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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 11-K


          [X]  Annual Report Pursuant to Section 15(d) of the Securities
               Exchange Act of 1934.
               For the fiscal year ended December 31, 2007; or

          [_]  Transition Report Pursuant to 15(d) of the Securities Exchange
               Act of 1934.
               For the transition period from ____________ to ____________


                         Commission file number: 0-12742




                  SPIRE CORPORATION 401(k) PROFIT SHARING PLAN
                  --------------------------------------------
                            (Full title of the plan)




                                SPIRE CORPORATION
                                -----------------
          (Name of issuer of the securities held pursuant to the plan)




                                ONE PATRIOTS PARK
                        BEDFORD, MASSACHUSETTS 01730-2396
                        ---------------------------------
                    (Address of principal executive offices)




================================================================================


                                SPIRE CORPORATION
                           401(k) PROFIT SHARING PLAN

                                Table of Contents



                                                                           Page
                                                                          Number
                                                                          ------

Report of Independent Registered Public Accounting Firm                     1

Financial Statements:

   Statements of Net Assets Available for Benefits                          2

   Statement of Changes in Net Assets Available for Benefits                3

   Notes to Financial Statements                                          4 - 8


Supplemental Schedule:

   Schedule H, Line 4i - Form 5500, Schedule of Assets
   (Held at End of Year)                                                    9

Signatures                                                                  10



Exhibits:

   Consent of Independent Registered Public Accounting Firm
   (filed herewith)                                                         11



             REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM


To the Plan Administrator
Spire Corporation 401(k) Profit Sharing Plan
Bedford, Massachusetts

We have audited the accompanying statements of net assets available for benefits
of Spire Corporation 401(k) Profit Sharing Plan (the Plan) as of December 31,
2007 and 2006 and the related statement of changes in net assets available for
benefits for the year ended December 31, 2007. These financial statements are
the responsibility of the Plan's management. Our responsibility is to express an
opinion on these financial statements based on our audits.

We conducted our audits in accordance with the standards of the Public Company
Accounting Oversight Board (United States). Those standards require that we plan
and perform the audit to obtain reasonable assurance about whether the financial
statements are free of material misstatement. We were not engaged to perform an
audit of the Plan's internal control over financial reporting. Our audits
included consideration of internal control over financial reporting as a basis
for designing audit procedures that are appropriate in the circumstances, but
not for the purpose of expressing an opinion on the effectiveness of the Plan's
internal control over financial reporting. Accordingly, we express no such
opinion. An audit also includes examining, on a test basis, evidence supporting
the amounts and disclosures in the financial statements, assessing the
accounting principles used and significant estimates made by management, and
evaluating the overall financial statement presentation. We believe that our
audits provide a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in
all material respects, the net assets available for benefits of the Plan as of
December 31, 2007 and 2006, and the changes in net assets available for benefits
for the year ended December 31, 2007, in conformity with accounting principles
generally accepted in the United States of America.

Our audits were performed for the purpose of forming an opinion on the basic
financial statements taken as a whole. The supplemental schedule of assets (held
at end of year) as of December 31, 2007 is presented for the purpose of
additional analysis and is not a required part of the basic financial statements
but is supplementary information required by the Department of Labor's Rules and
Regulations for Reporting under the Employee Retirement Income Security Act of
1974. The supplemental schedule is the responsibility of the Plan's management.
The supplemental schedule has been subjected to the auditing procedures applied
in the audits of the basic financial statements and, in our opinion, is fairly
stated in all material respects in relation to the basic financial statements
taken as a whole.


