United States
                       Securities and Exchange Commission
                             WASHINGTON, D.C. 20549


                                  Schedule 13G
                              (Amendment No. _8_)*

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934


                           RIGEL PHARMACEUTICALS, INC.
             ------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
             ------------------------------------------------------
                         (Title of Class of Securities)

                                    766559108
             ------------------------------------------------------
                                 (CUSIP Number)


                                 August 20, 2004
--------------------------------------------------------------------------------
             (Date of Event That Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

         |_|      Rule 13d-1(b)

         |X|      Rule 13d-1(c)

         |_|      Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).







CUSIP No.  766559108                                                                     Page 2 of 18 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta Partners
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)  X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         California
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       1,097,880
                                                                           Please see Attachment A & Footnote 1
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    -0-

                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power  1,097,880
                                                                           Please see Attachment A & Footnote 1
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,097,880         Please see Attachment A and Footnote 1
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         5.91%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

         IA
-------------------------------------------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!


Footnote 1: Includes the 837,463 shares of Common Stock and Warrants to purchase
            260,417  shares of Common  Stock held by the funds  affiliated  with
            Alta Partners and Alta Partners II. See Attachment A.





CUSIP No.  766559108                                                                     Page 3 of 18 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta Partners II, Inc.
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         California
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned                                   --------------------------------------------------------------
By Each Reporting                                    (6)      Shared Voting Power       1,097,880
Person With                                                                Please see Attachment A and Footnote 2
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    -0-

                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power  1,097,880
                                                                           Please see Attachment A and Footnote 2
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,097,880         Please see Attachment A and Footnote 2
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         5.91%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

         IA
-------------------------------------------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!


Footnote 2: Includes the 837,463 shares of Common Stock and Warrants to purchase
            260,417  shares of Common  Stock held by the funds  affiliated  with
            Alta Partners and Alta Partners II. See Attachment A.





CUSIP No. 766559108                                                                     Page 4 of 18 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta California Partners, L. P.
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       1,097,880
                                                                           Please see Attachment A & Footnote 3
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    -0-

                                                     --------------------------------------------------------------
                                                     (8)     Shared Dispositive Power   1,097,880
                                                                           Please see Attachment A & Footnote 3
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,097,880         Please see Attachment A and Footnote 3
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         5.91%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

         PN
-------------------------------------------------------------------------------------------------------------------

Footnote 3: Includes the 837,463 shares of Common Stock and Warrants to purchase
            260,417  shares of Common  Stock held by the funds  affiliated  with
            Alta Partners and Alta Partners II. See Attachment A.








CUSIP No. 766559108                                                                      Page 5 of 18 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta California Management Partners, L. P.
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       1,097,880
                                                                            Please see Attachment A & Footnote 4
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    -0-

                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power  1,097,880
                                                                            Please see Attachment A & Footnote 4
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,097,880         Please see Attachment A and Footnote 4
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         5.91%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)  Type Of Reporting Person

        PN
-------------------------------------------------------------------------------------------------------------------


Footnote 4: Includes the 837,463 shares of Common Stock and Warrants to purchase
            260,417  shares of Common  Stock held by the funds  affiliated  with
            Alta Partners and Alta Partners II. See Attachment A.







CUSIP No. 766559108                                                                      Page 6 of 18 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta Embarcadero Partners, LLC
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         California
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       1,097,880
                                                                            Please see Attachment A & footnote 5
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    -0-

                                                     --------------------------------------------------------------
                                                     (8)     Shared Dispositive Power   1,097,880
                                                                            Please see Attachment A & footnote 5
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,097,880         Please see Attachment A and Footnote 5
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         5.91%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

          CO
-------------------------------------------------------------------------------------------------------------------


Footnote 5: Includes the 837,463 shares of Common Stock and Warrants to purchase
            260,417  shares of Common  Stock held by the funds  affiliated  with
            Alta Partners and Alta Partners II. See Attachment A.





CUSIP No. 766559108                                                                      Page 7 of 18 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta BioPharma Partners II, L.P.
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       1,097,880
                                                                          Please see Attachment A & Footnote 6
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    -0-

                                                     --------------------------------------------------------------
                                                     (8)     Shared Dispositive Power   1,097,880
                                                                            Please see Attachment A & Footnote 6
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,097,880         Please see Attachment A and Footnote 6
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         5.91%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

         PN
-------------------------------------------------------------------------------------------------------------------

Footnote 6: Includes the 837,463 shares of Common Stock and Warrants to purchase
            260,417  shares of Common  Stock held by the funds  affiliated  with
            Alta Partners and Alta Partners II. See Attachment A.








