall be the initial President and Chief Executive
Officer of the Surviving Corporation, and the officers of the Company other than
the Chairman of the Board and Chief Executive Officer shall be the other initial
officers of the Surviving Corporation, each to hold office in accordance with
the Certificate of Incorporation and Bylaws of the Surviving Corporation.

      Section 1.6 Second Step Merger. Immediately following the Effective Time,
Parent shall cause the Surviving Corporation to merge into a Delaware
corporation (the "Second Merger Sub") that is a wholly owned subsidiary of
Parent (the "Second Step Merger"). There shall be no conditions to the
completion of the Second Step Merger other than the completion of the Merger.

                                   ARTICLE 2.
               CONVERSION OF SECURITIES; EXCHANGE OF CERTIFICATES

      Section 2.1 Conversion of Securities. At the Effective Time, by virtue of
the Merger and without any action on the part of the Company or the holders of
any of the following securities:

      (a) Conversion Generally.



                                       2



             (i) Each share of common stock, par value $0.001 per share, of the
Company ("Company Common Stock") issued and outstanding immediately prior to the
Effective Time, including shares of Company Common Stock resulting from the
conversion of any Series A Convertible Exchangeable Preferred Stock, par value
$0.001 per share, of the Company ("Series A Convertible Preferred Stock")
immediately prior to consummation of the Merger (other than any shares of
Company Common Stock to be canceled pursuant to Section 2.1(b) and Appraisal
Shares referred to in Section 2.1(e) ("Excluded Common Shares")), shall be
converted, subject to Section 2.2(e), into the right to receive: (A) 1.0000 (the
"Exchange Ratio") common share, no par value per share ("Parent Common Shares"),
of Parent (the "Common Share Consideration") and (B) $14.61 in cash (the "Common
Cash Consideration," and together with the Common Share Consideration, the
"Common Merger Consideration").

             (ii) Each share of Series A Convertible Preferred Stock issued and
outstanding immediately prior to the Effective Time (other than any shares of
Series A Convertible Preferred Stock to be canceled pursuant to Section 2.1(b)
and Appraisal Shares referred to in Section 2.1(e) ("Excluded Preferred Shares"
and, together with the Excluded Common Shares, "Excluded Shares")), excluding
shares of Series A Convertible Preferred Stock converted prior to consummation
of the Merger, shall be converted, subject to Section 2.2(e), into the right to
receive: (A) a number of Parent Common Shares (the "Preferred Share
Consideration"), determined to seven decimal places, equal to the product of the
number of shares of Company Common Stock into which such share of Series A
Convertible Preferred Stock is convertible immediately prior to the Effective
Time (the "Conversion Number") and the Exchange Ratio (the "Preferred Exchange
Ratio") and (B) an amount of cash, determined to seven decimal places (the
"Preferred Cash Consideration" and, together with the Preferred Share
Consideration, the "Preferred Merger Consideration"), equal to the product of
the Conversion Number and the Common Cash Consideration.

             (iii) All such shares of Company Common Stock and Series A
Convertible Preferred Stock shall no longer be outstanding and shall
automatically be canceled and retired and shall cease to exist, and each
certificate (a "Certificate") previously representing any such shares shall
thereafter represent only the right to receive the Common Merger Consideration
or the Preferred Merger Consideration (collectively, the "Merger
Consideration"), as the case may be, payable in respect of such shares of
Company Common Stock or Series A Convertible Preferred Stock, as the case may
be, and the right, if any, to receive cash in lieu of fractional Parent Common
Shares pursuant to Section 2.2(e) and any distributions or dividends pursuant to
Section 2.2(c).

      (b) Cancellation of Shares. Each share of Company Common Stock or Series A
Convertible Preferred Stock, if any, either (i) owned by Parent or any of its
Subsidiaries, (ii) held in the Company treasury or (iii) owned by any
wholly-owned Subsidiary of the Company immediately prior to the Effective Time
shall be canceled and retired and shall cease to exist and no Merger
Consideration or other consideration shall be delivered in exchange therefor.

      (c) Merger Sub. Each share of common stock of Merger Sub issued and
outstanding immediately prior to the Effective Time shall be converted into and
be exchanged for one newly and validly issued, fully paid and nonassessable
share of common stock of the Surviving Corporation.


                                       3


      (d) Change in Shares. If, between the date of this Agreement and the
Effective Time, the outstanding Parent Common Shares, shares of Company Common
Stock or shares of Series A Convertible Preferred Stock shall have been changed
into, or exchanged for, a different number of shares or a different class, by
reason of any stock dividend, subdivision, reclassification, recapitalization,
split, combination or exchange of shares, the Exchange Ratio, the Preferred
Exchange Ratio and the Option Exchange Ratio shall be correspondingly adjusted
to provide the holders of Company Common Stock, Series A Convertible Preferred
Stock and Company Options the same economic effect as contemplated by this
Agreement prior to such event.

      (e) Appraisal Rights. Notwithstanding anything in this Agreement to the
contrary, shares of Company Common Stock and Series A Convertible Preferred
Stock outstanding immediately prior to the Effective Time and held by a Company
stockholder who has not voted in favor of the Merger or consented thereto in
writing and who has properly demanded appraisal for such shares in accordance
with the DGCL (the "Appraisal Shares"), shall not be converted into a right to
receive the Merger Consideration as provided in Section 2.1(a), until such time
as such stockholder fails to perfect or withdraws or otherwise loses such
stockholder's right to appraisal. If after the Effective Time such stockholder
fails to perfect or withdraws or loses such stockholder's right to appraisal,
such shares of Company Common Stock or Series A Convertible Preferred Stock, as
the case may be, shall be treated as if they had been converted as of the
Effective Time into the right to receive the Merger Consideration as provided in
Section 2.1(a). The Company shall give Parent prompt notice of any demands
received by the Company pursuant to the DGCL for appraisal of shares of Company
Common Stock or Series A Convertible Preferred Stock, and Parent shall have the
right to participate in all negotiations and proceedings with respect to such
demands. The Company shall not settle, make any payments with respect to, or
offer to settle, any claim with respect to Appraisal Shares without the written
consent of Parent.

      (f) Adjustments to Preserve Tax Treatment.

          (i) If the amount obtained by dividing (x) the Aggregate Parent Share
Value by (y) the Closing Transaction Value is less than 0.4500, the following
shall occur:

              (A) The Exchange Ratio shall be adjusted to a number, rounded to
the nearest fourth decimal place, equal to (x) the product of 0.4500 and the
Closing Transaction Value, divided by (y) the product of the Aggregate Company
Share Number and the Closing Parent Share Price.

              (B) The Common Cash Consideration shall be adjusted to an amount,
rounded to the nearest cent, equal to the quotient obtained by dividing (x) the
amount obtained by subtracting the Aggregate Appraisal Value from the product of
0.5500 and the Closing Transaction Value, by (y) the Aggregate Company Share
Number.

          (ii) In the event that the Exchange Ratio and the Common Cash
Consideration are adjusted as provided for in this Section 2.1(f), all
references in this Agreement (including, for the avoidance of doubt, references
in Section 2.1(a)(ii)) to the "Exchange Ratio" and the "Common Cash
Consideration" shall refer to the Exchange Ratio and the Common Cash
Consideration as adjusted in this Section 2.1(f) except as may be otherwise
specified herein.



                                       4


          (iii) For purposes of this Section 2.1(f), the following terms shall
have the following meanings:

                (A) "Aggregate Appraisal Value" means the product of (x) the
aggregate number of Appraisal Shares determined at Closing, and (y) the sum of
(1) the Common Cash Consideration (before any adjustment pursuant to Section
2.1(f)) and (2) the product of the Exchange Ratio (before any adjustment
pursuant to Section 2.1(f)) and the Closing Parent Share Price.

                (B) "Aggregate Cash Amount" means the product of (x) the Common
Cash Consideration (before any adjustment pursuant to Section 2.1(f)) and (y)
the Aggregate Company Share Number.

                (C) "Aggregate Company Share Number" means the number obtained
by subtracting (x) the aggregate number of shares of Company Common Stock to be
cancelled in the Merger pursuant to Section 2.1(b) and (y) the aggregate number
of Appraisal Shares determined at Closing, from (z) the aggregate number of
shares of Company Common Stock outstanding on the Closing Date (assuming
exercise of the Warrant, if it is exercised prior to the Effective Time, and
exercise of any stock options, if such options are exercised prior to the
Effective Time).

                (D) "Aggregate Parent Share Number" means the product of (x)
the Exchange Ratio (before any adjustment pursuant to Section 2.1(f)) and (y)
the Aggregate Company Share Number.

                (E) "Aggregate Parent Share Value" means the product of (x) the
Aggregate Parent Share Number (before any adjustment pursuant to Section 2.1(f))
and (y) the Closing Parent Share Price.

                (F) "Closing Parent Share Price" means the mean between the
high and low selling prices, regular way, of a Parent Common Share on The Nasdaq
Stock Market on the date of the Effective Time, as reported by Bloomberg LP (or
if not so reported, as reported by such other reporting service as is reasonably
agreed to by the parties).

                (G) "Closing Transaction Value" means the sum of (x) the
Aggregate Cash Amount, (y) the Aggregate Parent Share Value and (z) the
Aggregate Appraisal Value.

          (iv) For purposes of this Section 2.1(f), all shares of Series A
Convertible Preferred Stock that are outstanding at Closing shall be deemed to
have been converted into Company Common Stock immediately prior to Closing in
accordance with their terms.

      (g) Associated Rights. References in this Agreement to Parent Common
Shares shall include, unless the context requires otherwise, the associated
rights ("Parent Rights") issued pursuant to the Amended and Restated Shareholder
Rights Plan Agreement, as amended and restated, dated as of April 8, 2002,
between Parent and Computershare Trust Company of Canada, as Rights Agent (the
"Parent Rights Plan"). References in this Agreement


                                       5



to Company Common Stock shall include, unless the context requires otherwise,
the Company Rights (defined in Section 3.3(a) below).

      Section 2.2 Exchange of Certificates.

      (a) Exchange Agent. As of the Effective Time, Parent shall deposit, or
shall cause to be deposited, with Computershare Trust Company of Canada or
another bank or trust company designated by Parent and satisfactory to the
Company (the "Exchange Agent"), for the benefit of the holders of shares of
Company Common Stock and Series A Convertible Preferred Stock, for exchange, in
accordance with this Article 2, through the Exchange Agent, sufficient cash and
certificates representing Parent Common Shares to make all deliveries pursuant
to this Article 2. Parent agrees to make available to the Exchange Agent, from
time to time as needed, cash sufficient to pay any dividends and other
distributions pursuant to Section 2.2(c). The Exchange Agent shall, pursuant to
irrevocable instructions delivered by Parent to the Exchange Agent on or prior
to the Effective Time, deliver to the holders of shares of Company Common Stock
and Series A Convertible Preferred Stock (other than holders of Excluded Shares)
the Merger Consideration contemplated to be paid for shares of Company Common
Stock and Series A Convertible Preferred Stock pursuant to this Agreement out of
the Exchange Fund. Except as contemplated by Sections 2.2(c) and 2.2(e) hereof,
the Exchange Fund shall not be used for any other purpose. Any cash and
certificates representing Parent Common Shares deposited with the Exchange Agent
shall be referred to as the "Exchange Fund."

      (b) Exchange Procedures. Promptly (and in any event, within five (5)
Business Days) after the Effective Time, Parent shall cause the Exchange Agent
to mail to each holder of record of a Certificate or Certificates which
immediately prior to the Effective Time represented outstanding shares of
Company Common Stock or Series A Convertible Preferred Stock (other than holders
of Excluded Shares) (i) a letter of transmittal (which shall specify that
delivery shall be effected, and risk of loss and title to the Certificates shall
pass, only upon proper delivery of the Certificates to the Exchange Agent and
shall be in customary form) and (ii) customary instructions for use in effecting
the surrender of the Certificates in exchange for the Merger Consideration
payable in respect of the shares represented by such Certificates, any cash in
lieu of fractional Parent Common Shares pursuant to Section 2.2(e) and any
distributions or dividends pursuant to Section 2.2(c). Upon surrender of a
Certificate for cancellation to the Exchange Agent together with such letter of
transmittal, properly completed and duly executed, and such other documents as
may be required pursuant to such instructions, the holder of such Certificate
shall be entitled to receive in exchange therefor the Merger Consideration
payable in respect of the shares represented by such Certificate, any cash in
lieu of fractional Parent Common Shares to which such holder is entitled
pursuant to Section 2.2(e) and any dividends or other distributions to which
such holder is entitled pursuant to Section 2.2(c), and the Certificate so
surrendered shall forthwith be canceled. No interest shall be paid or accrued on
any Cash Consideration, cash in lieu of fractional shares or any unpaid
dividends and distributions payable to holders of Certificates. In the event of
a transfer of ownership of shares of Company Common Stock or Series A
Convertible Preferred Stock which is not registered in the transfer records of
the Company, the Merger Consideration payable in respect of such shares of
Company Common Stock or Series A Convertible Preferred Stock together with any
cash to be paid upon due surrender of the Certificate and any other dividends or
distributions in respect thereof may be paid to a transferee if the Certificate
representing such shares of Company Common Stock or


                                       6



Series A Convertible Preferred Stock is presented to the Exchange Agent,
accompanied by all documents required to evidence and effect such transfer and
to evidence that any applicable stock transfer Taxes have been paid. Until
surrendered as contemplated by this Section 2.2, each Certificate shall be
deemed at any time after the Effective Time to represent only the right to
receive upon such surrender the Merger Consideration payable in respect of the
shares of Company Common Stock or Series A Convertible Preferred Stock
represented by such Certificate, cash in lieu of any fractional Parent Common
Shares to which such holder is entitled pursuant to Section 2.2(e) and any
dividends or other distributions to which such holder is entitled pursuant to
Section 2.2(c).

      (c) Distributions with Respect to Unexchanged Parent Common Shares. No
dividends or other distributions declared or made with respect to Parent Common
Shares, with a record date after the Effective Time, shall be paid to the holder
of any unsurrendered Certificate, and no cash payment in lieu of fractional
Parent Common Shares shall be paid to any such holder pursuant to Section
2.2(e), unless and until the holder of such Certificate shall surrender such
Certificate. Subject to the effect of escheat, Tax or other applicable Laws,
following surrender of any such Certificate, there shall be paid to such holder
of the certificates representing whole Parent Common Shares issuable in exchange
therefor, without interest, (i) the amount of any cash due pursuant to Section
2.1 and cash payable in lieu of fractional Parent Common Shares to which such
holder is entitled pursuant to Section 2.2(e) and the amount of dividends or
other distributions with a record date at or after the Effective Time
theretofore paid with respect to such whole Parent Common Shares and (ii) at the
appropriate payment date, the amount of dividends or other distributions, with a
record date at or after the Effective Time but prior to such surrender and a
payment date subsequent to such surrender, payable with respect to such whole
Parent Common Shares.

      (d) Further Rights in Company Common Stock. The Merger Consideration
issued upon conversion of a share of Company Common Stock or Series A
Convertible Preferred Stock in accordance with the terms hereof (including any
dividends or distributions pursuant to Section 2.2(c) or cash in lieu of
fractional shares pursuant to Section 2.2(e)) shall be deemed to have been
issued in full satisfaction of all rights pertaining to such share of Company
Common Stock or Series A Convertible Preferred Stock, as the case may be.

      (e) Fractional Shares. No fraction of a Parent Common Share will be issued
in connection with the Merger, and no certificates or scrip for any such
fractional shares shall be issued. In lieu thereof, each holder of shares of
Company Common Stock or Series A Convertible Preferred Stock who would otherwise
be entitled to receive a fraction of a Parent Common Share (after aggregating
all fractional Parent Common Shares to be received by such holder) shall, upon
surrender of such holder's Certificate(s), receive from Parent an amount of cash
(rounded to the nearest whole cent), without interest, equal to the product of
(i) such fraction, multiplied by (ii) the volume weighted average price, regular
way, on The Nasdaq Stock Market, as reported by Bloomberg LP (or if not so
reported, as reported by such other reporting service as is reasonably agreed to
by the parties) of the Parent Common Shares for the five (5) most recent trading
days ending on the full trading day immediately prior to the Effective Time (the
"Parent Closing Price").




                                       7


      (f) Termination of Exchange Fund. Any portion of the Exchange Fund which
remains undistributed to the holders of Company Common Stock and Series A
Convertible Preferred Stock for six (6) months after the Effective Time shall be
delivered to Parent, upon demand, and, from and after such delivery to Parent,
any holders of Company Common Stock or Series A Convertible Preferred Stock who
have not theretofore complied with this Article 2 shall thereafter look only to
Parent for the Merger Consideration payable in respect of such shares of Company
Common Stock or Series A Convertible Preferred Stock, as the case may be, any
cash in lieu of fractional Parent Common Shares to which they are entitled
pursuant to Section 2.2(e) and any dividends or other distributions with respect
to Parent Common Shares to which they are entitled pursuant to Section 2.2(c),
in each case, without any interest thereon.

      (g) No Liability. None of Parent, the Surviving Corporation or the Company
shall be liable to any holder of shares of Company Common Stock or Series A
Convertible Preferred Stock for any such Parent Common Shares (or dividends or
distributions with respect thereto) or cash from the Exchange Fund delivered to
a public official pursuant to any abandoned property, escheat or similar Law.

      (h) Lost Certificates. If any Certificate shall have been lost, stolen or
destroyed, upon the making of an affidavit of that fact by the Person claiming
such Certificate to be lost, stolen or destroyed and, if required by Parent, the
posting by such Person of a bond, in such reasonable amount as Parent may
direct, as indemnity against any claim that may be made against it with respect
to such Certificate, the Exchange Agent shall pay in exchange for such lost,
stolen or destroyed Certificate the Merger Consideration payable in respect of
the shares of Company Common Stock or Series A Convertible Preferred Stock
represented by such Certificate, any cash in lieu of fractional Parent Common
Shares to which the holders thereof are entitled pursuant to Section 2.2(e) and
any dividends or other distributions to which the holders thereof are entitled
pursuant to Section 2.2(c), in each case, without any interest thereon.

      (i) Withholding. Parent or the Exchange Agent shall be entitled to deduct
and withhold from the consideration otherwise payable pursuant to this Agreement
to any holder of Company Common Stock or Series A Convertible Preferred Stock
such amounts as Parent or the Exchange Agent are required to deduct and withhold
under the Code, or any Tax Law, with respect to the making of such payment. To
the extent that amounts are so withheld by Parent or the Exchange Agent, Parent
shall, or shall cause the Exchange Agent to, provide the applicable holder of
Company Common Stock or Series A Convertible Preferred Stock with notice of the
reason for withholding such amounts and such withheld amounts shall be treated
for all purposes of this Agreement as having been paid to the holder of Company
Common Stock Series A Convertible Preferred Stock, as the case may be, in
respect of whom such deduction and withholding was made by Parent or the
Exchange Agent.

      (j) Investment of Exchange Fund. The Exchange Agent shall invest any cash
included in the Exchange Fund, as directed by Parent, on a daily basis. Any
interest and other income resulting from such investments shall be paid to
Parent upon termination of the Exchange Fund pursuant to Section 2.2(f). In the
event the cash in the Exchange Fund shall be insufficient to fully satisfy all
of the payment obligations to be made by the Exchange Agent hereunder, Parent
shall promptly deposit cash into the Exchange Fund in an amount which is equal
to the deficiency in the amount of cash required to fully satisfy such payment
obligations.



                                       8


      Section 2.3 Stock Transfer Books. At the Effective Time, the stock
transfer books of the Company shall be closed and thereafter there shall be no
further registration of transfers of shares of Company Common Stock or Series A
Convertible Preferred Stock theretofore outstanding on the records of the
Company. From and after the Effective Time, the holders of Certificates
representing shares of Company Common Stock or Series A Convertible Preferred
Stock outstanding immediately prior to the Effective Time shall cease to have
any rights with respect to such shares of Company Common Stock or Series A
Convertible Preferred Stock except as otherwise provided herein or by Law. On or
after the Effective Time, any Certificates presented for any reason to the
Exchange Agent or Parent shall be converted into the Merger Consideration
payable in respect of the shares of Company Common Stock or Series A Convertible
Preferred Stock represented by such Certificates, any cash in lieu of fractional
Parent Common Shares to which the holders thereof are entitled pursuant to
Section 2.2(e) and any dividends or other distributions to which the holders
thereof are entitled pursuant to Section 2.2(c), without any interest thereon.

      Section 2.4 Stock Options.

      (a) The Company shall take all actions necessary to provide that,
immediately prior to the Effective Time, each Company Option then outstanding
under any Company Stock Option Plan shall become vested and exercisable with
respect to one hundred percent (100%) of the shares of Company Common Stock
subject to each such Company Option; provided that the holder of such Company
Option renders continuous service to the Company as an employee, consultant or
member of the Board of Directors of the Company from the date hereof until at
least immediately prior to the Effective Time. At the Effective Time, each
Company Option then outstanding under any Company Stock Option Plan, whether or
not then exercisable, shall be assumed and become an option to purchase Parent
Common Shares in accordance with this Section 2.4. Each Company Option so
assumed shall continue to have, and be subject to, the same terms and conditions
(including vesting schedule, as adjusted pursuant to the first sentence of this
Section 2.4(a)) as set forth in the applicable Company Stock Option Plan and any
agreements thereunder immediately prior to the Effective Time, except that, as
of the Effective Time, (i) each Company Option shall be exercisable (or shall
become exercisable in accordance with its terms) for that number of whole Parent
Common Shares equal to the product of the number of shares that were issuable
upon exercise of such Company Option immediately prior to the Effective Time
multiplied by the sum of (A) the Exchange Ratio and (B) the quotient obtained by
dividing the Common Cash Consideration by the Parent Closing Price (such sum,
the "Option Exchange Ratio"), rounded down to the nearest whole number of Parent
Common Shares, and (ii) the per share exercise price for the Parent Common
Shares issuable upon exercise of such Company Option so converted shall be equal
to the quotient determined by dividing the exercise price per share of Company
Common Stock at which such Company Option was exercisable immediately prior to
the Effective Time by the Option Exchange Ratio, rounded up to the nearest whole
cent. Notwithstanding the foregoing, the conversion of any Company Options which
are "incentive stock options," within the meaning of Section 422 of the Code,
into options to purchase Parent Common Shares shall be made so as not to
constitute a "modification" of such Company Options within the meaning of
Section 424 of the Code. Following the assumption of the Company Options, all
references to the Company in the Company Options and the Company Stock Option
Plans shall be deemed to refer to Parent.



                                       9


      (b) As soon as practicable after the Effective Time, Parent shall deliver
to each holder of an outstanding Company Option an appropriate notice setting
forth such holder's rights pursuant thereto and that such Company Option shall
continue in effect on the same terms and conditions (subject to the adjustments,
amendments and other terms required by this Section 2.4 and Section 6.16(e), as
applicable, after giving effect to the Merger).

      Section 2.5 Warrant. If outstanding immediately prior to the Effective
Time, at the Effective Time the Warrant shall cease to represent a right to
acquire shares of Company Common Stock and automatically shall be converted into
a warrant to purchase Parent Common Shares in accordance with its terms.

                                   ARTICLE 3.
                  REPRESENTATIONS AND WARRANTIES OF THE COMPANY

      Except as set forth on the disclosure schedule delivered by the Company to
Parent prior to the execution of this Agreement, which disclosure schedule
specifies the section or subsection of this Agreement to which the exception
relates, and subject to Section 9.13 (the "Company Disclosure Schedule"), the
Company represents and warrants to Parent and Merger Sub as follows:

      Section 3.1 Organization, Standing and Corporate Power. Each of the
Company and its Subsidiaries is a corporation duly organized, validly existing
and in good standing under the Laws of the jurisdiction in which it is organized
and has all requisite corporate power and authority to own, lease or operate its
properties and to carry on its business as now being conducted. Section 3.1 of
the Company Disclosure Schedule contains a true and complete list of each
jurisdiction where the Company is qualified to do business. Each of the Company
and its Subsidiaries has corporate or equivalent qualification to do business
and is in good standing in each jurisdiction in which the nature of its business
or the ownership, leasing or operation of its properties makes such
qualification or licensing necessary, other than in such jurisdictions where the
failure to be so qualified or licensed individually or in the aggregate is not
reasonably likely to have a Material Adverse Effect on the Company. The Company
has made available to Parent prior to the execution of this Agreement true and
complete copies of its Certificate of Incorporation (the "Company Certificate of
Incorporation") and Bylaws (the "Company Bylaws"), and the comparable
organizational documents of each of its Subsidiaries, in each case as amended to
date. The Company is not in violation of any of the provisions of the Company
Certificate of Incorporation or the Company Bylaws. The Company has made
available to Parent complete and accurate copies of the minutes (or, in the case
of minutes that have not yet been finalized, drafts thereof (if available)) of
all meetings of the stockholders of the Company and each of the Company's
Subsidiaries, the Board of Directors of the Company and each of the Company's
Subsidiaries and the committees of each of such Board of Directors, in each case
held at any time during the five years prior to the date of this Agreement.

      Section 3.2 Subsidiaries. Section 3.2 of the Company Disclosure Schedule
lists each of the Subsidiaries of the Company and, for each such Subsidiary, the
jurisdiction under which laws it was organized and, as of the date hereof, each
jurisdiction in which such Subsidiary has corporate or equivalent qualification
to do business. All the issued and outstanding shares of capital stock of, or
other equity interests in, each such Subsidiary have


                                       10



been validly issued and are fully paid and nonassessable and are owned directly
or indirectly by the Company free and clear of all pledges, liens, charges,
encumbrances or security interests of any kind or nature whatsoever
(collectively, "Liens"), and free of any restriction on the right to vote, sell
or otherwise dispose of such capital stock or other equity interests. Except
with respect to (a) the securities of non-Affiliates held for investment
purposes which do not constitute more than a 2% interest in any such
non-Affiliate or (b) the capital stock of, or voting securities or equity
interests in, its Subsidiaries, neither the Company nor any of its Subsidiaries
owns, directly or indirectly, any capital stock of, or other voting securities
or equity interests in, any corporation, partnership, joint venture, association
or other entity.

      Section 3.3 Capital Structure.

      (a) The authorized capital stock of the Company consists of 45,000,000
shares of Company Common Stock and 5,000,000 shares of preferred stock, par
value $.001 per share (of which 200,000 shares have been designated Series A
Preferred Stock ("Series A Preferred Stock") and 20,000 shares have been
designated Series A Convertible Preferred Stock (collectively with the Series A
Preferred Stock, the "Company Preferred Stock")). At the close of business on
June 11, 2004:

            (i) 21,077,288 shares of Company Common Stock were issued and
outstanding;

            (ii) an additional 866,800 shares of Company Common Stock were held
by the Company in its treasury;

            (iii) 858,707 shares of Company Common Stock were reserved and
available for issuance pursuant to the Company Stock Option Plans, and 3,388,825
shares of Company Common Stock were subject to outstanding Company Options;

            (iv) 200,000 shares of Series A Preferred Stock were reserved for
issuance in connection with the rights (the "Company Rights") issued pursuant to
the Amended and Restated Rights Agreement, dated as of November 16, 2001, by and
between the Company and American Stock Transfer & Trust Company, as Rights Agent
(the "Company Rights Plan");

            (v) 15,291 shares of Series A Convertible Preferred Stock were
issued and outstanding, which were convertible by their terms into 816,480
shares of Company Common Stock, and no shares of preferred stock of the Company
were held by the Company as treasury shares; and

            (vi) a warrant to acquire 1,000,000 shares of Company Common Stock
from the Company pursuant to the warrant agreement set forth on Section 3.3(a)
of the Company Disclosure Schedule, of which a complete and accurate copy was
previously made available or delivered to Parent (the "Warrant"), was issued and
outstanding.

      Section 3.3(a) of the Company Disclosure Schedule sets forth a true and
complete list, as of June 11, 2004, of all outstanding Company Options and all
outstanding Company Stock-Based Awards, granted under the Company Stock Option
Plans or otherwise, and all



                                       11



outstanding warrants to purchase shares of Company Common Stock, the number of
shares of Company Common Stock (or other stock) subject thereto, the grant
dates, expiration dates, exercise or base prices (if applicable) and vesting
schedules thereof.

      (b) All outstanding shares of capital stock of the Company are, and all
shares which may be issued pursuant to the Company Preferred Stock, Company
Options, Company Stock-Based Awards or the Warrant will be, when issued in
accordance with the terms thereof, duly authorized, validly issued, fully paid
and nonassessable and not subject to preemptive rights. There are no bonds,
debentures, notes or other indebtedness of the Company having the right to vote
(or convertible into, or exchangeable for, securities having the right to vote)
on any matters on which stockholders of the Company may vote.

      (c) Except as set forth above in Section 3.3(a), as of the close of
business on June 11, 2004:

            (i) there are not issued, reserved for issuance or outstanding (A)
any shares of capital stock or other voting securities or equity interests of
the Company, (B) any securities of the Company convertible into or exchangeable
or exercisable for shares of capital stock or other voting securities or equity
interests of the Company or (C) any warrants, calls, options or other rights to
acquire from the Company or any of its Subsidiaries, and no obligation of the
Company or any of its Subsidiaries to issue, any capital stock, voting
securities, equity interests or securities convertible into or exchangeable or
exercisable for capital stock or voting securities of the Company; and

            (ii) there are no outstanding obligations of the Company or any of
its Subsidiaries to repurchase, redeem or otherwise acquire any such securities
or to issue, deliver or sell, or cause to be issued, delivered or sold, any such
securities.

