UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM N-Q

QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS OF REGISTERED
MANAGEMENT INVESTMENT COMPANY

Investment Company Act file number:          811-21702          

          BlackRock Health Sciences Trust          
(Exact name of registrant as specified in charter)

100 Bellevue Parkway, Wilmington, DE 
19809 


(Address of principal executive offices) 
(Zip code) 

Robert S. Kapito, President
BlackRock Health Sciences Trust 
                                        40 East 52nd Street, New York, NY 10022                                        
(Name and address of agent for service)

Registrant's telephone number, including area code:          888-825-2257                    

Date of fiscal year end:          October 31, 2006
Date of reporting period:         January 31, 2006

Item 1. Schedule of Investments.
The Registrant’s unaudited schedule of investments as of the close of the reporting period pursuant to Rule 30b1-5 under the Investment Company Act of 1940 is as follows:

PORTFOLIO OF INVESTMENTS
JANUARY 31, 2006 (
unaudited)


BlackRock Health Sciences Trust (BME)

 
Shares
Description
Value
 

        LONG-TERM INVESTMENTS—96.8%  
        Common Stocks—96.8%  
        Canada—2.7%  
  417,100 1,2   Cardiome Pharma Corp. $ 5,676,731  

        France—0.5%  
  22,956     Sanofi-Avent (ADR) 1,055,976  

        Switzerland—7.7%  
  118,500     Novartis AG (ADR) 6,536,460  
  124,500     Roche Holding AG 9,815,393  

         
16,351,853
 

        United Kingdom—6.1%  
  91,200 2   AstraZeneca PLC 4,435,968  
  61,400     GlaxoSmithKline PLC (ADR) 3,146,136  
  110,500     Shire Pharmaceuticals PLC 5,386,875  

        Total United Kingdom 12,968,979  

        United States—79.8%  
  38,500 2   Abbott Laboratories 1,661,275  
  169,700 1,2   Abgenix, Inc. 3,745,279  
  58,600 1   Advanced Magnetics, Inc. 1,170,828  
  227,300 1   Alexion Pharmaceuticals, Inc. 6,550,786  
  18,300     Allergan, Inc. 2,130,120  
  88,000 1,2   Amgen, Inc. 6,414,320  
  34,279 1   Anady’s Pharmaceuticals, Inc. 376,041  
  133,715 1   Arena Pharmaceuticals, Inc. 2,269,144  
  34,900 1   Aspect Medical Systems, Inc. 1,262,333  
  44,200     Baxter International, Inc. 1,628,770  
  34,400     Becton Dickinson & Co. 2,229,120  
  193,933 1   BioMarin Pharmaceuticals, Inc. 2,274,834  
  166,200     Bristol-Myers Squibb Co. 3,787,698  
  210,300 1   Caremark Rx, Inc. 10,367,790  
  27,900     Cigna Corp. 3,392,640  
  124,500 1   Community Health Systems, Inc. 4,530,555  
  133,500 1   Cytyc Corp. 4,018,350  
  66,500 1   Davita, Inc. 3,640,875  
  30,700     Dentsply International, Inc. 1,648,590  
  15,600 1   DJ Orthopedics, Inc. 512,148  
  21,400 1   Dynavax Technologies Corp. 116,202  
  94,700 1   Exelixis, Inc. 1,020,866  
  45,200 1   Express Scripts, Inc. 4,126,308  
  292,600 1   Gene Logic, Inc. 1,155,770  
  45,026 1   Genentech, Inc. 3,868,634  
  18,200 1   Gilead Sciences, Inc. 1,107,834  
  47,600     Hospira, Inc. 2,130,100  
  29,958 1   ImClone Systems 1,079,387  
  47,867 1   InterMune, Inc. 968,349  
  197,264 1   Keryx Biopharmaceuticals, Inc. 3,162,142  
  72,300     Manor Care, Inc. 2,826,930  
  106,100 1   Medco Health Solutions, Inc. 5,740,010  
  107,400 1   Myogen, Inc. 4,008,168  
  378,800     Pfizer, Inc. 9,727,584  
  79,400 1   Regeneron Pharmaceuticals 1,209,262  
  199,372 1   Renovis, Inc. 4,061,208  
  132,100 1   Respironics, Inc. 4,759,563  
  321,900     Schering Plough Corp. 6,164,385  
  247,300     UnitedHealth Group, Inc. 14,694,566  
  110,900 1   Varian Medical Systems 6,677,289  
  93,000     Vertex Pharmaceuticals, Inc. 3,321,960  
  140,650 1   Viropharma, Inc. 3,264,486  
  197,900 1   WellPoint, Inc. 15,198,720  
  133,800     Wyeth 6,188,250  

