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Issuer Free Writing Prospectus     Filed Pursuant to Rule 433 Registration Statement No. 333-226450 Supplementing the Preliminary Prospectus Supplement dated August 13, 2018 (To Prospectus dated July 31, 2018) Pricing Term Sheet $1,500,000,000 Zoetis Inc. $300,000,000 Floating Rate Notes due 2021 $300,000,000 3.250% Senior Notes due 2021 $500,000,000 3.900% Senior Notes due 2028 $400,000,000 4.450% Senior Notes due 2048 August 13, 2018 Issuer:Zoetis Inc. Title:Floating Rate Notes3.250% Senior Notes due3.900% Senior Notes due4.450% Senior Notes due 202120212028due 2048 Principal Amount:$300,000,000$300,000,000$500,000,000$400,000,000 Maturity Date:August 20, 2021August 20, 2021August 20, 2028August 20, 2048 Interest PaymentFebruary 20, May 20,February 20 and AugustFebruary 20 and AugustFebruary 20 and August Dates:August 20 and20, commencing February20, commencing February20, commencing November 20,20, 201920, 2019February 20, 2019 commencing November 20, 2018 Coupon:-3.250%3.900%4.450% Benchmark-2.750% UST due August2.875% UST due August3.125% UST due May Treasury:15, 202115, 202815, 2048 Benchmark Treasury-100-05+ / 2.690%100-00+ / 2.873%101-19 / 3.043% Price and Yield: Spread to Benchmark-+60 bps+105 bps+145 bps Treasury: Spread to Base Rate:+44 bps--- InterestSecond London--- Determination Date:business day preceding the applicable interest reset date Interest Rate Basis:Three-month LIBOR--- Interest Reset Dates:February 20, May 20,--- August 20 and November 20

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Price to Public:    100.000% of the 99.887% of the principal99.811% of the principal99.295% of the principal amountamount amount principal amount Yield to Maturity:-3.290%3.923%4.493% Make-whole-+10 bps+20 bps+25 bps Redemption: Par Call:--On or after May 20, 2028On or after February 20, 2048 Day Count Fraction:Actual/36030/36030/36030/360 CUSIP/ISIN:98978VAR4 /98978VAQ6 /98978VAN3 /98978VAP8 / US98978VAR42US98978VAQ68US98978VAN38US98978VAP85 Denominations:$2,000 and integral multiples of $1,000 Ratings of theBaa1 / BBB (Moody’s /S&P) Notes*: Trade Date:August 13, 2018 Settlement Date:August 20, 2018 (T+5) Joint Book-RunningBarclays Capital Inc. Managers:Citigroup Global Markets Inc. J.P. Morgan Securities LLC Merrill Lynch, Pierce, Fenner & Smith Incorporated MUFG Securities Americas Inc. BNP Paribas Securities Corp. Goldman Sachs & Co. LLC HSBC Securities (USA) Inc. TD Securities (USA) LLC Senior Co-Managers:Rabo Securities USA, Inc. Standard Chartered Bank** Co-Managers:Loop Capital Markets LLC Wells Fargo Securities, LLC *The security ratings above are not a recommendation to buy, sell or hold the securities offered hereby. The ratings may be subject to revision or withdrawal at any time by the assigning rating organization, and each rating should be evaluated independently of any other rating. **Standard Chartered Bank will not effect any offers or sales of any notes in the United States unless it is through one or more U.S. registered broker-dealers as permitted by the regulations of FINRA. The issuer has filed a registration statement (including a prospectus and preliminary prospectus supplement) with the SEC for the offering to which this communication relates. Before you invest, you should read the prospectus in that registration statement and other documents the issuer has filed with the SEC for more complete information about the issuer and this offering. You may get these documents for free by visiting EDGAR on the SEC Web site at www.sec.gov. Alternatively, the issuer, any underwriter or any dealer participating in the offering will arrange to send you the prospectus supplement and accompanying prospectus if you request it by calling Barclays Capital Inc. toll-free at 1-888-603-5847, Citigroup Global Markets Inc. toll-free at 1-800-831-9146, J.P. Morgan Securities LLC collect at 1-212-834-4533, Merrill Lynch, Pierce, Fenner & Smith Incorporated toll-free at 1-800-294-1322 or MUFG Securities Americas Inc. toll-free at 1-877-649-6848. Any disclaimer or other notice that may appear below is not applicable to this communication and should be disregarded. Such disclaimer or notice was automatically generated as result of this communication being sent by Bloomberg or another email system. 2