      (d) As of the date hereof, there are no outstanding:

            (i) securities of the Company or any of its Subsidiaries convertible
into or exchangeable or exercisable for shares of capital stock or voting
securities or equity interests of any Subsidiary of the Company;

            (ii) warrants, calls, options or other rights to acquire from the
Company or any of its Subsidiaries, and no obligation of the Company or any of
its Subsidiaries to issue, any capital stock, voting securities, equity
interests or securities convertible into or exchangeable or exercisable for
capital stock or voting securities of any Subsidiary of the Company; or

            (iii) obligations of the Company or any of its Subsidiaries to
repurchase, redeem or otherwise acquire any such outstanding securities or to
issue, deliver or sell, or cause to be issued, delivered or sold, any such
securities.

      There are no outstanding contractual obligations of the Company or any of
its Subsidiaries to make any loan or guarantees to, or any equity or other
investment (in the form of a capital contribution or otherwise) in, any of the
Company's Subsidiaries or any other Person, other than guarantees by the Company
of any indebtedness or other obligations of any of its



                                       12



wholly-owned Subsidiaries and other than loans or guarantees made in the
ordinary course consistent with past practice to employees of the Company and
its Subsidiaries.

      (e) There are no outstanding contractual obligations of the Company or any
of its Subsidiaries (i) restricting the transfer of, (ii) affecting the voting
rights of, or (iii) granting any preemptive, right of first refusal or
antidilutive right with respect to, any Company Common Stock or Company
Preferred Stock or any capital stock of, or other securities in, any of the
Company's Subsidiaries.

      Section 3.4 Authority; Noncontravention.

      (a) The Company has all requisite corporate power and authority to execute
and deliver this Agreement and, subject to receipt of the Company Stockholder
Approval, to consummate the transactions contemplated by this Agreement. The
execution and delivery of this Agreement by the Company and the consummation by
the Company of the transactions contemplated by this Agreement have been duly
authorized by all necessary corporate action on the part of the Company and no
other corporate proceedings on the part of the Company are necessary to
authorize this Agreement or to consummate the transactions contemplated hereby,
other than obtaining the Company Stockholder Approval. This Agreement has been
duly executed and delivered by the Company and, assuming the due authorization,
execution and delivery by each of the other parties hereto, constitutes a legal,
valid and binding obligation of the Company, enforceable against the Company in
accordance with its terms, subject to bankruptcy, insolvency, fraudulent
transfer, moratorium, reorganization or similar Laws affecting the rights of
creditors generally and the availability of equitable remedies (regardless of
whether such enforceability is considered in a proceeding in equity or at law).
The Board of Directors of the Company, at a meeting duly called and held, duly
adopted resolutions (i) approving and declaring advisable this Agreement, the
Merger and the other transactions to be entered into by the Company contemplated
by this Agreement, (ii) declaring that it is in the best interests of the
stockholders of the Company that the Company enter into this Agreement and
consummate the Merger and the other transactions contemplated by this Agreement,
(iii) directing that the adoption of this Agreement be submitted as promptly as
practicable to a vote at the Company Stockholders' Meeting and (iv) recommending
that the stockholders of the Company adopt this Agreement and approve the
Merger, which resolutions, as of the date of this Agreement, have not been
subsequently rescinded, modified or withdrawn in any way.

      (b) The execution and delivery of this Agreement do not, and (assuming
receipt of the Company Stockholder Approval) the consummation of the Merger and
the other transactions to be entered into by the Company contemplated by this
Agreement and compliance by the Company with the provisions of this Agreement
will not, (i) conflict with, or result in any violation or breach of, or default
(with or without notice or lapse of time, or both) under, the Company
Certificate of Incorporation or the Company Bylaws or the comparable
organizational documents of any of its Subsidiaries, (ii) conflict with, or
result in any violation or breach of, or default (with or without notice or
lapse of time, or both) under, or give rise to a right of termination,
cancellation or acceleration of any obligation or to the loss of a benefit
under, or alter the rights or obligations of any party under, or result in the
creation of any Lien in or upon any of the properties or other assets of the
Company or any of its Subsidiaries under, any Contract to which the Company or
any of its Subsidiaries is a party or any of their respective properties or
other assets is subject or (iii) conflict with, or result in any violation or
breach of, or default (with or without notice or lapse of time, or both) under,
any Law applicable to the Company or any of its Subsidiaries or their respective


                                       13



properties or other assets or the rules and regulations of any stock exchange or
regulatory organization applicable to the Company or its Subsidiaries, other
than, in the case of clauses (ii) and (iii), any such conflicts, violations,
breaches, defaults, rights, losses or Liens that individually or in the
aggregate have not had and would not reasonably be expected to have a Material
Adverse Effect on the Company, and subject to, in the case of clauses (ii) and
(iii), the governmental filings, the obtaining of the Company Stockholder
Approval and the other matters referred to in Section 3.4(c).

      (c) No consent, approval, order or authorization of, action by or in
respect of, or registration, declaration or filing with, any federal, state,
local or foreign government, any court, administrative, regulatory or other
governmental agency, commission or authority or any non-governmental
self-regulatory agency, commission or authority (each, a "Governmental Entity")
is required by or with respect to the Company or any of its Subsidiaries in
connection with the execution and delivery of this Agreement by the Company or
the consummation of the Merger or the other transactions contemplated by this
Agreement by the Company, except for:

            (i) the filing of a premerger notification and report form under the
Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, and the rules
and regulations thereunder (the "HSR Act"), and the receipt, termination or
expiration, as applicable, of approvals or waiting periods required under the
HSR Act or any other applicable competition, merger control, antitrust or
similar Law;

            (ii) the filing with the United States Securities and Exchange
Commission (the "SEC") of (A) the Joint Proxy/Prospectus to be included in the
Registration Statement and (B) such reports under the Securities Exchange Act of
1934, as amended (the "Exchange Act"), as may be required in connection with
this Agreement and the transactions contemplated by this Agreement;

            (iii) the filing of the Certificate of Merger with the Secretary of
State of the State of Delaware and appropriate documents with the relevant
authorities of other states in which the Company or any of its Subsidiaries is
qualified to do business;

            (iv) filings with Governmental Entities to satisfy applicable
requirements of Canadian securities Laws and Blue Sky Laws;

            (v) any filings required under the rules and regulations of Nasdaq;
and

            (vi) such other consents, approvals, orders, authorizations,
actions, registrations, declarations and filings the failure of which to be
obtained or made individually or in the aggregate would not reasonably be
expected to have a Material Adverse Effect on the Company.

      Section 3.5 Company SEC Filings.



                                       14



      (a) The Company has since January 1, 2002 timely filed all reports,
schedules, forms, statements and other documents (including exhibits and other
information incorporated therein) with the SEC required to be filed by the
Company (the "Company SEC Filings"). As of their respective filing dates, or if
amended, the date of such amendment, the Company SEC Filings complied as to form
in all material respects with the requirements of the Securities Act of 1933, as
amended (the "Securities Act"), or the Exchange Act, as the case may be, and the
rules and regulations of the SEC promulgated thereunder applicable to such
Company SEC Filings. None of the Company SEC Filings, as of their respective
filing dates, or, if amended, the dates of such amendment, if any, filed prior
to the date hereof, contained any untrue statement of a material fact or omitted
to state a material fact required to be stated therein or necessary in order to
make the statements therein, in light of the circumstances under which they were
made, not misleading. As of the date hereof, except to the extent that
information contained in any Company SEC Filing has been revised, amended,
supplemented or superseded by a later-filed Company SEC Filing, to the Knowledge
of the Company, none of the Company SEC Filings contains any untrue statement of
a material fact or omits to state any material fact required to be stated
therein or necessary in order to make the statements made therein, in light of
the circumstances under which they were made, not misleading.

      (b) The financial statements (including the related notes) of the Company
included in the Company SEC Filings complied at the time they were filed, or if
amended, the date of such amendment, as to form in all material respects with
applicable accounting requirements and the published rules and regulations of
the SEC with respect thereto, were prepared in accordance with generally
accepted accounting principles in the United States ("GAAP") (except, in the
case of unaudited statements, as permitted by the rules and regulations of the
SEC) applied on a consistent basis during the periods involved (except as may be
indicated in the notes thereto) and each fairly presented in all material
respects the consolidated financial position of the Company and its Subsidiaries
as of the respective dates thereof and the consolidated results of their
operations and cash flows for the respective periods then ended (subject, in the
case of unaudited statements, to normal year-end audit adjustments).

      (c) Except as and to the extent set forth on the consolidated balance
sheet of the Company and its Subsidiaries as of December 31, 2003 included in
the Company's Form 10-K for the year ended December 31, 2003, including the
notes thereto (the "Company Form 10-K"), or in the financial statements included
in any Company SEC Filing filed prior to the date hereof with the SEC after
filing the Company Form 10-K, neither the Company nor any of its Subsidiaries
has any liabilities or obligations of any nature (whether accrued, absolute,
contingent or otherwise), except for (i) liabilities or obligations incurred in
the ordinary course of business consistent with past practice since December 31,
2003, (ii) liabilities and obligations incurred in connection with this
Agreement and the Company's performance of its obligations hereunder, and (iii)
liabilities and obligations that would not reasonably be expected to have a
Material Adverse Effect on the Company. None of the Subsidiaries of the Company
are, or have at any time since January 1, 2002 been, subject to the reporting
requirements of Sections 13(a) and 15(d) of the Exchange Act.

      (d) No "material contract" (as such term is defined in Item 601(b)(10) of
Regulation S-K of the SEC) filed as an exhibit to the Company Form 10-K has been
amended or


                                       15



modified, except for such amendments or modifications that have been filed as an
exhibit to a subsequently dated Company SEC Filing or are not currently required
to be filed with the SEC.

      Section 3.6 Absence of Certain Changes or Events. Except for liabilities
incurred in connection with this Agreement or as permitted pursuant to Section
5.1, since December 31, 2003, except as disclosed in the Filed Company SEC
Filings, the Company and each of its Subsidiaries have conducted their
businesses in the ordinary course consistent with past practice and there has
not been any Material Adverse Effect on the Company, and from such date to the
date hereof there has not been:

      (a) any material change by the Company or by any of its Subsidiaries in
its accounting methods not required pursuant to GAAP;

      (b) any declaration, setting aside or payment of any dividend or other
distribution with respect to the Company's or any of its Subsidiaries' capital
stock;

      (c) any split, combination or reclassification of the Company's or any of
its Subsidiaries' capital stock or any issuance of or the authorization of any
issuance of any other securities in respect of, in lieu of or in substitution
for, shares of its capital stock;

      (d) any revaluation by the Company or any of its Subsidiaries of any of
their assets having a Material Adverse Effect on the Company; or

      (e) any event or development that would, individually or in the aggregate,
reasonably be expected to prevent or materially delay the performance of this
Agreement by the Company.

      Section 3.7 Litigation. Except as and to the extent disclosed in the Filed
Company SEC Filings, there is no suit, claim, action or proceeding pending or,
to the Knowledge of the Company, threatened against or affecting the Company or
any of its Subsidiaries or any of their respective assets that individually or
in the aggregate has had or would reasonably be expected to have a Material
Adverse Effect on the Company, nor is there any judgment, decree, injunction,
rule or order of any Governmental Entity or arbitrator outstanding against, or,
to the Knowledge of the Company, any demand, investigation, audit, inquiry,
hearing, review or other similar action brought by any Governmental Entity
involving, the Company or any of its Subsidiaries or any of their respective
assets that individually or in the aggregate has had or would reasonably be
expected to have a Material Adverse Effect on the Company. There is no suit,
claim, action, proceeding, enforcement action or investigation pending or, to
the Knowledge of the Company, threatened against the Company or any of its
Subsidiaries that, as of the date hereof, challenges the validity or propriety
of, or seeks to prevent consummation of, the Merger or any other transaction
contemplated by this Agreement.




                                       16



      Section 3.8 Contracts.

      (a) Except as filed as exhibits to the Filed Company SEC Filings or as set
forth in Section 3.8 of the Company Disclosure Schedule, none of the Company or
any of its Subsidiaries is a party to or bound by any Contract as of the date
hereof:

            (i) any of the benefits to any party of which will be increased, or
the vesting of the benefits to any party of which will be accelerated, by the
occurrence of any of the transactions contemplated by this Agreement or the
value of any of the benefits to any party of which will be calculated on the
basis of any of the transactions contemplated by this Agreement; or

            (ii) which:

            (A) involves, or is reasonably expected to involve, aggregate
receipts or expenditures in excess of $1,000,000 in the aggregate or $300,000
per annum and is not cancelable by the Company within one year without penalty;

            (B) purports to impose any non-compete or exclusivity provisions in
the Designated Territory with respect to, or otherwise purports to restrict in
any material respect the development, marketing or distribution of or the
conduct of the Company's, its Subsidiaries' or its Affiliates' business with
respect to, drug delivery technology, marketed products or products in human
clinical trials, except for Contracts listed under Section 3.8(a)(ii)(E);

            (C) relates to the registration of securities;

            (D) is with an Affiliate of the Company (other than any Subsidiary
of the Company), excluding any Company Benefit Agreements;

            (E) relates in a material manner to the research, development,
distribution, sale, supply, license, marketing, manufacturing or
commercialization of Company Products & Technology, provides an exclusive
license to a third party relating to Intellectual Property Rights of the
Company, or is the in-license of material Intellectual Property relating to
Company Products & Technology other than pre-clinical trial agreements, clinical
trial agreements and service agreements entered into in the ordinary course of
business consistent with past practice;

            (F) would prohibit or materially delay the consummation of the
Merger or any of the other transactions contemplated by this Agreement; or

            (G) is a "material contract" (as such term is defined in Item
601(b)(10) of Regulation S-K of the SEC).

      Each Contract to which the Company or any of its Subsidiaries is a party
or by which the Company or any of its Subsidiaries is bound of the type
described in clauses (i) and (ii) above is referred to herein as a "Company
Material Contract." The Company has made



                                       17



available to Parent true and complete copies of all Company Material Contracts
as of the date hereof.

      (b) Each Company Material Contract is valid and binding on the Company and
each of its Subsidiaries party thereto and, to the Company's Knowledge, each
other party thereto, and is in full force and effect, except, insofar as this
representation is made as of the Closing Date, as would not be reasonably likely
to have a Material Adverse Effect on the Company. The Company has not received
any written notice from any other party to any Company Material Contract, and
otherwise has no Knowledge, that such third party intends to terminate, not
renew, or challenge the validity or enforceability of any Company Material
Contract, except for such terminations, non-renewals or challenges as would not
be reasonably likely to have a Material Adverse Effect on the Company. Neither
the Company nor any of its Subsidiaries, and, to the Knowledge of the Company,
no other party thereto, is in violation of or in default under (nor does there
exist any condition which upon the passage of time or the giving of notice or
both would cause such a violation of or default under) any Company Material
Contract to which it is a party or by which it or any of its properties or
assets is bound, except for violations or defaults that individually or in the
aggregate are not reasonably likely to have a Material Adverse Effect on the
Company.

      Section 3.9 Compliance with Laws; Permits. Each of the Company and its
Subsidiaries is in compliance with all Laws and rules and regulations of any
stock exchange or regulatory organization applicable to it, its properties or
other assets or its business or operation except for failures to be in
compliance that individually or in the aggregate have not had and would not
reasonably be expected to have a Material Adverse Effect on the Company. Each of
the Company and its Subsidiaries has in full force and effect all approvals,
authorizations, certificates, filings, consents, clearances, franchises,
licenses, notices and permits of or with all Governmental Entities
(collectively, "Permits"), including all Permits under the Federal Food, Drug
and Cosmetic Act of 1938, as amended (the "FDCA"), and the regulations of the
Federal Food and Drug Administration (the "FDA") promulgated thereunder,
necessary for it to own, lease or operate its properties and other assets and to
carry on its business and operations as presently conducted, except where the
failure to have such Permits individually or in the aggregate has not had and
would not reasonably be expected to have a Material Adverse Effect on the
Company. There has occurred no default under, or violation of, any such Permit,
except for any such default or violation that individually or in the aggregate
has not had and would not reasonably be expected to have a Material Adverse
Effect on the Company. The consummation of the Merger, in and of itself, will
not cause the revocation, limitation, suspension or cancellation of any such
Permit that individually or in the aggregate would reasonably be expected to
have a Material Adverse Effect on the Company.

      Section 3.10 Employee Benefit Plans.

      (a) Section 3.10(a) of the Company Disclosure Schedule sets forth a true
and complete list of each "employee benefit plan" as defined in Section 3(3) of
ERISA and any other plan, policy, program, practice, agreement, understanding or
arrangement (whether written or oral) providing compensation or other benefits
to any current or former director, officer, employee or consultant (or to any
dependent or beneficiary thereof) of the Company or any of its Subsidiaries,
which are as of the date hereof, or with respect to any plan intended to be
qualified



                                       18



under Section 401(a) of the Code, were within the past 6 years, maintained,
sponsored or contributed to by the Company or any of its Subsidiaries, or under
which the Company or any of its Subsidiaries has any obligation or liability,
whether actual or contingent, including all incentive, bonus, deferred
compensation, vacation, holiday, cafeteria, medical, disability, stock purchase,
stock option, stock appreciation, phantom stock, restricted stock or other
stock-based compensation plans, policies, programs, practices or arrangements
(each a "Company Benefit Plan"). Neither the Company nor, to the Knowledge of
the Company, any other Person or entity has any express commitment, whether
legally enforceable or not, to modify, change or terminate any Company Benefit
Plan, other than with respect to a modification, change or termination required
by ERISA or the Code or as otherwise contemplated by this Agreement. With
respect to each Company Benefit Plan, the Company has delivered to Parent true
and complete copies of (i) each Company Benefit Plan (or, if not written, a
written summary of its material terms), including all plan documents, adoption
agreements, trust agreements, insurance contracts or other funding vehicles and
all material amendments thereto, (ii) all summaries and summary plan
descriptions, including any summary of material modifications, provided by any
plan provider or to employees generally, (iii) the most recent annual reports
(Form 5500 series) filed with the United States Internal Revenue Service (the
"IRS") or United States Department of Labor (the "DOL") with respect to such
Company Benefit Plan (and, if the most recent annual report is a Form 5500R, the
most recent Form 5500C filed with respect to such Company Benefit Plan), (iv)
the most recent actuarial report or other financial statement relating to such
Company Benefit Plan, if any, (v) the most recent determination or opinion
letter, if any, issued by the IRS with respect to any Company Benefit Plan and
any pending request for such a determination letter, (vi) the most recent
nondiscrimination tests performed under the Code (including 401(k) and 401(m)
tests) for each Company Benefit Plan, if any, and (vii) all filings made with
any Governmental Entity since January 1, 2001, including any filings under the
Voluntary Compliance Resolution or Closing Agreement Program or the Department
of Labor Delinquent Filer Program.

      (b) Each Company Benefit Plan has been administered in all material
respects in accordance with its terms and all applicable Laws, including ERISA
and the Code, and contributions required to be made under the terms of any of
the Company Benefit Plans as of the date of this Agreement have been timely made
or, if not yet due, have been properly reflected on the most recent consolidated
balance sheet filed or incorporated by reference in the Company's SEC filings
prior to the date of this Agreement. With respect to the Company Benefit Plans,
no event has occurred and, to the Knowledge of the Company, there exists no
condition or set of circumstances in connection with which the Company could
reasonably be expected to be subject to any Material Adverse Effect (other than
for routine benefit liabilities) under the terms of, or with respect to, such
Company Benefit Plans, ERISA, the Code or any other applicable Law.

      (c) (i) Each Company Benefit Plan that is intended to qualify under
Section 401(a), Section 401(k), Section 401(m) or Section 4975(e)(6) of the Code
has either received a favorable determination letter from the IRS as to its
qualified status, taking into account the provisions of the legislation
collectively referred to as GATT, or the remedial amendment period for such
Company Benefit Plan has not yet expired, and each trust established in
connection with any Company Benefit Plan that is intended to be exempt from
federal income taxation under Section 501(a) of the Code is so exempt, and to
the Knowledge of the Company no fact or event



                                       19



has occurred that could adversely affect the qualified status of any such
Company Benefit Plan or the exempt status of any such trust, (ii) to the
Knowledge of the Company there has been no prohibited transaction (within the
meaning of Section 406 of ERISA or Section 4975 of the Code and other than a
transaction that is exempt under a statutory or administrative exemption) with
respect to any Company Benefit Plan that could result in liability to the
Company, (iii) each Company Benefit Plan can be amended, terminated or otherwise
discontinued after the Effective Time in accordance with its terms, without
liability (other than benefits payable under the terms of such Company Benefit
Plan and liability for ordinary administrative expenses typically incurred in a
termination event), (iv) no suit, administrative proceeding, action or other
litigation, including any audit or inquiry by the IRS or DOL (other than routine
benefit claims), has been brought, or to the Knowledge of the Company is
threatened, against or with respect to any such Company Benefit Plan, (v)
neither the Company nor any ERISA Affiliate has any liability under ERISA
Section 502(i), and (vi) all Tax, annual reporting and other governmental
filings required by ERISA and the Code with respect to each Company Benefit Plan
have been timely filed in all material respects with the appropriate
Governmental Entity and all notices and disclosures have been timely provided in
all material respects to participants.

      (d) No Company Benefit Plan is a multiemployer pension plan (as defined in
Section 3(37) of ERISA) (a "Multiemployer Plan") or other pension plan subject
to Title IV of ERISA and none of the Company or any ERISA Affiliate has
sponsored or contributed to or been required to contribute to a Multiemployer
Plan or other pension plan subject to Title IV of ERISA. No material liability
under Title IV of ERISA has been incurred by the Company or any ERISA Affiliate
that has not been satisfied in full, and no condition exists that presents a
material risk to the Company or any ERISA Affiliate of incurring or being
subject (whether primarily, jointly or secondarily) to a material liability
thereunder. None of the assets of the Company or any ERISA Affiliate is, or may
reasonably be expected to become, the subject of any lien arising under ERISA or
Section 412(n) of the Code.

      (e) No amount that could be received (whether in cash or property or the
vesting of property), as a result of the consummation of the transactions
contemplated by this Agreement or any other related agreement, by any employee,
officer or director of the Company or any of its Subsidiaries who is a
"disqualified individual" (as such term is defined in Treasury Regulation
Section 1.280G-1) under any Company Benefit Plan could be characterized as an
"excess parachute payment" (as defined in Section 280G(b)(1) of the Code).

      (f) Except as required by applicable Law, no Company Benefit Plan provides
any of the following retiree or post-employment benefits to any Person: medical,
disability or life insurance benefits. The Company and each ERISA Affiliate is
in material compliance with (i) the requirements of the applicable health care
continuation and notice provisions of the Consolidated Omnibus Budget
Reconciliation Act of 1985, as amended, and the regulations (including proposed
regulations) thereunder and any similar state Law and (ii) the applicable
requirements of the Health Insurance Portability and Accountability Act of 1996,
as amended, and the regulations (including the proposed regulations) thereunder.

      (g) With respect to employee benefit plans, programs, and other
arrangements providing incentive compensation or other benefits similar to those
provided under any Company Benefit Plan to any employee or former employee or
dependent thereof, which plan, program or


                                       20



arrangement is subject to the Laws of any jurisdiction outside of the United
States ("Foreign Plans"): (i) the Foreign Plans have been maintained in all
material respects in accordance with all applicable requirements and all
applicable Laws, (ii) if intended to qualify for special tax treatment, the
Foreign Plans meet all requirements for such treatment, (iii) if intended to be
funded and/or book-reserved, the Foreign Plans are fully funded and/or book
reserved, as appropriate, based upon reasonable actuarial assumptions, and (iv)
no material liability exists or reasonably could be imposed upon the assets of
the Company or any of its Subsidiaries by reason of such Foreign Plans.

      (h) There are no pending or, to the Knowledge of the Company, threatened
claims (other than claims for benefits in the ordinary course), lawsuits or
arbitrations which have been asserted or instituted against any Company Benefit
Plan, any fiduciaries thereof with respect to their duties to the Company
Benefit Plans or the assets of any of the trusts under any of the Company
Benefit Plans which could reasonably be expected to result in any material
liability of the Company or any of its Subsidiaries to the Pension Benefit
Guaranty Corporation, the Department of Treasury or the DOL.

      Section 3.11 Labor and Other Employment Matters.

      (a) To the Knowledge of the Company, each of the Company and each of its
Subsidiaries is in compliance with all applicable Laws respecting labor,
employment, fair employment practices, terms and conditions of employment,
workers' compensation, occupational safety, plant closings, and wages and hours.
None of the Company or any of its Subsidiaries is liable for any payment to any
trust or other fund or to any Governmental Entity, with respect to unemployment
compensation benefits, social security or other benefits or obligations for
employees (other than routine payments to be made in the ordinary course of
business and consistent with past practice). None of the Company or any of its
Subsidiaries is a party to any collective bargaining or other labor union
contract applicable to Persons employed by the Company or any of its
Subsidiaries, and, as of the date hereof, no collective bargaining agreement or
other labor union contract is being negotiated by the Company or any of its
Subsidiaries. As of the date hereof, there is no labor dispute, strike, slowdown
or work stoppage against the Company or any of its Subsidiaries pending or, to
the Knowledge of the Company, threatened which may interfere in any respect that
would have a Material Adverse Effect on the Company. No labor union or similar
organization has otherwise been certified to represent any Persons employed by
the Company or any of its Subsidiaries or, as of the date hereof, has applied to
represent such employees or is attempting to organize so as to represent such
employees. None of the Company, any of the Company's Subsidiaries or their
respective employees has committed any unfair labor practices in connection with
the operation of the respective businesses of the Company or any of its
Subsidiaries, and there is no charge or complaint against the Company or any of
its Subsidiaries by the National Labor Relations Board or any comparable state
or foreign agency pending or, to the Knowledge of the Company, threatened,
except where such unfair labor practice, charge or complaint would not,
individually or in the aggregate, reasonably be expected to have a Material
Adverse Effect on the Company. There are no material controversies pending or,
to the Knowledge of the Company, threatened, between the Company or any of its
Subsidiaries and any of their current or former employees, which controversies
have or could reasonably be expected to result in an action, suit, proceeding,
claim, arbitration or investigation before any Governmental Entity. To the
Knowledge of the


                                       21



Company, no employee of the Company or any of its Subsidiaries is in any
material respect in violation of any term of any employment contract,
non-disclosure agreement, non-competition agreement, or any restrictive covenant
to a former employer relating to the right of any such employee to be employed
by the Company or any of its Subsidiaries because of the nature of the business
conducted or presently proposed to be conducted by it or to the use of trade
secrets or proprietary information of others. As of the date hereof, no employee
at the level of director or above of the Company or any of its Subsidiaries has
given written notice terminating his or her employment with the Company or any
of its Subsidiaries.

      (b) The Company has identified in Section 3.11(b) of the Company
Disclosure Schedule and has made available to Parent true and complete copies
of:

            (i) (A) all severance and employment agreements with directors,
officers or employees of the Company or any of its Subsidiaries in effect as of
the date hereof, and (B) all consulting agreements in effect as of the date
hereof to which the Company or any of its Subsidiaries is a party that (1)
require a payment by the Company or a Subsidiary upon termination of such
agreement prior to the end of its current term, or (2) are not terminable with
or without cause within six months;

            (ii) all severance programs and policies of the Company and each of
its Subsidiaries with or relating to its employees in effect as of the date
hereof; and

            (iii) all plans, programs, agreements and other arrangements of the
Company and each of its Subsidiaries with or relating to its directors,
officers, employees or consultants which contain change in control provisions in
effect as of the date hereof (all agreements and arrangements in clauses (i)
through (iii), the "Company Benefit Agreements").

None of the execution and delivery of this Agreement or any other related
agreement or the consummation of the transactions contemplated hereby or thereby
will (either alone or in conjunction with any other event, such as termination
of employment) (i) result in any payment (including severance, unemployment
compensation, parachute or otherwise) becoming due to any director or any
employee of the Company or any of its Subsidiaries or Affiliates from the
Company or any of its Subsidiaries or Affiliates under any Company Benefit Plan
or otherwise, (ii) significantly increase any benefits otherwise payable under
any Company Benefit Plan or (iii) result in any acceleration of the time of
payment or vesting of any material benefits. As of the date hereof, no
individual who is a party to an employment agreement listed in Section 3.11(b)
of the Company Disclosure Schedule or any agreement incorporating change in
control provisions with the Company has terminated employment or been
terminated, nor to the Knowledge of the Company has any event occurred that
could give rise to a termination event, in either case under circumstances that
has given, or could give, rise to a severance obligation on the part of the
Company under such agreement.

      (c) The Company has provided Parent a list identifying as of the date
hereof all full-time and part-time employees of the Company and its Subsidiaries
and the employees' respective positions therewith.

      Section 3.12 Taxes.



