SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                _________________

                                  SCHEDULE 13G

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (Amendment No.) /2/

                                 NuVasive, Inc.
                                (Name of Issuer)

                    Common Stock, par value $0.001 per share
                         (Title of Class of Securities)

                                    670704105
                                 (CUSIP Number)

                                December 31, 2005
             (Date of Event Which Requires Filing of This Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

      |_| Rule 13d-1(b)

      |_| Rule 13d-1(c)

      |X| Rule 13d-1(d)

___________
      /1/ The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

      The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).



CUSIP No. 670704105                                      Page  2  of  9  Pages
                                      13G

--------------------------------------------------------------------------------
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     William Blair Capital Partners VII QP, L.P.
--------------------------------------------------------------------------------
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                 (a)  |_|
                                                                 (b)  |_|
--------------------------------------------------------------------------------
3.   SEC USE ONLY


--------------------------------------------------------------------------------
4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware
--------------------------------------------------------------------------------
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           0
               -----------------------------------------------------------------
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          795,880 (See Item 4)
               -----------------------------------------------------------------
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         0
               -----------------------------------------------------------------
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            795,880 (See Item 4)
--------------------------------------------------------------------------------
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     795,880 (See Item 4)
--------------------------------------------------------------------------------
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          |_|
--------------------------------------------------------------------------------
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     3.19%
--------------------------------------------------------------------------------
12.  TYPE OF REPORTING PERSON*

     PN
--------------------------------------------------------------------------------

                    *SEE INSTRUCTIONS BEFORE FILLING OUT!



CUSIP No. 670704105                                      Page  3  of  9  Pages
                                      13G

--------------------------------------------------------------------------------
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     William Blair Capital Partners VII, L.P.
--------------------------------------------------------------------------------
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                 (a)  |_|
                                                                 (b)  |_|
--------------------------------------------------------------------------------
3.   SEC USE ONLY


--------------------------------------------------------------------------------
4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware
--------------------------------------------------------------------------------
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           0
               -----------------------------------------------------------------
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          795,880 (See Item 4)
               -----------------------------------------------------------------
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         0
               -----------------------------------------------------------------
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            795,880 (See Item 4)
--------------------------------------------------------------------------------
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     795,880 (See Item 4)
--------------------------------------------------------------------------------
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          |_|
--------------------------------------------------------------------------------
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     3.19%
--------------------------------------------------------------------------------
12.  TYPE OF REPORTING PERSON*

     OO
--------------------------------------------------------------------------------

                    *SEE INSTRUCTIONS BEFORE FILLING OUT!



CUSIP No. 670704105                                      Page  4  of  9  Pages
                                      13G

--------------------------------------------------------------------------------
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     William Blair Capital Management VII, L.C.C.
--------------------------------------------------------------------------------
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                 (a)  |_|
                                                                 (b)  |_|
--------------------------------------------------------------------------------
3.   SEC USE ONLY


--------------------------------------------------------------------------------
4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware
--------------------------------------------------------------------------------
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           0
               -----------------------------------------------------------------
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          795,880 (See Item 4)
               -----------------------------------------------------------------
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         0
               -----------------------------------------------------------------
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            795,880 (See Item 4)
--------------------------------------------------------------------------------
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     795,880 (See Item 4)
--------------------------------------------------------------------------------
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          |_|
--------------------------------------------------------------------------------
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     3.19%
--------------------------------------------------------------------------------
12.  TYPE OF REPORTING PERSON*

     PN
--------------------------------------------------------------------------------

                    *SEE INSTRUCTIONS BEFORE FILLING OUT!



CUSIP No. 670704105                                      Page  5  of  9  Pages
                                      13G

--------------------------------------------------------------------------------
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     William Blair Capital Management VII, L.P.
--------------------------------------------------------------------------------
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

                                                                 (a)  |_|
                                                                 (b)  |_|
--------------------------------------------------------------------------------
3.   SEC USE ONLY


--------------------------------------------------------------------------------
4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware
--------------------------------------------------------------------------------
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           0
               -----------------------------------------------------------------
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          795,880 (See Item 4)
               -----------------------------------------------------------------
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         0
               -----------------------------------------------------------------
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            795,880 (See Item 4)
--------------------------------------------------------------------------------
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     795,880 (See Item 4)
--------------------------------------------------------------------------------
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          |_|
--------------------------------------------------------------------------------
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     3.19%
--------------------------------------------------------------------------------
12.  TYPE OF REPORTING PERSON*

     PN
--------------------------------------------------------------------------------

                    *SEE INSTRUCTIONS BEFORE FILLING OUT!



