UNITED
STATES
SECURITIES
AND EXCHANGE COMMISSION
Washington,
D.C. 20549
|
OMB
APPROVAL
OMB
Number: 3235-0145
Expires:
February 28, 2009
Estimated
average burden
hours
per response 14.5
|
Warren
T. Lazarow, Esq.
O’Melveny
& Myers LLP
2765
Sand Hill Road
Menlo
Park, CA 94025
(650)
473-2600
|
Paul
S. Scrivano, Esq.
O’Melveny
& Myers LLP
Times
Square Tower
7
Times Square
New
York, NY 10036
(212)
326-2000
|
|
1.
|
Names
of Reporting Persons
|
|
Palo
Alto Investors, Inc.
|
|
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
(a)
|
___
|
||
(b)
|
_X_
|
|
3.
|
SEC
Use Only
|
4. Source
of Funds (See Instructions)
|
AF
|
5. Check
if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or
2(e)
|
___
|
6. Citizenship
or Place of Organization
|
California
|
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
7. Sole
Voting Power
|
0
|
|
8. Shared
Voting Power
|
4,674,744
|
||
9. Sole
Dispositive Power
|
0
|
||
10. Shared
Dispositive Power
|
4,674,744
|
11. Aggregate
Amount Beneficially Owned by Each Reporting Person
|
4,674,744
|
12. Check
if the Aggregate Amount in Row (11) Excludes Certain Shares (See
Instructions)
|
13. Percent
of Class Represented by Amount in Row (11)
|
9.3%
|
14. Type
of Reporting Person (See Instructions)
|
CO,
HC
|
|
1.
|
Names
of Reporting Persons
|
|
Palo
Alto Investors, LLC
|
|
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
(a)
|
___
|
||
(b)
|
_X_
|
|
3.
|
SEC
Use Only
|
4. Source
of Funds (See Instructions)
|
AF
|
5. Check
if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or
2(e)
|
___
|
6. Citizenship
or Place of Organization
|
California
|
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
7. Sole
Voting Power
|
0
|
|
8. Shared
Voting Power
|
4,674,744
|
||
9. Sole
Dispositive Power
|
0
|
||
10. Shared
Dispositive Power
|
4,674,744
|
11. Aggregate
Amount Beneficially Owned by Each Reporting Person
|
4,674,744
|
12. Check
if the Aggregate Amount in Row (11) Excludes Certain Shares (See
Instructions)
|
13. Percent
of Class Represented by Amount in Row (11)
|
9.3%
|
14. Type
of Reporting Person (See Instructions)
|
IA,
OO
|
|
1.
|
Names
of Reporting Persons
|
|
William
Leland Edwards
|
|
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
(a)
|
___
|
||
(b)
|
_X_
|
|
3.
|
SEC
Use Only
|
4. Source
of Funds (See Instructions)
|
AF
|
5. Check
if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or
2(e)
|
___
|
6. Citizenship
or Place of Organization
|
U.S.A.
|
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
7. Sole
Voting Power
|
28,000
|
|
8. Shared
Voting Power
|
4,674,744
|
||
9. Sole
Dispositive Power
|
28,000
|
||
10. Shared
Dispositive Power
|
4,674,744
|
11. Aggregate
Amount Beneficially Owned by Each Reporting Person
|
4,702,744
|
12. Check
if the Aggregate Amount in Row (11) Excludes Certain Shares (See
Instructions)
|
13. Percent
of Class Represented by Amount in Row (11)
|
9.4%
|
14. Type
of Reporting Person (See Instructions)
|
IN,
HC
|
|
1.
|
Names
of Reporting Persons
|
|
Anthony
Joonkyoo Yun, MD
|
|
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
(a)
|
___
|
||
(b)
|
_X_
|
|
3.
|
SEC
Use Only
|
4. Source
of Funds (See Instructions)
|
AF
|
5. Check
if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or
2(e)
|
___
|
6. Citizenship
or Place of Organization
|
U.S.A.
|
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
7. Sole
Voting Power
|
0
|
|
8. Shared
Voting Power
|
4,674,744
|
||
9. Sole
Dispositive Power
|
0
|
||
10. Shared
Dispositive Power
|
4,674,744
|
11. Aggregate
Amount Beneficially Owned by Each Reporting Person
|
4,674,744
|
12. Check
if the Aggregate Amount in Row (11) Excludes Certain Shares (See
Instructions)
|
13. Percent
of Class Represented by Amount in Row (11)
|
9.3%
|
14. Type
of Reporting Person (See Instructions)
|
IN,
HC
|
|
1.
|
Names
of Reporting Persons
|
|
Palo
Alto Small Cap Master Fund, L.P.
|
|
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
(a)
|
___
|
||
(b)
|
_X_
|
|
3.
|
SEC
Use Only
|
4. Source
of Funds (See Instructions)
|
AF
|
5. Check
if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or
2(e)
|
___
|
6. Citizenship
or Place of Organization
|
Cayman
Islands
|
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
7. Sole
Voting Power
|
0
|
|
8. Shared
Voting Power
|
3,257,172
|
||
9. Sole
Dispositive Power
|
0
|
||
10. Shared
Dispositive Power
|
3,257,172
|
11. Aggregate
Amount Beneficially Owned by Each Reporting Person
|
3,257,172
|
12. Check
if the Aggregate Amount in Row (11) Excludes Certain Shares (See
Instructions)
|
13. Percent
of Class Represented by Amount in Row (11)
|
6.5%
|
14. Type
of Reporting Person (See Instructions)
|
PN
|
|
1.