CUSIP No. 766559108                                                                      Page 8 of 18 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta BioPharma Management Partners II, LLC.
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       1,097,880
                                                                            Please see Attachment A & footnote 7
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    -0-

                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power  1,097,880
                                                                            Please see Attachment A & footnote 7
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,097,880         Please see Attachment A and Footnote 7
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         5.91%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

         CO
-------------------------------------------------------------------------------------------------------------------


Footnote 7: Includes the 837,463 shares of Common Stock and Warrants to purchase
            260,417  shares of Common  Stock held by the funds  affiliated  with
            Alta Partners and Alta Partners II. See Attachment A.







CUSIP No. 766559108                                                                      Page 9 of 18 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alta Embarcadero BioPharma Partners II, LLC.
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         -0-
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       1,097,880
                                                                           Please see Attachment A & footnote 8
                                                     --------------------------------------------------------------
                                                     (7)     Sole Dispositive Power    -0-

                                                     --------------------------------------------------------------
                                                     (8)     Shared Dispositive Power  1,097,880
                                                                            Please see Attachment A & footnote 8
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,097,880         Please see Attachment A and Footnote 8
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         5.91%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

         CO
-------------------------------------------------------------------------------------------------------------------

Footnote 8: Includes the 837,463 shares of Common Stock and Warrants to purchase
            260,417  shares of Common  Stock held by the funds  affiliated  with
            Alta Partners and Alta Partners II. See Attachment A.





CUSIP No. 766559108                                                                        Page 10 of 18 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Farah Champsi
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         1,998
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       1,063,157
                                                                            Please see Attachment A & footnote 9
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power     1,998

                                                     --------------------------------------------------------------
                                                     (8)     Shared Dispositive Power    1,063,157
                                                                            Please see Attachment A & footnote 9
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,065,155         Please see Attachment A and Footnote 9
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         5.67%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

         IN
-------------------------------------------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!


Footnote 9: Includes the 837,463 shares of Common Stock and Warrants to purchase
            225,694  shares of Common  Stock held by the funds  affiliated  with
            Alta  Partners  II.  As a  result  of the  Alta  Partners  II  stock
            distribution  on 8/20/04,  the 1999 Farah  Champsi  Revocable  Trust
            received 1,998 shares of Common Stock.





CUSIP No. 766559108                                                                      Page 11 of 18 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Jean Deleage
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         29,038
Beneficially Owned
-By Each Reporting                                    -------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       1,097,880
                                                                            Please see Attachment A & footnote
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    29,038

                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power  1,097,880
                                                                            Please see Attachment A & footnote 10
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,126,918    Please see Attachment A and footnote 10
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         5.99%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

         IN
-------------------------------------------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!


Footnote 10: Includes the 837,463 shares of  Common Stock,  Warrants to purchase
             260,417  shares of Common Stock held by the funds  affiliated  with
             Alta  Partners and Alta  Partners  II. He received  9,593 shares of
             Common  Stock from the Alta  Partners  and Alta  Partners  II stock
             distribution  on 8/20/04.  He also holds  Stock  Options for 19,445
             shares of Common Stock. See Attachment A.






CUSIP No. 766559108                                                                      Page 12 of 18 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Garrett Gruener
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         15,864
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       34,723
                                                                            Please see Attachment A & footnote 11
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    15,864

                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power  34,723
                                                                            Please see Attachment A & footnote 11
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         50,587            Please see Attachment A and footnote 11
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)
         0.27%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

         IN
-------------------------------------------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!


Footnote 11: Includes  Warrants to purchase 34,723  shares of  Common Stock held
             by the funds  affiliated  with Alta  Partners.  He received  15,864
             shares of Common Stock from the Alta Partners stock distribution on
             8/20/04. See Attachment A.





CUSIP No. 766559108                                                                      Page 13 of 18 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Alix Marduel
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b) X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power           2,378
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power         1,063,157
                                                                            Please see Attachment A & footnote 12
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power      2,378
        `
                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power    1,063,157
                                                                            Please see Attachment A & footnote 12
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         1,065,535         Please see Attachment A and Footnote 12
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         5.67%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

         IN
-------------------------------------------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!


