As filed with the Securities and Exchange Commission on June 14, 2005
Registration No. 333-124951
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

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                                    FORM S-2/A

                                 AMENDMENT NO. 1

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

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                         PROVECTUS PHARMACEUTICALS, INC.
             (Exact name of registrant as specified in its charter)

             Nevada                      2834                      90-0233011
(State or other jurisdiction   (Primary Standard Industrial    (I.R.S. Employer
 of incorporation or            Identification Number)
 organization)                 Classification Code Number)


   7327 Oak Ridge Highway, Suite A, Knoxville, Tennessee 37931, (865) 769-4011

(Address,  including zip code,  and  telephone  number,  including  area code of
registrant's principal executive offices)

                             Timothy C. Scott, Ph.D.
                                    President
                         Provectus Pharmaceuticals, Inc.
                         7327 Oak Ridge Highway, Suite A
                           Knoxville, Tennessee 37931
                                 (865) 769-4011

(Name, address,  including zip code, and telephone number,  including area code,
of agent for service)

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                                    Copy to:

                          Linda Crouch-McCreadie, Esq.
                   Baker Donelson Bearman Caldwell & Berkowitz
                              207 Mockingbird Lane
                                    Suite 300
                          Johnson City, Tennessee 37904
                                 (423) 928-0181


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     Approximate date of commencement of proposed sale to the public:  From time
to time after the effective date of the  registration  statement until such time
that all of the shares of common stock registered hereunder have been sold.

     If any of the securities being registered on this Form are to be offered on
a delayed or continuous  basis  pursuant to Rule 415 under the Securities Act of
1933, check the following box: [X] 

     If the  registrant  elects to deliver its latest  annual report to security
holders, or a complete and legible facsimile thereof,  pursuant to Item 11(a)(1)
of this form, check the following box: [X]

                                       1


     If this form is filed to  register  additional  securities  for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list  the  Securities  Act  registration  statement  number  of the  earlier
effective registration statement for the same offering. [ ]

     If this form is a  post-effective  amendment  filed pursuant to Rule 462(c)
under the  Securities  Act,  check the following box and list the Securities Act
registration  statement number of the earlier effective  registration  statement
for the same offering. [ ]

     If this form is a  post-effective  amendment  filed pursuant to Rule 462(d)
under the  Securities  Act,  check the following box and list the Securities Act
registration  statement number of the earlier effective  registration  statement
for the same offering. [ ]

     If delivery of the  prospectus is expected to be made pursuant to Rule 434,
please check the following box. [ ]

                         CALCULATION OF REGISTRATION FEE




                                                                  Proposed               Proposed
   Title of each class of                                         maximum                 maximum        Amount of
         securities             Amount to be registered        offering price            aggregate      registration
      to be registered                    (1)                    per share            offering price        fee
---------------------------------------------------------------------------------------------------------------------
                                                                                                
Common Stock, $.001 par value     18,845,213    (2)               $0.60  (3)      $11,307,127             $ 1,330.85
                                  ----------                     -------        -------------             ----------
                                  18,845,213                                      $11,307,127             $ 1,330.85
                                  ==========                                    =============             ==========



     (1)  Pursuant  to Rule 416  under the  Securities  Act,  this  registration
statement also registers such  additional  number of shares of the  registrant's
common  stock,  $0.001 par  value,  as may be offered or issued as result of any
stock splits, stock dividends or similar transactions.


     (2)  Represents (a) up to 2,000,000  shares of common stock,  issuable upon
conversion  of  $1,000,000  in  the  aggregate   principal   amount  of  secured
convertible debentures held by DCOFI Master, LDC at a per share conversion price
of $0.75,  (b) up to 1,333,333 shares of common stock issuable upon the exercise
of a warrant held by DCOFI at per share exercise price equal to $0.935,  and (c)
up to 933,333  shares of common  stock  issuable  upon the exercise of a warrant
held by DCOFI at a per share exercise price of $0.8925.  Also  represents (a) up
to 2,000,000  shares of common stock,  issuable upon conversion of $1,000,000 in
the aggregate principal amount of secured  convertible  debentures held by Asset
Managers  International Ltd. at a per share conversion price of $0.75, (b) up to
1,000,000 shares of common stock issuable upon the exercise of a warrant held by
Asset  Managers  at per share  exercise  price  equal to  $0.935,  and (c) up to
700,000  shares of common stock  issuable upon the exercise of a warrant held by
Asset Managers at a per share exercise price of $0.8925.  Also represents (a) up
to 333,333  shares of common stock  issuable upon the exercise of a warrant held
by DC Asset Management, LLC, at a per share exercise price of $0.935, and (b) up
to 233,333  shares of common stock  issuable upon the exercise of a warrant held
by DC Asset, at a per share exercise price of $0.8925. Also represents (a) up to
1,000,000 shares of stock, issuable upon conversion of $500,000 in the aggregate
principal  amount  of  secured  convertible  debentures  held by  Alpha  Capital
Aktiengesellschaft  at a per share  conversion price of $0.75, (b) up to 666,667
shares of common  stock  issuable  upon the  exercise of a warrant held by Alpha
Capital per share exercise  price equal to $0.935,  and (c) up to 466,667 shares
of Common Stock issuable upon the exercise of a warrant held by Alpha Capital at


