Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  GROOPMAN JEROME
 2. Date of Event Requiring Statement (Month/Day/Year)
07/24/2013		 3. Issuer Name and Ticker or Trading Symbol
Onconova Therapeutics, Inc. [ONTX]
(Last)
(First)
(Middle)
C/O ONCONOVA THERAPEUTICS, INC., 375 PHEASANT RUN		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

NEWTOWN, PA 18940		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to purchase) 02/01/2012 02/01/2022 Common Stock 375 $ 6.13 D  
Stock Option (right to purchase) 12/19/2012 12/20/2022 Common Stock 375 $ 13.28 D  
Stock Option (right to purchase) 02/01/2014 02/02/2023 Common Stock 3,000 $ 13.28 D  
Stock Option (right to purchase)   (1) 02/02/2023 Common Stock 18,754 $ 13.28 D  
Stock Option (right to purchase) 04/25/2013 04/26/2023 Common Stock 375 $ 14.74 D  
Stock Option (right to purchase) 05/14/2013 05/15/2023 Common Stock 375 $ 14.74 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
GROOPMAN JEROME
C/O ONCONOVA THERAPEUTICS, INC.
375 PHEASANT RUN
NEWTOWN, PA 18940		   X      

Signatures

/s/ Ajay Bansal, as attorney in fact 07/24/2013
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) This option, representing a right to purchase a total of 18,754 shares of Common Stock, is immediately exercisable and vests over 4 years from February 1, 2013, with 25% vesting on February 1, 2014 and 75% vesting in 36 equal monthly installments thereafter, subject to continued service to the Issuer through each vesting date.
 
Remarks:
Two of Two.

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