Footnote 12: Includes  the  837,463  shares  of  Common  Stock  and  Warrants to
             purchase   225,694  shares  of  Common  Stock  held  by  the  funds
             affiliated  with Alta Partners II. As a result of the Alta Partners
             II stock  distribution on 8/20/04,  the  Lockard/Marduel  Revocable
             Trust received 2,378 shares of Common Stock.





CUSIP No. 766559108                                                                      Page 14 of 18 Pages
                                                  
-------------------------------------------------------------------------------------------------------------------
  (1)    Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons

         Guy Nohra
-------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
-------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

-------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States
-------------------------------------------------------------------------------------------------------------------
                             Please see Attachment A
Number Of Shares                                     (5)      Sole Voting Power         15,122
Beneficially Owned
By Each Reporting                                    --------------------------------------------------------------
Person With                                          (6)      Shared Voting Power       34,723
                                                                            Please see Attachment A & footnote 13
                                                     --------------------------------------------------------------
                                                     (7)      Sole Dispositive Power    15,112

                                                     --------------------------------------------------------------
                                                     (8)      Shared Dispositive Power  34,723
                                                                            Please see Attachment A & footnote 13
-------------------------------------------------------------------------------------------------------------------
  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

         49,845            Please see Attachment A and Footnote 13
-------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


-------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         0.27%             Please see Attachment A
-------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

         IN
-------------------------------------------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!


Footnote 13: Includes  Warrants  to  purchase 34,723 shares of Common Stock held
             by the funds affiliated with Alta Partners. As a result of the Alta
             Partners  stock  distribution  on 8/20/04,  the Nohra  Living Trust
             received  11,442  shares of Common  Stock and the Nohra 1996 Credit
             Trust received 3,680 shares of Common Stock.






Item 1.

(a) Name of Issuer: Rigel Pharmaceuticals, Inc. ("Issuer")

(b) Address of Issuer's Principal Executive Offices:

                  1180 Veterans Boulevard
                  South San Francisco, CA 94080

Item 2.

(a) Name of Person Filing:

         Alta Partners ("AP")
         Alta Partners II, Inc. ("AP II")
         Alta California Partners, L.P. ("ACP")
         Alta California Management Partners, L.P. ("ACMP")
         Alta Embarcadero Partners, LLC ("AEP")
         Alta BioPharma Partners II, L.P. ("ABP II")
         Alta BioPharma Management Partners II, LLC ("ABMP II")
         Alta Embarcadero BioPharma Partners II, LLC ("AEBP II")
         Farah Champsi ("FC")
         Jean Deleage ("JD")
         Garrett Gruener ("GG")
         Alix Marduel ("AM")
         Guy Nohra ("GN")

 (b) Address of Principal Business Office:

         One Embarcadero Center, Suite 4050
         San Francisco, CA  94111

 (c) Citizenship/Place of Organization:

         Entities:         AP               California
                           AP II            California
                           ACP              Delaware
                           ACMP             Delaware
                           AEP              California
                           ABP II           Delaware
                           ABMP II          Delaware
                           AEBP II          California

         Individuals:      FC               United States
                           JD               United States
                           GG               United States
                           AM               United States
                           GN               United States


(d) Title of Class of Securities: Common Stock


(e) CUSIP Number: 766559108

Item 3.        Not applicable.

Item 4         Ownership.



                             Please see Attachment A
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
                               AP        AP II         ACP         ACMP         AEP         ABP II       ABMP II
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
                                                                                
(a)     Beneficial         1,097,880   1,097,880    1,097,880   1,097,880    1,097,880     1,097,880    1,097,880
        Ownership
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
(b)     Percentage of        5.91%       5.91%        5.91%       5.91%        5.91%         5.91%        5.91%
        Class
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
(c)     Sole Voting Power     -0-         -0-          -0-         -0-          -0-           -0-          -0-
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Shared Voting      1,097,880   1,097,880    1,097,880   1,097,880    1,097,880     1,097,880    1,097,880
        Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Sole Dispositive      -0-         -0-          -0-         -0-          -0-           -0-          -0-
        Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Shared             1,097,880   1,097,880    1,097,880   1,097,880    1,097,880     1,097,880    1,097,880
        Dispositive Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------