                                       2

a per share exercise price of $0.8925.  Also represents (a) up to 300,000 shares
of common stock, issuable upon conversion of $150,000 in the aggregate principal
amount of secured convertible debentures held by Whalehaven Capital Fund Limited
at a per share  conversion  price of $0.75,  (b) up to 200,000  shares of common
stock  issuable  upon the exercise of a warrant held by  Whalehaven at per share
exercise  price equal to $0.935,  and (c) up to 140,000  shares of common  stock
issuable  upon the  exercise  of a  warrant  held by  Whalehaven  at a per share
exercise  price of $0.8925.  Also  represents (a) up to 800,000 shares of common
stock, issuable upon conversion of $450,000 in the aggregate principal amount of
secured  convertible  debentures held by Donald Adams at a per share  conversion
price of $0.75,  (b) up to  533,333  shares of common  stock  issuable  upon the
exercise of a warrant held by Donald Adams at per share  exercise price equal to
$0.935,  and (c) up to 373,333 shares of common stock issuable upon the exercise
of a warrant held by Donald Adams at a per share exercise price of $0.8925. Also
represents (a) up to 100,000 shares of common stock, issuable upon conversion of
$50,000 in the aggregate principal amount of secured convertible debentures held
by Peter K. Sivaslian at a per share conversion price of $0.75, (b) up to 66,667
shares of common stock  issuable upon the exercise of a warrant held by Peter K.
Sivaslian  at per share  exercise  price  equal to $0.935,  and (c) up to 46,667
shares of common stock  issuable upon the exercise of a warrant held by Peter K.
Sivaslian at a per share  exercise price of $0.8925.  Also  represents (a) up to
100,000  shares of common  stock,  issuable  upon  conversion  of $50,000 in the
aggregate  principal  amount of secured  convertible  debentures held by Stephen
Ross at a per share conversion price of $0.75, (b) up to 66,667 shares of common
stock  issuable upon the exercise of a warrant held by Stephen Ross at per share
exercise  price  equal to $0.935,  and (c) up to 46,667  shares of common  stock
issuable  upon the  exercise  of a warrant  held by Stephen  Ross at a per share
exercise  price of $0.8925.  Also  represents  up to 1,625,942  shares of common
stock issuable upon conversion of $1,185,959 in the aggregate  principal  amount
of a secured convertible debenture held by Gryffindor Capital Partners I, L.L.C.
at a per share conversion price of $0.737 for principal  converted and $0.55 for
interest  converted.  Also  represents  (a) up to 15,000  shares of common stock
issuable  upon the  exercise of a warrant  held by the  Irrevocable  Trust dated
December 28, 2004 f/b/o Olivia  Skriloff at a per share exercise price of $0.98,
and (b) up to 15,000  shares of common  stock  issuable  upon the  exercise of a
warrant  held by the  Irrevocable  Trust dated  December  28, 2004 f/b/o  Olivia
Skriloff at per share exercise price of $1.23.  Also represents (a) up to 15,000
shares of common  stock  issuable  upon the  exercise  of a warrant  held by the
Irrevocable  Trust dated December 28, 2004 f/b/o Samuel  Skriloff at a per share
exercise  price of $0.98,  and (b) up to 15,000 shares of common stock  issuable
upon the exercise of a warrant held by the Irrevocable  Trust dated December 28,
2004  f/b/o  Samuel  Skriloff  at a per  share  exercise  price of  $1.23.  Also
represents (a) up to 38,750 shares of common stock issuable upon the exercise of
a warrant held by David  Skriloff at a per share exercise price of $.98, and (b)
up to 38,750 shares of common stock issuable upon the exercise of a warrant held
by David Skriloff at a per share exercise price of $1.23. Also represents (a) up
to 56,250 shares of common stock issuable upon the exercise of a warrant held by
Richard  Smithline at a per share  exercise  price of $.98, and (b) up to 56,250
shares of common stock  issuable  upon the exercise of a warrant held by Richard
Smithline at a per share  exercise  price of $1.23.  Also  represents  (a) up to
150,000  shares of common stock  issuable upon the exercise of a warrant held by
M.W. Crow Family Trust L.P. at a per share exercise price of $.98, and (b) up to
150,000  shares of common stock  issuable upon the exercise of a warrant held by
M.W.  Crow Family  Trust,  L.P.  at a per share  exercise  price of $1.23.  Also
represents  (a) up to 360,000  shares of common stock issuable upon the exercise
of a warrant held by Damon D.  Testaverde at a per share exercise price of $.98,
and (b) up to the 280,000 shares of common stock issuable upon the exercise of a
warrant held by Damon D. Testaverde at a per share exercise price of $1.00. Also
represents (a) up to 40,000 shares of common stock issuable upon the exercise of
a warrant held by Network 1 Financial  Securities,  Inc. at a per share exercise
price of $.98,  and (b) up to 70,000  shares of common stock  issuable  upon the
exercise  of a warrant  held by Network 1  Financial  Securities,  Inc. at a per
share  exercise  price of $1.00.  Also  represents up to 75,000 shares of common
stock  issuable  upon the  exercise of a warrant  held by Martin  Stern at a per
share exercise price of $1.00. Also represents (a) up to 75,000 shares of common
stock issuable upon the exercise of a warrant held by Kenneth J. Spadaford of at
per share exercise price of $1.00. Also represents up to 75,000 shares of common
stock  issuable upon the exercise of a warrant held by William J. Crusoe of at a
per share exercise  price of $1.00.  Also  represents(a)  up to 57,848 shares of
common stock  issuable upon the exercise of a warrant held by Venture  Catalyst,
LLC at a per share  exercise  price of $0.75,  (b) up to 86,768 shares of common
stock issuable upon the exercise of a warrant held by Venture  Catalyst at a per
share exercise price of $1.00,  (c) up to 42,411 shares of common stock issuable
upon the exercise of a warrant held by Venture  Catalyst at a per share exercise
price of $0.75,  and (d) up to 63,612  shares of common stock  issuable upon the
exercise of a warrant held by Venture  Catalyst at a per share exercise price of
$1.00,  and (e) up to 149,000  shares of common stock issuable upon the exercise
of a warrant held by Venture Catalyst at a per share exercise price of $1.00.

