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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13G

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934

                               (AMENDMENT NO. 1)*



                         BIOCRYST PHARMACEUTICALS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)


                                  COMMON STOCK
--------------------------------------------------------------------------------
                         (Title of Class of Securities)



                                    09058V103
--------------------------------------------------------------------------------
                                 (CUSIP Number)


                                DECEMBER 31, 2005
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

[ ]      Rule 13d-1(b)

[X]      Rule 13d-1(c)

[ ]      Rule 13d-1(d)


------------------
*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



---------------                                               -----------------
CUSIP No.                                13G                  Page 2 of 8 Pages
---------------                                               -----------------


    1.      NAMES OF REPORTING PERSONS

            Great Point Partners, LLC

    2.      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
            (a)     [ ]

            (b)     [ ]

--------------------------------------------------------------------------------
    3.      SEC USE ONLY

--------------------------------------------------------------------------------
    4.      CITIZENSHIP OR PLACE OF ORGANIZATION

            USA
                         5.    SOLE VOTING POWER
   NUMBER OF SHARES            0

     BENEFICIALLY        6.    SHARED VOTING POWER
                                                                   0
    OWNED BY EACH
                         7.    SOLE DISPOSITIVE POWER
   REPORTING PERSON            0

         WITH            8.    SHARED DISPOSITIVE POWER
                                                                   0

    9.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                     0

    10.     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
            SHARES (See Instructions)                                        [ ]


    11.     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                     0%

   12.      TYPE OF REPORTING PERSON (See Instructions)

                     OO



---------------                                               -----------------
CUSIP No.                                13G                  Page 3 of 8 Pages
---------------                                               -----------------


    1.      NAMES OF REPORTING PERSONS

            Dr. Jeffrey R. Jay, M.D.

    2.      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
            (a)     [ ]

            (b)     [ ]

--------------------------------------------------------------------------------
    3.      SEC USE ONLY

--------------------------------------------------------------------------------
    4.      CITIZENSHIP OR PLACE OF ORGANIZATION

            USA

                         5.    SOLE VOTING POWER
   NUMBER OF SHARES                                       0

     BENEFICIALLY        6.    SHARED VOTING POWER
                                                                   0
    OWNED BY EACH
                         7.    SOLE DISPOSITIVE POWER
   REPORTING PERSON                                       0

         WITH            8.    SHARED DISPOSITIVE POWER
                                                                   0

    9.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                     0

    10.     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
            SHARES (See Instructions)                                        [ ]


    11.     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                     0%

    12.     TYPE OF REPORTING PERSON (See Instructions)

                     IN



---------------                                               -----------------
CUSIP No.                                13G                  Page 4 of 8 Pages
---------------                                               -----------------


     ITEM 1.

                    (a)      Name of Issuer

                             BioCryst Pharmaceuticals, Inc.

                    (b)      Address of Issuer's Principal Executive Offices

                             2190 Parkway Lake Drive
                             Birmingham, Alabama 35244


     ITEM 2.

                    (a)      Name of Person Filing

                                      Great Point Partners, LLC
                                      Dr. Jeffrey R. Jay, M.D.

                    The Reporting Persons have entered into a Joint Filing
                    Agreement, dated February 13, 2006, a copy of which is filed
                    with this Schedule 13G as Exhibit A, pursuant to which the
                    Reporting Persons have agreed to file this statement jointly
                    in accordance with the provisions of Rule 13d-1(k)(1) under
                    the Act.

                    (b)      Address of Principal Business Office, or if none,
                             Residence

                             The address of the principal business office of
                             each of the Reporting Persons is

                                      2 Pickwick Plaza
                                      Suite 450
                                      Greenwich, CT 06830

                    (c)      Citizenship

                    Great Point Partners, LLC is a limited liability company
                    organized under the laws of the State of Delaware. Dr.
                    Jeffrey R. Jay, M.D. is a citizen of the United States.

                    (d)      Title of Class of Securities

                             Common Stock

                    (e)      CUSIP Number

                             09058V103

     ITEM 3.        IF THIS STATEMENT IS FILED PURSUANT TO SS.240.13D-1(b) OR
                    240.13D.2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A:

                             Not Applicable.

                    (a)   [ ]   Broker or dealer registered under Section 15 of
                                the Act (15 U.S.C. 78o)

                    (b)   [ ]   Bank as defined in Section 3(a)(6) of the Act
                                (15 U.S.C. 78c).

                    (c)   [ ]   Insurance company as defined in Section 3(a)(19)
                                of the Act (15. U.S.C. 78c).

                    (d)   [ ]   Investment Company registered under Section 8 of
                                the Investment Company Act of 1940
                                (15 U.S.C. 80a-8).