                                       22


      (a) The Company and each of its Subsidiaries has duly and timely filed
with the appropriate Tax authorities or other Governmental Entities all Tax
Returns that it was required to file. All such Tax Returns are true and complete
in all material respects. All Taxes due and owing by any of the Company and its
Subsidiaries (whether or not shown on any Tax Returns) have been paid. Neither
the Company nor any of the Company's Subsidiaries currently is the beneficiary
of any extension of time within which to file any material Tax Return. No
written claim has ever been made by a Tax authority in a jurisdiction where any
of the Company and its Subsidiaries does not file Tax Returns that it is or may
be subject to taxation by that jurisdiction.

      (b) The unpaid Taxes of the Company and its Subsidiaries did not, as of
the date of the financial statements contained in the most recent Company SEC
Filings, exceed the reserve for Tax liability (excluding any reserve for
deferred Taxes established to reflect timing differences between book and Tax
income) set forth on the face of the balance sheets (rather than in any notes
thereto) contained in such financial statements. Since the date of the financial
statements in the most recent Company SEC Filings, neither the Company nor any
of its Subsidiaries has incurred any liability for Taxes outside the ordinary
course of business or otherwise inconsistent with past custom and practice.

      (c) No deficiencies for Taxes with respect to any of the Company and its
Subsidiaries have been claimed in writing, proposed or assessed by a Tax
authority. There are no pending or, based on written notice, threatened audits,
assessments, administrative proceedings, court proceedings or other actions for
or relating to any liability in respect of material Taxes of any of the Company
or its Subsidiaries. There are no matters under discussion with any Tax
Authority with respect to Taxes that are likely to result in an additional
liability for Taxes with respect to any of the Company or its Subsidiaries. No
issues relating to Taxes of the Company or any of its Subsidiaries were raised
by the relevant Tax authority in any completed audit or examination that would
reasonably be expected to recur with a Material Adverse Effect on Taxes in a
later taxable period. The Company has delivered or made available to Parent true
and complete copies of federal, state and local income Tax Returns of each of
the Company and its Subsidiaries and their predecessors for the years ended
December 31, 1997, 1998, 1999, 2000, 2001, 2002 and promptly upon their
availability, 2003, and true and complete copies of all examination reports and
statements of deficiencies assessed against or agreed to by any of the Company
and its Subsidiaries or any predecessors since December 31, 1999, with respect
to Taxes of any type. Neither the Company nor any of its Subsidiaries nor any
predecessor has waived any statute of limitations in respect of Taxes or agreed
to any extension of time with respect to a Tax assessment or deficiency, nor has
any request been made in writing for any such extension or waiver.

      (d) There are no material Liens for Taxes upon the assets of any of the
Company and its Subsidiaries (other than with respect to Permitted Liens for
Taxes or Liens for Taxes that are being contested in good faith and for which an
adequate reserve has been established). No power of attorney (other than powers
of attorney authorizing employees of the Company or any of its Subsidiaries to
act on behalf of the Company or such Subsidiaries, respectively) with respect to
any Taxes has been executed or filed with any Tax authority.




                                       23


      (e) None of the Company nor any of its Subsidiaries has been a United
States real property holding corporation within the meaning of Section 897(c)(2)
of the Code during the applicable period specified in Section 897(c)(1)(A)(ii)
of the Code. Each of the Company and its Subsidiaries has, within the time and
in the manner prescribed by applicable Law, withheld and paid over all material
Taxes required to have been withheld and paid over in connection with amounts
paid or owing to any employee, independent contractor, creditor, stockholder or
other third party (whether domestic or foreign).

      (f) Neither the Company nor any of its Subsidiaries has any liability for
the Taxes of any other Person (other than the Company and any of its
Subsidiaries) under Treasury Regulation Section 1.1502 - 6 (or any similar
provision of state, local, or foreign Law), as a transferee, by contract, or
otherwise. None of the Company nor any of its Subsidiaries has been a member of
an affiliated group filing a consolidated federal income Tax Return (other than
a group the common parent of which is the Company). None of the Company nor any
of its Subsidiaries is a party to, is bound by or has any obligation under any
Tax sharing, Tax allocation or Tax indemnity agreement or similar Contract or
arrangement.

      (g) Neither the Company nor any of its Subsidiaries has distributed the
stock of any corporation in a transaction satisfying the requirements of Section
355 of the Code since April 16, 1997, and neither the stock of the Company nor
the stock of any of its Subsidiaries has been distributed in a transaction
satisfying the requirements of Section 355 of the Code since April 16, 1997.

      (h) Neither the Company nor any of its Subsidiaries (i) is a partner for
Tax purposes with respect to any joint venture, partnership, or other
arrangement or contract which is treated by the parties as a partnership for Tax
purposes, (ii) owns a single member limited liability company which is treated
as a disregarded entity, (iii) is a "United States shareholder" (as defined in
Section 951(b) of the Code) of a "controlled foreign corporation" as defined in
Section 957 of the Code, (iv) is a "personal holding company" as defined in
Section 542 of the Code or (v) is a "passive foreign investment company" within
the meaning of Section 1297 of the Code.

      (i) Neither the Company nor any of its Subsidiaries has entered into or
participated in any transaction identified as a "listed transaction" for
purposes of Treasury Regulations Sections 1.6011-4(b)(2) or 301.6111-2(b)(2).

      Section 3.13 Environmental Matters. Except as disclosed in the Filed
Company SEC Filings:

      (a) The Company and each of its Subsidiaries (i) are in compliance with
all, and are not subject to any liability, in each case with respect to any,
applicable Environmental Laws, (ii) hold or have applied for all Environmental
Permits necessary to conduct their current operations and (iii) are in
compliance with their respective Environmental Permits, except, in each case, as
would not, and would not reasonably be expected to, individually or in the
aggregate have a Material Adverse Effect on the Company.

      (b) Since January 1, 2000, neither the Company nor any of its Subsidiaries
has received any written notice, demand, letter, claim or request for
information from any


                                       24



Governmental Entity alleging that the Company or any of its Subsidiaries may be
in violation of, or liable under, any Environmental Law. Since January 1, 2000
to the date hereof, neither the Company nor any of its Subsidiaries has received
any written notice, demand, letter, claim or request for information alleging
that the Company or any of its Subsidiaries may be in violation of, or liable
under, any Environmental Law.

      (c) Since January 1, 2000, neither the Company nor any of its Subsidiaries
(i) has entered into or agreed to any consent decree or order or is subject to
any judgment, decree or judicial order relating to compliance with Environmental
Laws, Environmental Permits or the investigation, sampling, monitoring,
treatment, remediation, removal or cleanup of Hazardous Materials and, to the
Knowledge of the Company, no investigation, litigation or other proceeding is
pending or threatened in writing with respect thereto or (ii) is an indemnitor
in connection with any claim threatened or asserted in writing by any
third-party indemnitee for any liability under any Environmental Law or relating
to any Hazardous Materials.

      (d) None of the real property owned or leased by the Company or any of its
Subsidiaries is listed or, to the Knowledge of the Company, proposed for listing
on the "National Priorities List" under CERCLA.

      (e) There have been no Hazardous Materials generated by the Company or any
of its Subsidiaries that have been disposed of by the Company, or to its
Knowledge, any third party, or come to rest at any site that has been listed or,
to the Knowledge of the Company, proposed for listing on the "National
Priorities List" under CERCLA, as updated through the date hereof, or any
similar state or foreign list of sites requiring investigation or cleanup,
except as would not, and would not reasonably be expected to, individually or in
the aggregate, have a Material Adverse Effect on the Company.

      Section 3.14 Title to Properties.

      (a) Each of the Company and its Subsidiaries has good and valid title to,
or valid leasehold or sublease interests or other comparable contract rights in
or relating to all of its properties and other assets (other than Intellectual
Property and other intangible assets) necessary for the conduct of its business
as currently conducted, except as have been disposed of in the ordinary course
of business consistent with past practice and except for defects in title,
easements, restrictive covenants and similar encumbrances that individually or
in the aggregate have not materially interfered with, and would not reasonably
be expected to materially interfere with, its ability to conduct its business as
presently conducted. All such properties and other assets, other than properties
and other assets in which the Company or any of its Subsidiaries has a leasehold
or sublease interest or other comparable contract right, are free and clear of
all Liens, except for Permitted Liens and for defects in title, easements,
restrictive covenants and similar encumbrances that individually or in the
aggregate have not materially interfered with, and would not reasonably be
expected to materially interfere with, its ability to conduct its business as
presently conducted.

      (b) Each of the Company and its Subsidiaries has complied with the terms
of all leases or subleases to which it is a party and under which it is in
occupancy, and all leases to which the Company is a party and under which it is
in occupancy are in full force and effect, except for such failure to comply or
be in full force and effect that individually or in the


                                       25



aggregate has not had and would not reasonably be expected to have a Material
Adverse Effect on the Company. Each of the Company and its Subsidiaries is in
possession of the properties or assets purported to be leased under all its
leases, except for such failure to be in possession that individually or in the
aggregate has not had and would not reasonably be expected to have a Material
Adverse Effect on the Company. Neither the Company nor any of its Subsidiaries
has received as lessee any written notice from the lessor of any event or
occurrence that has resulted or could result (with or without the giving of
notice, the lapse of time or both) in a default with respect to any material
lease or sublease to which it is a party.

      Section 3.15 Intellectual Property.

      (a) Section 3.15(a) of the Company Disclosure Schedule sets forth, as of
the date hereof, a true and complete list of all patents and applications
therefor, registered trademarks and applications therefor and material domain
name registrations owned by the Company or any of its Subsidiaries. Such
intellectual property rights as listed in Section 3.15(a) of the Company
Disclosure Schedule, together with any rights in the Intellectual Property owned
or licensed by the Company or any of its Subsidiaries, are collectively referred
to herein as "Intellectual Property Rights." All Intellectual Property Rights
necessary to conduct the business of the Company and its Subsidiaries as
presently conducted (including the manufacture, use or sale of Company Products
& Technology) are either (i) owned by, or subject to an obligation of assignment
to, the Company or a Subsidiary of the Company free and clear of all Liens other
than Permitted Liens or (ii) licensed to the Company or a Subsidiary of the
Company free and clear of all Liens, other than Permitted Liens, subject in the
case of both (i) and (ii) to any rights granted by the Company or its
Subsidiaries to any third party pursuant to any license agreements disclosed in
the Company Disclosure Schedule or under a license to use such information for
evaluation purposes provided pursuant to confidentiality and nondisclosure
agreements or material transfer agreements entered into in the ordinary course
of business. There are no actions, suits, proceedings or claims pending or, to
the Knowledge of the Company, threatened in writing or in a manner that would
reasonably be expected to result in any actions, suits, proceedings or claims
with regard to the ownership or licensing by the Company or any of its
Subsidiaries of any Intellectual Property Rights.

      (b) To the Knowledge of the Company, the Intellectual Property Rights of
the Company or any of its Subsidiaries have not been infringed or
misappropriated, and are not being infringed or misappropriated, in a manner
which individually or in the aggregate has had or would reasonably be expected
to have a Material Adverse Effect on the Company.

      (c) There are no actions, suits, proceedings or claims pending or, to the
Knowledge of the Company, threatened in writing or in a manner that would
reasonably be expected to result in any actions, suits, proceedings or claims
claiming that the Company or any of its Subsidiaries has infringed or is
infringing (including with respect to the manufacture, use or sale by the
Company or any of its Subsidiaries of any Company Products & Technology or to
the operations of the Company and its Subsidiaries) any intellectual property
rights of any Person. To the Knowledge of the Company, there is no intellectual
property right or other legal right (except as may be contained in any Company
Material Contract) that could be asserted by a Person to exclude or prevent the
Company or any of its Subsidiaries from developing, manufacturing, using or
selling any Company Products & Technology that is material to the


                                       26



conduct of the business of the Company and its Subsidiaries. To the Knowledge of
the Company, other than pursuant to a license to use such information for
evaluation purposes provided pursuant to nondisclosure agreements or material
transfer agreements entered into in the ordinary course of business, there is no
contractual restriction on the use of any Intellectual Property Rights which are
owned by or licensed to the Company, other than as set forth in the agreements
identified in the Company Disclosure Schedule.

      (d) The patent applications listed in Section 3.15(a) of the Company
Disclosure Schedule that are owned by the Company or any of its Subsidiaries are
pending and have not been abandoned (except in the ordinary course of
prosecution), and have been prosecuted in the ordinary course. All patents,
registered trademarks and applications therefor owned by the Company or any of
its Subsidiaries that are material to the conduct of the business of the Company
or its Subsidiaries have been duly registered and/or filed with or issued by
each appropriate Governmental Entity in the jurisdiction(s) indicated in Section
3.15(a) of the Company Disclosure Schedule, all necessary affidavits of
continuing use have been timely filed, and all necessary maintenance fees have
been timely paid to continue all such rights in effect except with respect to
abandoned applications, patents or trademarks in the ordinary course of
prosecution and maintenance. None of the patents listed in Section 3.15(a) of
the Company Disclosure Schedule that are owned by the Company or any of its
Subsidiaries has been declared invalid, in whole or in part, by any Governmental
Entity. There are no ongoing interferences, oppositions, reissues,
reexaminations or other proceedings involving any of the patents or patent
applications listed in Section 3.15(a) of the Company Disclosure Schedule and
owned by the Company or any of its Subsidiaries, including ex parte and
post-grant proceedings, in the United States Patent and Trademark Office or in
any foreign patent office or similar administrative agency, other than such
interferences, oppositions, reissues, reexaminations or proceedings that
individually or in the aggregate have not had and would not reasonably be
expected to have a Material Adverse Effect on the Company. Each of the patents
owned by the Company or any of its Subsidiaries to the Knowledge of the Company
does not fail to name an inventor or name a Person not an inventor of the claims
thereof under circumstances that would rise to the level of a violation of 37
CFR 1.56(c) or foreign equivalent thereof as determined in accordance with the
Laws of the jurisdiction in which such patent is issued. Each inventor named on
the patents and patent applications listed in Section 3.15(a) of the Company
Disclosure Schedule that are owned by the Company or any of its Subsidiaries,
alone or together with any joint owners, has executed an agreement agreeing to
assign or actually assigning his or her entire right, title and interest in and
to such patent or patent application, and the inventions embodied and claimed
therein, to the Company or a Subsidiary of the Company, alone or together with
any joint owners as appropriate. To the Knowledge of the Company, no such
inventor has any contractual or other obligation that would preclude any such
assignment or otherwise conflict with the obligations of such inventor to the
Company or such Subsidiary or appropriate owners under such agreement with the
Company or such Subsidiary or such appropriate owners, as the case may be.

      (e) Section 3.15(e) of the Company Disclosure Schedule sets forth a true
and complete list of all Contracts with respect to any options, rights or
licenses relating to Intellectual Property Rights granted (i) to the Company or
any of its Subsidiaries (other than Contracts commonly generated in the ordinary
course of business (including software licenses for generally available
software, employee assignment agreements, nondisclosure agreements, consulting
agreements, material transfer agreements, service agreements, clinical trial
agreements and



                                       27




evaluation agreements)) or (ii) by the Company or any of its Subsidiaries to any
other Person (other than agreements commonly generated in the ordinary course of
business (including software licenses for generally available software, employee
assignment agreements, nondisclosure agreements, consulting agreements, material
transfer agreements, service agreements, clinical trial agreements and
evaluation agreements)), in the case of each of clauses (i) and (ii) other than
Contracts that are not material to the business of the Company and its
Subsidiaries taken as a whole. Section 3.15(e) of the Company Disclosure
Schedule sets forth, as of the date hereof, all Contracts under which the
Company or any Subsidiary of the Company is obligated to make any payments of
amounts in excess of $50,000 (in any form, including royalties, milestones and
other contingent payments) to third parties for use of any Intellectual Property
Rights with respect to the commercialization of any of the Company Products &
Technology.

      (f) The Company and its Subsidiaries have taken reasonable steps to
maintain their material trade secrets in confidence, including entering into
Contracts that generally require licensees, contractors and other third persons
with access to such trade secrets to keep such trade secrets confidential.

      (g) Section 3.15(g) of the Company Disclosure Schedule sets forth a true
and complete list of each application or official request for any extension
(i.e., under Hatch-Waxman) of the term of any patent owned or licensed by the
Company or any of its Subsidiaries relating to any Company Products & Technology
that was subject to regulatory review, including an identification of the patent
and the term extension requested.

      (h) As used in this Agreement, "Company Products & Technology" means the
drug products or candidates being sold or manufactured by the Company or that
are the subject of human clinical trials conducted for or by the Company, each
of which is set forth in Section 3.15(h) of the Company Disclosure Schedule, and
the drug delivery platform technologies listed in Section 3.15(h) of the Company
Disclosure Schedule.

      Section 3.16 Development, Distribution, Marketing, Supply and
Manufacturing Agreements. Section 3.16 of the Company Disclosure Schedule sets
forth, as of the date hereof, a true and complete list of all Contracts to which
the Company or any of its Subsidiaries is a party (i) relating in a material
manner to research, development, distribution, sale, supply, license, marketing
or manufacturing of any product of the Company or any Subsidiary of the Company
or any product or patent or other Intellectual Property Right licensed by the
Company or any Subsidiary of the Company to any third party, in each case that
have a remaining value of $250,000 or more individually and (ii) relating in a
material manner to the distribution by third parties of any product of the
Company or any Subsidiary of the Company or any product or patent or other
Intellectual Property Right licensed by the Company or any Subsidiary of the
Company to any third party. The Company has made available to Parent a true and
complete copy of each such Contract.

      Section 3.17 Regulatory Compliance.

      (a) As to each product subject to the FDCA and the FDA regulations
promulgated thereunder or similar Laws in any foreign jurisdiction that are
developed, manufactured, tested, distributed, labeled, stored and/or marketed by
the Company or any of its


                                       28



Subsidiaries (each such product, a "Medical Device", a "Biologic" or a "Drug",
as the case may be), each such Medical Device, Biologic or Drug is being
developed, manufactured, tested, distributed, labeled, stored and/or marketed by
the Company and, to the Knowledge of the Company, marketed, by each other Person
developing, manufacturing, testing, distributing, labeling, storing and/or
marketing such Medical Device or Drug on behalf of the Company, in compliance
with all applicable FDA, state and foreign Laws, including those relating to
investigational use, premarket clearance or marketing approval to test,
manufacture or market a Medical Device, and investigational new drug
applications, investigational device exemptions, new drug applications,
biological license applications or abbreviated new drug applications to test,
manufacture or market a new Biologic or a new Drug, good manufacturing and
quality systems requirements, labeling, advertising, record keeping, filing of
reports and security, and in compliance with the American Medical Association's
guidelines on gifts to physicians, except for failures in compliance that
individually or in the aggregate have not had and would not reasonably be
expected to have a Material Adverse Effect on the Company. As of the date
hereof, neither the Company nor any of its Subsidiaries has received and, to the
Knowledge of the Company, none of its or its Subsidiaries' licensees have
received, any material notice or other material communication from the FDA or
any other Governmental Entity (i) contesting the investigational or premarket
clearance or approval of, the testing of, the uses of or the labeling or
promotion of any products of the Company or any of its Subsidiaries or (ii)
otherwise alleging any material violation applicable to any Medical Device,
Biologic or Drug by the Company or any of its Subsidiaries of any Law, including
Notice of Inspectional Observations (Form FDA 483), Notices of Adverse Findings,
Warning Letters, Untitled Letters or other similar communication by any
Governmental Entity.

      (b) No Medical Device, Biologic or Drug is under consideration for or has
been recalled, withdrawn, suspended, or discontinued (other than for commercial
or other business reasons) or required a field notification, field alert, or
field correction by the Company or any of its Subsidiaries in the United States
or outside the United States (whether voluntarily or otherwise). No proceedings
in the United States or outside of the United States of which the Company has
Knowledge (whether completed or pending) seeking the recall, withdrawal,
suspension, seizure or discontinuance of any Medical Device, Biologic or Drug
are pending against the Company or any of its Subsidiaries or, to the Knowledge
of the Company, any licensee of any Medical Device, Biologic or Drug, nor have
any such proceedings been pending at any time in the five year period prior to
the date hereof. To the Knowledge of the Company, there are no facts,
circumstances or conditions that would reasonably be expected to form the basis
for any audit, investigation, suit, claim, action (legal or regulatory) or
proceeding (legal or regulatory) with respect to a recall, withdrawal,
suspension, seizure or discontinuance, or a change in the marketing
classification or labeling of any Drug, Medical Device or Biologic of the
Company or with respect to any of the Company Products & Technology. True and
complete copies of all material data of the Company with respect to the safety
or efficacy of the Medical Devices, Biologics, Drugs or Company Products &
Technology have been made available to Parent.

      (c) All clinical trials and, to the Knowledge of the Company, all studies,
tests and preclinical studies conducted by or on behalf of the Company or any of
its Subsidiaries were and, if still pending, are being conducted in all material
respects in accordance with experimental protocols, procedures and controls
pursuant to accepted professional scientific standards and all


                                       29



applicable Laws and Permits. The descriptions of the results of such studies,
tests and trials submitted to FDA and other Governmental Entities are true and
complete in all material respects and fairly present the data derived from such
studies, tests and trials, and neither the Company nor any of its Subsidiaries
has Knowledge of any such studies, tests or trials the results of which the
Company or any of its Subsidiaries believes reasonably call into question its
studies, tests, or trial results. Neither the Company nor any of its
Subsidiaries has received any notices or correspondence from any Governmental
Entity requiring the termination of, suspension of, or modification which
materially affects the design, end points or intended purpose of, any studies,
tests or preclinical or clinical trials conducted by or on behalf of the Company
or any of its Subsidiaries.

      (d) All reports, documents, claims, notices, or approvals required to be
filed, obtained, maintained, or furnished to any Governmental Entity for each
material Medical Device, Biologic or Drug by the Company or any of its
Subsidiaries have been so filed, obtained, maintained or furnished, and all such
reports, documents, claims and notices were true and complete in all material
respects on the date filed (or were corrected in or supplemented by a subsequent
filing). As to each Medical Device, Biologic or Drug of the Company or any of
its Subsidiaries for which a premarket approval application, biological license
application, new drug application, premarket clearance or approval,
investigational new drug application, ANDA investigational device exemption
other state or foreign regulatory application has been submitted, approved or
cleared, the Company and its Subsidiaries are in compliance with all legal
requirements including 21 U.S.C. Sections 360c and 355 or 21 C.F.R. Parts
800, 312, 314, 600 or 601 et seq., respectively, and other applicable Laws and
all terms and conditions of such licenses or applications, except for any such
failure or failures to be in compliance which individually or in the aggregate
has not had and would not reasonably be expected to have a Material Adverse
Effect on the Company. As to each such Drug, the Company and any relevant
Subsidiary of the Company, and the officers, employees or agents of the Company
or such Subsidiary, have included in the application for such Drug, where
required, the certification described in 21 U.S.C. Section 335a(k)(1) or any
similar Law and the list described in 21 U.S.C. Section 335a(k)(2) or any
similar Law, and each such certification and list was true and correct in all
material respects when made. In addition, the Company and its Subsidiaries are
in substantial compliance with all applicable registration and listing
requirements set forth in 21 U.S.C. Section 360 and 21 C.F.R. Part 207 and all
similar Laws.

      (e) No article of any Medical Device, Biologic or Drug manufactured and/or
distributed by the Company or any of its Subsidiaries is (i) adulterated within
the meaning of 21 U.S.C. Section 351 (or similar Laws) (ii) misbranded within
the meaning of 21 U.S.C. Section 352 (or similar Laws) or (iii) a product that
is in violation of 21 U.S.C. Section 355, Section 360c or 42 U.S.C. Section 262
(or similar Laws), except for failures to be in compliance with the foregoing
that individually or in the aggregate have not had and would not reasonably be
expected to have a Material Adverse Effect on the Company.

      (f) Neither the Company nor any of its Subsidiaries, nor, to the Knowledge
of the Company, any officer, Affiliate, employee or agent of the Company or any
of its Subsidiaries, has made an untrue statement of a material fact or
fraudulent statement to the FDA or any other Governmental Entity, failed to
disclose a material fact required to be disclosed to the FDA or any other
Governmental Entity, or committed an act, made a statement, or failed to


                                       30




make a statement that, at the time such disclosure was made, would reasonably be
expected to provide a basis for the FDA or any other Governmental Entity to
invoke its policy respecting "Fraud, Untrue Statements of Material Facts,
Bribery, and Illegal Gratuities", set forth in 56 Fed. Reg. 46191 (September 10,
1991) or any similar policy. Neither the Company nor any of its Subsidiaries,
nor, to the Knowledge of the Company, any officer, employee or agent of the
Company or any of its Subsidiaries, has been convicted of any crime or engaged
in any conduct for which debarment is mandated by 21 U.S.C. Section 335a(a), or
any similar Law or authorized by 21 U.S.C. Section 335a(b), or any similar Law.

      (g) Neither the Company nor any of its Subsidiaries has received any
written notice that the FDA or any other Governmental Entity has (i) commenced,
or threatened to initiate, any action to withdraw its approval or request the
recall of any Medical Device, Biologic or Drug, (ii) commenced, or threatened to
initiate, any action to enjoin production of any Medical Device, Biologic or
Drug or (iii) to the Company's Knowledge, commenced, or threatened to initiate,
any action to enjoin the production of any Medical Device, Biologic or Drug
produced at any facility where any Medical Device, Biologic or Drug is
manufactured, tested or packaged, except for any such action that individually
or in the aggregate has not had and would not reasonably be expected to have a
Material Adverse Effect on the Company.

      (h) To the Knowledge of the Company, there are no facts, circumstances or
conditions that would reasonably be expected to form the basis for any material
investigation, suit, claim, audit, action (legal or regulatory) or proceeding
(legal or regulatory) by a Governmental Entity against or affecting the Company
or any of its Subsidiaries relating to or arising under (i) the FDCA or the
regulations of the FDA promulgated thereunder or (ii) the Health Care Laws.

      (i) Notwithstanding the foregoing, each representation and warranty made
by the Company in this Section 3.17 with respect to the Medical Devices,
Biologics or Drugs licensed by the Company to third parties (to the extent the
Company has assumed or retained no responsibility for regulatory compliance) set
forth on Section 3.17(h) of the Company Disclosure Schedule shall be deemed to
be limited to the Company's Knowledge.

      Section 3.18 Corporate Governance Matters.

      (a) The Company and to the Company's Knowledge each of its officers are in
compliance in all material respects with (i) the applicable provisions of the
Sarbanes-Oxley Act of 2002 and the related rules and regulations promulgated
under such act or the Exchange Act (in each case, as currently in effect, the
"Sarbanes-Oxley Act") and (ii) the applicable qualification requirements and
corporate governance rules and regulations promulgated by the National
Association of Securities Dealers. The Company has delivered to Parent the
information required to be disclosed by the Company and certain of its officers
to the Company's Board of Directors or any committee thereof pursuant to the
certification requirements of Rule 13a-14 under the Exchange Act. Since the date
such provisions became applicable to the Company and its Subsidiaries, all
auditing services and non-audit services provided to the Company and each of its
Subsidiaries have been approved by the audit committee of the Company's Board of
Directors in compliance with Section 10A(h) or Section 10A(i) of the Exchange
Act, and to the Company's Knowledge, no registered public accounting firm or any
associate thereof that


                                       31



performs any audit for the Company or any of its Subsidiaries has provided to
the Company or any of its Affiliates any service prohibited by Section 10A(g) of
the Exchange Act. Except as permitted by the Exchange Act, including Sections
13(k)(2) and (3), since the enactment of the Sarbanes-Oxley Act, neither the
Company nor any of its Subsidiaries has, directly or indirectly, made, entered
into, arranged, renewed, modified (in any material way) or forgiven any personal
loans to any executive officer or director of the Company.

      (b) The management of the Company has (i) in accordance with Rule 13a-15
under the Exchange Act, designed disclosure controls and procedures (as such
term is defined in Rule 13a-15(e) under the Exchange Act) to ensure that
material information relating to the Company, including its Subsidiaries, is
made known to the management of the Company by others within those entities, and
(ii) disclosed, based on its most recent evaluation prior to the date hereof, to
the Company's auditors and the audit committee of the Company's Board of
Directors (A) any significant deficiencies in the design or operation of
internal controls over financial reporting ("Internal Controls") which are
reasonably likely to adversely affect the Company's ability to record, process,
summarize and report financial information and has disclosed to the Company's
auditors any material weaknesses in Internal Controls and (B) any fraud, whether
or not material, that involves management or other employees who have a
significant role in the Company's Internal Controls. The Company has made
available to Parent a summary of any such disclosure made by management to the
Company's auditors and/or audit committee since December 31, 2003.