                                       3


Also  represents  (a) up to  21,677  shares of common  stock  issuable  upon the
exercise of a warrant held by Trek Properties, LLC at a per share exercise price
of $0.75,  (b) up to 32,519 shares of common stock issuable upon the exercise of
a warrant held by Trek Properties at a per share exercise price of $1.00, (c) up
to 22,339 shares of common stock issuable upon the exercise of a warrant held by
Trek  Properties at a per share  exercise  price of $0.75,  and (d) up to 33,513
shares of common  stock  issuable  upon the  exercise of a warrant  held by Trek
Properties at a per share exercise price of $1.00,  and (e) up to 140,000 shares
of common stock issuable upon the exercise of a warrant held by Trek  Properties
at a per share exercise price of $1.00.  Also  represents up to 25,000 shares of
common stock issuable upon the exercise of a warrant held by Kevin Richardson at
a per share  exercise  price of $1.00.  Also  represents  (a) 631,833  shares of
common  stock held by certain  selling  shareholders  and (b) 947,750  shares of
common stock  issuable  upon the  exercise of a warrant held by certain  selling
shareholders.



     (3) Estimated  solely for the purpose of calculating the  registration  fee
pursuant to Rule 457(c) under the Securities Act of 1933, as amended, based upon
the average of the high and low sale price of the  registrant's  common stock as
reported on the OTC Electronic Bulletin Board on May 6, 2005.


     (4) A total of $1,412.00 was previously paid by Provectus  Pharmaceuticals,
Inc. in  connection  with the filing of its  Registration  Statement on Form S-2
(Registration No. 333-124951) on May 16, 2005.