        Total United States 170,189,469  

        Total Common Stocks (cost $176,072,551) 206,243,008  

1



BlackRock Health Sciences Trust (BME) (continued)

 
Shares
Description
Value
 

        SHORT-TERM INVESTMENTS—2.5%  
        Money Market Fund—0.5%  
  1,010,084     Fidelity Institutional Money Market Prime Portfolio $    1,010,084  
 
       
 
Principal
       
 
Amount 
       
 
         
 
    U.S. Government and Agency Zero Coupon Bond—2.0%  
  $4,300,000 3   Federal Home Loan Bank, 4.34%, 02/01/06 4,300,000  

        Total Short-Term Investments (cost $5,310,085) 5,310,084  

 
       
 
Contracts
       
 
       
        OUTSTANDING CALL OPTION PURCHASED—0.0%  
             
  180     Alexion Pharmaceuticals, Inc., strike price $35, expires 05/20/06 (cost $13,770) 13,500  

        Total investments before outstanding options written—99.3% (cost $181,396,4054) 211,566,592  

        OUTSTANDING OPTIONS WRITTEN—(0.5)%  
        OUTSTANDING PUT OPTIONS WRITTEN—0.0%  
  (180)     Alexion Pharmaceuticals, Inc., strike price $25, expires 05/20/06 (18,000 )
  (100)     Amgen, Inc., strike price $70, expires 02/18/06 (4,500 )
  (250)     Anadys Pharmaceuticals, Inc., strike price $10, expires 03/14/06 (6,750 )
  (300)     Arena Pharmaceuticals, Inc., strike price $15, expires 02/18/06 (7,500 )
  (325)     Keryx Biopharmaceuticals, Inc., strike price $15, expires 02/18/06 (10,562 )
  (166)     Myogen, Inc., strike price $30, expires 02/18/06 (2,490 )
  (125)     Respironics, Inc., strike price $35, expires 03/18/06 (12,500 )
  (490)     Viropharma, Inc., strike price $20, expires 03/18/06 (47,775 )

        Total Outstanding Put Options Written (premium received $135,347) (110,077 )

        OUTSTANDING CALL OPTIONS WRITTEN—(0.5)%  
  (100)     Abbott Laboratories, strike price $45, expires 03/18/06 (5,000 )
  (35)     Allergan, Inc., strike price $125, expires 04/22/06 (7,000 )
  (200)     Amgen, Inc., strike price $80, expires 02/18/06 (2,000 )
  (150)     Arena Pharmaceuticals, Inc., strike price $17.50, expires 03/18/06 (13,500 )
  (100)     Aspect Medical Systems, Inc., strike price $40, expires 05/20/06 (19,000 )
  (100)     Baxter International, Inc., strike price $40, expires 02/18/06 (1,000 )
  (100)     Becton Dickinson & Co., strike price $65, expires 03/18/06 (15,000 )
  (400)     BioMarin Pharmaceuticals, Inc., strike price $12.50, expires 04/22/06 (36,000 )
  (54,400)     Cardiome Pharma Corp., strike price $10.20, expires 02/17/06 (186,592 )
  (525)     Caremark Rx, Inc., strike price $55, expires 02/18/06 (5,250 )
  (90)     Cigna Corp., strike price $115, expires 02/18/06 (66,600 )
  (110)     Cigna Corp., strike price $120, expires 02/18/06 (40,700 )
  (150)     Community Health Systems, Inc., strike price $40, expires 02/18/06 (6,000 )
  (150)     Community Health Systems, Inc., strike price $40, expires 03/18/06 (3,750) )
  (550)     Cytyc Corp., strike price $30, expires 02/18/06 (56,375 )
  (16,500)     DaVita, Inc., strike price $57.50, expires 02/17/06 (7,688 )
  (40)     Dentsply International, Inc., strike price $55, expires 02/18/06 (2,300 )
  (40)     Dentsply International, Inc., strike price $60, expires 02/18/06 (400 )
  (170)     Express Scripts, Inc., strike price $95, expires 02/18/06 (22,100 )
  (125)     Genentech, Inc., strike price $100, expires 02/18/06 (1,250 )
  (182)     Gilead Sciences, Inc., strike price $60, expires 02/18/06 (43,680 )
  (50)     GlaxoSmithKline PLC, strike price $55, expires 02/18/06 (750 )
  (195)     Hospira, Inc., strike price $45, expires 02/18/06 (18,525 )
  (75)     ImClone Systems, Inc., strike price $40, expires 03/18/06 (6,750 )
  (36)     InterMune, Inc., strike price $20, expires 03/18/06 (5,130 )
  (100)     InterMune, Inc., strike price $22.50, expires 02/18/06 (1,250 )
  (213)     Keryx Biopharmaceuticals, Inc., strike price $17.50, expires 03/18/06 (13,845 )
  (100)     Manor Care, Inc., strike price $40, expires 02/18/06 (2,250 )
  (300)     Medco Health Solutions, Inc., strike price $60, expires 02/18/06 (3,000 )
  (100)     Myogen, Inc., strike price $35, expires 02/18/06 (30,000 )
  (200)     Myogen, Inc., strike price $45, expires 03/18/06 (14,500 )
  (17,000)     Novartis AG, strike price $57, expires 03/17/06 (6,832 )
  (189)     Pfizer, Inc., strike price $25, expires 03/18/06 (21,735 )
  (50)     Renovis, Inc., strike price $20, expires 03/18/06 (9,000 )
  (30)     Respironics, Inc., strike price $35, expires 02/18/06 (4,650 )
  (100)     Respironics, Inc., strike price $40, expires 04/22/06 (8,000 )
  (45,000)     Roche Holding AG, strike price $76.85, expires 02/17/06 (52,695 )
  (46,000)     Schering-Plough Corp., strike price $21, expires 03/17/06 (7,231 )
  (100)     Shire Pharmaceuticals PLC, strike price $47.5, expires 03/18/06 (34,000 )

