SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                   ----------

                                    FORM 8-K

                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the

                         Securities Exchange Act of 1934

         Date of Report (Date of earliest event reported) June 10, 2004

                              REPLIGEN CORPORATION

              (Exact name of registration as specified in charter)

     Delaware                       0-14656                       04-2729386
 (State or other                  (Commission                   (IRS Employer
 jurisdiction of                  File Number)               Identification No.)
  incorporation)

41 Seyon Street, Bldg. 1, Suite 100, Waltham, MA                    02453
         (Address of principal executive offices)                 (Zip Code)

Registrant's telephone number, including area code (781) 250-0111


--------------------------------------------------------------------------------
         (Former name or former address, if changed since last report.)



Item 12. Results of Operations and Financial Condition.

      On June 10, 2004, Repligen Corporation announced its financial results for
the fourth quarter and fiscal year ended March 31, 2004. The full text of the
press release issued in connection with the announcement is attached as Exhibit
99.1 to this Current Report on Form 8-K.

      The information in this Form 8-K and the exhibit attached hereto shall not
be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of
1934 (the "Exchange Act") or otherwise subject to the liabilities of that
section, nor shall it be deemed incorporated by reference in any filing under
the Securities Act of 1933 or the Exchange Act, except as expressly set forth by
specific reference in such a filing.



                                   SIGNATURES

      Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                       REPLIGEN CORPORATION


Dated: June 10, 2003                   By: /s/ Walter C. Herlihy
                                           ---------------------
                                           Walter C. Herlihy
                                           President and Chief Executive Officer



                                  EXHIBIT INDEX

         Exhibit No.                     Exhibit
         -----------                     -------

            99.1              Press Release, dated June 10, 2004