                      ------------------------------------

     The registrant  hereby amends this  registration  statement on such date or
dates as may be necessary to delay its effective date until the registrant shall
file a further  amendment  which  specifically  states  that  this  registration
statement shall  thereafter  become effective in accordance with Section 8(a) of
the Securities  Act of 1933 or until this  registration  statement  shall become
effective on such date as the Commission,  acting pursuant to said Section 8(a),
may determine.
================================================================================
                                       4




SUBJECT TO COMPLETION, DATED JUNE 14, 2005 
                             =============

PROSPECTUS

                         PROVECTUS PHARMACEUTICALS, INC.


                        18,845,213 Shares of Common Stock

     This  prospectus  relates  to the  sale  by  the  selling  shareholders  of
18,845,213 shares of our common stock, par value $0.001.


     The  selling  shareholders  may sell the  shares  from  time to time at the
prevailing market price or in negotiated  transactions.  We will not receive any
of the proceeds from the sale of the shares by the selling shareholders. We have
agreed to pay the expenses in connection with the registration of these shares.

     The  selling  shareholders  may be deemed to be  "underwriters"  within the
meaning  of the  Securities  Act of 1933,  which we refer to as the  "Securities
Act."

     Our  common  stock is quoted on the OTC  Electronic  Bulletin  Board of the
National Association of Securities Dealers under the trading symbol "PVCT".

     AS YOU REVIEW THIS PROSPECTUS,  YOU SHOULD  CAREFULLY  CONSIDER THE MATTERS
DESCRIBED IN "RISK FACTORS" BEGINNING ON PAGE 4.

     Neither the  Securities and Exchange  Commission,  which we refer to as the
"SEC," nor any state securities  commission has approved or disapproved of these
securities  or  passed on the  adequacy  or  accuracy  of this  prospectus.  Any
representation to the contrary is a criminal offense.

           The date of this prospectus is ________________ ___, 2005.

     YOU SHOULD RELY ONLY ON THE  INFORMATION  CONTAINED IN THIS  DOCUMENT OR TO
WHICH WE HAVE  REFERRED YOU. WE HAVE NOT  AUTHORIZED  ANYONE TO PROVIDE YOU WITH
INFORMATION THAT IS DIFFERENT.  THIS DOCUMENT MAY ONLY BE USED WHERE IT IS LEGAL
TO SELL THESE SECURITIES.  THE INFORMATION IN THIS DOCUMENT MAY ONLY BE ACCURATE
ON THE DATE OF THIS DOCUMENT.

                                       5



                                TABLE OF CONTENTS

Prospectus Summary.............................................................7
The Offering................................................................9-11
Risk Factors..................................................................12
Forward Looking Statements....................................................18
Use Of Proceeds...............................................................18
Agreements With Purchasers of Secured Convertible Debentures..................18
Agreements With Gryffindor Capital Partner I, L.L.C...........................19
Agreement With Financial Consultants..........................................20
Description Of Other Transactions.............................................21
Selling Shareholders..........................................................21
Description Of Securities.....................................................23
Plan Of Distribution..........................................................24
Indemnification Of Officers And Directors..................................26-27
Where You Can Find More Information About Us..................................27
Incorporation Of Certain Information By Reference..........................27-28
Experts.......................................................................28
Legal Matters.................................................................28


Exhibit "A" - Form 10-KSB for year ended December 31, 2004...................A-1
Exhibit "B" - Form 10-QSB for quarter ended March 31, 2005...................B-1




================================================================================





                                       6


                                      
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                               Prospectus Summary

     You should  read the  following  summary  together  with the more  detailed
information  and  consolidated  financial  statements  and related notes thereto
appearing  elsewhere in this  prospectus  and in the documents  incorporated  by
reference in this prospectus.  You should read the entire prospectus,  including
the documents incorporated by reference in this prospectus, before you invest in
our common stock.  This  prospectus  contains  forward-looking  statements.  The
outcome of the events described in these  forward-looking  statements is subject
to  risks,  and  actual  results  could  differ  materially.  Read  this  entire
prospectus  carefully,  especially  the risks  described  under "Risk  Factors."
Unless  otherwise  indicated,  "we," "us," "our" and similar  terms,  as well as
references to the "Company" and "Provectus," refer to Provectus Pharmaceuticals,
Inc. and its subsidiaries and not to the selling shareholders.