                                 SCHEDULE 13G

Item 1(a). Name of Issuer:

           NuVasive, Inc. (the "Company")

Item 1(b). Address of Issuer's Principal Executive Offices:

           4545 Towne Centre Court
           San Diego, CA  92131

Item 2(a). Name of Persons Filing:

      This statement is filed jointly by each of the following Persons pursuant
      to Rule 13d-1(k) promulgated by the Securities and Exchange Commission
      ("SEC") under Section 13 of the Securities Exchange Act of 1934, as
      amended (the "Act"): (i) William Blair Capital Partners VII QP, L.P., a
      Delaware limited partnership (the "Fund"), by virtue of its direct
      beneficial ownership of Common Stock and (ii) William Blair Capital
      Partners VII, L.P., a Delaware limited partnership (the "Fund"), by virtue
      of its direct beneficial ownership of Common Stock and (iii) William Blair
      Capital Management VII, L.L.C. ("WBCPCO," together with the Fund, each a
      "Reporting Person" and collectively, "Reporting Persons"), a Delaware
      limited liability company, by virtue of its being the general partner of
      the general partner of the Fund. (iv) William Blair Capital Management
      VII, L.P. ("WBCPCO," together with the Fund, each a "Reporting Person" and
      collectively, "Reporting Persons"), a Delaware limited liability company,
      by virtue of its being the general partner of the Fund. By virtue of being
      members of the Board of Managers of WBCPCO (the "Board"), Timothy Burke,
      John Ettelson, Robert D. Blank, David G. Chandler, Arda Minocherhomjee,
      Timothy M. Murray, and Robert Healy may be deemed to possess indirect
      beneficial ownership of the Common Stock, but such beneficial ownership is
      disclaimed. Only the Board, acting upon the consent of a majority of the
      members of the Board at any meeting of the Board where a quorum is
      present, possesses the right to vote, direct the vote, dispose or direct
      the disposition of the Common Stock. No individual has sole power to vote,
      direct the vote, dispose or direct the disposition of the Common Stock.
      The Reporting Persons have entered into an Agreement Related to the Joint
      Filing of Schedule 13G, dated February 9, 2006, a copy of which is filed
      with this Schedule 13G as Exhibit A, pursuant to which the Reporting
      Persons have agreed to file this statement jointly in accordance with the
      provisions of Rule 13d-1(k) under the Act. Information with respect to
      each of the Reporting Persons is given solely by such Reporting Person,
      and no Reporting Person assumes responsibility for the accuracy or
      completeness of information provided by another Reporting Person. By their
      signature on this statement, each of the Reporting Persons agrees that
      this statement is filed on behalf of such Reporting Person. The Reporting
      Persons may be deemed to constitute a "group" for purposes of Section
      13(d)(3) of the Act. The Reporting Persons expressly disclaim that they
      have agreed to act as a group other than as described in this statement.

Item 2(b). Address of Principal Business Office or, if none, Residence:

           The address of the principal business office of each of the
           Reporting Persons is 222 West Adams Street, Chicago, Illinois 60606.

Item 2(c). Citizenship:

           The Fund is a Delaware limited partnership and WBCPCO is a Delaware
           limited liability company.

Item 2(d). Title of Class of Securities:

           Common Stock, par value $0.001 per share ("Common Stock").

Item 2(e). CUSIP No.:

           670704105

Item 3.    If this statement is filed pursuant to Rules 13d-1(b) or
           13d-2(b) or (c), check whether the person filing is a:

           Not Applicable.

Item 4.    Ownership (as of December 31, 2005):

           As of December 31, 2005, the Fund was the registered owner Of
           795,880 shares of Common Stock or approximately 3.19% of the total
           number of shares of Common Stock outstanding as of such date (based
           upon information provided by the Company). By virtue of the
           relationship between the Fund and WBCPCO described in Item 2(a),
           WBCPCO may be deemed to possess indirect beneficial ownership of and
           shares the power to vote or direct the vote of the shares of Common
           Stock beneficially owned by the Fund. WBCPCO disclaims beneficial
           ownership of the shares of Common Stock owned by the Fund. The
           filing of this statement by WBCPCO shall not be construed as an
           admission that they are, for the purpose of Section 13(d) or Section
           13(g) of the Act, the beneficial owner of any securities covered by
           this statement.

                                  Page 6 of 9



Item 5.  Ownership of Five Percent or Less of a Class:

If this statement is being filed to report the fact that as of the date hereof
the reporting person has ceased to be the beneficial owner of more than five
percent of the class of securities, check the following |X|.