2



BlackRock Health Sciences Trust (BME) (continued)

 
Contracts
Description
Value
 

      OUTSTANDING CALL OPTIONS WRITTEN—(cont’d)  
  (460)   UnitedHealth Group, Inc., strike price $65, expires 02/18/06 $ (6,900)  
  (15,000)   Varian Medical Systems, Inc., strike price $57.50, expires 03/17/06 (64,637)  
  (110)   Vertex Pharmaceuticals, Inc., strike price $35, expires 02/18/06 (18,150)  
  (111)   Vertex Pharmaceuticals, Inc., strike price $40, expires 03/18/06 (12,210)  
  (350)   Viropharma, Inc., strike price $22.50, expires 02/18/06 (50,750)  
  (235)   WellPoint, Inc., strike price $80, expires 02/18/06 (12,925)  
  (425)   WellPoint, Inc., strike price $80, expires 03/18/06 (68,000)  
  (274)   Wyeth, strike price $47.50, expires 02/18/06 (5,480)  

      Total outstanding Call Options Written (premium received $958,742) (1,020,380)  

      Total outstanding options written (premium received $1,094,089) (1,130,457)  

      Total investments net of outstanding options written—98.8% $210,436,135  
      Other assets in excess of liabilities—1.2% 2,595,159  

      Net Assets—100.0%    
1  Non-income producing security.  
  2 Security, or a portion thereof, pledged as collateral for outstanding options written.  
  3  Rate shown is the yield to maturity as of January 31, 2006.  
  4 Cost for Federal income tax purposes is $183,818,068. The net unrealized appreciation on a tax basis is $27,748,524, consisting of $28,750,630 gross unrealized appreciation and $1,002,106 gross unrealized depreciation.  


KEY TO ABBREVIATIONS

ADR — American Depositary Receipts
 
   

3


Item 2. Controls and Procedures.
(a) The Registrant's principal executive and principal financial officers have evaluated the Registrant's disclosure controls and procedures within 90 days of this filing and have concluded, as of that date, that the Registrant’s disclosure controls and procedures were reasonably designed to ensure that information required to be disclosed by the Registrant in this Form N-Q was recorded, processed, summarized, and reported within the required time periods and that information to be disclosed by the Registrant in this Form N-Q was accumulated and communicated to the Registrant’s management , including its principal executive and principal financial officers, as appropriate to allow timely decisions regarding required disclosure.

(b) There were no changes in the Registrant's internal control over financial reporting (as defined in Rule 30a-3(d) under the 1940 Act (17 CFR 270.30a -3(d)) that occurred during the Registrant's last fiscal quarter that have materially affected, or are reasonably likely to materially affect, the Registrant's internal control over financial reporting.

Item 3. Exhibits.

Separate certifications of the Registrant’s Principal Executive and Financial Officers pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 are attached as EX-99.CERT.


SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

(Registrant)     BlackRock Health Sciences Trust     

By:      /s/ Henry Gabbay                                                                      
Name: Henry Gabbay
Title: Treasurer and Principal Financial Officer
Date: March 31, 2006

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the Registrant and in the capacities and on the dates indicated.

By:      /s/ Robert S. Kapito                                                                  
Name: Robert S. Kapito
Title: President and Principal Executive Officer
Date: March 31, 2006

By:      /s/ Henry Gabbay                                                                      
Name: Henry Gabbay
Title: Treasurer and Principal Financial Officer
Date: March 31, 2006