Our Company

     Provectus Pharmaceuticals,  Inc., a Nevada corporation, and its five wholly
owned subsidiaries,  Xantech  Pharmaceuticals,  Inc.,  Provectus Biotech,  Inc.,
Provectus   Devicetech,   Inc.,  Provectus   Pharmatech,   Inc.,  and  Pure-ific
Corporation,  develop,  license  and market and plan to sell  products  in three
sectors of the healthcare industry:

     o    Over-the-counter products, which we refer to as "OTC products;"

     o    Prescription drugs; and

     o    Medical device systems.

     We manage Provectus and the  subsidiaries on an integrated  basis, and when
we refer to "we" or "us" or "the Company" in this registration statement on Form
S-2, we refer to all six corporations considered as a single unit.


     Through  discovery  and  use of  state-of-the-art  scientific  and  medical
technologies,  the  founders of our  pharmaceutical  business  have  developed a
portfolio of patented,  patentable,  and proprietary  technologies  that support
multiple  products in the  prescription  drug,  medical  device and OTC products
categories  (including  patented  technologies for: (a) treatment of cancer; (b)
novel therapeutic  medical devices;  (c) enhancing  contrast in medical imaging;
(d) improving signal  processing during  biomedical  imaging;  and (e) enhancing
production of biotechnology  products). Our prescription drug products encompass
the  areas of  dermatology  and  oncology  and  involve  several  types of small
molecule-based  drugs.  Our  medical  device  systems  include  therapeutic  and
cosmetic  lasers,  while our OTC products  address markets  primarily  involving
skincare  applications.  None of our  prescription  drug  products are currently
being sold as their  development  is not yet complete.  At December 31, 2004, we
reported  medical  device  sales of  $13,125  and as of March  31,  2005 we have
reported  medical  device  sales of  $984.  We have  also  initiated  sales  and
distribution of our OTC product Pure-ific via our website www.pureific.com,  and
we reported  sales of $18,728 at December 31, 2004 and $2,394 at March 31, 2005.
We are not currently selling our other OTC products.


     Our company faces significant risks. And our ongoing operations continue to
be dependent upon our ability to raise capital.  We only have four employees and
our future success  depends  significantly  on these  employees.  Please see the
section of this prospectus  entitled "Risk Factors" for more  information  about
the risks faced by us.


     This  prospectus is accompanied by our Annual Report on Form 10-KSB for the
year ended  December 31, 2004,  and our Quarterly  Report on Form 10-QSB for the
quarter ended March 31, 2005.


     Our principal executive office is located at 7327 Oak Ridge Highway,  Suite
A, Knoxville, Tennessee 37931, telephone (865) 769-4011.

                                       7


Risk Factors

     Investing  in shares of our common stock  involves  significant  risk.  You
should  consider the information  under the caption "Risk Factors"  beginning on
page 4 of this  prospectus  in  deciding  whether to purchase  the common  stock
offered under this prospectus.

Our History

     Provectus    Pharmaceuticals,    Inc.,   formerly   known   as   "Provectus
Pharmaceutical, Inc." and "SPM Group, Inc.," was incorporated under Colorado law
on  May  1,  1978.   SPM  Group  ceased   operations  in  1991,   and  became  a
development-stage  company  effective  January 1, 1992,  with the new  corporate
purpose  of  seeking  out  acquisitions  of  properties,  businesses,  or merger
candidates,  without  limitation as to the nature of the business  operations or
geographic location of the acquisition candidate.

     On April 1, 2002, SPM Group changed its name to "Provectus  Pharmaceutical,
Inc." and  reincorporated  in  Nevada  in  preparation  for a  transaction  with
Provectus Pharmaceuticals,  Inc., a privately-held Tennessee corporation,  which
we refer to as "PPI." On April 23, 2002, an Agreement and Plan of Reorganization
between Provectus  Pharmaceutical and PPI was approved by the written consent of
a majority of the outstanding shares of Provectus  Pharmaceutical.  As a result,
holders  of  6,680,000  shares  of  common  stock  of  Provectus  Pharmaceutical
exchanged their shares for all of the issued and  outstanding  shares of PPI. As
part of the acquisition, Provectus Pharmaceutical changed its name to "Provectus
Pharmaceuticals,  Inc." and PPI became a wholly owned  subsidiary  of Provectus.
For accounting purposes, we treat this transaction as a recapitalization of PPI.