Item 6.  Ownership of More Than Five Percent on Behalf of Another
         Person:

         Not Applicable.

Item 7.  Identification and Classification of the Subsidiary Which
         Acquired the Security Being Reported on By the Parent Holding
         Company:

         Not Applicable.

Item 8.  Identification and Classification of Members of the Group:

         Not Applicable.

Item 9.  Notice of Dissolution of a Group:

         Not Applicable.

Item 10. Certification:

         Not Applicable.

                                  Page 7 of 9


                                    SIGNATURE

      After reasonable inquiry and to the best of our knowledge and belief, the
undersigned certify that the information set forth in this statement is true,
complete and correct.

Date: February 9, 2006

                           WILLIAM BLAIR CAPITAL PARTNERS VII QP, L.P.


                           By:  William Blair Capital Management VII, L.P.
                                   Its:   General Partner


                           By:  William Blair Capital Management
                                   VII, L.L.C.
                                   Its:   General Partner


                                   By: /s/ David G. Chandler
                                   ---------------------------------------
                                   Title: Managing Director

                           William Blair Capital Management VII, L.P.

                           By:  William Blair Capital Management VII, L.L.C.
                           Its:  General Partner


                           By: /s/ David G. Chandler
                           -----------------------------------------------
                           Title: Managing Director

                           William Blair Capital Management VII, L.L.C.


                           By:  /s/ David G. Chandler
                           -----------------------------------------------
                           Title: Managing Director

                           WILLIAM BLAIR CAPITAL PARTNERS VII, L.P.

                           By:  William Blair Capital Management VII, L.P.
                                   Its:  General Partner

                           By:  William Blair Capital Management
                                   VII, L.L.C.
                                   Its:   General Partner


                                   By: /s/ David G. Chandler
                                   ---------------------------------------
                                   Title: Managing Director

                           William Blair Capital Management VII, L.P.

                           By:  William Blair Capital Management VII, L.L.C.
                           Its:  General Partner


                           By: /s/ David G. Chandler
                           -----------------------------------------------
                           Title: Managing Director

                           William Blair Capital Management VII, L.L.C.


                           By:  /s/ David G. Chandler
                           -----------------------------------------------
                           Title: Managing Director

                                  Page 8 of 9


EXHIBIT A

                    AGREEMENT REGARDING THE JOINT FILING OF
                                 SCHEDULE 13G

                            -----------------------

William Blair Capital Partners VII QP, L.P., William Blair Capital Partners VII,
L.P., William Blair Capital Management VII, L.L.C. and William Blair Capital
Management VII, L.P. hereby agree that the Statement on Schedule 13G to which
this agreement is attached as an exhibit, as well as all future amendments to
such Statement, shall be filed jointly on behalf of each of them. This agreement
is intended to satisfy the requirements of Rule 13d-1(k) (1) (iii) under the
Securities Exchange Act of 1934, as amended.

Date: February 9, 2006

                           WILLIAM BLAIR CAPITAL PARTNERS VII QP, L.P.

                           By:  William Blair Capital Management VII, L.P.
                                   Its:   General Partner

                           By:  William Blair Capital Management
                                   VII, L.L.C.
                                   Its:   General Partner


                                   By: /s/ David G. Chandler
                                   ---------------------------------------
                                   Title: Managing Director

                           William Blair Capital Management VII, L.P.

                           By:  William Blair Capital Management VII, L.L.C.
                           Its:  General Partner


                           By: /s/ David G. Chandler
                           -----------------------------------------------
                           Title: Managing Director

                           William Blair Capital Management VII, L.L.C.


                           By:  /s/ David G. Chandler
                           -----------------------------------------------
                           Title: Managing Director


                           WILLIAM BLAIR CAPITAL PARTNERS VII, L.P.

                           By:  William Blair Capital Management VII, L.P.
                                   Its:   General Partner

                           By:  William Blair Capital Management
                                   VII, L.L.C.
                                   Its:   General Partner

                                   By: /s/ David G. Chandler
                                   ---------------------------------------
                                   Title: Managing Director

                           William Blair Capital Management VII, L.P.

                           By:  William Blair Capital Management VII, L.L.C.
                           Its:  General Partner

                           By: /s/ David G. Chandler
                           -----------------------------------------------
                           Title: Managing Director

                           William Blair Capital Management VII, L.L.C.

                           By:  /s/ David G. Chandler
                           -----------------------------------------------
                           Title: Managing Director


                                  Page 9 of 9