/s/ Carlin, Charron & Rosen, LLP

CARLIN, CHARRON & ROSEN, LLP

Westborough, Massachusetts
June 27, 2008


                                        1

                  SPIRE CORPORATION 401(k) PROFIT SHARING PLAN
                 Statements of Net Assets Available for Benefits
                           December 31, 2007 and 2006




                                                               2007             2006
                                                           ------------     ------------
                                                                      
Assets

Investments:
     At fair value:
     Common stock - Spire Corporation                      $  3,284,103     $  1,608,632
     Mutual funds                                             5,341,544        4,352,003
     Participant loans                                          133,171           87,924
     Hartford Fixed Income Fund                                 179,031          170,252
                                                           ------------     ------------

Money market receivable                                           4,732               --
                                                           ------------     ------------

Total assets                                                  8,942,581        6,218,811

Liabilities

     Excess contributions payable                                29,149           47,710
                                                           ------------     ------------

Net assets reflecting all investments at fair value           8,913,432        6,171,101

Adjustment from fair value to contract value for fully
     benefit responsive investment contracts                      7,976           10,666
                                                           ------------     ------------

Net assets available for benefits                          $  8,921,408     $  6,181,767
                                                           ============     ============





                       See notes to financial statements.


                                        2

                  SPIRE CORPORATION 401(k) PROFIT SHARING PLAN
            Statement of Changes in Net Assets Available for Benefits
                      For the Year Ended December 31, 2007




                                                        
Additions to net assets:
     Investment income:
         Interest and dividends                            $    359,917
         Interest on loans                                        7,137
         Net appreciation in fair value of investments        2,436,707
                                                           ------------
                                                              2,803,761

     Participant contributions                                  433,863
                                                           ------------

Total additions                                               3,237,624
                                                           ------------

Deductions from net assets:
     Benefits paid to participants                              497,590
     Administrative fees                                            393
                                                           ------------

Total deductions                                                497,983
                                                           ------------

Net increase                                                  2,739,641

Net assets available for benefits:

     Beginning of year                                        6,181,767
                                                           ------------

     End of year                                           $  8,921,408
                                                           ============





                       See notes to financial statements.


                                        3

                  SPIRE CORPORATION 401(k) PROFIT SHARING PLAN
                          Notes to Financial Statements
                      For the Year Ended December 31, 2007


1.   PLAN DESCRIPTION

     The following description of the Spire Corporation 401(k) Profit Sharing
     Plan (the Plan) provides only general information. Participants should
     refer to the Plan agreement for a more complete description of the Plan's
     provisions.

     General
     -------

     The Plan is a defined contribution plan covering all employees of Spire
     Corporation (the Company) who have completed 90 days of service and are age
     twenty-one or older. The Plan is subject to the provisions of the Employee
     Retirement Income Security Act of 1974 (ERISA).

     Contributions
     -------------

     Each year, participants may contribute up to the maximum amount of pre-tax
     annual compensation as determined under the Internal Revenue Code.
     Participants who have attained age 50 before the end of the Plan year are
     eligible to make catch-up contributions. Participants may also contribute
     amounts representing distributions from other qualified defined benefit or
     defined contribution plans. Participants direct the investment of their
     contributions into various investment options offered by the Plan. The Plan
     currently offers the Company's common stock, twenty-one mutual funds, and
     an insurance contract as investment options for participants. The Company
     may contribute, at the determination of the board of directors, a
     discretionary matching contribution on the first 15 percent of base
     compensation that a participant contributes to the Plan. The Company's
     matching contribution is invested directly in Company common stock. The
     Company may also make a profit sharing contribution. In 2007, the Company
     did not make matching or profit sharing contributions. Contributions are
     subject to certain limitations.

     Participant Accounts
     --------------------

     Each participant's account is credited with the participant's contributions
     and the Company's matching contribution (if any) and an allocation of (a)
     the Company's profit sharing contribution (if any), and (b) plan earnings.
     Allocations are based on participant earnings or account balances, as
     defined. The benefit to which a participant is entitled is the benefit that
     can be provided from the participant's vested account.

     Vesting
     -------

     Participants are immediately vested in voluntary contributions plus actual
     earnings thereon. Vesting in the Company matching contribution is based on
     years of continuous service. A participant is 100 percent vested after six
     years of credited service.

     Forfeited Accounts
     ------------------

     At December 31, 2007 and 2006, forfeited nonvested accounts totaled $32,714
     and $28,950, respectively. These amounts may be used to reduce future
     employer contributions.