     On  November  19,  2002,  we  acquired  Valley  Pharmaceuticals,   Inc.,  a
privately-held  Tennessee  corporation  formerly  known as  Photogen,  Inc.,  by
merging  our  subsidiary  PPI with and into  Valley  and  naming  the  surviving
corporation  "Xantech  Pharmaceuticals,  Inc." Valley has minimal operations and
had no  revenues  prior to the  transaction  with us. By  acquiring  Valley,  we
acquired our most important intellectual property, including issued U.S. patents
and patentable inventions, with which we intend to develop:

     o    prescription  drugs,   medical  and  other  devices  (including  laser
          devices) and over-the-counter pharmaceutical products in the fields of
          dermatology and oncology; and

     o    technologies  for  the  preparation  of  human  and  animal  vaccines,
          diagnosis  of   infectious   diseases  and  enhanced   production   of
          genetically engineered drugs.

     Prior to the acquisition of Valley,  we were considered to be, and continue
to be, in the  development  stage and have not  generated  any revenues from the
assets we acquired.

     On December 5, 2002, we acquired the assets of Pure-ific L.L.C., a Utah
limited liability company, and created a wholly owned subsidiary, Pure-ific
Corporation, to operate that business. We acquired the product formulations for
Pure-ific personal sanitizing sprays, along with the "Pure-ific" trademarks. We
intend to continue product development and begin to market a line of personal
sanitizing sprays and related products to be sold over the counter under the
"Pure-ific" brand name.

     On June 3, 2004,  we formed the  remaining  three  subsidiaries,  Provectus
Biotech, Inc., Provectus Devicetech, Inc. and Provectus Pharmatech, Inc.


     We  reported  sales  of  $18,728  at  December  31,  2004  of our  product,
Pure-ific. and $2,394 at March 31, 2005.


                                       8



The Offering

Securities offered     18,845,213  shares of common stock. (1)

Use of proceeds        We will not receive any proceeds from the sale of the 
                       common stock by the selling shareholders. Please see the
                       section of this prospectus entitled "Use of Proceeds"
                       for more information.

-------------------------------

(1) Includes:

o    up to  2,000,000  shares  of  common  stock  issuable  upon  conversion  of
     $1,000,000  in  the  aggregate  principal  amount  of  secured  convertible
     debentures  held by DCOFI  Master  LDC at a per share  conversion  price of
     $0.75,

o    up to 1,333,333  shares of common stock issuable upon exercise of a warrant
     held by DCOFI Master LDC at a per share exercise price of $0.935,

o    up to 933,333  shares of common stock  issuable  upon exercise of a warrant
     held by DCOFI Master LDC at a per share exercise price of $0.8925,

o    up to  2,000,000  shares  of  common  stock  issuable  upon  conversion  of
     $1,000,000  in  the  aggregate  principal  amount  of  secured  convertible
     debentures  held  by  Asset  Managers  International  Ltd.  at a per  share
     conversion price of $0.75,

o    up to 1,000,000  shares of common stock issuable upon exercise of a warrant
     held by Asset Managers  International Ltd. at a per share exercise price of
     $0.935,

o    up to 700,000  shares of common stock  issuable  upon exercise of a warrant
     held by Asset Managers  International Ltd. at a per share exercise price of
     $0.8925,

o    up to 333,333  shares of common stock  issuable  upon exercise of a warrant
     held by DC Asset Management, LLC at a per share exercise price of $0.935,

o    up to 233,333  shares of common stock  issuable  upon exercise of a warrant
     held by DC Asset Management, LLC at a per share exercise price of $0.8925,

o    up to 1,000,000 shares of common stock issuable upon conversion of $500,000
     in the aggregate principal amount of secured convertible debentures held by
     Alpha Capital Aktiengesellschaft at a per share conversion price of $0.75,

o    up to 666,667  shares of common stock  issuable  upon exercise of a warrant
     held by Alpha Capital  Aktiengesellschaft  at a per share exercise price of
     $0.935,

o    up to 466,667  shares of common stock  issuable  upon exercise of a warrant
     held by Alpha Capital  Aktiengesellschaft  at a per share exercise price of
     $0.8925,

o    up to 300,000 shares of common stock  issuable upon  conversion of $150,000
     in the aggregate principal amount of secured convertible debentures held by
     Whalehaven Capital Fund Limited at a per share conversion price of $0.75,

o    up to 200,000  shares of common stock  issuable  upon exercise of a warrant
     held by Whalehaven  Capital Fund Limited at a per share  exercise  price of
     $0.935,

o    up to 140,000  shares of common stock  issuable  upon exercise of a warrant
     held by Whalehaven  Capital Fund Limited at a per share  exercise  price of
     $0.8925,

o    up to 800,000 shares of common stock  issuable upon  conversion of $450,000
     in the aggregate principal amount of secured convertible debentures held by
     Donald Adams at a per share conversion price of $0.75,

