Ownership Submission
FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  RA CAPITAL MANAGEMENT, LLC
2. Date of Event Requiring Statement (Month/Day/Year)
09/23/2008
3. Issuer Name and Ticker or Trading Symbol
BIOSPECIFICS TECHNOLOGIES CORP [BSTC]
(Last)
(First)
(Middle)
C/O RA CAPITAL MANAGEMENT, LLC, 800 BOYLSTON STREET, SUITE 1500
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

BOSTON, MA 02199
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 615,348 (1)
I
see footnote (2)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
RA CAPITAL MANAGEMENT, LLC
C/O RA CAPITAL MANAGEMENT, LLC
800 BOYLSTON STREET, SUITE 1500
BOSTON, MA 02199
    X    
ALDRICH RICHARD
C/O RA CAPITAL MANAGEMENT, LLC
800 BOYLSTON STREET, SUITE 1500
BOSTON, MA 02199
    X    
Kolchinsky Peter
C/O RA CAPITAL MANAGEMENT, LLC
800 BOYLSTON STREET, SUITE 1500
BOSTON, MA 02199
    X    
RA Capital Biotech Fund LP
C/O RA CAPITAL MANAGEMENT, LLC
800 BOYLSTON STREET, SUITE 1500
BOSTON, MA 02199
    X    
RA Capital Biotech Fund II, L.P.
C/O RA CAPITAL MANAGEMENT, LLC
800 BOYLSTON STREET, SUITE 1500
BOSTON, MA 02199
    X    

Signatures

Peter Kolchinsky, Manager of RA Capital Management, LLC 09/26/2008
**Signature of Reporting Person Date

Richard H. Aldrich 09/26/2008
**Signature of Reporting Person Date

Peter Kolchinsky 09/26/2008
**Signature of Reporting Person Date

Peter Kolchinsky, Manager of RA Capital Management, LLC, the General Partner of RA Capital Healthcare Fund, L.P. 09/26/2008
**Signature of Reporting Person Date

Peter Kolchinsky, Manager of RA Capital Management, LLC, the General Partner of RA Capital Healthcare Fund II, L.P. 09/26/2008
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) These shares represent 607,644 shares held by RA Capital Healthcare Fund, L.P. ("Fund I"), and 7,704 shares held by RA Capital Healthcare Fund II, L.P. ("Fund II").
(2) RA Capital Management, LLC (the "General Partner") is the general partner of both Fund I and Fund II, and Richard H. Aldrich and Peter Kolchinsky are the sole managers of the General Partner. Each of the Reporting Persons disclaims his or its beneficial ownership of any shares of the above named Issuer reported herein, except to the extent of his or its pecuniary interest therein.

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