Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  CORCORAN KEVIN P
 2. Date of Event Requiring Statement (Month/Day/Year)
03/27/2012		 3. Issuer Name and Ticker or Trading Symbol
PACIFIC BIOSCIENCES OF CALIFORNIA INC [PACB]
(Last)
(First)
(Middle)
PACIFIC BIOSCIENCES OF CALIFORNIA, INC., 1380 WILLOW ROAD		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
SVP, Market Development
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

MENLO PARK, CA 94025		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 8,049
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy)   (1) 11/26/2017 Common Stock 112,500 $ 1.96 D  
Stock Option (right to buy)   (2) 09/17/2018 Common Stock 37,500 $ 6.96 D  
Stock Option (right to buy)   (3) 02/17/2020 Common Stock 50,000 $ 8.5 D  
Stock Option (right to buy)   (4) 07/29/2020 Common Stock 12,500 $ 12.74 D  
Stock Option (right to buy)   (5) 03/15/2021 Common Stock 150,000 $ 14.24 D  
Stock Option (right to buy)   (6) 02/15/2022 Common Stock 250,000 $ 4.79 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
CORCORAN KEVIN P
PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
1380 WILLOW ROAD
MENLO PARK, CA 94025		       SVP, Market Development  

Signatures

Brian Dow, Attorney-in-fact for Kevin P. Corcoran 04/03/2012
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The shares subject to the option are fully vested and exercisable.
(2) 1/5th of the shares subject to the option vested on June 1, 2009 and the balance of the shares have vested and will vest monthly thereafter over the next four years, provided that the Reporting Person continues to serve through each vesting date.
(3) 1/5th of the shares subject to the option vested on June 1, 2010 and the balance of the shares have vested and will vest monthly thereafter over the next four years, provided that the Reporting Person continues to serve through each vesting date.
(4) 1/5th of the shares subject to the option vested on June 1, 2011 and the balance of the shares have vested and will vest monthly thereafter over the next four years, provided that the Reporting Person continues to serve through each vesting date.
(5) 1/5th of the shares subject to the option vested on March 15, 2012 and the balance of the shares have vested and will vest monthly thereafter over the next four years, provided that the Reporting Person continues to serve through each vesting date.
(6) 1/5th of the shares subject to the option will vest on February 15, 2013 and the balance of the shares will vest monthly thereafter over the next four years, provided that the Reporting Person continues to serve through each vesting date.

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