                                       9


o    up to 533,333  shares of common stock  issuable  upon exercise of a warrant
     held by Donald Adams at a per share exercise price of $0.935,

o    up to 373,333  shares of common stock  issuable  upon exercise of a warrant
     held by Donald Adams at a per share exercise price of $0.8925,

o    up to 100,000 shares of common stock issuable upon conversion of $50,000 in
     the aggregate  principal amount of secured  convertible  debentures held by
     Peter K. Sivaslian at a per share conversion price of $0.75,

o    up to 66,667  shares of common stock  issuable  upon  exercise of a warrant
     held by Peter K. Sivaslian at a per share exercise price of $0.935,

o    up to 46,667  shares of common stock  issuable  upon  exercise of a warrant
     held by Peter K. Sivaslian at a per share exercise price of $0.8925,

o    up to 100,000 shares of common stock issuable upon conversion of $50,000 in
     the aggregate  principal amount of secured  convertible  debentures held by
     Stephen Ross at a per share conversion price of $0.75,

o    up to 66,667  shares of common stock  issuable  upon  exercise of a warrant
     held by Stephen Ross at a per share exercise price of $0.935,

o    up to 46,667  shares of common stock  issuable  upon  exercise of a warrant
     held by Stephen Ross at a per share exercise price of $0.8925,

o    up to 1,625,942  shares of common  stock  issuable on the  conversion  of a
     secured convertible debenture held by Gryffindor Capital Partners I, L.L.C.
     at a per share conversion price of $0.737 for principal converted and $0.55
     for interest converted,

o    up to 15,000  shares of common stock  issuable on the exercise of a warrant
     held by the Irrevocable Trust dated December 28, 2004 f/b/o Olivia Skriloff
     at a per share exercise price of $0.98,

o    up to 15,000  shares of common stock  issuable upon the exercise of warrant
     held by the Irrevocable Trust dated December 28, 2004 f/b/o Olivia Skriloff
     at a per share exercise price of $1.23,

o    up to 15,000 shares of common stock issuable upon the exercise of a warrant
     held by the Irrevocable Trust dated December 28, 2004 f/b/o Samuel Skriloff
     at a per share exercise price of $0.98,

o    up to 15,000 shares of common stock issuable upon the exercise of a warrant
     held by the Irrevocable Trust dated December 28, 2004 f/b/o Samuel Skriloff
     at a per share exercise price of $1.23,

o    up to 38,750 shares of common stock issuable upon the exercise of a warrant
     held by David Skriloff at a per share exercise price of $0.98,

o    up to 38,750 shares of common stock issuable upon the exercise of a warrant
     held by David Skriloff at a per share exercise price of $1.23,

o    up to 56,250 shares of common stock issuable upon the exercise of a warrant
     held by Richard Smithline at a per share exercise price of $0.98,

o    up to 56,250 shares of common stock issuable upon the exercise of a warrant
     held by Richard Smithline at a per share exercise price of $1.23,

o    up to  150,000  shares of common  stock  issuable  upon the  exercise  of a
     warrant  held by the M.W.  Crow Family  Trust,  LP at a per share  exercise
     price of $0.98,

o    up to  150,000  shares of common  stock  issuable  upon the  exercise  of a
     warrant  held by the M.W.  Crow Family  Trust,  LP at a per share  exercise
     price of $1.23,

o    up to  360,000  shares of common  stock  issuable  upon the  exercise  of a
     warrant held by Damon D. Testaverde at a per share exercise price of $0.98,

                                       10


o    up to  280,000  shares of common  stock  issuable  upon the  exercise  of a
     warrant held by Damon D. Testaverde at a per share exercise price of $1.00,


o    up to 40,000 shares of common stock issuable upon the exercise of a warrant
     held by Network 1 Financial Securities,  Inc. at a per share exercise price
     of $0.98,

o    up to 70,000 shares of common stock issuable upon the exercise of a warrant
     held by Network 1 Financial Securities,  Inc. at a per share exercise price
     of $1.00,


o    up to 75,000 shares of common stock issuable upon the exercise of a warrant
     held by Martin Stern at a per share exercise price of $1.00, 

o    up to 75,000 shares of common stock issuable upon the exercise of a warrant
     held by Kenneth J. Spadaford of at per share exercise price of $1.00,

