Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Mendez Manuel O.
 2. Date of Event Requiring Statement (Month/Day/Year)
11/05/2009		 3. Issuer Name and Ticker or Trading Symbol
ORASURE TECHNOLOGIES INC [OSUR]
(Last)
(First)
(Middle)
220 EAST FIRST STREET		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
VP, Marketing and Sales
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

BETHLEHEM, PA 18015		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 5,000 (1)
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Options   (2) 05/26/2019 Common Stock 25,000 $ 3.3 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Mendez Manuel O.
220 EAST FIRST STREET
BETHLEHEM, PA 18015		       VP, Marketing and Sales  

Signatures

/s/ Jack E. Jerrett, as Attorney-in Fact for Manuel O. Mendez 11/12/2009
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Grant of restricted shares under the OraSure Technologies, Inc. 2000 Stock Award Plan, all of which vest on May 26, 2011. Vesting shall cease upon voluntary termination of employment.
(2) Grant of non-qualified stock options, vesting over a four year period, with one-fourth vesting on May 26, 2010 and the remainder vesting ratably on a monthly basis over the next 36 months. Vesting shall cease upon voluntary termination of employment.

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