      Section 3.19 Insurance. Section 3.19 of the Company Disclosure Schedule
contains a true and complete list of all policies of fire, liability, workers'
compensation, title and other forms of insurance owned, held by or applicable to
the Company (or its assets or business) as of the date hereof, and the Company
has heretofore made available to Parent a true and complete copy of all such
policies, including all occurrence-based policies applicable to the Company (or
its assets or business) for all periods prior to the Closing Date. All such
policies (or substitute policies with substantially similar terms and
underwritten by insurance carriers with substantially similar or higher ratings)
are in full force and effect, all premiums due with respect thereto have been
paid as of the date hereof, and, insofar as this representation is made as of
the Closing Date, there has not been a lapse of coverage between the date hereof
and the Effective Time with respect to the matters covered by any such policies.
Such policies are sufficient for compliance by the Company in all material
respects with all Contracts to which the Company is a party, and each of the
Company and its Subsidiaries has complied in all material respects with the
provisions of each such policy under which it is an insured party. There are no
pending or, to the Knowledge of the Company, threatened claims under any
insurance policy that individually or in the aggregate have had or would
reasonably be expected to have a Material Adverse Effect on the Company

      Section 3.20 Voting Requirements. The affirmative vote of holders of a
majority of the outstanding shares of Company Common Stock at the Company
Stockholders' Meeting or any adjournment or postponement thereof to adopt this
Agreement and approve the Merger (the "Company Stockholder Approval") is the
only action or vote of the holders of any class or series of capital stock of
the Company necessary to adopt this Agreement and approve the transactions
contemplated hereby.




                                       32



      Section 3.21 State Takeover Statutes; Self-Dealing. The Board of Directors
of the Company has approved the terms of this Agreement and the consummation of
the Merger and the other transactions contemplated by this Agreement, and such
approval represents all the action necessary to render inapplicable to this
Agreement, the Merger and the other transactions contemplated by this Agreement,
the provisions of Section 203 of the DGCL and the provisions of Section Fifth of
the Company Certificate of Incorporation. No other Delaware or Colorado state
takeover statute (including any "fair price," "merger moratorium" or "control
share acquisition" statute or regulation) or similar Delaware or Colorado
statute or regulation applies to or purports to apply to this Agreement or the
Merger or the other transactions contemplated by this Agreement.

      Section 3.22 Brokers; Advisory Fees. No broker, investment banker,
financial advisor or other Person, other than Banc of America Securities LLC, is
entitled to any broker's, finder's, financial advisor's or other similar fee or
commission in connection with the transactions contemplated by this Agreement
based upon arrangements made by or on behalf of the Company. The Company has
delivered or made available to Parent true and complete copies of all agreements
under which any such fees or expenses are payable and all indemnification and
other agreements related to the engagement of the persons to whom such fees are
payable.

      Section 3.23 Opinion of Financial Advisor. The Board of Directors of the
Company has received the opinion of its financial advisor, Banc of America
Securities LLC, dated the date, or shortly prior to the date, of this Agreement,
to the effect that, as of the date of such opinion, the Merger Consideration to
be received by the holders of shares of Company Common Stock is fair, from a
financial point of view, to such holders. A signed copy of the written opinion
confirming such oral opinion will be delivered to Parent promptly after delivery
thereof to the Company.

      Section 3.24 Company Rights Plan. Neither the execution and delivery of
this Agreement nor the consummation of the Merger and the other transactions
contemplated hereby will (a) cause any of the Company Rights to become
exercisable, (b) cause Parent or Merger Sub to be an Acquiring Person (each as
defined in the Company Rights Plan) or (c) give rise to a Distribution Date, a
Stock Acquisition Date, a Section 11(a)(ii) event or a Section 13 Event (each as
defined in the Company Rights Plan).

                                   ARTICLE 4.
             REPRESENTATIONS AND WARRANTIES OF PARENT AND MERGER SUB

      Except as set forth on the disclosure schedule delivered by Parent to the
Company prior to the execution of this Agreement, which disclosure schedule
specifies the section or subsection of this Agreement to which the exception
relates, and subject to Section 9.13 (the "Parent Disclosure Schedule"), Parent
and Merger Sub represent and warrant to the Company as follows:

      Section 4.1 Organization, Standing and Corporate Power. Each of Parent and
its Subsidiaries is a corporation duly organized, validly existing and in good
standing under the Laws of the jurisdiction in which it is organized and has all
requisite corporate power and authority to carry on its business as now being
conducted. Section 4.1 of the Parent Disclosure Schedule contains a true and
complete list of each jurisdiction where Parent is qualified to do


                                       33



business. Each of Parent and its Subsidiaries has corporate or equivalent
qualification to do business and is in good standing in each jurisdiction in
which the nature of its business or the ownership, leasing or operation of its
properties makes such qualification or licensing necessary, other than in such
jurisdictions where the failure to be so qualified or licensed individually or
in the aggregate is not reasonably likely to have a Material Adverse Effect on
Parent. Parent has made available to the Company prior to the execution of this
Agreement true and complete copies of its Notice of Articles (the "Parent Notice
of Articles") and Articles (the "Parent Articles") and the Certificate of
Incorporation and Bylaws of Merger Sub, in each case as amended to the date
hereof. Neither Parent nor Merger Sub is in violation of any of the provisions
of the Parent Notice of Articles or the Parent Articles or its Certificate of
Incorporation or Bylaws, as applicable.

      Section 4.2 Subsidiaries. Section 4.2 of the Parent Disclosure Schedule
lists each of the Subsidiaries of Parent and, for each such Subsidiary, the
jurisdiction under which laws it was organized and, as of the date hereof, each
jurisdiction in which Subsidiary has corporate or equivalent qualification to do
business. All the issued and outstanding shares of capital stock of, or other
equity interests in, each such Subsidiary have been validly issued and are fully
paid and nonassessable and are owned directly or indirectly by Parent free and
clear of all Liens, and free of any restriction on the right to vote, sell or
otherwise dispose of such capital stock or other equity interests. Except with
respect to (a) the securities of non-Affiliates held for investment purposes
which do not constitute more than a 2% interest in any such non-Affiliate or (b)
the capital stock of, or voting securities or equity interests in, its
Subsidiaries, neither Parent nor any of its Subsidiaries owns, directly or
indirectly, any capital stock of, or other voting securities or equity interests
in, any corporation, partnership, joint venture, association or other entity.

      Section 4.3 Capital Structure.

      (a) The authorized capital stock of Parent consists of 500,000,000 Parent
Common Shares and 5,000,000 first preference shares, no par value (the "Parent
Preferred Shares"). At the close of business on June 10, 2004:

            (i) 69,581,317 Parent Common Shares were issued and outstanding;

            (ii) no Parent Common Shares were held by Parent in its treasury;

            (iii) 7,949,457 Parent Common Shares were reserved and available for
issuance pursuant to the Parent Stock Option Plans;

            (iv) 7,066,877 Parent Common Shares were subject to outstanding
Parent Options;

            (v) no Parent Common Shares were subject to vesting and restrictions
on transfer pursuant to agreements with Parent;



                                       34




            (vi) no Parent Preferred Shares were issued or outstanding or were
held by Parent as treasury shares;

            (vii) 9,692,637 Parent Common Shares were reserved and available for
issuance pursuant to conversion of outstanding convertible notes; and

            (viii) Parent has issued Parent Rights pursuant to the Parent Rights
Plan.

      Section 4.3(a) of the Parent Disclosure Schedule sets forth a true and
complete list, as of May 31, 2004, of all Parent Options and all outstanding
Parent Share-Based Awards, granted under the Parent Stock Option Plans or
otherwise, and all outstanding warrants, the number of Parent Common Shares (or
other stock) subject thereto, the grant dates, expiration dates, exercise or
base prices (if applicable) and vesting schedules thereof.

      (b) All outstanding shares of capital stock of Parent are, and all shares
which may be issued pursuant to the Parent Preferred Shares or Parent Options
will be, when issued in accordance with the terms thereof, duly authorized,
validly issued, fully paid and nonassessable, not subject to preemptive rights
and not subject to a hold period under securities Laws of Canada subject to
requirements of general application or the Toronto Stock Exchange (in each case,
other than in respect of control persons). Other than Parent's outstanding 3%
convertible senior notes due 2023 (the "Parent Convertible Notes"), there are no
bonds, debentures, notes or other indebtedness of Parent having the right to
vote (or convertible into, or exchangeable for, securities having the right to
vote) on any matters on which stockholders of Parent may vote.

      (c) Except as set forth above in Section 4.3(a) and except for the Parent
Convertible Notes and the Parent Common Shares to be issued in connection with
the Merger, as of the close of business on June 10, 2004:

            (i) there are not issued, reserved for issuance or outstanding: (A)
any shares of capital stock or other voting securities or equity interests of
Parent or any of its Subsidiaries; (B) any securities of Parent or any of its
Subsidiaries convertible into or exchangeable or exercisable for shares of
capital stock or other voting securities or equity interests of Parent or of any
Subsidiary of Parent; or (C) any warrants, calls, options or other rights to
acquire from Parent or any of its Subsidiaries, and no obligation of Parent or
any of its Subsidiaries to issue, any capital stock, voting securities, equity
interests or securities convertible into or exchangeable or exercisable for
capital stock or voting securities of Parent or any Subsidiary of Parent;

            (ii) there are not any outstanding obligations of Parent or any of
its Subsidiaries to repurchase, redeem or otherwise acquire any such securities
or to issue, deliver or sell, or cause to be issued, delivered or sold, any such
securities; and

            (iii) there are no outstanding contractual obligations of Parent or
any of its Subsidiaries to make any loan or guarantee to, or any equity or other
investment (in the form of a capital contribution or otherwise) in, any of
Parent's Subsidiaries or any other Person, other than guarantees by Parent of
any indebtedness or other obligations of any of its wholly-



                                       35


owned Subsidiaries and other than loans or guarantees made in the ordinary
course consistent with past practice to employees of Parent and its
Subsidiaries.

      (d) The Parent Common Shares to be issued in connection with the Merger,
when issued as contemplated herein, will be duly authorized, validly issued,
fully paid and nonassessable and will not be issued in violation of any
preemptive rights.

      (e) There are no outstanding contractual obligations of Parent or any of
its Subsidiaries (i) affecting the voting rights of, or (ii) except as provided
for in the Parent Convertible Notes, granting any preemptive, right of first
refusal or antidilutive right with respect to, any Parent Common Shares or
Parent Preferred Shares or any capital stock of, or other securities in, any of
Parent's Subsidiaries.

      Section 4.4 Authority; Noncontravention.

      (a) Each of Parent and Merger Sub has all requisite corporate power and
authority to execute and deliver this Agreement and to consummate the
transactions contemplated by this Agreement. The execution and delivery of this
Agreement and the consummation of the transactions contemplated by this
Agreement have been duly authorized by all necessary corporate action on the
part of Parent and Merger Sub and no other corporate proceedings on the part of
Parent or Merger Sub are necessary to authorize this Agreement or to consummate
the transactions contemplated hereby, other than, in the case of Parent with
respect to the consummation of the Merger, obtaining the Parent Shareholder
Approval. This Agreement has been duly executed and delivered by each of Parent
and Merger Sub and, assuming the due authorization, execution and delivery by
the Company, constitutes a legal, valid and binding obligation of Parent and
Merger Sub, as applicable, enforceable against Parent and Merger Sub, as
applicable, in accordance with its terms, subject to bankruptcy, insolvency,
fraudulent transfer, moratorium, reorganization or similar Laws affecting the
rights of creditors generally and the availability of equitable remedies
(regardless of whether such enforceability is considered in a proceeding at
equity or at law). The Board of Directors of Parent, at a meeting duly called
and held, duly adopted resolutions: (i) approving this Agreement, the Share
Issuance and the other transactions to be entered into by Parent contemplated by
this Agreement; (ii) declaring that it is in the best interest of Parent and its
shareholders that Parent enter into this Agreement and that the transactions
contemplated by this Agreement, including the Merger and the Share Issuance, be
consummated, (iii) directing that the Share Issuance be submitted as promptly as
practicable to a vote at the Parent Shareholders' Meeting; (iv) recommending
that the shareholders of Parent approve the Share Issuance and (v) appointing
David R. Bethune as an additional director to the Board of Directors of Parent
effective as of the Effective Time, and appointing David R. Bethune as Vice
Chairman for a period of three months, commencing at the Effective Time, which
resolutions, as of the date of this Agreement, have not been subsequently
rescinded, modified or withdrawn in any way.

      (b) The execution and delivery of this Agreement do not, and (assuming
receipt of Parent Shareholder Approval) the consummation of the Merger and the
other transactions contemplated by this Agreement to be entered into by Parent
or Merger Sub and compliance by Parent and Merger Sub with the provisions of
this Agreement will not: (i) conflict with, or result in any violation or breach
of, or default (with or without notice or lapse of time, or


                                       36




both) under, the Parent Notice of Articles and the Parent Articles or the
Certificate of Incorporation or Bylaws of Merger Sub; (ii) conflict with, or
result in any violation or breach of, or default (with or without notice or
lapse of time, or both) under, or give rise to a right of, or result in,
termination, cancellation or acceleration of any obligation or to the loss of a
benefit under, or result in the creation of any Lien in or upon any of the
properties or other assets of Parent or Merger Sub under, any Contract to which
Parent or Merger Sub is a party or any of their respective properties or other
assets is subject; or (iii) conflict with, or result in any violation or breach
of, or default (with or without notice or lapse of time, or both) under, any Law
applicable to Parent or Merger Sub or their respective properties or other
assets or the rules and regulations of the Toronto Stock Exchange or any other
stock exchange or regulatory organization applicable to Parent or its
Subsidiaries, other than, in the case of clauses (ii) and(iii), any such
conflicts, violations, breaches, defaults, rights, losses or Liens that
individually or in the aggregate have not had and would not reasonably be
expected to have a Material Adverse Effect on Parent or Merger Sub, and subject
to, in the case of clauses (ii) and (iii), the governmental filings, the
obtaining of the Parent Shareholder Approval and the other matters referred to
in Section 4.4(c).

      (c) No consent, approval, order or authorization of, action by or in
respect of, or registration, declaration or filings with, any Governmental
Entity is required by or with respect to Parent or Merger Sub in connection with
the execution and delivery of this Agreement by Parent and Merger Sub or the
consummation by Parent and Merger Sub of the Merger or the other transactions
contemplated by this Agreement by Parent, except for:

            (i) the filing of a premerger notification and report form under the
HSR Act, and the receipt, termination or expiration, as applicable, of approvals
or waiting periods required under the HSR Act or any other applicable
competition, merger control, antitrust or similar Law;

            (ii) the filing with the SEC of (A) the Joint Proxy/Prospectus to be
included in the Registration Statement and (B) such reports under the Exchange
Act as may be required in connection with this Agreement and the transactions
contemplated by this Agreement;

            (iii) the filing of the Certificate of Merger with the Secretary of
State of the State of Delaware and appropriate documents with the relevant
authorities of other states in which Parent or any of its Subsidiaries is
qualified to do business;

            (iv) filings with Governmental Entities to satisfy applicable
requirements of Canadian securities Laws and Blue Sky Laws;

            (v) any filings required under the rules and regulations of Nasdaq
and the Toronto Stock Exchange; and

            (vi) such other consents, approvals, orders, authorizations,
actions, registrations, declarations and filings the failure of which to be
obtained or made individually or in the aggregate would not reasonably be
expected to have a Material Adverse Effect on Parent.




                                       37



            Section 4.5 Parent SEC Filings.

      (a) Parent has since January 1, 2002 timely filed all reports, schedules,
forms, statements and other documents (including exhibits and other information
incorporated therein) (i) that Parent would be required to file with the SEC if
Parent were a reporting person under the Exchange Act (other than requirements
arising under Sections 14 and 16 of the Exchange Act) (collectively, the "Parent
SEC Filings") and (ii) required to be filed by Parent in accordance with
Canadian securities laws (collectively, the "Canadian Filings"). As of their
respective filing dates, and if amended, the date of such amendment, (A) the
Parent SEC Filings complied as to form in all material respects with the
requirements of the Securities Act, the Exchange Act and the rules and
regulations promulgated thereunder applicable to such Parent SEC Filings and (B)
the Canadian Filings complied as to form in all material respects with the
requirements of British Columbia corporate and Canadian securities laws
applicable to such filings. None of the Parent SEC Filings, as of their
respective filing dates, and, if amended, the dates of such amendment, if any,
filed prior to the date hereof, contained any untrue statement of a material
fact or omitted to state a material fact required to be stated therein or
necessary in order to make the statements therein, in light of the circumstances
under which they were made, not misleading. As of the date hereof, except to the
extent that information contained in any Parent SEC Filing has been revised,
amended, supplemented or superseded by a later filed Parent SEC Filing with the
SEC, to the Knowledge of Parent, none of the Parent SEC Filings contains any
untrue statement of a material fact or omits to state any material fact required
to be stated therein or necessary in order to make the statements made therein,
in light of the circumstances under which they were made, not misleading.

      (b) The financial statements (including the related notes) of Parent
included in the Parent SEC Filings complied at the time they were filed, or if
amended, the date of such amendment, as to form in all material respects with
applicable accounting requirements and the published rules and regulations of
the SEC with respect thereto, were prepared in accordance with GAAP (except, in
the case of unaudited statements, as permitted by the rules and regulations of
the SEC) applied on a consistent basis during the periods involved (except as
may be indicated in the notes thereto) and each fairly presented in all material
respects the consolidated financial position of Parent and its consolidated
Subsidiaries as of the respective dates thereof and the consolidated results of
their operations and cash flows for the respective periods then ended (subject,
in the case of unaudited statements, to normal year-end audit adjustments).

      (c) Except as and to the extent set forth on the consolidated balance
sheet of Parent and its Subsidiaries as of December 31, 2003 included in
Parent's Form 10-K for the year ended December 31, 2003, including the notes
thereto (the "Parent Form 10-K"), or in the financial statements included in any
Parent SEC Filing filed prior to the date hereof with the SEC after filing the
Parent Form 10-K, neither Parent nor any of its Subsidiaries has any liabilities
or obligations of any nature (whether accrued, absolute, contingent or
otherwise), except for (i) liabilities or obligations incurred in the ordinary
course of business consistent with past practice since December 31, 2003, (ii)
liabilities and obligations incurred in connection with this Agreement and
Parent's performance of its obligations hereunder, and (iii) liabilities and
obligations that would not reasonably be expected to have a Material Adverse
Effect on Parent.


                                       38


None of the Subsidiaries of Parent are, or have at any time since January 1,
2002 been, subject to the reporting requirements of Sections 13(a) and 15(d) of
the Exchange Act.

      (d) No "material contract" (as such term is defined in Item 601(b)(10) of
Regulation S-K of the SEC) filed as an exhibit to the Parent Form 10-K has been
amended or modified, except for such amendments or modifications that have been
filed with the SEC as an exhibit to a subsequently dated Parent SEC Filing or
would not currently be required to be filed with the SEC if Parent were a
reporting Person under the Exchange Act.

      Section 4.6 Absence of Certain Changes or Events. Except for liabilities
incurred in connection with this Agreement or as permitted pursuant to Section
5.2, since December 31, 2003, except as disclosed in the Filed Parent SEC
Filings, Parent and each of its Subsidiaries have conducted their businesses in
the ordinary course consistent with past practice and there has not been any
Material Adverse Effect on Parent, and from such date to the date hereof there
has not been:

      (a) any material change by Parent or by any of its Subsidiaries in its
accounting methods not required pursuant to GAAP;

      (b) any declaration, setting aside or payment of any dividend or other
distribution with respect to Parent's or any of its Subsidiaries' capital stock;

      (c) any split, combination or reclassification of Parent's or any of its
Subsidiaries' capital stock or any issuance of or the authorization of any
issuance of any other securities in respect of, in lieu of or in substitution
for, shares of its capital stock;

      (d) any revaluation by Parent or any of its Subsidiaries of any of their
assets having a Material Adverse Effect on Parent; or

      (e) any event or development that would, individually or in the aggregate,
reasonably be expected to prevent or materially delay the performance of this
Agreement by Parent.

      Section 4.7 Litigation. Except as and to the extent disclosed in the Filed
Parent SEC Filings there is no suit, claim, action or proceeding pending or, to
the Knowledge of Parent, threatened against or affecting Parent or any of its
Subsidiaries or any of their respective assets that individually or in the
aggregate has had or would reasonably be expected to have a Material Adverse
Effect on Parent, nor is there any judgment, decree, injunction, rule or order
of any Governmental Entity or arbitrator outstanding against, or, to the
Knowledge of Parent, any demand, requirement, investigation, audit, inquiry,
hearing, review or other similar action brought by any Governmental Entity
involving, Parent or any of its Subsidiaries or any of their respective assets
that individually or in the aggregate has had or would reasonably be expected to
have a Material Adverse Effect on Parent. There is no suit, claim, action,
proceeding, enforcement action or investigation pending or, to the Knowledge of
Parent, threatened against Parent or any of its Subsidiaries that, as of the
date hereof, challenges the validity or propriety of, or seeks to prevent
consummation of, the Merger or any other transaction contemplated by this
Agreement.




                                       39



      Section 4.8 Contracts.

      (a) Except as filed as exhibits to the Filed Parent SEC Filings or as
disclosed in Section 4.8 of the Parent Disclosure Schedule, none of Parent or
any of its Subsidiaries is a party to or bound by any Contract which, as of the
date hereof (i) would prohibit or materially delay the consummation of the
Merger or any of the other transactions contemplated by this Agreement; (ii) is
a "material contract" (as such term is defined in Item 601(b)(10) of Regulation
S-K of the SEC); (iii) any of the benefits to any party of which will be
increased, or the vesting of the benefits to any party of which will be
accelerated, by the occurrence of any of the transactions contemplated by this
Agreement or the value of any of the benefits to any party of which will be
calculated on the basis of any of the transactions contemplated by this
Agreement; or (iv) relates to the registration of securities. Each Contract to
which Parent or any of its Subsidiaries is a party or by which Parent or any of
its Subsidiaries is bound of the type described in this Section 4.8, whether or
not set forth in Section 4.8 of the Parent Disclosure Schedule, is referred to
herein as a "Parent Material Contract." As of the date hereof, Parent has made
available to the Company true and complete copies of all Parent Material
Contracts.

      (b) Each Parent Material Contract is valid and binding on Parent and each
of its Subsidiaries party thereto and, to Parent's Knowledge, each other party
thereto, and is in full force and effect, except, insofar as this representation
is made as of the Closing Date, as would not be reasonably likely to have a
Material Adverse Effect on Parent. Parent has not received any written notice
from any other party to any Parent Material Contract, and otherwise has no
Knowledge, that such third party intends to terminate, not renew, or challenge
the validity or enforceability of any Parent Material Contract, except for such
terminations, non-renewals or challenges as would not be reasonably likely to
have a Material Adverse Effect on Parent. Neither Parent nor any of its
Subsidiaries, and, to the Knowledge of Parent, no other party thereto, is in
violation of or in default under (nor does there exist any condition which upon
the passage of time or the giving of notice or both would cause such a violation
of or default under) any Parent Material Contract to which it is a party or by
which it or any of its properties or assets is bound, except for violations or
defaults that individually or in the aggregate are not reasonably likely to have
a Material Adverse Effect on Parent.

      Section 4.9 Compliance with Laws; Permits. Each of Parent and its
Subsidiaries is in compliance with all Laws and rules and regulations of any
stock exchange or regulatory organization applicable to it, its properties or
other assets or its business or operation, except for failures to be in
compliance that individually or in the aggregate have not had and would not
reasonably be expected to have a Material Adverse Effect on Parent. Each of
Parent and its Subsidiaries has in effect all Permits, including all Permits
under the FDCA, and the regulations of the FDA promulgated thereunder, necessary
for it to own, lease or operate its properties and other assets and to carry on
its business and operations as presently conducted, except where the failure to
have such Permits individually or in the aggregate has not had and would not
reasonably be expected to have a Material Adverse Effect on Parent. There has
occurred no default under, or violation of, any such Permit, except for any such
default or violation that individually or in the aggregate has not had and would
not reasonably be expected to have a Material Adverse Effect on Parent. The
consummation of the Merger, in and of itself, will not cause the revocation or
cancellation of any such Permit that individually or in the aggregate would
reasonably be expected to have a Material Adverse Effect on Parent.




                                       40



      Section 4.10 Intellectual Property.

      (a) Parent and/or its Subsidiaries owns or licenses all Intellectual
Property necessary for the conduct of Parent's business, as presently conducted,
free and clear of all Liens other than Permitted Liens, subject to any rights
granted by Parent or its Subsidiaries to any third party under any licenses set
out in the Parent Disclosure Schedule or under a license to use such information
for evaluation purposes provided pursuant to nondisclosure agreements or
material transfer agreements entered into in the ordinary course of business. To
the Knowledge of Parent, there has been and is no infringement, misappropriation
or violation by third parties of any of Parent's Intellectual Property, except
as such infringement, misappropriation or violation, individually or in the
aggregate, has not had and would not reasonably be expected to have a Material
Adverse Effect on Parent. There is no action, suit, proceeding or claim pending
or, to the Knowledge of Parent, threatened in writing or in a manner that would
reasonably be expected to result in any action, suit, proceeding or claim by
others challenging Parent's or a Subsidiary's rights in or to any such
Intellectual Property. The Intellectual Property owned by Parent has not been
adjudged invalid or unenforceable, in whole or in part, by any Governmental
Entity, and there is no pending or to the Knowledge of Parent, threatened
action, suit, proceeding or claim by others challenging the validity or scope of
any such Intellectual Property.

      (b) There is no action, suit, proceeding or claim pending, or to the
Knowledge of Parent, threatened in writing or in a manner that would reasonably
be expected to result in any action, suit, proceeding or claim, by others that
Parent or a Subsidiary has infringed, misappropriated or otherwise violated, or
infringes, misappropriates or otherwise violates, any Intellectual Property or
other proprietary rights of others, and Parent has not received any written
notice of such claim. To the Knowledge of Parent, there is no intellectual
property right or other legal right (except as may be contained in any Material
Contract of Parent) that could be asserted by a Person to exclude or prevent
Parent or any of its Subsidiaries from developing, manufacturing, or selling any
current product of Parent or its Subsidiaries that is material to the conduct of
the business of Parent and its Subsidiaries. To the Knowledge of Parent, no
employee of Parent or a Subsidiary is in or has ever been in violation of any
material term of any employment contract, patent disclosure agreement, invention
assignment agreement, non-competition agreement, non-solicitation agreement,
nondisclosure agreement or any restrictive covenant to or with a former employer
where the basis of such violation relates to such employee's employment with
Parent or actions undertaken by the employee while employed with Parent, except
as such violation would not have a Material Adverse Effect on Parent.

      Section 4.11 Taxes.

      (a) Parent and each of its Subsidiaries has duly and timely filed with the
appropriate Tax authorities or other Governmental Entities all Tax Returns that
it was required to file. All such Tax Returns are true and complete in all
material respects. All Taxes due and owing by any of Parent and its Subsidiaries
(whether or not shown on any Tax Returns) have been paid. Neither Parent nor any
of Parent's Subsidiaries currently is the beneficiary of any extension of time
within which to file any material Tax Return. No written claim has ever been
made by a Tax authority in a jurisdiction where any of Parent and its
Subsidiaries does not file Tax Returns that it is or may be subject to taxation
by that jurisdiction.




                                       41



      (b) The unpaid Taxes of Parent and its Subsidiaries did not, as of the
date of the financial statements contained in the most recent Parent SEC
Filings, exceed the reserve for Tax liability (excluding any reserve for
deferred Taxes established to reflect timing differences between book and Tax
income) set forth on the face of the balance sheets (rather than in any notes
thereto) contained in such financial statements. Since the date of the financial
statements in the most recent Parent SEC Filings, neither Parent nor any of its
Subsidiaries has incurred any liability for Taxes outside the ordinary course of
business or otherwise inconsistent with past custom and practice.

      (c) No deficiencies for Taxes with respect to any of Parent and its
Subsidiaries have been claimed in writing, proposed or assessed by a Tax
authority. There are no pending or, based on written notice, threatened audits,
assessments, administrative proceedings, court proceedings or other actions for
or relating to any liability in respect of material Taxes of any of Parent or
its Subsidiaries.

      Section 4.12 Regulatory Compliance.

      (a) Parent and its Subsidiaries are, to the Knowledge of Parent, in
compliance with the Health Care Laws material to the operation of their
businesses as now being conducted except for failures to be in compliance that
individually or in the aggregate have not had and would not reasonably be
expected to have a Material Adverse Effect on Parent. Neither Parent nor any of
its Subsidiaries has received any written notice that the FDA or any other
Governmental Entity has (i) commenced, or threatened to initiate, any action to
withdraw its approval or request the recall of any of its products, (ii)
commenced, or threatened to initiate, any action to enjoin production of any of
its products or (iii) to Parent's Knowledge, commenced, or threatened to
initiate, any action to enjoin the production of any of its products produced at
any facility where any such product is manufactured, tested or packaged, except
for any such action that individually or in the aggregate has not had and would
not reasonably be expected to have a Material Adverse Effect on Parent.

      (b) All clinical trials and, to the Knowledge of Parent, all studies,
tests and preclinical studies conducted by or on behalf of Parent or any of its
Subsidiaries were and, if still pending, are being conducted in all material
respects in accordance with experimental protocols, procedures and controls
pursuant to accepted professional scientific standards and all applicable Laws
and Permits. The descriptions of the results of such studies, tests and trials
submitted to FDA and other Governmental Entities are true and correct in all
material respects and fairly present the data derived from such studies, tests
and trials, and neither Parent nor any of its Subsidiaries has Knowledge of any
such studies, tests or trials the results of which Parent or any of its
Subsidiaries believes reasonably call into question its studies, tests, or trial
results. Neither Parent nor any of its Subsidiaries has received any notices or
correspondence from any Governmental Entity requiring the termination of,
suspension of, or modification which materially affects the design, end points
or intended purpose of, any studies, tests or preclinical or clinical trials
conducted by or on behalf of Parent or any of its Subsidiaries.