                            AEBP II        FC          JD           GG           AM           GN
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
(a)     Beneficial         1,097,880   1,065,155    1,126,918     50,587     1,065,535      49,845
        Ownership
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
(b)     Percentage of        5.91%       5.67%        5.99%       0.27%        5.67%         0.27%
        Class
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
(c)     Sole Voting Power     -0-        1,998       29,038       15,864       2,378        15,122
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Shared Voting      1,097,880    1,063,157   1,097,880     34,723     1,063,157      34,723
        Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Sole Dispositive      -0-         1,998      29,038       15,864       2,378        15,122
        Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Shared             1,097,880    1,063,157   1,097,880     34,723     1,063,157      34,723
        Dispositive Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------


Item 5.        Ownership of Five Percent or Less of a Class

Not Applicable.

Item 6.        Ownership of More than Five Percent on Behalf of Another Person

Not applicable.

Item 7.        Identification   and   Classification  of  the  Subsidiary  Which
               Acquired the  Security  Being  Reported on By the Parent  Holding
               Company.

Not applicable.

Item 8.        Identification and Classification of Members of the Group

No reporting person is a member of a group as defined in Section
240.13d-1(b)(1)(ii)(H) of the Act.

Item 9.        Notice of Dissolution of Group

Not applicable.

Item 10.       Certification

By signing below we certify  that, to the best of our knowledge and belief,  the
securities  referred to above were acquired and are held in the ordinary  course
of business  and were not  acquired  and are not held for the purpose of or with
the  effect  of  changing  or  influencing  the  control  of the  issuer  of the
securities  and were not  acquired and are not held in  connection  with or as a
participant in any transaction having that purpose or effect.

EXHIBITS

A:       Joint Filing Statement



                                    Signature

         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


Date:    August 30, 2004



                                                  

ALTA PARTNERS                                        ALTA CALIFORNIA PARTNERS, L.P.

                                                     By:  Alta California Management Partners, L.P.,


By:      /s/ Jean Deleage                            By:      /s/ Jean Deleage          .
   -----------------------------------------            ------------------------------------------
         Jean Deleage, President                              Jean Deleage, General Partner


ALTA CALIFORNIA MANAGEMENT PARTNERS, L.P.            ALTA EMBARCADERO PARTNERS, LLC



By:      /s/ Jean Deleage                            By:      /s/ Jean Deleage
   -----------------------------------------            -----------------------------------------
         Jean Deleage, General Partner                        Jean Deleage, Member

ALTA  PARTNERS II, INC.

By:      /s/ Jean Deleage
   -----------------------------------------
         Jean Deleage, President

ALTA BIOPHARMA PARTNERS II, L.P.                     ALTA BIOPHARMA MANAGEMENT PARTNERS II, LLC
By: Alta BioPharma Management Partners II, LLC


By:      /s/ Farah Champsi                           By:      /s/ Farah Champsi
   -----------------------------------------            -----------------------------------------
         Farah Champsi, Managing Director                     Farah Champsi, Managing Director

ALTA EMBARCADERO BIOPHARMA PARTNERS II, LLC


By:      /s/ Farah Champsi                                    /s/ Alix Marduel
   -----------------------------------------         --------------------------------------------
         Farah Champsi, Manager                               Alix Marduel


         /s/ Jean Deleage                                    /s/ Guy Nohra
   -----------------------------------------         --------------------------------------------
         Jean Deleage                                        Guy Nohra


         /s/ Garrett Gruener                                 /s/ Farah Champsi
   -----------------------------------------         --------------------------------------------
         Garrett Gruener                                     Farah Champsi


                                    EXHIBIT A

                            AGREEMENT OF JOINT FILING



Date:    August 30, 2004


                                    Signature

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.



                                                  
ALTA PARTNERS                                       ALTA CALIFORNIA PARTNERS, L.P.


                                                    By:  Alta California Management Partners, L.P.,


By:      /s/ Jean Deleage                            By:       /s/ Jean Deleage          .
   -----------------------------------------            ------------------------------------------
         Jean Deleage, President                              Jean Deleage, General Partner


ALTA CALIFORNIA MANAGEMENT PARTNERS, L.P.            ALTA EMBARCADERO PARTNERS, LLC



By:      /s/ Jean Deleage                            By:      /s/ Jean Deleage
   -----------------------------------------            -----------------------------------------
         Jean Deleage, General Partner                        Jean Deleage, Member

ALTA  PARTNERS II, INC.