     Participant Loans
     -----------------

     Participants may borrow from their fund accounts a minimum of $1,000 up to
     a maximum equal to $50,000 or 50 percent of their vested account balance,
     whichever is less. The maximum number of

                                        4

     outstanding loans at any given time is five. Loan terms range from 1 to 10
     years, but not beyond the Normal Retirement Date. The loans are secured by
     the balance in the participant's account and bear interest at a rate
     commensurate with local prevailing rates as determined by the plan
     administrator. Interest rates are Prime Rate + 1% and currently range from
     5% to 9.5%. Principal and interest are repaid through payroll deductions.

     Payments of Benefits
     --------------------

     On termination of service for any reason, a participant may elect to
     receive a lump-sum amount equal to the value of the participant's vested
     interest in his or her account or annual installments over a period of not
     more than a participant's and his or her beneficiary's assumed life
     expectancy determined at the time of distribution. Withdrawals may be made
     under certain other circumstances in accordance with the Plan document.

     Administrative Costs
     --------------------

     Except for loan fees, which are charged against the borrowers' accounts,
     administrative costs of the Plan are paid by the Company.


2.   SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

     Basis of Accounting
     -------------------

     The financial statements of the Plan are prepared on the accrual basis of
     accounting in conformity with accounting principles generally accepted in
     the United States of America.

     Use of Estimates
     ----------------

     The preparation of financial statements in conformity with generally
     accepted accounting principles generally accepted in the United States of
     America requires management to make estimates and assumptions that affect
     the reported amounts of net assets, liabilities and changes therein and
     disclosure of contingent assets and liabilities, if any. Actual results
     could differ from those estimates.

     Recent Accounting Standard Changes
     ----------------------------------

     In September 2006, the FASB issued SFAS No. 157, "Fair Value Measurements".
     This standard addresses how companies should measure fair value when they
     are required to use a fair-value measure for recognition or disclosure
     purposes under GAAP. This standard is effective for all financial
     statements issued for fiscal years beginning after November 15, 2007.
     Relative to SFAS No. 157, the FASB issued FASB Staff Position ("FSP") 157-1
     and 157-2. FSP No. 157-1 amends SFAS No. 157 to exclude SFAS No. 13,
     "Accounting for Leases", and its related interpretive accounting
     pronouncements that address leasing transactions, while FSP 157-2 delays
     the effective date of SFAS No. 157 for all non-financial assets and
     non-financial liabilities, except those that are recognized or disclosed at
     fair value in the financial statements on a recurring basis. The Plan is in
     the process of evaluating whether the adoption of FSP No. 157-2 will have a
     material effect on its financial position, results of operations or cash
     flows.

     Investment Valuation
     --------------------

     Investments in mutual funds are stated at fair value based on quoted market
     prices, which represents the net asset value of shares held by the Plan at
     year end. Investments in the Spire Corporation common stock are stated at
     fair value based on the quoted market price on the last business day of the
     year for Company's common stock.

                                        5

     Investments in benefit responsive insurance contracts are stated at fair
     value as determined by the custodian of those Plan assets. The difference
     between fair value and contract value of the benefit responsive insurance
     contracts are presented as an adjustment to net assets available for
     benefits.

     Other investment securities are stated at fair value based on their quoted
     market prices on the last business day of the year. Participant loans are
     valued at cost, which approximates fair value.

     Investment Transactions and Investment Income
     ---------------------------------------------

     Investment transactions are accounted for on a trade-date basis. Interest
     income is recorded on the accrual basis. Dividend income is recorded on the
     ex-dividend date.

     The Plan presents in the statement of changes in net assets the net
     appreciation or depreciation in the fair value of its investments that
     consists of the realized gains or losses and unrealized appreciation or
     depreciation on those investments.

     Payment of Benefits
     -------------------

     Benefits are recorded when paid.