      (c) All reports, documents, claims, notices, or approvals required to be
filed, obtained, maintained, or furnished to any Governmental Entity for each
material medical device, biologic or drug developed, marketed, manufactured or
sold by Parent or any of its Subsidiaries


                                       42



(each a "Parent Product") have been so filed, obtained, maintained or furnished,
and all such reports, documents, claims and notices were true and correct in all
material respects on the date filed (or were corrected in or supplemented by a
subsequent filing). As to each such Parent Product, Parent and any relevant
Subsidiary, and the officers, employees or agents of Parent or such Subsidiary,
have included in the application for such Parent Product, where required, the
certification described in 21 U.S.C. Section 335a(k)(1) or any similar Law and
the list described in 21 U.S.C. Section 335a(k)(2) or any similar Law, and each
such certification and list was true and complete in all material respects when
made. In addition, Parent and its Subsidiaries are in substantial compliance
with all applicable registration and listing requirements set forth in 21 U.S.C.
Section 360 and 21 C.F.R. Part 207 and all similar Laws.

      (d) Neither Parent nor any of its Subsidiaries, nor, to the Knowledge of
Parent, any officer, Affiliate, employee or agent of Parent or any of its
Subsidiaries, has made an untrue statement of a material fact or fraudulent
statement to the FDA or any other Governmental Entity, failed to disclose a
material fact required to be disclosed to the FDA or any other Governmental
Entity, or committed an act, made a statement, or failed to make a statement
that, at the time such disclosure was made, would reasonably be expected to
provide a basis for the FDA or any other Governmental Entity to invoke its
policy respecting "Fraud, Untrue Statements of Material Facts, Bribery, and
Illegal Gratuities", set forth in 56 Fed. Reg. 46191 (September 10, 1991) or any
similar policy. Neither Parent nor any of its Subsidiaries, nor, to the
Knowledge of Parent, any officer, employee or agent of Parent or any of its
Subsidiaries, has been convicted of any crime or engaged in any conduct for
which debarment is mandated by 21 U.S.C. Section 335a(a), or any similar Law or
authorized by 21 U.S.C. Section 335a(b), or any similar Law.

      (e) Neither Parent nor any of its Subsidiaries has received any written
notice that the FDA or any other Governmental Entity has (i) commenced, or
threatened to initiate, any action to withdraw its approval or request the
recall of any Parent Product, (ii) commenced, or threatened to initiate, any
action to enjoin production of any Parent Product or (iii) to Parent's
Knowledge, commenced, or threatened to initiate, any action to enjoin the
production of any Parent Product produced at any facility where any Parent
Product is manufactured, tested or packaged, except for any such action that
individually or in the aggregate has not had and would not reasonably be
expected to have a Material Adverse Effect on Parent.

      (f) To the Knowledge of Parent, there are no facts, circumstances or
conditions that would reasonably be expected to form the basis for any material
investigation, suit, claim, audit, action (legal or regulatory) or proceeding
(legal or regulatory) by a Governmental Entity against or affecting Parent or
any of its Subsidiaries relating to or arising under (i) the FDCA or the
regulations of the FDA promulgated thereunder or (ii) the Health Care Laws.

      Section 4.13 Corporate Governance Matters.

      (a) Parent and to Parent's Knowledge each of its officers are in
compliance in all material respects with (i) the applicable provisions of the
Sarbanes-Oxley Act, (ii) the applicable qualification requirements and corporate
governance rules and regulations promulgated by the National Association of
Securities Dealers and any other regulatory organization applicable to Parent
and (iii) the equivalent applicable Canadian securities laws,

                                       43



rules and regulations. Parent has delivered to the Company the information
required to be disclosed by Parent and certain of its officers to Parent's Board
of Directors or any committee thereof pursuant to the certification requirements
of Rule 13a-14 under the Exchange Act. Since the date such provisions became
applicable to Parent and its Subsidiaries, all auditing services and non-audit
services provided to Parent and each of its Subsidiaries have been approved by
the audit committee of Parent's Board of Directors in compliance with Section
10A(h) or Section 10A(i) of the Exchange Act and the equivalent applicable
Canadian securities laws, and to Parent's Knowledge no registered public
accounting firm or any associate thereof that performs any audit for Parent or
any of its Subsidiaries has provided to Parent or any of its Affiliates any
service prohibited by Section 10A(g) of the Exchange Act. Except as permitted by
the Exchange Act, including Sections 13(k)(2) and (3), since the enactment of
the Sarbanes-Oxley Act, neither Parent nor any of its Subsidiaries has, directly
or indirectly, made, entered into, arranged, renewed, modified (in any material
way) or forgiven any personal loans to any executive officer or director of
Parent.

      (b) The management of Parent has (i) in accordance with Rule 13a-15 under
the Exchange Act, designed disclosure controls and procedures (as such term is
defined in Rule 13a-15(e) under the Exchange Act) to ensure that material
information relating to Parent, including its Subsidiaries, is made known to the
management of Parent by others within those entities, and (ii) disclosed, based
on its most recent evaluation prior to the date hereof, to Parent's auditors and
the audit committee of Parent's Board of Directors (A) any significant
deficiencies in the design or operation of Internal Controls which are
reasonably likely to adversely affect Parent's ability to record, process,
summarize and report financial information and has disclosed to Parent's
auditors any material weaknesses in Parent's Internal Controls and (B) any
fraud, whether or not material, that involves management or other employees who
have a significant role in Parent's Internal Controls. Parent has made available
to the Company a summary of any such disclosure made by management to Parent's
auditors and/or audit committee since December 31, 2003.

      Section 4.14 Interim Operations of Merger Sub. Each of Merger Sub and
Second Merger Sub is a direct, wholly-owned subsidiary of Parent formed solely
for the purpose of effecting the Merger or the Second Step Merger, respectively,
and has conducted no activity and has incurred no liability or obligation other
than as contemplated by this Agreement.

      Section 4.15 Parent Shareholder Approval. The affirmative vote of the
holders of a majority of the Parent Common Shares represented at the Parent
Shareholders' Meeting or any adjournment or postponement thereof (provided that
a quorum of shares are represented in Person or by proxy at such meeting or such
adjournment or postponement thereof) is required by the rules and regulations of
Nasdaq to approve the Share Issuance (the "Parent Shareholder Approval"). No
other action or vote of the holders of any class or series of capital stock of
Parent or Merger Sub is necessary to approve the Share Issuance or otherwise in
connection with this Agreement or the transactions contemplated hereby.

      Section 4.16 Brokers. No broker, investment banker, financial advisor or
other Person, other than Merrill Lynch & Co., the fees and expenses of which
will be paid by Parent, is entitled to any broker's, finder's, financial
advisors or other similar fee or commission in


                                       44



connection with the transactions contemplated by this Agreement based upon
arrangements made by or on behalf of Parent.

      Section 4.17 Opinion of Financial Advisor. The Board of Directors of
Parent has received the opinion of its financial advisor, Merrill Lynch & Co.,
dated the date, or shortly prior to the date, of this Agreement, to the effect
that, as of the date of such opinion, the Merger Consideration to be paid by
Parent is fair, from a financial point of view, to Parent.

      Section 4.18 Sufficient Funds. Parent and its Subsidiaries will have at or
prior to the Closing and at the Effective Time sufficient immediately available
funds and sufficient authorized but unissued shares or treasury Parent Common
Shares to pay the Merger Consideration upon consummation of the Merger.

                                   ARTICLE 5.
                                   COVENANTS

      Section 5.1 Conduct of Business by the Company. During the period from the
date of this Agreement to the earlier of the termination of this Agreement or
the Effective Time (unless required by applicable Law or the regulations or
requirements of any stock exchange or regulatory organization applicable to the
Company and its Subsidiaries, or as set forth in Schedule 5.1 or as otherwise
permitted or provided for by this Agreement), the Company shall, and shall cause
its Subsidiaries to, carry on their respective businesses in the ordinary course
of business consistent with past practice and, to the extent consistent
therewith, use reasonable best efforts to preserve intact its current business
organizations, keep available the services of its current officers and employees
and preserve its relationships with customers, suppliers, licensors, licensees,
distributors and others having business dealings with them with the intention
that its goodwill and ongoing business shall be unimpaired in any material
respect at the Effective Time. Without limiting the generality of the foregoing,
during the period from the date of this Agreement to the Effective Time (unless
required by applicable Law or the regulations or requirements of any stock
exchange or regulatory organization applicable to the Company and its
Subsidiaries, or as set forth in Schedule 5.1 or as otherwise permitted by this
Agreement), the Company shall not, and shall not permit any of its Subsidiaries,
without the prior written consent of Parent (it being understood and agreed that
Parent shall consider each request by the Company for consent in good faith and
shall respond to each such request in a timely manner, which shall be within
seven calendar days (or such shorter time as may be reasonably required under
the circumstances) after the date of receipt of such request accompanied by
explanatory documentation reasonably acceptable to Parent), to:

      (a) (i) declare, set aside or pay any dividends on, or make any other
distributions (whether in cash, stock or property) in respect of, any of its
capital stock, other than mandatory paid in kind dividends with respect to the
Series A Convertible Preferred Stock to the extent required by the Company's
Certificate of Designations, Preferences and Rights of Series A Convertible
Exchangeable Preferred Stock filed with the Secretary of State of the State of
Delaware on July 18, 2000 (the "2000 Certificate of Designations"), and other
dividends or distributions by a wholly-owned Subsidiary to the Company, (ii)
split, combine or reclassify any of its capital stock or issue or authorize the
issuance of any other securities in respect of, in lieu of or in substitution
for shares of its capital stock or (iii) purchase, redeem or otherwise acquire





                                       45



any shares of its capital stock or any other securities thereof or any rights,
warrants or options to acquire any such shares or other securities, except for
purchases, redemptions or other acquisitions of capital stock or other
securities required under the terms of any plans, arrangements or Contracts
existing on the date hereof between the Company or any of its Subsidiaries and
any director, officer, employee or consultant of the Company or any of its
Subsidiaries (true and complete copies of which have been heretofore delivered
to Parent);

      (b) issue, deliver, sell, grant, pledge or otherwise subject to any Lien
any shares of its capital stock, any other voting securities or any securities
convertible into, or any rights, warrants or options to acquire, any such
shares, voting securities or convertible securities (other than (i) the issuance
of shares of Company Common Stock upon the exercise of the Warrant or upon the
exercise of Company Options outstanding on the date hereof or upon the
conversion of Series A Convertible Preferred Stock outstanding on the date
hereof, in each case in accordance with their terms on the date hereof, and (ii)
preferred stock purchase rights under the Company Rights Plan), or any "phantom"
stock, "phantom" stock rights, stock appreciation rights or stock based
performance units;

      (c) amend (i) the Company Certificate of Incorporation or the Company
Bylaws or other comparable charter or organizational documents of any of the
Company's Subsidiaries (other than pursuant to Section 1.4(a) hereof) or (ii)
the Company's Certificate of Designation of the Series A Preferred Stock filed
with the Secretary of State of the State of Delaware on September 25, 1998 or
the 2000 Certificate of Designations;

      (d) directly or indirectly acquire or agree to acquire (i) by merging or
consolidating with, or by purchasing assets of, or by any other manner, any
Person or division, business or equity interest of any Person or (ii) any assets
which, in the case of both clause (i) and (ii), individually have a purchase
price in excess of $500,000 or, in the aggregate, have a purchase price in
excess of $1,000,000, except for capital expenditures (which are subject to
paragraph (g) below), licenses of Intellectual Property (which are subject to
paragraphs (g) and (j) below), and purchases of raw materials, equipment, and
supplies in the ordinary course of business consistent with past practice;

      (e) other than as required by existing Contracts, sell, lease, license,
mortgage or otherwise subject to any Lien or otherwise dispose of any of its
properties or assets (including securitizations) (other than Intellectual
Property and other intangible assets which are subject to paragraphs (g) and (j)
below), except (i) sales and disposals of inventory and assets (including
inventory of products) in the ordinary course of business consistent with past
practice and (ii) the incurrence of Permitted Liens;

      (f) (i) incur any indebtedness for borrowed money or guarantee any such
indebtedness of another Person, issue or sell any debt securities or calls,
options, warrants or other rights to acquire any debt securities of the Company
or any of its Subsidiaries, guarantee any debt securities of another Person,
enter into any "keep well" or other agreement to maintain any financial
statement condition of another Person or enter into any arrangement having the
economic effect of any of the foregoing or (ii) outside the ordinary course of
business, make any loans, advances or capital contributions to, or investments
in, any other Person, except, in the case of both clauses (i) and (ii), with
respect to a wholly-owned Subsidiary or immaterial


                                       46



amounts or in connection with the purchase of supplies or materials in the
ordinary course of business consistent with past practice;

      (g) make or agree to make any new capital expenditure or expenditures
(including leases and in-licenses), or enter into any Contract or Contracts
providing for capital expenditures which, in the aggregate, are in excess of
$250,000, other than such expenditures as are in accordance with the Company's
current capital budget (a copy of which has been delivered to Parent);

      (h) (i) pay, discharge, settle or satisfy any claims, liabilities,
obligations or litigation (absolute, accrued, asserted or unasserted, contingent
or otherwise) in excess of $100,000 in the aggregate, other than the payment,
discharge, settlement or satisfaction in accordance with their terms, of claims,
liabilities, obligations or litigation disclosed, reflected or reserved against
in the most recent consolidated financial statements (or the notes thereto) of
the Company included in the Filed Company SEC Filings (for amounts not in excess
of such reserves) or incurred since the date of such financial statements in the
ordinary course of business consistent with past practice, or pursuant to
existing Contracts or any additional Contracts permitted by this Section 5.1 or
in connection with, or as otherwise provided or contemplated by, this Agreement
or any of the transactions contemplated hereby, (ii) cancel any indebtedness
owed to the Company or any of its Subsidiaries, except in the ordinary course of
business consistent with past practice, (iii) waive or assign any claims or
rights of substantial value or (iv) waive any benefits of, fail to enforce, or
agree to modify in any respect, or consent to any matter with respect to which
consent is required (A) under any standstill or similar agreements prohibiting a
third party from purchasing equity interests of the Company or any of its
Subsidiaries to which the Company or any of its Subsidiaries is a party or (B)
other than in the ordinary course of business consistent with past practice, any
material confidentiality or similar agreements to which the Company or any of
its Subsidiaries is a party;

      (i) terminate or modify or amend in any materially adverse respect any
Company Material Contract, other than modifications, amendments, or terminations
that are immaterial, or waive, release or assign any material rights or claims
thereunder;

      (j) enter into any material Company Contracts in the fields of ocular,
oncology, dermatology, urology, or pain management relating in a material manner
to the research, development, distribution, sale, license, marketing,
co-promotion or manufacturing by third parties of the Company Products &
Technology or products licensed by the Company or its Subsidiaries, or the
Intellectual Property Rights of the Company or its Subsidiaries, other than
pursuant to (i) confidentiality agreements containing customary terms and
conditions entered into in the ordinary course of business consistent with past
practice, (ii) consulting agreements entered into in the ordinary course of
business consistent with past practice which individually have aggregate values
of no more than $100,000, (iii) agreements with third party service providers
entered into in the ordinary course of business consistent with past practice,
(iv) clinical trial, feasibility study (excluding any having ocular
applications) or service agreements entered into in the ordinary course of
business consistent with past practice, and (v) any such Contracts currently in
place (that have been delivered to Parent prior to the date hereof) in
accordance with their terms as of the date hereof;




                                       47



      (k) enter into any Contract to the extent consummation of the transactions
contemplated by this Agreement or compliance by the Company with the provisions
of this Agreement would reasonably be expected to conflict with, or result in a
violation or breach of, or default (with or without notice or lapse of time, or
both) under, or give rise to a right of, or result in, termination, cancellation
or acceleration of any obligation or to the loss of a benefit under, or result
in the creation of any Lien other than Permitted Liens in or upon any of the
properties or other assets of the Company or any of its Subsidiaries under, or
give rise to any increased, additional, accelerated, or guaranteed right or
entitlements of any third party under, or result in any material alteration of,
any provision of such Contract;

      (l) sell, transfer or out-license to any Person or otherwise extend,
amend, modify, abandon, or make part of the public domain any rights to the
Intellectual Property Rights of the Company or any of its Subsidiaries, other
than pursuant to (i) confidentiality agreements entered into in the ordinary
course of business consistent with past practice containing customary terms
which do not impose any obligations on the Company or its Subsidiaries other
than those relating to the treatment of confidential information and (ii) any
such Contracts currently in place (that have been disclosed in writing to Parent
prior to the date hereof) in accordance with their terms as of the date hereof;

      (m) enter into any Contract containing any restriction on the ability of
the Company or any of its Subsidiaries to assign its rights, interests or
obligations thereunder, unless such restriction would not prohibit the
assignment of such Contract to Parent or any of its Subsidiaries in connection
with or following the consummation of the Merger and the other transactions
contemplated by this Agreement;

      (n) enter into any Contract that purports to limit or otherwise restrict
the Company or any of its Subsidiaries or any of their respective Affiliates or
any successor thereto, from engaging or competing in any line of business or in
any geographic area;

      (o) except as required to ensure that any Company Benefit Plan or Company
Benefit Agreement is not then out of compliance with applicable Law or to comply
with any Contract or Company Benefit Plan or Company Benefit Agreement entered
into prior to the date hereof (true and complete copies of which have been
heretofore delivered or made available to Parent) or as in accordance with the
Company's 2004 payroll budget (a true and complete copy of which has been
delivered or made available to Parent);

            (i) adopt, enter into, terminate or amend (A) any collective
bargaining agreement or Company Benefit Plan or (B) any Company Benefit
Agreement or other agreement, plan or policy involving the Company or any of its
Subsidiaries and one or more of their respective current or former directors,
officers, employees or consultants relating to compensation for services in such
capacities;

            (ii) increase in any manner (other than as described in other
clauses of this paragraph (o)) the compensation, bonus or fringe or other
benefits of, or pay any bonus of any kind or amount whatsoever to, any current
or former director, officer or employee;




                                       48



            (iii) pay any benefit or amount not required under any Company
Benefit Plan or Company Benefit Agreement or any other benefit plan or
arrangement of the Company or any of its Subsidiaries as in effect on the date
of this Agreement;

            (iv) grant or pay any severance or termination pay or increase in
any manner the severance or termination pay of any current or former director,
officer, employee or consultant of the Company or any of its Subsidiaries
outside the ordinary course of business consistent with past practice (including
size, timing and scope);

            (v) grant any awards under any bonus, incentive, performance or
other compensation plan or arrangement, Company Benefit Agreement or Company
Benefit Plan (including the grant of Company Options, restricted stock of the
Company, "phantom" stock, stock appreciation rights, "phantom" stock rights,
stock based or stock related awards, performance units or restricted stock or
the removal of existing restrictions in any Company Benefit Agreements, Company
Benefit Plans or agreements or awards made thereunder);

            (vi) amend or modify any Company Option or the Warrant, except as
required pursuant to this Agreement;

            (vii) take any action to secure the payment after the Effective Time
of compensation or benefits under any employee plan, agreement, contract or
arrangement or Company Benefit Plan or Company Benefit Agreement;

            (viii) take any action to accelerate the vesting or payment of any
compensation or benefit under any Company Benefit Plan or Company Benefit
Agreement, other than as required by this Agreement; or

            (ix) materially change any actuarial or other assumption used to
calculate funding obligations with respect to any Company Pension Plan or change
the manner in which contributions to any Company Pension Plan are made or the
basis on which such contributions are determined;

      (p) except as required by GAAP or by a Governmental Entity, (i) make any
change in accounting methods, principles or practices, or (ii) write up, write
down or write off the book value of any assets, individually or in the
aggregate;

      (q) except in the ordinary course of business consistent with past
practice, make any material Tax election or settle or compromise any material
liability for Taxes, change any annual Tax accounting period, change any method
of Tax accounting, file any material amendment to a Tax Return, enter into any
closing agreement relating to any material Tax, surrender any right to claim a
material Tax refund, or consent to any extension or waiver of the statute of
limitations period applicable to any material Tax claim or assessment;

      (r) acquire or in-license, or agree to acquire or in-license, from any
Person, any Intellectual Property, except for such licenses or acquisitions that
do not involve an upfront payment or payments in any 12-month period in excess
of $250,000 or that otherwise are in the ordinary course of business consistent
with past practice (including in size and nature);




                                       49



      (s) adopt a plan of complete or partial liquidation, dissolution, or
recapitalization or a plan of reorganization;

      (t) make any amendment or other modification to the Company Rights Plan,
and the Board of Directors of the Company shall not take any action with respect
to, or make any determination under, the Company Rights Plan, including any
redemption of the Company Rights; (u) take any action that is intended, or that
could reasonably be expected to, result in any of the conditions to the Merger
set forth in Article 7 not being satisfied; or

            (v) authorize or enter into any agreement or otherwise make any
commitment to do any of the foregoing.

      Section 5.2 Conduct of Business by Parent Pending the Closing. Parent
agrees that, between the date of this Agreement and the Effective Time, except
as specifically permitted by any other provision of this Agreement or unless the
Company shall otherwise agree in writing, Parent shall maintain its existence in
good standing under applicable Law, and Parent and its Subsidiaries shall
continue to conduct their businesses such that the primary business of Parent
and its Subsidiaries, taken as a whole, shall involve biotechnology or
pharmaceuticals. Without limiting the foregoing, and as an extension thereof,
except as specifically permitted by any other provision of this Agreement or as
set forth on Schedule 5.2, the Parent shall not and shall not permit any of its
Subsidiaries to (unless required by applicable Laws or the regulations or
requirements of any stock exchange or regulatory organization applicable to
Parent and its Subsidiaries), between the date of this Agreement and the
Effective Time, directly or indirectly, do, or agree to do, any of the
following, without the prior written consent of the Company (it being understood
and agreed that the Company shall consider each request by Parent for consent in
good faith and shall respond to each such request in a timely manner, which
shall be within seven calendar days (or such shorter time as may be reasonably
required under the circumstances) after the date of receipt of such request
accompanied by explanatory documentation reasonably acceptable to the Company):

      (a) amend or otherwise change the Parent Notice of Articles or Parent
Articles;

      (b) declare, set aside, make or pay any dividend or other distribution,
payable in cash, stock, property or otherwise, with respect to any of its
capital stock;

      (c) split, combine or reclassify any of its capital stock or issue or
authorize the issuance of any other securities in respect of, in lieu of or in
substitution for shares of its capital stock;

      (d) directly or indirectly acquire or agree to acquire by merging or
consolidating with, or by purchasing any equity interest in or any portion of
the assets of, any Person or division thereof, or license any products,
technology or Intellectual Property of a third party, except for (i) capital
expenditures, purchases of raw materials, equipment and supplies and in-bound
licensing of off-the-shelf software, in each case in the ordinary course of
business consistent with past practice and (ii) any such transactions in which
the fair market value of the


                                       50



total consideration issued in exchange therefor (excluding royalties on future
product sales with respect to products not then marketed) shall not be
reasonably expected to exceed $200,000,000 in the aggregate, provided that any
such transactions do not present individually or in the aggregate a material
risk of delaying the Merger or any other transaction contemplated by this
Agreement;

      (e) license its products, technology or Intellectual Property or sell its
rights to its products or technology to third parties, except (i) pursuant to
arrangements in effect as of the date hereof, (ii) for sales of inventory in the
ordinary course of business consistent with past practice and (iii) for any such
transactions for which both the fair market value of the total consideration
issued in exchange therefor (excluding royalties on future product sales with
respect to products not then marketed) shall not be reasonably expected to
exceed $200,000,000 in the aggregate and provided that any such transactions do
not individually or in the aggregate present a material risk of delaying the
Merger or any other transaction contemplated by this Agreement;

      (f) adopt a plan of complete or partial liquidation or dissolution;

      (g) take any action that is intended or would reasonably be expected to
result in any of the conditions to the Merger set forth in Article 7 not being
satisfied;

      (h) terminate or modify or amend in any materially adverse respect any
Parent Material Contract listed on Section 5.2(h) to the Parent Disclosure
Schedule, or take any action under any such Contract that is reasonably likely
to have a Material Adverse Effect on Parent; or

      (i) authorize or enter into any agreement or otherwise make any commitment
to do any of the foregoing.

      Nothing in the foregoing Section 5.2(e) however shall apply to a Parent
Takeover, as to which any Parent obligations are set forth solely in Section
6.3(b) of this Agreement.

      Section 5.3 Tax-Free Reorganization Treatment.

      (a) Neither Company nor Parent shall, nor shall they permit any of their
respective Subsidiaries to, take or cause to be taken any action (whether before
or after the Transaction) that would disqualify the Transaction as a
reorganization within the meaning of Section 368(a) of the Code (including any
action that would prevent the Transaction from satisfying the requirements of
Treasury Regulation Section 1.367(a)-3(c)(1)). Parent and the Company shall use
their reasonable best efforts, and shall cause their respective Subsidiaries to
use their reasonable best efforts, to take or cause to be taken any action
(whether before or after the Transaction) that is required to cause the
Transaction to qualify as a reorganization within the meaning of Section 368(a)
of the Code (including any action that is required to satisfy the requirements
of Treasury Regulation Section 1.367(a)-3(c)(1)).

      (b) Each of the Company and Parent shall report the Transaction as a
reorganization within the meaning of Section 368 of the Code, unless otherwise
required pursuant to a "determination" within the meaning of Section 1313(a) of
the Code. Parent will cause the Company to comply with all applicable reporting
requirements set forth in the Treasury


                                       51



Regulations under Section 367 of the Code, including Treasury Regulation Section
1.367(a)-3(c)(6).

      (c) The parties hereto shall cooperate and use their commercially
reasonable efforts in order for Parent to obtain the opinion of Latham & Watkins
LLP described in Section 7.2(c) and for the Company to obtain the opinion of
Morrison & Foerster LLP described in Section 7.3(c). In connection therewith,
both Parent (together with Merger Sub) and the Company shall deliver to Latham &
Watkins LLP and Morrison & Foerster LLP representation letters, dated and
executed as of the dates of such opinions, in substantially the form attached to
this Agreement as Exhibits 7.2(c)(i) and 7.2(c)(ii), respectively.

      Section 5.4 Control of Other Party's Business. Nothing contained in this
Agreement shall give Parent or Merger Sub, directly or indirectly, the right to
control or direct the operations of the Company prior to the consummation of the
Merger. Prior to the consummation of the Merger, the Company shall exercise,
consistent with the terms and conditions of this Agreement, complete control and
supervision over its operations.

                                   ARTICLE 6.

                              ADDITIONAL AGREEMENTS

      Section 6.1 Registration Statement; Proxy Statement.

      (a) As promptly as practicable after the execution of this Agreement,
Parent and the Company shall prepare a joint proxy statement relating to the
Company Stockholders' Meeting and Parent Shareholders' Meeting (together with
any amendments thereof or supplements thereto, the "Proxy Statement") and Parent
shall prepare and file with the SEC a registration statement on Form S-4
(together with all amendments thereto, the "Registration Statement"; the
prospectus contained in the Registration Statement together with the Proxy
Statement, the "Joint Proxy/Prospectus"), in which the Proxy Statement shall be
included, in connection with the registration under the Securities Act of the
Parent Common Shares to be issued to the stockholders of the Company as Merger
Consideration. Each of Parent and the Company shall use reasonable best efforts
to cause the Registration Statement to become effective as promptly as
practicable, and, prior to the effective date of the Registration Statement,
Parent shall take all or any action reasonably required under any applicable
securities Laws in connection with the issuance of Parent Common Shares in the
Merger or the registration or qualification thereof. Each of Parent and the
Company shall furnish all information concerning it and the holders of its
capital stock as the other may reasonably request in connection with such
actions and the preparation of the Registration Statement and Proxy Statement.
As promptly as reasonably practicable after the Registration Statement shall
have become effective and the Proxy Statement shall have been cleared by the
SEC, the Company and Parent shall mail the Joint Proxy/Prospectus to their
respective shareholders; provided, however, that the parties shall consult and
cooperate with each other in determining the appropriate time for mailing the
Joint Proxy/Prospectus in light of the date set for the Company Stockholders'
Meeting and the Parent Shareholders' Meeting. No filing of, or amendment or
supplement to, the Proxy Statement shall be made by the Company or Parent, and
no filing of, or amendment or supplement to, the Registration Statement shall be
made by Parent, in each case, without providing the other party a reasonable
opportunity to review and comment thereon, which comments shall be considered in



                                       52



good faith. Parent shall advise the Company, promptly after it receives notice
thereof, of the time when the Registration Statement has become effective or any
supplement or amendment has been filed, of any request by the SEC for amendment
of the Registration Statement or comments thereon and responses thereto and
requests by the SEC for additional information, of the issuance of any stop
order, or the suspension of the qualification of the Parent Common Shares
issuable in connection with the Merger for offering or sale in any jurisdiction.
Parent and the Company shall each advise the other, promptly after it receives
notice thereof, of any request by the SEC for amendment of the Proxy Statement
or the Registration Statement or comments thereon and responses thereto or
requests by the SEC for additional information.

