FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person *   Celentano John E 2. Date of Event Requiring Statement (Month/Day/Year) 11/30/2005 3. Issuer Name and Ticker or Trading Symbol BRISTOL MYERS SQUIBB CO [(BMY)] (Last) (First) (Middle) BRISTOL-MYERS SQUIBB COMPANY, 777 SCUDDERS MILL ROAD 4. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) President, Health Care Group 5. If Amendment, Date Original Filed(Month/Day/Year) (Street) PLAINSBORO, NJ 08536 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5) Common Stock, $0.10 par value 31,694 (1) D   Common Stock, $0.10 par value 2,388.79 I By BMY Savings & Investment Program

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Executive Option (right to buy)	01/04/2000(2)	01/03/2009	Common Stock, $0.10 par value	22,400	$ 62.95	D	Â
Executive Option (right to buy)	  (2)	01/02/2010	Common Stock, $0.10 par value	1,788	$ 61.09	D	Â
Executive Option (right to buy)	03/06/2002(2)	03/05/2011	Common Stock, $0.10 par value	19,718	$ 59.78	D	Â
Option (right to buy)	  (3)	12/01/2006	Common Stock, $0.10 par value	12,620	$ 27.43	D	Â
Option (right to buy)	03/04/1998(4)	03/03/2007	Common Stock, $0.10 par value	12,620	$ 32	D	Â
Option (right to buy)	06/04/2005(4)	06/03/2007	Common Stock, $0.10 par value	20,250	$ 28.9	D	Â
Option (right to buy)	03/03/1999(4)	03/02/2008	Common Stock, $0.10 par value	22,400	$ 48.45	D	Â
Option (right to buy)	  (3)	12/20/2008	Common Stock, $0.10 par value	17,878	$ 58.06	D	Â
Option (right to buy)	03/07/2001(3)	03/06/2010	Common Stock, $0.10 par value	22,348	$ 42.64	D	Â
Option (right to buy)	03/05/2003(3)	03/04/2012	Common Stock, $0.10 par value	27,000	$ 48.08	D	Â
Option (right to buy)	03/04/2004(3)	03/03/2013	Common Stock, $0.10 par value	42,500	$ 23.14	D	Â
Option (right to buy)	  (3)	03/01/2014	Common Stock, $0.10 par value	33,333	$ 28.11	D	Â
Option (right to buy)	  (3)	02/28/2015	Common Stock, $0.10 par value	26,250	$ 25.45	D	Â

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Celentano John E BRISTOL-MYERS SQUIBB COMPANY 777 SCUDDERS MILL ROAD PLAINSBORO, NJ 08536	Â	Â	  President, Health Care Group	Â

Signatures

/s/ Celentano, John E.		12/07/2005
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Includes shares of restricted stock with one-third vesting on each of the third, fourth and fifth anniversaries of the grant date.
(2)	One half of the shares is exercisable 25% per year, on a cumulative basis, commencing one year after the date of grant. The other half of the shares vests 25% per year and is exercisable on the earlier to occur of (i) the closing share price achieving a price threshold and remaining at that threshold for a given number of days or (ii) the eighth anniversary of the grant date.
(3)	Exercisable as to 25% of the shares annually, on a cumulative basis, commencing one year after the date of grant.
(4)	Currently Exercisable.

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