3.   INVESTMENTS

     Investments that represent five percent or more of the Plan's net assets
     are as follows:
                                                        December 31,
                                                  -------------------------
                                                     2007           2006
                                                  ----------     ----------
     Mutual funds
          Oppenheimer Quest Opportunity Value     $  831,305     $  854,265
          Franklin Flexible Capital Growth         1,114,589      1,058,695
          American Funds Europacific Growth          725,646        485,937
          Eaton Vance Large Cap Value                451,696        352,755

     Common stock
          Spire Corporation                        3,284,103      1,608,632


     During 2007 the Plan's investments (including investments bought, sold, and
     held during the year) appreciated in value as follows:

           Mutual funds                           $  163,462
           Common stock                            2,273,245
                                                  ----------
                                                  $2,436,707
                                                  ==========

                                        6

4.   NONPARTICIPANT-DIRECTED INVESTMENTS

     Information about the net assets and the significant components of the
     changes in net assets relating to nonparticipant-directed investments is as
     follows:
                                                        December 31,
                                                  -------------------------
                                                     2007           2006
                                                  ----------     ----------
     Net assets:
        Common stock - Spire Corporation          $3,268,876     $1,592,053
        Other                                        393,040         35,002
                                                  ----------     ----------

     Total nonparticipant-directed                $3,661,916     $1,627,055
                                                  ==========     ==========

     Changes in net assets during 2007:
        Benefits paid to participants             $ (215,973)
        Net appreciation                           2,250,834
                                                  ----------
                                                  $2,034,861
                                                  ==========


5.   INVESTMENT CONTRACT WITH INSURANCE COMPANY

     In 1995, the Plan entered into a benefit-responsive investment contract
     with The Hartford Group (Hartford). Hartford maintains the contributions in
     a general account. The account is credited with earnings on the underlying
     investments and charged for participant withdrawals and administrative
     expenses. The contract is included in the statements of net assets
     available for benefits at fair value as determined using the market
     approach based on market prices of similar contracts. The adjustment from
     fair value to contract value for the investment contract is based on the
     contract value as reported to the Plan by Hartford. Contract value
     represents contributions made under the contract, plus earnings, less
     participant withdrawals and administrative expenses. Participants may
     ordinarily direct the withdrawal or transfer of all or a portion of their
     investment at contract value.

     The fair value of the investment contract at December 31, 2007 and 2006 was
     $179,031 and $170,252, respectively. The average yield was 3% for both 2007
     and 2006. The interest crediting rate was 3.36% and 3.29% for 2007 and
     2006, respectively.

     Certain events, such as the premature termination of the contract by the
     Plan or the termination of the Plan, would limit the Plan's ability to
     transact at contract value with Hartford. The Plan administrator believes
     the occurrence of such events that would also limit the Plan's ability to
     transact at contract value with Plan participants is not probable.


6.   PLAN TERMINATION

     Although it has not expressed any intent to do so, the Company has the
     right under the Plan to discontinue its contributions at any time and to
     terminate the Plan subject to the provisions of ERISA. In the event of plan
     termination, participants would become 100 percent vested in their employer
     contributions.


7.   INCOME TAX STATUS

     The Internal Revenue Service has determined and informed the Company by a
     letter dated May 23, 1995, that the Plan and related trust are designed in
     accordance with applicable sections of the Internal Revenue Code (IRC).
     Although the Plan has been amended since receiving the determination
     letter, the plan administrator believes that the Plan is designed and is
     currently being operated in compliance with the applicable requirements of
     the IRC.

                                        7

8.   EXCESS CONTRIBUTIONS

     Benefit distributions for the plan year ended December 31, 2007 and 2006
     include payments of $29,149 and $47,710, respectively, made to certain
     active participants to return to them excess deferral contributions as
     required to satisfy the relevant nondiscrimination provisions of the Plan
     for the prior year.

     Contributions received for the year ended December 31, 2007 are net of
     payments of $29,149 made on March 31, 2008 to certain active participants
     to return to them excess deferral contributions as required to satisfy the
     relevant nondiscrimination provisions of the Plan. That amount is also
     included in the plan's statement of net assets available for benefits as
     excess contributions payable at December 31, 2007.


9.   RISKS AND UNCERTAINTIES

     The Plan invests in various investment securities. Investment securities
     are exposed to various risks, such as interest rate, market, and credit
     risks. Due to the level of risk associated with certain investment
     securities, it is at least reasonably possible that changes in the values
     of investment securities will occur in the near term and that such changes
     could materially affect participants' account balances and the amounts
     reported in the statement of net assets available for benefits.