By:      /s/ Jean Deleage
   -----------------------------------------
         Jean Deleage, President

ALTA BIOPHARMA PARTNERS II, L.P.                           ALTA BIOPHARMA MANAGEMENT PARTNERS II, LLC
By: Alta BioPharma Management Partners II, LLC


By:      /s/ Farah Champsi                           By:      /s/ Farah Champsi
   -----------------------------------------            -----------------------------------------
         Farah Champsi, Managing Director                     Farah Champsi, Managing Director

ALTA EMBARCADERO BIOPHARMA PARTNERS II, LLC


By:      /s/ Farah Champsi                                    /s/ Alix Marduel
   -----------------------------------------         --------------------------------------------
         Farah Champsi, Manager                               Alix Marduel


         /s/ Jean Deleage                                     /s/ Guy Nohra
   -----------------------------------------            -----------------------------------------
         Jean Deleage                                         Guy Nohra


         /s/ Garrett Gruener                                  /s/ Farah Champsi
   -----------------------------------------            -----------------------------------------
         Garrett Gruener                                     Farah Champsi




                                  Attachment A

Alta Partners provides  investment  advisory services to several venture capital
funds including Alta California  Partners,  L.P. and Alta Embarcadero  Partners,
LLC. On August 20, 2004,  Alta California  distributed  352,434 shares of Common
Stock to its general and limited partners,  and Alta Embarcadero  Partners,  LLC
distributed  8,049  shares of Common  Stock to its  members.  As a result of the
distribution,  Alta California Partners,  L.P. now beneficially owns Warrants to
purchase 33,947 shares of Common Stock, and Alta Embarcadero  Partners,  LLC now
beneficially  owns  Warrants  to  purchase  776  shares  of  Common  Stock.  The
respective  general  partners and members of Alta  California  Partners L.P. and
Alta  Embarcadero  Partners,  LLC exercise sole voting and investment power with
respect to the shares owned by such funds.

Certain  principals  of Alta  Partners are general  partners of Alta  California
Management  Partners,  L.P.  (which  is a  general  partner  of Alta  California
Partners, L.P.), and members Alta Embarcadero Partners, LLC. As general partners
and members of such  funds,  they may be deemed to share  voting and  investment
powers  over the  shares  held by the funds.  The  principals  of Alta  Partners
disclaim  beneficial  ownership of all such shares held by the foregoing  funds,
except to the extent of their proportionate pecuniary interests therein.

Alta Partners II, Inc. provides  investment advisory services to several venture
capital funds  including Alta BioPharma  Partners II, L.P. and Alta  Embarcadero
BioPharma Partners II, LLC. On August 20, 2004, Alta BioPharma Partners II, L.P.
distributed  403,892 shares of Common Stock to its general and limited partners,
and Alta  Embarcadero  BioPharma  Partners II, LLC distributed  14,858 shares of
Common Stock to its members.  As a result of the  distribution,  Alta  BioPharma
Partners  II, L.P.  now  beneficially  owns  807,748  shares of Common Stock and
Warrants  to  purchase  217,686  shares of Common  stock,  and Alta  Embarcadero
BioPharma  Partners II, LLC now beneficially owns 29,715 shares Common Stock and
Warrants to purchase  8,008 shares of Common  Stock.  The managing  directors of
Alta  BioPharma  Partners II, L.P. and  managers of Alta  Embarcadero  BioPharma
Partners II, LLC  exercise  sole voting and  investment  power in respect to the
shares owned by such funds.

Certain  principals  of Alta  Partners II, Inc.  are managing  directors of Alta
BioPharma  Management  II, LLC (which is the general  partner of Alta  BioPharma
Partners II, L.P.), and managers of Alta Embarcadero BioPharma Partners II, LLC.
As managing directors and managers of such entities, they may be deemed to share
voting and investment powers over the shares beneficially held by the funds. The
principals of Alta Partners II, Inc. disclaim  beneficial  ownership of all such
shares held by the foregoing funds,  except to the extent of their proportionate
pecuniary interests therein.