      (b) The information supplied by Parent for inclusion in the Registration
Statement and the Proxy Statement shall not, at (i) the time the Registration
Statement is declared effective, (ii) the time the Proxy Statement (or any
amendment thereof or supplement thereto) is first mailed to the stockholders of
the Company, (iii) the time the Proxy Statement (or any amendment thereof or
supplement thereto) is first mailed to shareholders of Parent, (iv) the time of
the Company Stockholders' Meeting and (v) the time of the Parent Shareholders'
Meeting, contain any untrue statement of a material fact or omit to state any
material fact required to be stated therein or necessary in order to make the
statements therein not misleading. If at any time prior to the Effective Time
any event or circumstance relating to Parent or any of its Subsidiaries, or
their respective officers or directors, should be discovered by Parent which
should be set forth in an amendment or a supplement to the Registration
Statement or Proxy Statement, Parent shall promptly inform the Company and, to
the extent required by applicable Law, an appropriate amendment or supplement
describing such event or circumstance shall be promptly filed with the SEC and
disseminated to stockholders of the Company and shareholders of Parent, as
applicable. All documents that Parent is responsible for filing with the SEC in
connection with the transactions contemplated herein will comply as to form and
substance in all material respects with the applicable requirements of the
Securities Act and the rules and regulations thereunder and the Exchange Act and
the rules and regulations thereunder.

      (c) The information supplied by the Company for inclusion in the
Registration Statement and the Proxy Statement shall not, at (i) the time the
Registration Statement is declared effective, (ii) the time the Proxy Statement
(or any amendment thereof or supplement thereto) is first mailed to the
stockholders of the Company, (iii) the time the Proxy Statement (or any
amendment thereof or supplement thereto) is first mailed to shareholders of
Parent, (iv) the time of the Company Stockholders' Meeting and (v) the time of
the Parent Shareholders' Meeting, contain any untrue statement of a material
fact or omit to state any material fact required to be stated therein or
necessary in order to make the statements therein not misleading. If at any time
prior to the Effective Time any event or circumstance relating to the Company or
any of its Subsidiaries, or their respective officers or directors, should be
discovered by the Company which should be set forth in an amendment or a
supplement to the Registration Statement or Proxy Statement, the Company shall
promptly inform Parent and, to the extent required by applicable Law, an
appropriate amendment or supplement describing such event or circumstance shall
be promptly filed with the SEC and disseminated to stockholders of the Company
and shareholders of Parent, as applicable. All documents that the Company is
responsible for filing with the SEC in connection with the transactions
contemplated herein will comply as to form and substance in all material
respects with the applicable requirements of the


                                       53



Securities Act and the rules and regulations thereunder and the Exchange Act and
the rules and regulations thereunder.

      (d) The Company shall use its reasonable best efforts to cause to be
delivered to Parent a letter of Deloitte & Touche LLP, its independent auditors,
dated (i) as of a date within two days of the date on which the Registration
Statement shall become effective and (ii) within two days of the Closing Date,
and addressed to Parent, in form and substance customary for "comfort" letters
delivered by independent public accountants in connection with registration
statements similar to the Registration Statement, the cost of which shall be
shared by the Company and Parent equally.

      Section 6.2 Shareholders' Meetings.

      (a) The Company shall duly call and hold a meeting of its stockholders
(the "Company Stockholders' Meeting") as promptly as practicable in accordance
with applicable Law following the date the Registration Statement becomes
effective and the Proxy Statement is cleared by the SEC and after coordination
with Parent, provided that the meeting shall be held not later than five
Business Days prior to the Outside Date (provided that the Company shall not be
required to hold the Company Stockholders' Meeting prior to the date of the
Parent Stockholders' Meeting), for the purpose of voting upon the adoption of
this Agreement and approval of the Merger. In connection with the Company
Stockholders' Meeting and the transactions contemplated hereby, the Company will
(i) subject to applicable Law, use its reasonable best efforts (including
postponing or adjourning the Company Stockholders' Meeting to obtain a quorum or
to solicit additional proxies) to obtain the necessary approvals by its
stockholders of this Agreement and the Merger and (ii) otherwise comply with all
legal requirements applicable to the Company Stockholders' Meeting.

      (b) Parent shall duly call and hold a meeting of its shareholders (the
"Parent Shareholders' Meeting") as promptly as practicable in accordance with
applicable Law following the date the Registration Statement becomes effective
and the Proxy Statement is cleared by the SEC and after coordination with the
Company, provided that the meeting shall be held not later than five Business
Days prior to the Outside Date (provided that Parent shall not be required to
hold the Parent Shareholders' Meeting prior to the date of the Company
Stockholders' Meeting), for the purpose of voting upon the approval of the Share
Issuance. In connection with the Parent Shareholders' Meeting and the
transactions contemplated hereby, Parent will (i) subject to applicable Law, use
its reasonable best efforts (including postponing or adjourning Parent
Shareholders' Meeting to obtain a quorum or to solicit additional proxies) to
obtain the necessary approvals by its shareholders of the Share Issuance and
(ii) otherwise comply with all legal requirements applicable to the Parent
Shareholders' Meeting.

      (c) The Board of Directors of the Company shall recommend adoption of this
Agreement and approval of the Merger by the stockholders of the Company (the
"Company Recommendation"). Subject to Section 6.4, the Company shall not
withdraw or adversely modify (or propose to withdraw or adversely modify) such
recommendation, and the Joint Proxy/Prospectus shall contain such
recommendation.

      (d) The Board of Directors of Parent shall recommend the approval of the
Share Issuance by the shareholders of Parent (the "Parent Recommendation"), and
the Joint


                                       54



Proxy/Prospectus shall contain such recommendation. Parent shall not withdraw or
adversely modify (or propose to withdraw or adversely modify) such
recommendation, and the Joint Proxy/Prospectus shall contain such
recommendation.

      Section 6.3 Access to Information; Parent Takeover Proposal;
Confidentiality.

      (a) Except as required pursuant to any confidentiality agreement or
similar agreement or arrangement to which the Company or Parent or any of their
respective Subsidiaries is a party (which such Person shall use reasonable best
efforts to cause the counterparty to waive) from the date of this Agreement to
the Effective Time, the Company and Parent shall, and shall cause each of its
Subsidiaries and each of their respective directors, officers, employees,
accountants, consultants, legal counsel, investment bankers, advisors, and
agents and other representatives (collectively, "Representatives") to (i)
provide to the other party and its respective Representatives access at
reasonable times upon prior notice to the officers, employees, agents,
properties, offices and other facilities of such party and its Subsidiaries and
to the books and records thereof and (ii) subject to applicable Laws relating to
the exchange of information, furnish promptly such information concerning the
business, properties, Contracts, assets, liabilities, personnel and other
aspects of itself and its Subsidiaries as the other party and its
Representatives may reasonably request. No investigation conducted pursuant to
this Section 6.3(a) shall affect or be deemed to modify or limit any
representation or warranty made in this Agreement.

      (b) From and after the date of this Agreement until the earlier of the
Effective Time or termination of this Agreement pursuant to Article 7, Parent
agrees that in the event it receives a written offer or proposal concerning a
Parent Takeover (as defined below) or any written inquiry which it reasonably
believes could lead to such an offer or proposal, Parent shall promptly (and in
any event within 36 hours) notify the Company that it has received such an offer
or proposal and shall thereafter keep the Company reasonably informed as to the
status of such offer, proposal or inquiry. As used in this Agreement, "Parent
Takeover" shall mean any of the following transactions: (i) a merger,
consolidation, business combination, recapitalization or similar transaction
involving Parent pursuant to which the stockholders of Parent immediately
preceding such transaction hold less than 50% of the aggregate voting power of
the surviving or resulting entity of such transaction or the parent of such
entity; (ii) a sale or other disposition by Parent or any of its Subsidiaries,
directly or indirectly, of assets representing collectively in excess of 50% of
the consolidated assets of Parent and its Subsidiaries immediately prior to such
sale; (iii) the issuance, sale or other disposition of securities (or options,
rights or warrants to purchase, or securities convertible into or exchangeable
for such securities, in each case by Parent or any Subsidiary representing 50%
or more of the voting power of Parent; or (iv) the acquisition by any person or
group (including by way of a tender offer or an exchange offer or issuance by
Parent), directly or indirectly, of beneficial ownership or a right to acquire
beneficial ownership of shares representing in excess of 50% of the voting power
of the then outstanding shares of capital stock of Parent.

      (c) With respect to the information disclosed pursuant to this Section
6.3, the parties shall comply with, and shall cause their respective
Representatives to comply with, all of their respective obligations under the
confidentiality agreement, dated March 23, 2004, previously executed by the
Company and Parent (the "Confidentiality Agreement"); provided,


                                       55



however, the restrictions on Parent, its Subsidiaries and Affiliates, and their
respective Representatives set forth in paragraphs 3 and 4.3 of the
Confidentiality Agreement shall be inapplicable with respect to any of the
transactions set forth in this Agreement.

      Section 6.4 No Solicitation of Transactions.

      (a) The Company agrees that it and its Subsidiaries shall not, and shall
not authorize or permit any of their respective directors, officers or employees
and shall use reasonable best efforts not to permit their respective
Representatives (provided that such agreement shall not apply with respect to
employees of the Company below the level of director) to, directly or
indirectly:

            (i) solicit, initiate, encourage, knowingly facilitate or induce any
inquiry with respect to, or the making, submission or announcement of, any
Acquisition Proposal;

            (ii) participate or engage in any discussions or negotiations
regarding, or furnish to any Person any nonpublic information with respect to,
or take any other action to facilitate any inquiries or the making of any
proposal that constitutes or may reasonably be expected to lead to, any
Acquisition Proposal, except to notify such Person as to the existence of these
provisions (except to the extent permitted pursuant to this Section 6.4);

            (iii) approve, endorse or recommend any Acquisition Proposal with
respect to the Company (except to the extent permitted by this Section 6.4); or

            (iv) enter into any letter of intent or similar document or any
agreement, commitment or understanding contemplating or otherwise relating to
any Acquisition Proposal or a transaction contemplated thereby (except for
confidentiality agreements permitted pursuant to Section 6.4(c)).

            (v) The Company shall immediately terminate, and shall cause the
Company Subsidiaries to immediately terminate, and shall instruct the
Representatives of it and its Subsidiaries to immediately terminate, all
discussions or negotiations, if any, with any third party with respect to, or
any that could reasonably be expected to lead to or contemplate the possibility
of, an Acquisition Proposal. The Company shall as soon as practicable demand
that each Person which has executed within the twelve-month period prior to the
date of this Agreement a confidentiality agreement with the Company or any of
its Affiliates or Subsidiaries or any of its or their Representatives with
respect to such Person's consideration of a possible Acquisition Proposal to
immediately return or destroy (which destruction shall be certified in writing
by such Person to the Company) all confidential information heretofore furnished
by the Company or any of its Affiliates or Subsidiaries or any of its or their
Representatives to such Person or any of its Affiliates or Subsidiaries or any
of its or their Representatives.

      (b) Promptly (but in any event within 36 hours) after receipt of any
Acquisition Proposal or any request for nonpublic information or inquiry which
it reasonably believes could lead to an Acquisition Proposal, the Company shall
provide Parent with written notice of the material terms and conditions of such
Acquisition Proposal, request or inquiry, and the identity of the Person or
group making any such Acquisition Proposal, request or inquiry, and


                                       56



a copy of all written materials provided in connection with such Acquisition
Proposal, request or inquiry. After receipt of the Acquisition Proposal, request
or inquiry, the Company shall promptly keep Parent informed in all material
respects of the status and details (including material amendments or proposed
material amendments) of any such Acquisition Proposal, request or inquiry and
shall promptly provide to Parent a copy of all written materials subsequently
provided in connection with such Acquisition Proposal, request or inquiry.

      (c) If the Company receives an Acquisition Proposal which (i) constitutes
a Superior Proposal or (ii) which the Board of Directors of the Company in good
faith concludes could reasonably be expected to result in a Superior Proposal,
the Company shall promptly provide to Parent written notice that shall state
expressly (A) that it has received an Acquisition Proposal which constitutes a
Superior Proposal or which could reasonably be expected to result in a Superior
Proposal, and (B) the identity of the party making such Acquisition Proposal and
the material terms and conditions of the Acquisition Proposal (the "Superior
Proposal Notice") and may then take the following actions (either directly or
through its Subsidiaries or any of their respective directors, officers,
employees or Representatives):

            (i) furnish nonpublic information to the third party making such
Acquisition Proposal, provided, that (A) prior to so furnishing, the Company
receives from the third party an executed confidentiality agreement containing
customary standstill provisions and other terms and conditions that are no less
restrictive to such third party than the terms and conditions of the
Confidentiality Agreement, and (B) contemporaneously with furnishing any such
nonpublic information to such third party, the Company furnishes a copy of such
nonpublic information to Parent (to the extent such nonpublic information has
not been previously so furnished); and

            (ii) participate or engage in any discussions or negotiations with
the third party with respect to the Acquisition Proposal.

      (d) For a period of not less than five Business Days after Parent's
receipt from the Company of each Superior Proposal Notice, the Company shall, if
requested by Parent, negotiate in good faith with Parent to revise this
Agreement so that the Acquisition Proposal that constituted a Superior Proposal
no longer constitutes a Superior Proposal.

      (e) Notwithstanding anything in this Agreement to the contrary, in
response to the receipt of a Superior Proposal that has not been withdrawn and
continues to constitute a Superior Proposal after the Company's compliance with
Section 6.4(d), the Board of Directors of the Company may withhold, withdraw or
modify the Company Recommendation and, in the case of a Superior Proposal that
is a tender or exchange offer made directly to its stockholders, may recommend
that its stockholders accept the tender or exchange offer (any of the foregoing
actions, whether by the Board of Directors or a committee thereof, a "Change of
Recommendation"), if both of the following conditions in Sections 6.4(e)(i) and
6.4(e)(ii) are met:

            (i) the Company Stockholder Approval has not been obtained; and



                                       57



            (ii) the Board of Directors of the Company has concluded in good
faith, following the receipt of advice of its outside legal counsel, that, in
light of such Superior Proposal, the failure of the Board of Directors to effect
a Change of Recommendation would result in a breach of its fiduciary obligations
to its stockholders under applicable Law.

      (f) Notwithstanding anything to the contrary contained in this Agreement,
(i) the obligation of the Company to call, give notice of, convene and hold the
Company Stockholders' Meeting and to hold a vote of the Company's stockholders
on this Agreement and the Merger at the Company Stockholders' Meeting shall not
be limited or otherwise affected by the commencement, disclosure, announcement
or submission to it of any Acquisition Proposal (whether or not a Superior
Proposal), or by any Change of Recommendation and (ii) in any case in which the
Company withholds or withdraws the Company Recommendation pursuant to Section
6.4(e), the Company shall nonetheless submit this Agreement to a vote of its
stockholders. The Company agrees that it shall not submit to the vote of its
stockholders any Acquisition Proposal (whether or not a Superior Proposal) or
propose to do so.

      (g) Nothing contained in this Agreement shall be deemed to restrict the
Company from complying with Rules 14d-9 or 14e-2 under the Exchange Act or be
deemed to restrict the Company or Parent from making such other disclosures as
may be required by federal securities Laws or applicable fiduciary duties Laws.

      (h) Nothing contained in Section 5.1 of this Agreement shall be deemed to
limit or restrict in any manner the rights of the Company pursuant to this
Section 6.4.

      Section 6.5 Appropriate Action; Consents; Filings.

      (a) The Company and Parent shall use their reasonable best efforts to:

            (i) take, or cause to be taken, all appropriate action, and do, or
cause to be done, all things necessary, proper or advisable under applicable Law
or otherwise to consummate and make effective the transactions contemplated by
this Agreement as promptly as practicable;

            (ii) obtain from any Governmental Entities any consents, licenses,
permits, waivers, approvals, authorizations or orders required (A) to be
obtained or made by the Company or Parent, respectively, or any of their
Subsidiaries, (B) to avoid any action or proceeding by any Governmental Entity
(including those in connection with the HSR Act and antitrust and competition
Laws of any other applicable jurisdiction), in connection with the
authorization, execution and delivery of this Agreement and the consummation of
the transactions contemplated herein, including the Merger, and (C) to prevent a
Material Adverse Effect on the Company or Parent, respectively, from occurring
prior to or after the Effective Time;

            (iii) make all necessary filings, and thereafter make any other
required submissions, with respect to this Agreement, the Merger and the Share
Issuance required of the Company or Parent, respectively, under (A) the
Securities Act and the Exchange Act, and any other applicable federal or state
or Canadian or other foreign securities Laws, (B)



                                       58



the HSR Act and antitrust and competition Laws of any other applicable
jurisdiction, (C) the rules and regulations of the Toronto Stock Exchange, and
(D) any other applicable Law; and

            (iv) give (or shall cause their respective Subsidiaries to give) any
notices to third parties or any Governmental Entity required by the Company or
Parent, respectively, and use, and cause their respective Subsidiaries to use,
reasonable best efforts to obtain any non-governmental third party consents, (A)
necessary to consummate the transactions contemplated in this Agreement, (B)
required to be disclosed in the Company Disclosure Schedule or the Parent
Disclosure Schedule, as applicable, or (C) required to prevent a Material
Adverse Effect on the Company or Parent, respectively, from occurring prior to
or after the Effective Time.

      (b) Without limiting Section 6.5(a), Parent and the Company shall duly
file with the U.S. Federal Trade Commission and the Antitrust Division of the
Department of Justice, and in any applicable Canadian or foreign jurisdiction
with the appropriate Governmental Entity, the notification and report form
required under the HSR Act or the antitrust or competition laws of such Canadian
or foreign jurisdiction with respect to the transactions contemplated by this
Agreement as promptly as practicable, and in any event within ten (10) days
after the date hereof. Nothing in this Agreement shall be deemed to require
Parent or the Company to agree to, or proffer to, divest or hold separate any
assets or other portion of any business of Parent, the Company or any of their
respective Subsidiaries.

      (c) Parent and the Company shall cooperate with each other in connection
with the making of all filings, the giving of all notices and the obtaining of
all consents referenced in Section 6.5(a), including, with respect to filings,
providing copies of all such filings (other than information with respect to
third parties) to the non-filing party and its advisors prior to filing and, if
requested, to consider all reasonable additions, deletions or changes suggested
in connection therewith, subject to applicable Law. Subject to applicable Law,
each of Parent and the Company shall keep the other apprised of the status of
matters relating to the completion of the transactions contemplated hereby,
including promptly furnishing the other with copies of written notices or other
communications received by Parent or the Company, as the case may be, or any of
their respective Affiliates from any third party or Governmental Entity with
respect to the transactions contemplated hereby. Parent and the Company shall
have the right to review in advance, and to the extent practicable each shall
consult the other on, all the information relating to the Company and its
Subsidiaries or Parent and its Subsidiaries, as the case may be, that appears in
any filing made with, or written materials submitted to, any third party and/or
any Governmental Entity in connection with the Merger and the other transactions
contemplated by this Agreement. In the event that either party shall fail to
obtain any third party consent described in Section 6.5(a), such party shall use
reasonable best efforts, and shall take any such actions reasonably requested by
the other party hereto (it being understood that such action may become
effective at or after the Effective Time), to minimize any adverse effect upon
the Company and Parent, their respective Subsidiaries, and their respective
businesses resulting, or which could reasonably be expected to result after the
Effective Time, from the failure to obtain such consent.

      (d) Subject to, but without limiting the foregoing Sections 6.5(a) and
(b), Parent and the Company shall each use reasonable best efforts to avoid the
entry of, or to have


                                       59



vacated or terminated, any decree, order, or judgment that would restrain,
prevent or delay the Closing, on or before the Outside Date, including defending
through litigation on the merits any claim asserted in any court by any Person,
and to avoid or eliminate each and every impediment under any antitrust,
competition or trade regulation Law that may be asserted by any Government
Entity with respect to the Merger so as to enable the Closing to occur as soon
as reasonably possible (and in any event no later than the Outside Date).

      (e) From the date of this Agreement until the Effective Time, each party
shall promptly notify the other party in writing of any pending or, to the
Knowledge of the Company or Parent, as appropriate, threatened action, suit,
arbitration or other proceeding or investigation by any Governmental Entity or
any other Person (i) challenging or seeking damages in connection with the
Merger or the conversion of Company Common Stock into Parent Common Shares
pursuant to the Merger or (ii) seeking to restrain or prohibit the consummation
of the Merger or otherwise limit the right of Parent or its Subsidiaries to own
or operate all or any portion of the businesses or assets of the Company or its
Subsidiaries.

      (f) The Company and Parent shall cooperate and use reasonable best efforts
to obtain the agreement of the holder of the Warrant to exercise the Warrant
prior to Closing. At Parent's direction, the Company shall exercise its option
to cause all outstanding shares of Series A Convertible Preferred Stock to be
converted into Company Common Stock prior to Closing.

      (g) Subject to applicable Law, between the date hereof and the Effective
Time, the Company and Parent will consult and cooperate on matters relating to
the integration of Parent's and the Company's respective businesses and
personnel following the Effective Time and will periodically meet to discuss and
review such matters.

      Section 6.6 Certain Notices. From and after the date of this Agreement
until the Effective Time, each party hereto shall promptly notify the other
party hereto of (a) the occurrence, or non-occurrence, of any event that would
be likely to cause any condition to the obligations of any party to effect the
Merger and the other transactions contemplated by this Agreement not to be
satisfied or (b) the failure of the Company or Parent, as the case may be, to
comply with or satisfy any covenant, condition or agreement to be complied with
or satisfied by it pursuant to this Agreement which would reasonably be expected
to result in any condition to the obligations of any party to effect the Merger
and the other transactions contemplated by this Agreement not to be satisfied;
provided, however, that the delivery of any notice pursuant to this Section 6.6
shall not cure any breach of any representation or warranty, the failure to
comply with any covenant, the failure to meet any condition or otherwise limit
or affect the remedies available hereunder to the party receiving such notice.
Subject to applicable Law, promptly after the date hereof, Parent and the
Company shall establish a process for an ongoing dialogue and shall communicate
on a regular basis from and after the date of this Agreement until the Effective
Time with respect to significant business developments of the parties, including
any transaction of a type required to be disclosed on a Current Report filed on
Form 8-K pursuant to the Exchange Act (or that would be required to be disclosed
by a reporting person under the Exchange Act).




                                       60



      Section 6.7 Public Announcements. Parent and the Company will consult with
each other before issuing, and provide each other the opportunity to review and
make reasonable comment upon, any press release or making any public statement
with respect to this Agreement and the transactions contemplated hereby and,
except as may be required by applicable Law or any listing agreement with Nasdaq
or the Toronto Stock Exchange, will not issue any such press release or make any
such public statement prior to such consultation; provided, however, each of
Parent and the Company may make any public statement in response to specific
questions by the press, analysts, investors or those attending industry
conferences or financial analyst conference calls, so long as any such
statements are not inconsistent with previous press releases, public disclosures
or public statements made jointly by Parent and the Company and do not reveal
non-public information regarding the other party.

      Section 6.8 Nasdaq and Toronto Stock Exchange Listings. Parent shall use
reasonable best efforts to cause (a) the Parent Common Shares to be issued in
the Merger to be approved, subject to customary conditions, for listing upon the
Effective Time on Nasdaq and on the Toronto Stock Exchange, or on such other
national securities exchange or Designated Offshore Securities Market as the
Parent Common Shares are then listed and (b) the Parent Common Shares issued
upon the exercise of converted Company Options or upon the exercise of the
Company Warrant as converted pursuant to Section 2.5 hereof, if applicable, to
be approved, subject to customary conditions, for listing on Nasdaq and the
Toronto Stock Exchange or on such other national securities exchange or
Designated Offshore Securities Market as the Parent Common Shares are then
listed. Parent shall use reasonable best efforts to insure that there are no
legal or regulatory restrictions or limitation on the ability to transfer or
resell such Parent Common Shares in Canada or the United States, except for
restrictions generally arising under applicable United States and Canadian Law.

      Section 6.9 Indemnification of Directors and Officers.

      (a) For six (6) years after the Effective Time, Parent shall, and shall
cause the Surviving Corporation to, indemnify and hold harmless, and provide
advancement of expenses to, all past and present directors and officers of the
Company or any of its Subsidiaries and their respective estates, heirs and
personal representatives (the "Indemnified Parties") to the fullest extent
permitted by the DGCL and other applicable Law against any costs or expenses
(including reasonable expenses of counsel) as incurred (provided such
Indemnified Party provides an undertaking to the extent required by the DGCL to
repay such expenses if it is ultimately determined that such Indemnified Party
is not entitled to indemnification), judgments, fines, losses, claims, damages,
liabilities, and amounts paid in settlement in connection with any claim,
action, suit, proceeding or investigation, whether civil, criminal,
administrative or investigative, arising out of or pertaining to acts or
omissions occurring at or prior to the Effective Time (including acts or
omissions occurring in connection with the approval of this Agreement and the
consummation of the transactions contemplated hereby) in the performance of
their duties on behalf of the Company or any such Subsidiary, as applicable or
otherwise arising out of or pertaining to in whole or in part the fact that such
person is or was a director or officer of the Company or any of its
Subsidiaries.

      (b) For six (6) years from the Effective Time, Parent shall, or shall
cause the Surviving Corporation to, cause to be maintained in effect for the
benefit of the Company's



                                       61



current directors and officers an insurance and indemnification policy that
provides coverage for acts or omissions occurring prior to the Effective Time
(the "D&O Insurance") covering each such Person currently covered by the
officers' and directors' liability insurance policies of the Company on terms
with respect to coverage and in amounts no less favorable in the aggregate than
those of the Company's policies in effect on the date hereof; provided, however,
that the Surviving Corporation shall not be required to pay an annual premium
for the D&O Insurance in excess of the amount set forth on Schedule 6.9(b);
provided, further, Parent shall use reasonable best efforts to select a D&O
insurance carrier which lists as an approved counsel the law firm (the
"Designated Law Firm") with which the person identified on Schedule 6.9(b) (the
"Designated Person") is then associated. In lieu of the foregoing, Parent may
obtain, or request that the Company obtain, from such insurance carrier extended
reporting period coverage under the Company's existing officers' and directors'
insurance policies; provided, however, Parent shall not be required to pay more
than the amount set forth on Schedule 6.9(b) in the aggregate for such extended
reporting period coverage and provided, further, that such extended reporting
period coverage is no less favorable to the Company's officers and directors
than the foregoing coverage. If such coverage cannot be obtained for such
amounts, Parent shall provide, in consultation with the Persons currently
covered by the Company's directors' and officers' insurance, the maximum amount
of coverage as may be obtained for such amounts.

      (c) Parent shall, and shall cause the Surviving Corporation to, cause to
be maintained in effect in the Surviving Corporation's Certificate of
Incorporation and Bylaws provisions with respect to indemnification and
advancement of expenses that are at least as favorable to the intended
beneficiaries as those contained in the Company Certificate of Incorporation and
the Company Bylaws as in effect on the date hereof.

      (d) Any Indemnified Party wishing to claim indemnification under paragraph
(a) of this Section 6.9, upon learning of any such claim, action, suit,
proceeding or investigation, shall promptly notify Parent thereof, but the
failure to so notify shall not relieve Parent of any liability it may have to
such Indemnified Party unless, and only to the extent that, Parent is materially
prejudiced thereby. In the event of any such claim, action, suit, proceeding or
investigation, (i) the Indemnified Parties may retain counsel reasonably
satisfactory to Parent (it being understood that such counsel must be included
on the list of approved counsel maintained by Parent's or the Surviving
Corporation's (or its successors') insurance carrier under the applicable D&O
Insurance, that the Designated Law Firm and the Designated Person are each
satisfactory to Parent and that if the Designated Law Firm is not on such list
and the Designated Person is selected by the Indemnified Parties to represent
them as co-counsel in accordance herewith, Parent shall pay the reasonable fees
and expenses of the Designated Person and the Designated Law Firm incurred with
respect to such representation in addition to fees and expenses of approved
counsel), and Parent shall pay all reasonable fees and expenses of such counsel
for the Indemnified Parties promptly as statements therefor are received;
provided, however, except to the extent the Indemnified Parties are entitled to
retain the Designated Law Firm and the Designated Person as co-counsel, Parent
shall be obligated pursuant to this paragraph (d) to pay for only one firm of
counsel for all Indemnified Parties unless the use of one counsel for such
Indemnified Parties would present such counsel with a conflict of interest, (ii)
Parent, the Surviving Corporation and the Indemnified Parties will cooperate in
the defense of any such matter, and (iii) Parent and the Surviving Corporation
shall not be liable for any settlement effected without the prior written
consent of Parent, provided that Parent shall



                                       62



consent to any Covered Settlement. For purposes of this Section 6.9(d), a
"Covered Settlement" shall mean a settlement for monetary damages only which (i)
is covered under the D&O Insurance and does not exceed the limits of the
applicable D&O Insurance covering such claim, (ii) does not contain an admission
of liability on behalf of Parent, the Surviving Corporation or their Affiliates
or any other non-monetary conditions binding on Parent, the Surviving
Corporation or their Affiliates, and (iii) has been consented to by the
insurance carrier under such D&O Insurance (if such consent is required under
the terms of such D&O Insurance).