                    (e)   [ ]   An investment adviser in accordance with
                                ss.240.13d-1(b)(1)(ii)(E).



---------------                                               -----------------
CUSIP No.                                13G                  Page 5 of 8 Pages
---------------                                               -----------------


                    (f)   [ ]   An employee benefit plan or endowment fund in
                                accordance with ss.240.13d-1(b)(1)(ii)(F).

                    (g)   [ ]   A parent holding company or control person in
                                accordance with ss.240.13d-1(b)(1)(ii)(G).

                    (h)   [ ]   A savings associations as defined in Section
                                3(b) of the Federal Deposit Insurance Act (12
                                U.S.C. 1813).

                    (i)   [ ]   A church plan that is excluded from the
                                definition of an investment company under
                                Section 3(c)(14) of the Investment Company Act
                                of 1940 (15 U.S.C. 80a-3).

                    (j)   [ ]   Group, in accordance with
                                ss.240.13d-1(b)(1)(ii)(J).

     ITEM 4.        OWNERSHIP


                    Provide the following information regarding the aggregate
                    number and percentage of the class of securities of the
                    issuer identified in Item 1.

                    1.    GREAT POINT PARTNERS, LLC

                    (a)   Amount beneficially owned: 0.

                    (b)   Percent of class: 0%.

                    (c)   Number of shares as to which the person has:

                          (i)      Sole power to vote or to direct the vote:
                                   - 0 -

                          (ii)     Shared power to vote or to direct
                                   the vote: 0.

                          (iii)    Sole power to dispose or to direct the
                                   disposition of:   - 0 -.

                          (iv)     Shared power to dispose or to direct the
                                   disposition of: 0.

                    2. DR. JEFFREY R. JAY, M.D.

                    (a)   Amount beneficially owned: 0

                    (b)   Percent of class: 0%.

                    (c)   Number of shares as to which the person has:

                          (i)      Sole power to vote or to direct the vote:
                                   0.

                          (ii)     Shared power to vote or to direct
                                   the vote: 0.

                          (iii)    Sole power to dispose or to direct the
                                   disposition of: 0.

                          (iv)     Shared power to dispose or to direct the
                                      disposition of: 0.


ITEM 5.             OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

                    Yes.

ITEM 6.             OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER
                    PERSON:

                    Not Applicable.



---------------                                               -----------------
CUSIP No.                                13G                  Page 6 of 8 Pages
---------------                                               -----------------


ITEM 7.             IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
                    ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT
                    HOLDING COMPANY

                    Not Applicable.

ITEM 8.             IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

                    Not Applicable.

ITEM 9.             NOTICE OF DISSOLUTION OF GROUP

                    Not Applicable.

ITEM 10.            CERTIFICATION

By signing below I certify that, to the best of my knowledge and belief, the
securities referred to above were not acquired and are not held for the purpose
of or with the effect of changing or influencing the control of the issuer of
the securities and were not acquired and are not held in connection with or as
participant in any transaction having that purpose or effect.



---------------                                               -----------------
CUSIP No.                                13G                  Page 7 of 8 Pages
---------------                                               -----------------


                                    SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

Date:  February 13, 2006

                            GREAT POINT PARTNERS, LLC

                             By:  /s/ Dr. Jeffrey R. Jay, M.D.
                                  ----------------------------------------------
                                  Dr. Jeffrey R. Jay, M.D.,
                                   as senior managing member

                             /s/ Dr. Jeffrey R. Jay, M.D.
                             ---------------------------------------------------
                             DR. JEFFREY R. JAY, M.D.



                                                                       EXHIBIT A


              AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13G


The undersigned hereby agree as follows:

         (i)      Each of them is individually  eligible to use the Schedule 13G
to which this Exhibit is attached,  and such  Schedule 13G is filed on behalf of
each of them; and

         (ii)     Each of them is  responsible  for the  timely  filing  of such
Schedule 13G and any amendments  thereto,  and for the completeness and accuracy
of the information concerning such person contained therein; but none of them is
responsible for the  completeness or accuracy of the information  concerning the
other  persons  making the filing,  unless  such  person  knows or has reason to
believe that such information is inaccurate.

Date:  February 13, 2006

                            GREAT POINT PARTNERS, LLC

                             By:  /s/ Dr. Jeffrey R. Jay, M.D.
                                  ----------------------------------------------
                                  Dr. Jeffrey R. Jay, M.D.,
                                   as senior managing member

                             /s/ Dr. Jeffrey R. Jay, M.D.
                             ---------------------------------------------------
                             DR. JEFFREY R. JAY, M.D.