Mr. Jean Deleage,  Director, is a managing director of Alta BioPharma Management
Partners II, LLC (which is the general  partner of Alta  BioPharma  Partners II,
L.P.),  a manager of Alta  Embarcadero  BioPharma  Partners  II,  LLC, a general
partner of Alta  California  Management  Partners,  L.P.  (which is the  general
partner of Alta California  Partners,  L.P.),  and a member of Alta  Embarcadero
Partners,  LLC. Thus he currently shares voting and dispositive  powers over the
807,748 shares of Common Stock beneficially owned by Alta BioPharma Partners II,
L.P.,  and  the  29,715  shares  of  Common  Stock  beneficially  owned  by Alta
Embarcadero BioPharma Partners II, LLC. He disclaims beneficial ownership of all
such  shares  held by all of the  foregoing  funds  except to the  extent of his
proportionate  pecuniary interests therein. As a result of the Alta Partners and
Alta Partners II, Inc.  stock  distributions,  Mr.  Deleage  received a total of
9,593 shares of Common Stock. He holds stock options for 19,445 shares of Common
Stock: options for 8,333 shares were granted on June 30, 2004, options for 8,333
shares were granted on January 26,  2004,  options for 1,667 shares were granted
on June 26,  2003,  options  for 556 shares  were  granted on June 20,  2002 and
options for 556 shares were granted on July 19, 2001.

Ms. Farah Champsi is a managing director of Alta BioPharma  Management  Partners
II, LLC (which is the general partner of Alta BioPharma Partners II, L.P.) and a
manager of Alta  Embarcadero  BioPharma  Partners  II, LLC.  Thus she  currently
shares  voting and  dispositive  powers over the 807,748  shares of Common Stock
beneficially  owned by Alta BioPharma Partners II, L.P. and the 29,715 shares of
Common Stock beneficially owned by Alta Embarcadero  BioPharma Partners II, LLC.
She  disclaims  beneficial  ownership  of all  such  shares  held  by all of the
foregoing funds except to the extent of her  proportionate  pecuniary  interests
therein. As a result of the Alta Partners II stock distribution on 8/20/04,  the
1999 Farah Champsi Revocable Trust received 1,998 shares of Common Stock.

                                                     Page 1 of 2 of Attachment A



                            Attachment A (continued)


Mr. Garrett Gruener is a general partner of Alta California Management Partners,
L.P.  (which is the general  partner of Alta  California  Partners,  L.P.) and a
member of Alta Embarcadero  Partners,  LLC. He disclaims beneficial ownership of
all such shares held by all of the  foregoing  funds except to the extent of his
proportionate  pecuniary  interests therein.  Mr. Gruener received 15,864 shares
from the Alta Partners stock distribution on 8/20/04.

Dr. Alix Marduel is a managing  director of Alta BioPharma  Management  Partners
II, LLC (which is the general partner of Alta BioPharma Partners II, L.P.) and a
manager of Alta  Embarcadero  BioPharma  Partners  II, LLC.  Thus she  currently
shares  voting and  dispositive  powers over the 807,748  shares of Common Stock
beneficially  owned by Alta BioPharma  Partners II, L.P. and the 2,915 shares of
Common Stock beneficially owned by Alta Embarcadero  BioPharma Partners II, LLC.
She  disclaims  beneficial  ownership  of all  such  shares  held  by all of the
foregoing funds except to the extent of her  proportionate  pecuniary  interests
therein. As a result of the Alta Partners II stock distribution on 8/20/04,  the
Lockard/Marduel Revocable Trust received 2,378 shares of Common Stock.

Mr. Guy Nohra is a general partner of Alta California Management Partners,  L.P.
(which is the general partner of Alta California  Partners,  L.P.). He disclaims
beneficial  ownership  of all such  shares  held by all of the  foregoing  funds
except to the extent of his  proportionate  pecuniary  interests  therein.  As a
result of the Alta  Partners  stock  distribution  on 8/20/04,  the Nohra Living
Trust  received  11,442  shares of Common  Stock and the Nohra 1996 Credit Trust
received 3,680 shares of Common Stock.


Alta Partners and Alta Partners II, Inc. are venture capital firms that share an
office in San Francisco. Alta Partners is California Corporation.  Alta Partners
II,  Inc. is a  California  Corporation.  Alta  California  Partners,  L.P. is a
Delaware Limited  Partnership,  Alta Embarcadero  Partners,  LLC is a California
Limited  Liability  Company,  Alta  BioPharma  Partners  II,  L.P. is a Delaware
Limited  Partnership,  and Alta  Embarcadero  BioPharma  Partners  II,  LLC is a
California Limited Liability Company.




















                                                     Page 2 of 2 of Attachment A