      (e) Notwithstanding any other provision of this Agreement to the contrary,
the provisions of this Section 6.9 are intended to be for the benefit of each
Indemnified Party. The obligations of Parent and the Surviving Corporation under
this Section 6.9 shall not be terminated or modified in such a manner as to
adversely affect any Indemnified Party to whom this Section 6.9 applies without
the express written consent of such affected Indemnified Party.

      Section 6.10 Plan of Reorganization. This Agreement is intended to
constitute a "plan of reorganization" within the meaning of Treasury Regulation
Section 1.368-2(g).

      Section 6.11 Affiliate Letters. The Company shall, promptly after the date
hereof and prior to the mailing of the Joint Proxy/Prospectus, deliver to Parent
a list setting forth the names of all persons the Company expects to be, at the
time of the Company Stockholders' Meeting, "affiliates" of the Company for
purposes of Rule 145 under the Securities Act. The Company shall furnish such
information and documents as Parent may reasonably request for the purpose of
reviewing the list. The Company shall use reasonable best efforts to cause each
Person who is identified as an affiliate in the list furnished or supplemented
pursuant to this Section 6.11 to execute a written agreement, promptly following
the date hereof, in substantially the form of Exhibit 6.11 hereto.

      Section 6.12 Section 16 Matters. Prior to the Effective Time the Board of
Directors of the Company or an appropriate committee of non-employee directors
thereof, shall adopt a resolution consistent with the interpretive guidance of
the SEC so that the disposition by any officer or director of the Company who is
a covered Person of the Company for purposes of Section 16 of the Exchange Act
of shares of Company Common Stock or Company Options pursuant to this Agreement
and the Merger shall be an exempt transaction for purposes of Section 16 of the
Exchange Act.

      Section 6.13 Stock Award Matters.

      (a) The Company shall, and shall cause the administrator(s) of each of the
Company Stock Option Plans to, take any and all actions necessary (under the
applicable Company Stock Option Plan and otherwise) to cause the Company Options
to be treated in accordance with Section 2.4 hereof, including if necessary
amending the Company Stock Option Plans and, if necessary, obtaining the consent
of the optionholders to such treatment.

      (b) Parent shall file one or more registration statements on Form S-8 (or
any other successor or other appropriate form) within five (5) Business Days
after the Closing Date, and, if required, one or more registration statements on
Form S-3 (or any other successor or other appropriate form) within twenty (20)
days after the Closing Date, in each case with respect to the Parent Common
Shares subject to options issued pursuant to Section 2.4 and shall maintain the



                                       63



effectiveness of such registration statement or registration statements (and
maintain the current status of the prospectus or prospectuses contained therein)
for so long as such options remain outstanding.

      Section 6.14 Company ESPP. The Company shall take all actions necessary to
provide that, following the date hereof, no additional shares of Company Common
Stock shall be issued under the Company's 1997 Employee Stock Purchase Plan (the
"Company ESPP") and all accumulated payroll deferrals shall be distributed to
participants under the Company ESPP as soon as practicable following the date
hereof.

      Section 6.15 Board of Directors of Parent; Vice Chairman. Effective as of
the Effective Time, the size of the Board of Directors of Parent shall be
increased from eight (8) to ten (10) members by the appointment of two
additional directors of Parent in accordance with this Section 6.15. David R.
Bethune shall be appointed as an additional director of Parent effective at the
Effective Time. An individual selected by the Board of Directors of the Company
from among its members, who shall be reasonably acceptable to the Board of
Directors of Parent, consistent with the policies of its Corporate Governance
and Nominating Committee, shall be appointed as an additional director of Parent
effective at the Effective Time. If David R. Bethune resigns his seat on the
Board of Directors of Parent within four months following the Effective Time,
the vacancy resulting from his resignation shall be filled promptly by an
individual identified prior to the Effective Time who shall have been selected
by the Board of Directors of the Company from among its members and who shall be
reasonably acceptable to the Board of Directors of Parent consistent with the
policies of its Corporate Governance and Nominating Committee as notified by
Parent to the Company prior to the Effective Time. David R. Bethune shall be
appointed Vice Chairman of the Board of Directors of Parent for a term of three
months commencing at the Effective Time. Parent's chief executive officer, in
consultation with such Vice Chairman of the Board of Directors of Parent, shall
be directly responsible for the oversight and direction of the integration of
the businesses of the Company and Parent including with respect to the orderly
transition of the Company.

      Section 6.16 Benefit Matters.

      (a) For a period of not less than twelve (12) months following the
Effective Time, the employees of the Company who remain in the employment of the
Surviving Corporation and its Subsidiaries (the "Continuing Employees") shall
receive health insurance coverage, a 401(k) plan (including matching
contributions) and employee benefits generally that, in each case, are in the
aggregate substantially comparable to the employee benefits provided under the
Company's employee benefit plans to such employees immediately prior to the
Effective Time; provided, that neither Parent nor the Surviving Corporation nor
any of their Subsidiaries shall have any obligation to issue, or adopt any plans
or arrangements providing for the issuance of shares of capital stock, warrants,
options or other rights in respect of any shares of capital stock of any entity
or any securities convertible or exchangeable into such shares pursuant to any
such plans or arrangement; provided, further, that no plans or arrangements of
the Company or any of its Subsidiaries providing for such issuance shall be
taken into account in determining whether employee benefits are substantially
comparable in the aggregate. Nothing contained herein shall be construed as
requiring, and the Company shall take no action that would have the effect of
requiring, Parent or the Surviving Corporation to continue any specific


                                       64



plans or to continue the employment of any specific Person or, from modifying
the terms or carriers of any specific plans.

      (b) With respect to any employee benefit plan maintained by Parent or
Surviving Corporation on or after the Effective Time and in which the Continuing
Employees are otherwise eligible to enroll, Parent will, or will cause the
Surviving Corporation to (i) waive all limitations as to preexisting conditions,
exclusions and waiting periods with respect to participation and coverage
requirements otherwise applicable to Continuing Employees, and (ii) provide each
Continuing Employee with credit for any co-payments or deductibles paid prior to
the Effective Time in satisfying any applicable deductible or out-of-pocket
requirements under any employee benefit plan or Included Benefit that
constitutes a welfare benefit under Section 3(1) of ERISA.

      (c) On and after the Effective Time, Parent shall, or shall cause the
Surviving Company to, recognize the service of each Continuing Employee with the
Company or its Subsidiaries for purposes of determining entitlement to vacation
and vacation pay and for purposes of vesting and eligibility under any employee
benefit plan in which the Continuing Employee is eligible to participate, but
not for purposes of benefit accrual under any "employee pension benefit plan" as
defined in Section 3(2) of ERISA.

      (d) Prior to the Effective Time, the Company shall take all actions
necessary to amend the Company 401(k) Savings and Retirement Plan (the "401(k)
Plan") to provide that, on and after the Effective Time, no additional
investments shall be permitted under the Company stock fund under the 401(k)
Plan (other than amounts invested in such fund as of the Effective Time).

      (e) (i) Unless and to the extent otherwise instructed by the Company prior
to the Closing Date, Parent shall take all actions necessary to, immediately
following the Effective Time, offer each holder of an Eligible Assumed Option
(as defined below) an amendment at such holder's election to provide that each
Eligible Assumed Option shall be exercisable until the earlier of (A) the
expiration of its term or (B) in the case of an Eligible Assumed Option held by
a non-employee director of the Company, twelve (12) months following the date of
the termination of such holder's directorship at Parent, the Company or any of
Parent's Affiliates, and in the case any other Eligible Assumed Option, twelve
(12) months following the date of termination by Parent or any of its Affiliates
of the employment or consultancy of the holder of such Eligible Assumed Option
in the event of such termination of employment or consultancy without "Cause"
(as defined below) within the twelve (12) month period immediately following the
Effective Time.

            (ii) For purposes of this Section 6.16(e), "Cause" shall mean (A) if
the employee or consultant materially violates any term of his/her employment or
consultancy or any policies of Parent or any of its Affiliates and such
violation is not substantially remedied within 30 days of written notice from
Parent to such employee or consultant; (B) willful misfeasance, gross negligence
or nonfeasance of duty by such employee or consultant that is reasonably likely
to be detrimental or damaging or that has the effect of injuring or damaging the
reputation, business or business relationships of Parent or any of its
Affiliates or any of their respective officers, directors or employees; (C) any
arrest, indictment


                                       65



(defined as any proceeding in which "probable cause" is found), conviction (or
the civil equivalent) of such employee or consultant or a plea of guilty or nolo
contendere by such employee or consultant to a charge based on a federal or
state felony or serious criminal or civil offense (even if the crime is
classified under the applicable law as a "misdemeanor"), including, but not
limited to (x) crimes or civil offenses involving theft, embezzlement, fraud,
dishonesty or moral turpitude; (y) crimes or civil offenses based on banking or
securities laws (including the Sarbanes-Oxley Act); and (z) civil enforcement
actions brought by federal or state regulatory agencies (including the SEC); or
(D) willful or prolonged and unapproved absence from work by the employee or
consultant or failure, neglect or refusal by the employee or consultant to
perform his/her duties and responsibilities as determined by the chief executive
officer of Parent in his sole discretion.

            (iii) For purposes of this Section 6.16(e), "Eligible Assumed
Option" shall mean a Company Option that (A) is assumed and becomes exercisable
for Parent Common Shares pursuant to Section 2.4(a) and (B) is not intended to
qualify as an incentive stock option within the meaning of Code Section 422
immediately after the Effective Time. For the avoidance of doubt, Eligible
Assumed Options shall include the portion of those Company Options that do not
qualify as incentive stock options within the meaning of Code Section 422
immediately after the Effective Time notwithstanding whether the option or grant
agreements evidencing such Company Options express an intention to qualify as
incentive stock options.

                                   ARTICLE 7.
                               CLOSING CONDITIONS

      Section 7.1 Conditions to Each Party's Obligation to Effect the Merger.
The respective obligations of each party to effect the Merger is subject to the
satisfaction or (to the extent permitted by Law) waiver on or prior to the
Closing Date of the following conditions:

      (a) Company Stockholder Approval; Parent Shareholder Approval. The Company
Stockholder Approval and the Parent Shareholder Approval shall have been
obtained.

      (b) HSR Act. The waiting period (and any extension thereof) applicable to
the Merger under the HSR Act shall have been terminated or shall have expired.

      (c) No Injunctions or Restraints; Illegality. No temporary restraining
order, preliminary or permanent injunction or other judgment or prohibition or
order issued by any court of competent jurisdiction or any other Law
(collectively, "Restraints") shall be in effect preventing the consummation of
the Merger; provided, however, that the parties hereto shall use their
reasonable best efforts to have any such order, injunction, judgment or other
prohibition vacated or terminated. There shall not be any statute, rule,
regulation or order enacted by any U.S. or Canadian Governmental Entity which
makes the consummation of the Merger illegal. There shall not be pending by any
Governmental Entity any suit, action or proceeding seeking to prohibit the
consummation of the Merger or seeking to place material limitations on the
ownership of shares of capital stock of the surviving corporation in the Merger
or the Second Step Merger.




                                       66



      (d) Effectiveness of the Registration Statement. The Registration
Statement shall have been declared effective by the SEC under the Securities
Act. No stop order suspending the effectiveness of the Registration Statement
shall have been issued by the SEC and no proceedings for that purpose shall have
been initiated by the SEC and be continuing.

      (e) Nasdaq and TSX Listing. The Parent Common Shares to be issued in the
Merger shall have been approved for listing on Nasdaq and the Toronto Stock
Exchange, subject to customary conditions (not involving hold periods or
restrictions or limitations on the ability to transfer such Parent Common Shares
in Canada or the United States, except for restrictions or limitations generally
arising under applicable United States or Canadian Laws) and official notice of
issuance.

      (f) Consents and Approvals. Other than filing the Certificate of Merger
and filings pursuant to the HSR Act, all consents, approvals and authorizations
of any Governmental Entity required of Parent, the Company or any of their
respective Subsidiaries to consummate the Merger, the failure of which to be
obtained or taken, individually or in the aggregate, would have a Material
Adverse Effect on Parent (determined, for purposes of this clause, after giving
effect to the Merger), shall have been obtained.

      (g) Governmental Entities. There shall not be pending by any Governmental
Entity any suit, action or proceeding (i) seeking to prohibit or materially
limit the ownership or operation by Parent or the Surviving Corporation of the
business or a material portion of the assets of the Company and its
Subsidiaries, taken as a whole, or to compel Parent or the Surviving Corporation
to divest any material portion of the business of the Company and its
Subsidiaries, taken as a whole, as a result of the Merger, or (ii) seeking to
prohibit Parent or the Surviving Corporation from effectively controlling in any
material respect the business or operations of the Company and its Subsidiaries
taken as a whole.

      (h) Restraints. No Restraint that would reasonably be expected to result,
directly or indirectly, in any of the effects referred to in clauses (i) or (ii)
of paragraph (g) of this Section 7.1 shall be in effect.

      Section 7.2 Conditions to Obligations of Parent and Merger Sub. The
obligations of Parent and Merger Sub to effect the Merger are further subject to
the satisfaction or (to the extent permitted by Law) waiver on or prior to the
Closing Date of the following conditions:

      (a) Representations and Warranties. The representations and warranties of
the Company contained in this Agreement shall be true and correct (without
giving effect to any limitation as to "materiality" or "Material Adverse Effect"
set forth therein) as of the date of this Agreement and as of the Closing Date
as though made on the Closing Date (except to the extent such representations
and warranties expressly relate to an earlier date, in which case as of such
earlier date), except where the failure of such representation and warranty to
be so true and correct (without giving effect to any limitation as to
"materiality" or "Material Adverse Effect" set forth therein) would not,
individually or in the aggregate, result in a Material Adverse Effect on the
Company. Parent shall have received a certificate signed on behalf of the
Company by the chief executive officer and the chief financial officer of the
Company to such effect.




                                       67



      (b) Performance of Obligations of the Company. The Company shall have
performed in all material respects all obligations required to be performed by
it under this Agreement at or prior to the Closing Date, and Parent shall have
received a certificate signed on behalf of the Company by the chief executive
officer and the chief financial officer of the Company to such effect.

      (c) Parent Tax Opinion. Parent shall have received the opinion of Latham &
Watkins LLP, dated as of the Effective Time, to the effect that on the basis of
the facts, representations and assumptions set forth in such opinion, the
Transaction will be treated for federal income tax purposes as a reorganization
within the meaning of Section 368(a) of the Code, and Section 367(a)(1) of the
Code will not apply to a stockholder's surrender of Company Common Stock or
Series A Convertible Preferred Stock pursuant to the Transaction (except in the
case of a Company stockholder who is or will be a "five-percent transferee
shareholder," within the meaning of Treasury Regulation Section
1.367(a)-3(c)(5)(ii), and does not enter into a gain recognition agreement in
the form provided in Treasury Regulation Section 1.367(a)-8). In rendering such
opinion, Latham & Watkins LLP shall receive and rely upon representations
contained in letters of Parent and the Company to be delivered as of the
Effective Time substantially in the forms attached hereto as Exhibits 7.2(c)(i)
and 7.2(c)(ii), respectively. The opinion referred to in this Section 7.2(c)
shall not be waivable after receipt of the Company Stockholder Approval or the
Parent Shareholder Approval referred to in Section 7.1(a), unless further
stockholder approval is obtained with appropriate disclosure.

      Section 7.3 Conditions to Obligation of the Company. The obligation of the
Company to effect the Merger is further subject to the satisfaction or (to the
extent permitted by Law) waiver on or prior to the Closing Date of the following
conditions:

      (a) Representations and Warranties. The representations and warranties of
Parent and Merger Sub contained in this Agreement shall be true and correct
(without giving effect to any limitation as to "materiality" or "Material
Adverse Effect" set forth therein) as of the date of this Agreement and as of
the Closing Date as though made on the Closing Date (except to the extent such
representations and warranties expressly relate to an earlier date, in which
case as of such earlier date), except where the failure of such representation
and warranty to be so true and correct (without giving effect to any limitation
as to "materiality" or "Material Adverse Effect" set forth therein) would not,
individually or in the aggregate, result in a Material Adverse Effect on Parent
or Merger Sub. The Company shall have received a certificate signed on behalf of
Parent by the chief executive officer and the chief financial officer of Parent
to such effect.

      (b) Performance of Obligations of Parent and Merger Sub. Parent and Merger
Sub shall have performed in all material respects all obligations required to be
performed by them under this Agreement at or prior to the Closing Date, and the
Company shall have received a certificate signed on behalf of Parent by the
chief executive officer and the chief financial officer of Parent to such
effect.

      (c) Company Tax Opinion. The Company shall have received the opinion of
Morrison & Foerster LLP, dated as of the Effective Time, to the effect that on
the basis of the facts, representations and assumptions set forth in such
opinion, the Transaction will be treated



                                       68



for federal income tax purposes as a reorganization within the meaning of
Section 368(a) of the Code, and Section 367(a)(1) of the Code will not apply to
a stockholder's surrender of Company Common Stock or Series A Convertible
Preferred Stock pursuant to the Transaction (except in the case of a Company
stockholder who is or will be a "five-percent transferee shareholder," within
the meaning of Treasury Regulation Section 1.367(a)-3(c)(5)(ii), and does not
enter into a gain recognition agreement in the form provided in Treasury
Regulation Section 1.367(a)-8). In rendering such opinion, Morrison & Foerster
LLP shall receive and rely upon representations contained in letters of Parent
and the Company to be delivered as of the Effective Time substantially in the
form attached hereto as Exhibits 7.2(c)(i) and 7.2(c)(ii), respectively. The
opinion referred to in this Section 7.3(c) shall not be waivable after receipt
of the Company Stockholder Approval or the Parent Shareholder Approval referred
to in Section 7.1(a), unless further stockholder approval is obtained with
appropriate disclosure.

                                   ARTICLE 8.
                        TERMINATION, AMENDMENT AND WAIVER

      Section 8.1 Termination. This Agreement may be terminated at any time
prior to the Effective Time, by action taken or authorized by the Board of
Directors of the terminating party or parties, whether before or after approval
of the matters presented in connection with the Merger by the stockholders of
the Company or the shareholders of Parent:

      (a) by mutual written consent of Parent and the Company, which consent
shall have been approved by action of their respective Boards of Directors;

      (b) by written notice of either the Company or Parent, if the Merger shall
not have been consummated prior to December 15, 2004 (the "Outside Date");
provided, however, the right to terminate this Agreement under this Section
8.1(b) shall not be available to any party whose failure to fulfill any
obligation under this Agreement has been the cause of, or results in, the
failure of the Merger to occur on or before such date; provided, further, that
in the event the failure of the Merger to be consummated by such date is caused
by a pending investigation or review by a Governmental Entity, either Parent or
the Company (unless such extending party or such extending party's failure to
fulfill any obligation under this Agreement has been the cause of, or results
in, the existence or continuance of the pending investigation or review) may
extend the Outside Date to February 15, 2005;

      (c) by written notice of either the Company or Parent, if any Governmental
Entity shall have issued an order, decree or ruling or taken any other action
permanently restraining, enjoining or otherwise prohibiting the Merger, and such
order, decree, ruling or other action shall have become final and nonappealable
(which order, decree, ruling or other action the parties shall have used their
reasonable best efforts to resist, resolve or lift, as applicable, in accordance
with Section 6.5);

      (d) by written notice of Parent, if (i) the Board of Directors of the
Company shall have withdrawn or adversely modified, or shall have adopted
resolutions to withdraw or adversely modify, the Company Recommendation; or (ii)
the Board of Directors of the Company shall have approved or recommended, or
shall have adopted resolutions to approve or recommend, to the stockholders of
the Company, an Acquisition Proposal other than that contemplated by this
Agreement;




                                       69



      (e) by written notice of the Company, if the Board of Directors of Parent
shall have withdrawn or adversely modified, or shall have adopted resolutions to
withdraw or adversely modify, the Parent Recommendation;

      (f) by written notice of Parent, if there has been a breach by the Company
of any representation, warranty, covenant or agreement contained in this
Agreement which (i) would result in a failure of a condition set forth in
Section 7.2(a) or 7.2(b) and (ii) cannot be cured prior to the Outside Date,
provided that Parent shall have given the Company written notice, delivered at
least twenty days prior to such termination, stating Parent's intention to
terminate this Agreement pursuant to this Section 8.1(f) and the basis for such
termination;

      (g) by written notice of the Company, if there has been a breach by Parent
of any representation, warranty, covenant or agreement contained in this
Agreement which (i) would result in a failure of a condition set forth in
Section 7.3(a) or 7.3(b) and (ii) cannot be cured prior to the Outside Date,
provided that the Company shall have given Parent written notice, delivered at
least twenty days prior to such termination, stating the Company's intention to
terminate this Agreement pursuant to this Section 8.1(g) and the basis for such
termination; or

      (h) by written notice of either Parent or the Company if (i) the Company
Stockholder Approval shall not have been obtained at the Company Stockholders'
Meeting duly convened therefor (or at any adjournment or postponement thereof)
at which a quorum is present and the vote to adopt and approve this Agreement is
taken, or (ii) the Parent Shareholder Approval shall not have been obtained at
the Parent Shareholders' Meeting duly convened therefor (or at any adjournment
or postponement thereof) at which a quorum is present and the vote to approve
the Share Issuance is taken.

      Section 8.2 Effect of Termination.

      (a) Limitation on Liability. In the event of termination of this Agreement
by either the Company or Parent as provided in Section 8.1, this Agreement shall
forthwith become void and there shall be no liability or obligation on the part
of Parent, Merger Sub or the Company or their respective Subsidiaries, officers
or directors, except with respect to Sections 6.3(c) and 8.2 and Article 9 and
with respect to any liabilities or damages incurred or suffered by a party as a
result of the willful and material breach by the other party of any of its
representations, warranties, covenants or other agreements set forth in this
Agreement.

      (b) Termination Expenses.

            (i) If this Agreement is terminated pursuant to Section 8.1(f) or
under circumstances in which a Termination Fee is due pursuant to Section
8.2(c), then the Company shall pay Parent an amount equal to the sum of Parent's
Expenses for which Parent has not theretofore been reimbursed by the Company up
to an amount equal to (together with all such theretofore reimbursed amounts) $2
million. If this Agreement is terminated pursuant to Section 8.1(g), then Parent
shall pay to the Company an amount equal to the sum of the Company's Expenses
for which the Company has not theretofore been reimbursed by Parent up to an
amount equal to (together with all such theretofore reimbursed amounts) $2
million. Payment of Expenses pursuant to the foregoing sentences of this Section
8.2(b) shall be made not later than two Business Days after delivery to the
other party of notice of demand for payment


                                       70



and a documented itemization setting forth in reasonable detail all Expenses of
the party entitled to receive payment (which itemization may be supplemented and
updated from time to time by such party until the ninetieth day after such party
delivers such notice of demand for payment).

            (ii) If, following a Change of Recommendation in accordance with
Section 6.4(e) which the Company shall have publicly announced, the Company
shall have requested in writing that Parent terminate this Agreement pursuant to
Section 8.1(d), and Parent shall not have so terminated this Agreement within
seven days following such request, Parent shall pay to the Company an amount
equal to $2 million within two Business Days after the expiration of such
period.

      (c) Termination Fee.

            (i) In the event that this Agreement is terminated pursuant to
Section 8.1(d), then the Company shall pay to Parent, within two Business Days
following written notice of such termination, a termination fee of $25 million
(the "Termination Fee").

            (ii) In the event that the Board of Directors of the Company shall
have withdrawn or adversely modified the Company Recommendation prior to the
Company Stockholders' Meeting and this Agreement is terminated pursuant to
Section 8.1(h)(i), then the Company shall pay to Parent, within two Business
Days following written notice of such termination, the Termination Fee.

            (iii) In the event that (A) (i) the Company fails to hold the
Company Stockholders' Meeting on or prior to the fifth (5th) Business Day prior
to the Outside Date, and (x) at such time there are no restrictions under
applicable Law, imposed by a Governmental Entity or arising from any act or
omission of Parent that prohibit or materially impede or delay the Company from
holding the Company Stockholders' Meeting by the fifth (5th) Business Day prior
to the Outside Date and (y) there were no such restrictions effective prior to
such time that prevented or materially impeded or delayed the Company from
calling or holding the Company Stockholders' Meeting by the fifth (5th) Business
Day prior to the Outside Date, and (z) Parent has duly called the Parent
Shareholders' Meeting to be held on or prior to the fifth (5th) Business Day
prior to the Outside Date and this Agreement is terminated pursuant to Section
8.1(b), (ii) this Agreement is terminated pursuant to Section 8.1(f) as a result
of a breach by the Company of any covenant or agreement in this Agreement or
(iii) this Agreement is terminated pursuant to Section 8.1(h)(i), and in the
case of each of the foregoing clauses (i), (ii) and (iii), at any time after the
date of this Agreement and before such termination pursuant to Section 8.1(b) or
(f) or, in the case of termination under Section 8.1(h)(i), the vote on this
Agreement at the Company Stockholders' Meeting (or any adjournment or
postponement thereof), as the case may be, an Acquisition Proposal with respect
to the Company shall have been publicly announced and (B) an Acquisition
Proposal with respect to the Company is consummated or the Company enters into a
definitive agreement with respect to an Acquisition Proposal, in either case,
within twelve months following the termination of this Agreement, then the
Company shall pay the Termination Fee to Parent within two Business Days after
the earlier of the consummation of such Acquisition Proposal or execution of a
definitive agreement with respect to such Acquisition Proposal.




                                       71



      (d) Termination Payments. All payments under this Section 8.2 shall be
made by wire transfer of immediately available funds to an account designated by
the party entitled to receive payment. The Company and Parent acknowledge that
the agreements contained in this Section 8.2 are an integral part of the
transactions contemplated by this Agreement and that, without these agreements,
neither the Company nor Parent would enter into this Agreement. Accordingly, if
Parent or the Company fails promptly to pay any amount due pursuant to this
Section 8.2 and, in order to obtain such payment, Parent or the Company, as the
case may be, commences a suit which results in a judgment against the other
party for the fee set forth in this Section 8.2, such defaulting party shall pay
to the prevailing party its costs and expenses (including reasonable attorneys'
fees and expenses) in connection with such suit, together with interest on the
amount of the fee at the prime rate of Citibank, N.A. in effect on the date such
payment was required to be made.

      Section 8.3 Amendment. This Agreement may be amended by the parties hereto
by action taken by or on behalf of their respective Boards of Directors at any
time prior to the Effective Time; provided, however, that, after approval of the
Merger or the Share Issuance by the stockholders of the Company or the
shareholders of Parent, as the case may be, no amendment may be made without
further stockholder approval which, by Law or in accordance with the rules of
Nasdaq or the Toronto Stock Exchange, requires further approval by such
stockholders. This Agreement may not be amended except by an instrument in
writing signed by the parties hereto.

      Section 8.4 Waiver. At any time prior to the Effective Time, any party
hereto may (a) extend the time for the performance of any of the obligations or
other acts of the other party hereto, (b) waive any inaccuracies in the
representations and warranties of the other party contained herein or in any
document delivered pursuant hereto, and (c) waive compliance by the other party
with any of the agreements or conditions contained herein; provided, however,
that after any approval of the transactions contemplated by this Agreement by
the stockholders of the Company or the shareholders of Parent, there may not be,
without further approval of such stockholders, any extension or waiver of this
Agreement or any portion thereof which, by Law or in accordance with the rules
of Nasdaq or the Toronto Stock Exchange, requires further approval by such
stockholders. Any such extension or waiver shall be valid only if set forth in
an instrument in writing signed by the party or parties to be bound thereby, but
such extension or waiver or failure to insist on strict compliance with an
obligation, covenant, agreement or condition shall not operate as a waiver of,
or estoppel with respect to, any subsequent or other failure.

      Section 8.5 Fees and Expenses. Subject to Sections 6.1(d), 8.2(a) and
8.2(b), all Expenses incurred by the parties hereto shall be borne solely and
entirely by the party which has incurred the same.

                                   ARTICLE 9.
                               GENERAL PROVISIONS

      Section 9.1 Non-Survival of Representations and Warranties. None of the
representations and warranties in this Agreement or in any instrument delivered
pursuant to this


                                       72



Agreement shall survive the Effective Time. This Section 9.1 shall not limit any
covenant or agreement of the parties which by its terms contemplates performance
after the Effective Time.