10.  RECONCILIATION OF FINANCIAL STATEMENTS TO FORM 5500

     The following is a reconciliation of net assets available for benefits at
     December 31 per the financial statements to the 2007 Form 5500:


                                                                           2007           2006
                                                                        ----------     ----------

                                                                                 
     Net assets available for benefits per the financial statements     $8,921,408     $6,181,767
     Plus: Excess contributions payable                                     29,149         47,710
                                                                        ----------     ----------
     Net assets available for benefits per the 2007 Form 5500           $8,950,557     $6,229,477
                                                                        ==========     ==========


     The following is a reconciliation of participant contributions for the
     year ended December 31, 2007 per the financial statements to the 2007
     Form 5500:

                                                                     
     Participant contributions per the financial statements             $  433,863
     Less: Prior year excess contributions payable                         (47,710)
     Plus: Current year excess contributions payable                        29,149
                                                                        ----------
     Participant contributions per the Form 5500                        $  415,302






                                        8

                                SPIRE CORPORATION
                           401(k) PROFIT SHARING PLAN

                         Schedule H, Line 4i - Form 5500
                    Schedule of Assets (Held at End of Year)
                                December 31, 2007

E.I.N. 04-2457335
Plan Number 002


(a)       (b)                                        (c)                                   (d)               (e)
                                          Description of Investment
    Identity of Issue,                    Including Maturity Date,
    Borrower, Lessor or                   Rate of Interest, Collateral,                                    Current
    Similar Party                         Par or Maturity Value                             Cost            Value
-------------------------------------------------------------------------------------------------------------------
                                                                                             
*   Spire Corporation                     126,156 shares of common stock                $1,295,427       $3,284,103
    OppenheimerFunds                      Oppenheimer Quest Opportunity Value                  n/a          831,305
    Franklin Templeton Investments        Franklin Flexible Capital Growth                     n/a        1,114,589
    Third Avenue                          Third Avenue Small Cap Value A                       n/a            7,299
    American Funds                        Europacific Growth                                   n/a          725,646
    Hartford Life Insurance Co.           Fixed Income                                         n/a          187,007
    AIM Funds                             AIM Cash Reserve Shares                              n/a          287,845
    American Funds                        American Balanced                                    n/a          260,212
    Franklin Templeton Investments        Franklin Small-Mid Cap Growth                        n/a           79,037
    MFS Investment Management             Mass Investors Growth Stock                          n/a           22,220
    Eaton Vance                           Large Cap Value                                      n/a          451,696
    Eaton Vance                           Income Fund of Boston                                n/a          237,362
    Allianz Funds                         RCM Global Technology                                n/a          146,466
    American Funds                        New Perspective                                      n/a          198,833
    OppenheimerFunds                      Oppenheimer Strategic Income                         n/a          154,125
    Sentinel Group Funds                  Sentinel Small Company                               n/a          142,578
    PIMCO Funds                           Total Return                                         n/a          154,485
    Davis Funds                           Davis New York Venture                               n/a          154,694
    Evergreen Investments                 Evergreen Money Market                               n/a          139,564
    Pioneer Investments                   Pioneer Cash Reserves                                n/a           32,714
    Goldman Sachs                         MidCap Value A                                       n/a          107,171
    Allianz NJF                           Dividend Value R                                     n/a           98,435
    Participant Loans                     Interest rates 5% to 9.5%                            n/a          133,171
                                                                                                         ----------
                                                                                                         $8,950,557
                                                                                                         ==========


*  Represents party-in-interest

The independent registered public accounting firm's report should be read with
this supplementary schedule.

                                        9

SIGNATURE


       Pursuant to the requirements of the Securities Exchange Act of 1934, the
Investment Committee of the Spire Corporation 401(k) Profit Sharing Plan have
duly caused this annual report to be signed on their behalf by the undersigned
hereunto duly authorized.




                                    SPIRE CORPORATION 401(k) PROFIT SHARING PLAN



Date:  June 27, 2008                By: /s/ Christian Dufresne
                                        -------------------------------------
                                        Christian Dufresne
                                        Chief Financial Officer and Treasurer











                                       10