|
Names
of Reporting Persons
|
|
Palo
Alto Small Cap Fund, L.P.
|
|
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
(a)
|
___
|
||
(b)
|
_X_
|
|
3.
|
SEC
Use Only
|
4. Source
of Funds (See Instructions)
|
AF
|
5. Check
if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or
2(e)
|
___
|
6. Citizenship
or Place of Organization
|
Delaware
|
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
7. Sole
Voting Power
|
0
|
|
8. Shared
Voting Power
|
2,775,762
|
||
9. Sole
Dispositive Power
|
0
|
||
10. Shared
Dispositive Power
|
2,775,762
|
11. Aggregate
Amount Beneficially Owned by Each Reporting Person
|
2,775,762
|
12. Check
if the Aggregate Amount in Row (11) Excludes Certain Shares (See
Instructions)
|
13. Percent
of Class Represented by Amount in Row (11)
|
5.5%
|
14. Type
of Reporting Person (See Instructions)
|
PN
|
|
(a)
|
William
Leland Edwards, Palo Alto Investors, LLC ("PAI LLC"), Palo Alto Investors,
Inc. ("PAI Corp"), Palo Alto Small Cap Master Fund, L.P. (“Small Cap
Master”), Palo Alto Small Cap Fund, L.P. (“Small Cap”) and Anthony
Joonkyoo Yun, MD (collectively, the
"Filers").
|
|
(b)
|
The
business address of the Filers (other than Small Cap Master)
is:
|
|
470
University Avenue, Palo Alto,
CA 94301
|
|
The
business address of Small Cap Master
is:
|
|
Citco
Fund Services (Bermuda) Limited, Washington Mall West, 2nd
Floor, 7 Reid Street, Hamilton HM 11,
Bermuda
|
|
(c)
|
Present
principal occupation or employment or the Filers and the name, principal
business and address of any corporation or other organization in which
such employment is conducted:
|
|
PAI
LLC is an investment adviser registered with the Securities and Exchange
Commission and is the general partner of, and investment adviser to,
investment limited partnerships, including without limitation Small Cap
Master and Small Cap. The sole manager of PAI LLC is PAI
Corp. Mr. Edwards is the controlling shareholder of PAI Corp
and the controlling owner of PAI LLC. Mr. Yun is the president
of PAI Corp and PAI LLC. Small Cap Master invests in securities
of companies, and Small Cap invests in securities of companies indirectly
as a limited partner of Small Cap
Master.
|
|
(d)
|
During
the last five years, none of the Filers has been convicted in a criminal
proceeding (excluding traffic violations or similar
misdemeanors).
|
|
(e)
|
During
the last five years, none of the Filers was a party to a civil proceeding
of a judicial or administrative body of competent jurisdiction and as a
result of such proceeding was or is subject to a judgment, decree or final
order enjoining future violations of, or prohibiting or mandating
activities subject to, federal or state securities laws or finding any
violation with respect to such
laws.
|
|
(f)
|
Mr.
Edwards and Mr. Yun are United States
citizens.
|
Purchaser
|
Source of Funds
|
Amount
|
|||
PAI
LLC
|
Funds
Under Management
|
$ | 31,042,599 |
Filer
|
Date
|
Transaction
|
Number
of Shares
Purchased or Sold
|
Average Price Per Share
|
|||||||
PAI
LLC
|
12/10/2009
|
Sale
|
4,000,000 | $ | 4.24 |
PALO
ALTO INVESTORS, INC.
By: /s/ Mark
Shamia
Mark Shamia, Chief Operating
Officer
|
PALO
ALTO INVESTORS, LLC
By: /s/ Mark
Shamia
Mark Shamia, Chief Operating
Officer
|
PALO
ALTO SMALL CAP MASTER FUND, L.P.
By: Palo
Alto Investors, LLC, General Partner
By: Palo
Alto Investors, Manager
By: /s/ Mark
Shamia
Mark Shamia, Chief Operating
Officer
|
PALO
ALTO SMALL CAP FUND, L.P.
By: Palo
Alto Investors, LLC, General Partner
By: Palo
Alto Investors, Manager
By: /s/ Mark
Shamia
Mark Shamia, Chief Operating
Officer
|
/s/
Anthony Joonkyoo
Yun
Anthony Joonkyoo Yun,
MD
|
/s/
William Leland
Edwards
William Leland
Edwards
|
PALO
ALTO INVESTORS, INC.
By: /S/
Mark Shamia, Chief Operating Officer
|
PALO
ALTO INVESTORS, LLC
By: /S/
Mark Shamia, Chief Operating Officer
|
PALO
ALTO SMALL CAP MASTER FUND, L.P.
By: Palo
Alto Investors, LLC, General Partner
By: Palo
Alto Investors, Manager
By: /s/ Mark
Shamia
Mark Shamia, Chief Operating
Officer
|
PALO
ALTO SMALL CAP FUND, L.P.
By: Palo
Alto Investors, LLC, General Partner
By: Palo
Alto Investors, Manager
By: /s/ Mark
Shamia
Mark Shamia, Chief Operating
Officer
|
/S/
Anthony Joonkyoo Yun, MD
|
/S/
William Leland Edwards
|