      Section 9.2 Notices. Any notices or other communications required or
permitted under, or otherwise in connection with this Agreement shall be in
writing and shall be deemed to have been duly given when delivered in person or
upon confirmation of receipt when transmitted by facsimile transmission (but
only if followed by transmittal by national overnight courier or hand for
delivery on the next Business Day) or on the next Business Day if transmitted by
national overnight courier, in each case as follows:

      (a) If to Parent or Merger Sub, addressed to it at:

          QLT Inc.
          887 Great Northern Way
          Vancouver, British Columbia
          Canada
          V5T 4T5
          Fax: (604) 707-7369
          Attn:  President and Chief Executive Officer

          with a copy to:

          Latham & Watkins LLP
          135 Commonwealth Drive
          Menlo Park, California 94025
          Fax: (650) 463-2600
          Attention:  Ora T. Fisher

          and a copy to:

          Farris, Vaughan, Wills & Murphy
          2500-700 W. Georgia St.
          Vancouver, British Columbia
          V7X 1B3
          Fax: (604) 661-9349
          Attention:  R. Hector MacKay-Dunn, QC

      (b) If to the Company, addressed to it at:

          Atrix Laboratories, Inc.
          2579 Midpoint Drive
          Fort Collins, CO
          Fax: (970) 482-5978
          Attn:  Chairman of the Board and Chief Executive Officer

          with a copy to:



                                       73




          Morrison & Foerster LLP
          5200 Republic Plaza
          370 Seventeenth Street
          Denver, Colorado 80202-5638
          Fax:  (303) 592-1510
          Attention: Warren L. Troupe

      Section 9.3 Certain Definitions. For purposes of this Agreement, the term:

      (a) "Acquisition Proposal" means any offer or proposal made by a Person
other than Parent or Merger Sub concerning any (a) merger, consolidation,
business combination, or similar transaction involving the Company or any
Subsidiary of the Company pursuant to which the stockholders of the Company
immediately prior to such transaction would own less than 85% of the aggregate
voting power of the entity surviving or resulting from such transaction (or the
ultimate parent entity thereof), (b) sale, exclusive license or other
disposition directly or indirectly of assets of the Company or the Company's
Subsidiaries representing 15% or more of the consolidated assets of the Company
and the Company's Subsidiaries, (c) issuance, sale, or other disposition of
securities (or options, rights or warrants to purchase, or securities
convertible into or exchangeable for, such securities) in each case by the
Company representing 15% or more of the voting power of the Company or (d)
transaction in which any Person shall acquire beneficial ownership, or the right
to acquire beneficial ownership or any group shall have been formed which
beneficially owns or has the right to acquire beneficial ownership of, 15% or
more of the outstanding voting capital stock of the Company.

      (b) "Affiliate" of any Person means another Person that directly or
indirectly, through one or more intermediaries, controls, is controlled by, or
is under common control with, such first Person.

      (c) "ANDA" means abbreviated new drug application.

      (d) "beneficial ownership" (and related terms such as "beneficially owned"
or "beneficial owner") has the meaning set forth in Rule 13d-3 under the
Exchange Act.

      (e) "BLA" means biologics license application.

      (f) "Blue Sky Laws" means state securities or "blue sky" Laws.

      (g) "Business Day" means any day on which banks are not required or
authorized to close in the City of New York or the Province of British Columbia.

      (h) "CERCLA" means the Comprehensive Environmental Response, Compensation
and Liability Act of 1980, as amended as of the date hereof.

      (i) "Company Option" means any option to purchase Company Common Stock.

      (j) "Company Stock-Based Award" means any stock appreciation right,
"phantom" stock right, performance unit, right to receive shares of Company
Common Stock on


                                       74



a deferred basis or other right (other than Company Preferred Stock, Company
Options and the Warrant) that are linked to the value of Company Common Stock.

      (k) "Company Stock Option Plans" means the Company's Amended and Restated
Performance Stock Option Plan, as amended, Non-Qualified Stock Option Plan, as
amended, 2000 Stock Incentive Plan, 1999 Non-Employee Director Stock Incentive
Plan and 1997 Employee Stock Purchase Plan and in each case, the addendums
thereto, or any other plan, agreement or arrangement pursuant to which Company
Options have been issued as of the Effective Time.

      (l) "Contracts" means any of the agreements, contracts, leases, powers of
attorney, notes, loans, evidence of indebtedness, letters of credit, settlement
agreements, franchise agreements, undertakings, covenants not to compete,
employment agreements, licenses, instruments, obligations, commitments, binding
purchase and sales orders and other executory commitments to which either party
is a party or to which any of the assets of either party are subject, whether
oral or written, express or implied.

      (m) "control" (including the terms "controlled by" and "under common
control with") means the possession, directly or indirectly or as trustee or
executor, of the power to direct or cause the direction of the management or
policies of a Person, whether through the ownership of securities or as trustee
or executor, by Contract or credit arrangement or otherwise.

      (n) "delivered" or "made available" (or words of similar import) shall
include all documents and materials made available in the Company's data room in
Denver, Colorado or Parent's data room in Vancouver, British Columbia, as the
case may be.

      (o) "Designated Offshore Securities Market" has the meaning ascribed to
such term in Rule 902(b) under the Securities Act.

      (p) "Designated Territory" means the United States, Canada, the European
Union and Japan.

      (q) "Environmental Laws" means any Law relating to the pollution,
protection, investigation or restoration of the environment, health and safety
as affected by the environment or natural resources, including those relating to
the use, handling, presence, transportation, treatment, storage, disposal,
release, threatened release or discharge of Hazardous Materials or noise, odor,
wetlands, pollution or contamination.

      (r) "Environmental Permits" means any permit, approval, identification
number, license and other authorization required under any applicable
Environmental Law.

      (s) "ERISA" means the Employee Retirement Income Security Act of 1974, as
amended, and the regulations promulgated thereunder.

      (t) "ERISA Affiliate" means any entity or trade or business (whether or
not incorporated) other than the Company that together with the Company is
considered under common control and treated as a single employer under Section
4.14(b), (c), (m) or (o) of the Code.



                                       75



      (u) "Expenses" includes all reasonable out-of-pocket expenses (including
all reasonable fees and expenses of counsel, accountants, investment bankers,
experts and consultants to a party hereto and its Affiliates) incurred by a
party or on its behalf in connection with or related to the authorization,
preparation, negotiation, execution and performance of this Agreement and the
transactions contemplated hereby, including the preparation, printing, filing
and mailing of the Registration Statement and Joint Proxy/Prospectus, as
applicable, and the solicitation of shareholder or stockholder approvals and all
other matters related to the transactions contemplated hereto.

      (v) "Filed Company SEC Filings" means the Company SEC Filings filed by the
Company and publicly available prior to the date of this Agreement.

      (w) "Filed Parent SEC Filings" means the Parent SEC Filings filed by
Parent with the SEC and publicly available prior to the date of this Agreement.

      (x) "group" is defined as in the Exchange Act, except where the context
otherwise requires.

      (y) "Hazardous Materials" means (i) any petroleum, petroleum products,
byproducts or breakdown products, radioactive materials, asbestos-containing
materials or polychlorinated biphenyls or (ii) any chemical, material or other
substance defined or regulated as toxic or hazardous or as a pollutant or
contaminant or waste under any applicable Environmental Law.

      (z) "Intellectual Property" means intellectual property or other
proprietary rights of every kind, foreign or domestic, including all patents,
patent applications, inventions (whether or not patentable), processes,
products, technologies, discoveries, copyrightable and copyrighted works, web
site content, apparatus, trade secrets, trademarks, trademark registrations and
applications, domain names, service marks, service mark registrations and
applications, trade names, trade secrets, know-how, trade dress, copyright
registrations, customer lists, confidential marketing and customer information,
licenses, confidential technical information, software, and all documentation
thereof.

      (aa) "Knowledge" of (i) the Company means the actual knowledge of the
persons listed in respect of the Company in Section 9.3(aa) of the Company
Disclosure Schedule, and (ii) Parent means the actual knowledge of persons
listed in respect of Parent in such same Section 9.3(aa), in each case after
such investigation as would be performed by a reasonable individual in the
ordinary course of his or her duties.

      (bb) "Law" means any federal, state, local, municipal, foreign (including
Canadian, federal and provincial), international, multinational or other
administrative order, constitution, law, ordinance, rule, guidance, principle of
common law, regulation, statute or treaty, including (i) all federal and state
fraud and abuse laws, including the federal Anti-Kickback Statute (42 U.S.C.
Section1320a-7(b)), the federal Stark Law (42 U.S.C. Section1395nn and
Section1395(q)), the civil False Claims Act (31 U.S.C. Section 3729 et seq.),
and the regulations promulgated pursuant to such statutes; (ii) the federal Food
Drug and Cosmetic Act; (iii) Medicare; (iv) Medicaid; and (v) quality, safety,
pricing and accreditation standards and requirements of all


                                       76



applicable state Laws or regulatory bodies (collectively, items (i) through (v)
are referred to herein as "Health Care Laws").

      (cc) "Material Adverse Effect", as used with respect to the Company or
Parent, as the case may be, means any change, effect, event, occurrence, state
of facts or development which individually or in the aggregate would reasonably
be expected to result in any change or effect, that (i) is materially adverse to
the business, financial condition, assets, liabilities (contingent or otherwise)
or results of operations of such entity and its Subsidiaries, in each case taken
as a whole, or (ii) would reasonably be expected to prevent or materially impede
or delay the consummation by such entity of the Merger or the other transactions
contemplated by this Agreement; provided, however, none of the following shall
be deemed, either alone or in combination, to constitute, and none of the
following shall be taken into account in determining whether there has been or
will be, a Material Adverse Effect: any change, effect, event, occurrence, state
of facts or development (A)(1) in Canadian, United States or global financial or
securities markets or the Canadian, United States or global economy in general,
including any fluctuation, in and of itself, in the price of Parent Common
Shares or shares of Company Common Stock, as the case may be (it being
understood that the facts or occurrences giving rise or contributing to such
fluctuation may be deemed to constitute, or be taken into account in determining
whether there has been or will be, a Material Adverse Effect), (2) in the
biopharmaceutical industry in general, or (3) in Laws of general applicability
(or interpretations thereof by Governmental Entities), in each case to the
extent that the effects thereof do not materially disproportionately impact the
Company and its Subsidiaries, taken as a whole, or Parent and its Subsidiaries,
taken as a whole, as the case may be; (B) relating to the execution or public
announcement of this Agreement and the transactions contemplated hereby, or any
actions or omissions taken as required in this Agreement; (C) arising from
changes in GAAP or regulatory accounting requirements; and (D) resulting from
actions, recommendations or decisions of the FDA with respect to NDAs, BLAs,
ANDAs or sNDAs of the Company, Parent or any of their respective actual or
potential competitors.

      (dd) "Nasdaq" means the Nasdaq Stock Market.

      (ee) "NDA" means new drug application.

      (ff) "Parent Option" means any option to purchase Parent Common Shares.

      (gg) "Parent Share-Based Award" means any stock appreciation rights,
"phantom" stock rights, performance units, rights to receive Parent Common
Shares on a deferred basis or other rights (other than Parent Preferred Shares
and the Parent Options) that are linked to the value of Parent Common Shares.

      (hh) "Parent Stock Option Plan" Parent's 1998 Incentive Stock Option Plan
and 2000 Incentive Stock Option Plan.

      (ii) "Permitted Lien" means (i) Liens for Taxes, assessments or similar
charges incurred in the ordinary course of business consistent with past
practice that are not yet due and payable or are being contested in good faith;
(ii) pledges or deposits made in the ordinary course of business consistent with
past practice; (iii) Liens of mechanics, materialmen, warehousemen or other like
Liens securing obligations incurred in the ordinary course of


                                       77



business consistent with past practice that are not yet due and payable or are
being contested in good faith; (iv) Liens incurred in connection with capital
leases and purchase money financings solely with respect to properties so
financed; and (v) similar Liens and encumbrances which are incurred in the
ordinary course of business consistent with past practice and which do not in
the aggregate materially detract from the value of such assets or properties or
materially impair the use thereof in the operation of such business.

      (jj) "Person" means an individual, corporation, partnership, limited
liability company, joint venture, association, trust, unincorporated
organization or other entity; and

      (kk) "Share Issuance" means the issuance of Parent Common Shares pursuant
to Section 2.1(a).

      (ll) "sNDA" means supplemental new drug application.

      (mm) "Subsidiary" or "Subsidiaries" of any Person means, with respect to
such Person, any corporation, partnership, joint venture or other legal entity
of which such Person (either alone or through or together with any other
subsidiary), owns, directly or indirectly, 50% or more of the stock or other
equity interests the holders of which are generally entitled to vote for the
election of the Board of Directors or other governing body of such corporation
or other legal entity.

      (nn) "Superior Proposal" means any bona fide offer or proposal (on its
most recently amended or modified terms, if amended or modified (each such
amendment or modification being deemed a new Superior Proposal)) made by a
Person other than Parent or Merger Sub that concerns any merger, consolidation,
tender offer, exchange offer, asset acquisition (including by exclusive
license), stock or other securities issuance, business combination or similar
transaction involving the Company or any Subsidiary of the Company that if
consummated would result in a third party (or its stockholders) owning, directly
or indirectly, all or substantially all of the shares of Company Common Stock
then outstanding (or of the surviving entity in a merger or the direct or
indirect parent of the surviving entity in a merger) or all or substantially all
the assets of the Company, which the Board of Directors of the Company
determines in good faith (after consultation with a financial advisor of
nationally recognized reputation) to be (i) more favorable to the stockholders
of the Company from a financial point of view (taking into account probability
of closing and all other terms and conditions of such proposal and this
Agreement and any changes to the financial terms of this Agreement proposed by
Parent in response to such offer or otherwise) than the Merger and (ii)
reasonably capable of being completed, taking into account all financial, legal,
regulatory and other aspects of such proposal.

      (oo) "Taxes" means all taxes of whatever kind or nature, including those
on or measured by or referred to as income, gross receipts, sales, use, ad
valorem, franchise, profits, license, withholding, payroll, employment, excise,
severance, stamp, occupation, premium, value added, property or windfall profits
taxes, customs, duties or other similar fees, assessments or charges of any kind
whatsoever (together with any interest and any penalties, additions to tax or
additional amounts), whether disputed or not, imposed by any Governmental Entity
or taxing authority (domestic or foreign).




                                       78



      (pp) "Tax Returns" means any report, return (including information
return), claim for refund, or statement relating to Taxes or required to be
filed with any Tax authority (domestic or foreign), including any schedule or
attachment thereto, and including any amendments thereof.

      (qq) "Treasury Regulations" means the United States Treasury regulations
promulgated under the Code.

      Section 9.4 Terms Defined Elsewhere. The following terms are defined
elsewhere in this Agreement, as indicated below:

     "2000 Certificate of Designations"                           Section 5.1(a)
     "401(k) Plan"                                               Section 6.16(d)
     "Aggregate Appraisal Value"                                  Section 2.1(f)
     "Aggregate Cash Amount"                                      Section 2.1(f)
     "Aggregate Company Share Number"                             Section 2.1(f)
     "Aggregate Parent Share Number"                              Section 2.1(f)
     "Aggregate Parent Share Value"                               Section 2.1(f)
     "Agreement"                                                        Preamble
     "Appraisal Shares"                                           Section 2.1(e)
     "Biologic"                                                  Section 3.17(a)
     "Canadian Filings"                                           Section 4.5(a)
     "Cause"                                                 Section 6.16(e)(ii)
     "Certificate of Merger"                                         Section 1.2
     "Certificate"                                           Section 2.1(a)(iii)
     "Change of Recommendation"                                   Section 6.4(e)
     "Closing"                                                       Section 1.2
     "Closing Date"                                                  Section 1.2
     "Closing Parent Share Price"                                 Section 2.1(f)
     "Closing Transaction Value"                                  Section 2.1(f)
     "Code"                                                             Recitals
     "Common Cash Consideration"                               Section 2.1(a)(i)
     "Common Merger Consideration"                             Section 2.1(a)(i)
     "Common Share Consideration"                              Section 2.1(a)(i)
     "Company"                                                          Preamble
     "Company Benefit Agreements"                           Section 3.11(b)(iii)
     "Company Benefit Plan"                                      Section 3.10(a)
     "Company Bylaws"                                                Section 3.1
     "Company Certificate of Incorporation"                          Section 3.1
     "Company Common Stock"                                    Section 2.1(a)(i)
     "Company Disclosure Schedule"                                     Article 3
     "Company ESPP"                                                 Section 6.14
     "Company Form 10-K"                                          Section 3.5(c)
     "Company Material Contract"                                  Section 3.8(a)
     "Company Preferred Stock"                                    Section 3.3(a)
     "Company Products & Technology"                             Section 3.15(h)
     "Company Recommendation"                                     Section 6.2(c)



                                       79





     "Company Rights Plan"                                    Section 3.3(a)(iv)
     "Company Rights"                                         Section 3.3(a)(iv)
     "Company SEC Filings"                                        Section 3.5(a)
     "Company Stockholder Approval"                                 Section 3.20
     "Company Stockholders' Meeting"                              Section 6.2(a)
     "Confidentiality Agreement"                                  Section 6.3(c)
     "Continuing Employees"                                      Section 6.16(a)
     "Conversion Number"                                      Section 2.1(a)(ii)
     "Covered Settlement"                                         Section 6.9(d)
     "D&O Insurance"                                              Section 6.9(b)
     "Designated Law Firm"                                        Section 6.9(b)
     "Designated Person"                                          Section 6.9(b)
     "DGCL"                                                             Recitals
     "DOL"                                                       Section 3.10(a)
     "Drug"                                                      Section 3.17(a)
     "Effective Time"                                                Section 1.2
     "Eligible Assumed Option"                              Section 6.16(e)(iii)
     "Exchange Act"                                          Section 3.4(c)(iii)
     "Exchange Agent"                                             Section 2.2(a)
     "Exchange Fund"                                              Section 2.2(a)
     "Exchange Ratio"                                          Section 2.1(a)(i)
     "Excluded Common Shares"                                  Section 2.1(a)(i)
     "Excluded Preferred Shares"                              Section 2.1(a)(ii)
     "Excluded Shares"                                        Section 2.1(a)(ii)
     "FDA"                                                           Section 3.9
     "FDCA"                                                          Section 3.9
     "First Step Merger"                                                Recitals
     "Foreign Plan"                                              Section 3.10(g)
     "GAAP"                                                       Section 3.5(b)
     "Governmental Entity"                                        Section 3.4(c)
     "HSR Act"                                                 Section 3.4(c)(i)
     "Indemnified Parties"                                        Section 6.9(a)
     "Intellectual Property Rights"                              Section 3.15(a)
     "Internal Controls"                                         Section 3.18(b)
     "IRS"                                                       Section 3.10(a)
     "Joint Proxy/Prospectus"                                     Section 6.1(a)
     "Liens"                                                         Section 3.2
     "Medical Device"                                            Section 3.17(a)
     "Merger"                                                           Recitals
     "Merger Consideration"                                  Section 2.1(a)(iii)
     "Merger Sub"                                                       Preamble
     "Multiemployer Plan"                                        Section 3.10(d)
     "Option Exchange Ratio"                                      Section 2.4(a)
     "Outside Date"                                               Section 8.1(b)
     "Parent"                                                           Preamble
     "Parent Form 10-K"                                           Section 4.5(c)
     "Parent Articles"                                               Section 4.1



                                       80




            "Parent Closing Price"                                Section 2.2(e)
            "Parent Common Shares"                             Section 2.1(a)(i)
            "Parent Convertible Notes"                            Section 4.3(b)
            "Parent Disclosure Schedule"                               Article 4
            "Parent Material Contract"                            Section 4.8(a)
            "Parent Notice of Articles"                              Section 4.1
            "Parent Preferred Shares"                             Section 4.3(a)
            "Parent Product"                                     Section 4.12(c)
            "Parent Recommendation"                               Section 6.2(d)
            "Parent Rights"                                       Section 2.1(g)
            "Parent Rights Plan"                                  Section 2.1(g)
            "Parent SEC Filings"                                  Section 4.5(a)
            "Parent Shareholder Approval"                           Section 4.15
            "Parent Shareholders' Meeting"                        Section 6.2(b)
            "Parent Takeover"                                     Section 6.3(b)
            "Permits"                                                Section 3.9
            "Preferred Cash Consideration"                    Section 2.1(a)(ii)
            "Preferred Exchange Ratio"                        Section 2.1(a)(ii)
            "Preferred Merger Consideration"                  Section 2.1(a)(ii)
            "Preferred Share Consideration"                   Section 2.1(a)(ii)
            "Proxy Statement"                                     Section 6.1(a)
            "Registration Statement"                              Section 6.1(a)
            "Representatives"                                     Section 6.3(a)
            "Restraints"                                          Section 7.1(c)
            "Sarbanes-Oxley Act"                                 Section 3.18(a)
            "SEC"                                             Section 3.4(c)(ii)
            "Second Merger Sub"                                      Section 1.6
            "Second Step Merger"                                     Section 1.6
            "Securities Act"                                      Section 3.5(a)
            "Series A Convertible Preferred Stock"             Section 2.1(a)(i)
            "Series A Preferred Stock"                            Section 3.3(a)
            "Superior Proposal Notice"                            Section 6.4(c)
            "Surviving Corporation"                                  Section 1.1
            "Termination Fee"                                  Section 8.2(c)(i)
            "Transaction"                                               Recitals
            "Warrant"                                         Section 3.3(a)(iv)

      Section 9.5 Interpretation. When a reference is made in this Agreement to
an Article, a Section, Exhibit or Schedule, such reference shall be to an
Article of, a Section of, or an Exhibit or Schedule to, this Agreement unless
otherwise indicated. The table of contents and headings contained in this
Agreement are for reference purposes only and shall not affect in any way the
meaning or interpretation of this Agreement. Whenever the words "include",
"includes" or "including" are used in this Agreement, they shall be deemed to be
followed by the words "without limitation". The words "hereof", "herein" and
"hereunder" and words of similar import when used in this Agreement shall refer
to this Agreement as a whole and not to any particular provision of this
Agreement. All terms defined in this Agreement shall have the defined meanings
when used in any certificate or other document made or delivered pursuant hereto




                                       81



unless otherwise defined therein. The definitions contained in this Agreement
are applicable to the singular as well as the plural forms of such terms and to
the masculine as well as to the feminine and neuter genders of such term. Any
agreement, instrument or statute defined or referred to herein or in any
agreement or instrument that is referred to herein means such agreement,
instrument or statute as from time to time amended, modified or supplemented,
including (in the case of agreements or instruments) by waiver or consent and
(in the case of statutes) by succession of comparable successor statutes and
references to all attachments thereto and instruments incorporated therein.
References to a person or Person are also to its permitted successors and
assigns. All amounts expressed as "$" or "dollars" shall mean U.S. dollars.

      Section 9.6 Severability. If any term or other provision of this Agreement
is invalid, illegal or incapable of being enforced by any rule of Law or public
policy, all other conditions and provisions of this Agreement shall nevertheless
remain in full force and effect. Upon such determination that any term other
provision is invalid, illegal or incapable of being enforced, the parties hereto
shall negotiate in good faith to modify this Agreement so as to effect the
original intent of the parties as closely as possible to the fullest extent
permitted by applicable Law in an acceptable manner to the end that the
transactions contemplated hereby are fulfilled to the extent possible.

      Section 9.7 Entire Agreement. This Agreement (together with the Exhibits,
Parent and Company Disclosure Schedules and the other documents delivered
pursuant hereto) and the Confidentiality Agreement constitute the entire
agreement of the parties and supersede all prior agreements and undertakings,
both written and oral, between the parties, or any of them, with respect to the
subject matter hereof.

      Section 9.8 Assignment. Neither this Agreement nor any of the rights,
interests or obligations hereunder shall be assigned, in whole or in part, by
operation of Law or otherwise by any of the parties without the prior written
consent of the other parties. Subject to the preceding sentence, this Agreement
will be binding upon, inure to the benefit of, and be enforceable by, the
parties and their respective successors and assigns. Any assignment contrary to
the provisions of this Section 9.8 shall be void.

      Section 9.9 Parties in Interest. This Agreement shall be binding upon and
inure solely to the benefit of each party hereto and their respective successors
and assigns, and nothing in this Agreement, express or implied, other than
pursuant to Section 6.9, is intended to or shall confer upon any other Person
any right, benefit or remedy of any nature whatsoever under or by reason of this
Agreement.

      Section 9.10 Mutual Drafting. Each party hereto has participated in the
drafting of this Agreement, which each party acknowledges is the result of
extensive negotiations between the parties.

      Section 9.11 Governing Law. This Agreement shall be governed by, and
construed in accordance with, the Laws of the State of Delaware, regardless of
the Laws that might otherwise govern under applicable principles of conflicts of
laws thereof.

      Section 9.12 Enforcement. The parties agree that irreparable damage would
occur and that the parties would not have any adequate remedy at law in the
event that any of the


                                       82



provisions of this Agreement were not performed in accordance with their
specific terms or were otherwise breached. It is accordingly agreed that the
parties shall be entitled to an injunction or injunctions to prevent breaches of
this Agreement and to enforce specifically the terms and provisions of this
Agreement in any Federal court located in the State of Delaware or in any state
court in the State of Delaware, this being in addition to any other remedy to
which they are entitled at law or in equity. In addition, each of the parties
hereto (a) consents to submit itself to the personal jurisdiction of any Federal
court located in the State of Delaware or of any state court located in the
State of Delaware in the event any dispute arises out of this Agreement or the
transactions contemplated by this Agreement, (b) agrees that it will not attempt
to deny or defeat such personal jurisdiction by motion or other request for
leave from any such court and (c) agrees that it will not bring any action
relating to this Agreement or the transactions contemplated by this Agreement in
any court other than a Federal court located in the State of Delaware or a state
court located in the State of Delaware (other than to enforce the judgment of
such court). EACH OF PARENT, MERGER SUB AND THE COMPANY HEREBY IRREVOCABLY
WAIVES ALL RIGHT TO TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM
(WHETHER BASED ON CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR RELATING TO
THIS AGREEMENT OR THE ACTIONS OF PARENT, MERGER SUB AND THE COMPANY IN THE
NEGOTIATION, ADMINISTRATION, PERFORMANCE AND ENFORCEMENT HEREOF.

      Section 9.13 Disclosure. Any matter disclosed in any section of a party's
Disclosure Schedule shall be considered disclosed for other sections of such
Disclosure Schedule, for which it is reasonably apparent that such matter is
pertinent to a particular section of a party's Disclosure Schedule. The
provision of monetary or other quantitative thresholds for disclosure does not
and shall not be deemed to create or imply a standard of materiality hereunder.

      Section 9.14 Counterparts. This Agreement may be executed in one or more
counterparts, and by the different parties hereto in separate counterparts, each
of which when executed shall be deemed to be an original but all of which taken
together shall constitute one and the same agreement.

                            [Signature page follows]





                                       83



      IN WITNESS WHEREOF, Parent, Merger Sub and the Company have caused this
Agreement to be executed as of the date first written above by their respective
officers thereunto duly authorized.

                               QLT INC.

                               By: /s/ Paul J. Hastings
                                  --------------------------------------------
                                  Name:  Paul J. Hastings
                                  Title: President and Chief Executive Officer


                               ASPEN ACQUISITION CORP.



                               By: /s/ Paul J. Hastings
                                  ---------------------------------------------
                                  Name:  Paul J. Hastings
                                  Title: President


                               ATRIX LABORATORIES, INC.



                               By: /s/ David R. Bethune
                                  ---------------------------------------------
                                  Name:   David R. Bethune
                                  Title:  Chairman of the Board and Chief
                                          Executive Officer




                 [SIGNATURE PAGE-AGREEMENT AND PLAN OF MERGER]


ADDITIONAL INFORMATION

In connection with QLT's proposed acquisition of Atrix, QLT intends to file with
the SEC a registration statement on Form S-4, containing a joint proxy
statement/prospectus and other relevant materials. INVESTORS AND SECURITY
HOLDERS OF QLT AND ATRIX ARE URGED TO READ THE JOINT PROXY STATEMENT/PROSPECTUS
AND THE OTHER RELEVANT MATERIALS WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL
CONTAIN IMPORTANT INFORMATION ABOUT QLT, ATRIX AND THE ACQUISITION. The joint
proxy statement/prospectus and other relevant materials (when they become
available), and any other documents filed by QLT or Atrix with the SEC, may be
obtained free of charge at the SEC's web site at www.sec.gov. In addition,
investors and security holders may obtain free copies of the documents (when
they are available) filed with the SEC by QLT by directing a request to: QLT
Inc., 887 Great Northern Way, Vancouver, BC, Canada, Attn: Investor Relations.
Investors and security holders may obtain free copies of the documents filed
with the SEC by Atrix by contacting Atrix Laboratories, Inc., 2579 Midpoint
Drive, Fort Collins, CO, Attn: Investor Relations.

QLT, Atrix and their respective executive officers and directors may be deemed
to be participants in the solicitation of proxies from the stockholders of QLT
and Atrix in favor of the acquisition. Information about the executive officers
and directors of QLT and their ownership of QLT common shares is set forth in
the proxy statement for QLT's 2004 Annual Meeting of Shareholders, which was
filed with the SEC as Exhibit 99.1 to Form 10-K/A on April 28, 2004. Information
about the executive officers and directors of Atrix and their ownership of Atrix
common stock is set forth in the proxy statement for Atrix's 2004 Annual Meeting
of Stockholders, which was filed with the SEC on April 5, 2004. Investors and
security holders may obtain more detailed information regarding the direct and
indirect interests of QLT, Atrix and their respective executive officers and
directors in the acquisition by reading the joint proxy statement/prospectus
regarding the acquisition when it becomes available.