o    up to 75,000 shares of common stock issuable upon the exercise of a warrant
     held by William J. Crusoe of at a per share exercise price of $1.00,
         
o    up to 57,848 shares of common stock issuable upon the exercise of a warrant
     held by Venture Catalyst, LLC at a per share exercise price of $0.75,

o    up to 86,768 shares of common stock issuable upon the exercise of a warrant
     held by Venture Catalyst, LLC at a per share exercise price of $1.00,

o    up to 42,411 shares of common stock issuable upon the exercise of a warrant
     held by Venture Catalyst, LLC at a per share exercise price of $0.75,

o    up to 63,612 shares of common stock issuable upon the exercise of a warrant
     held by Venture Catalyst, LLC at a per share exercise price of $1.00,

o    up to  149,000  shares of common  stock  issuable  upon the  exercise  of a
     warrant  held by Venture  Catalyst,  LLC at a per share  exercise  price of
     $1.00,

o    up to 21,677 shares of common stock issuable upon the exercise of a warrant
     held by Trek Properties, LLC at a per share exercise price of $0.75,

o    up to 32,519 shares of common stock issuable upon the exercise of a warrant
     held by Trek Properties, LLC at a per share exercise price of $1.00,

o    up to 22,339 shares of common stock issuable upon the exercise of a warrant
     held by Trek Properties, LLC at a per share exercise price of $0.75,

o    up to 33,513 shares of common stock issuable upon the exercise of a warrant
     held by Trek Properties, LLC at a per share exercise price of $1.00,

o    up to  140,000  shares of common  stock  issuable  upon the  exercise  of a
     warrant  held by Trek  Properties,  LLC at a per  share  exercise  price of
     $1.00,

o    up to 25,000 shares of common stock issuable upon the exercise of a warrant
     held by Kevin Richardson at a per share exercise price of $1.00, and 

o    631,833 shares of common stock held by certain selling shareholders, and up
     to 947,750  shares of common  stock  issuable  upon the exercise of certain
     warrants held by certain selling shareholders.


                                       11


                                  Risk Factors

     Before you purchase our securities, you should carefully consider the risks
described  below  and  the  other  information  contained  in  this  prospectus,
including our financial  statements and related notes. The risks described below
are not the only ones facing our company.  Additional  risks not presently known
to us or  that we  currently  deem  immaterial  may  also  impair  our  business
operations.  If any of the  adverse  events  described  in this  "Risk  Factors"
section  actually  occurs,  our business,  results of  operations  and financial
condition could be materially  adversely affected and you might lose all or part
of your investment.

Because of our limited operations and the fact that we are currently  generating
limited revenue, we may be unable to pay our debts when they become due.


     As of March 31, 2005 we had  $2,484,959 in debt,  net of a debt discount of
$743,218,  and $83,290 of accrued  interest on our balance sheet,  consisting of
$1,185,959  in  principal  and $2,943 in accrued  but  unpaid  interest  owed to
Gryffindor;  $1,100,000 in principal and $32,572 in accrued interest owed to the
holders of our  convertible  debentures and $199,000 in principal and $17,775 in
accrued  interest owed to Dr. Wachter.  The amounts due to Gryffindor are due in
November  2005,  the  amounts  due to the  holders  of  the  Senior  Convertible
Debentures  are due in March 2007, and the amounts due to Dr. Wachter are due in
2009.  Because of the  convertible  nature of the debt owed to Gryffindor and to
the holders of the convertible debentures, we may not have to repay this debt if
the debt is  converted  into  shares of our common  stock.  However,  we can not
assure you that this debt will be converted into common stock and we may have to
repay this  indebtedness.  Our  ability  to satisfy  our  current  debt  service
obligations  and any additional  obligations we might incur will depend upon our
future  financial  and  operating  performance,  which,  in turn,  is subject to
prevailing economic conditions and financial, business, competitive, legislative
and regulatory  factors,  many of which are beyond our control. If our cash flow
and capital resources are insufficient to fund our debt service obligations,  we
may be forced to reduce or delay  planned  acquisitions,  expansion  and capital
expenditures,  sell assets,  obtain additional equity capital or restructure our
debt.  Additionally,  our creditors  could  accelerate our payment  obligations,
commence foreclosure  proceedings against our assets or force us into bankruptcy
or  liquidation.  In such events,  any proceeds may not be sufficient to pay off
our creditors.  We cannot assure you that our operating  results,  cash flow and
capital  resources  will be sufficient for payment of our debt service and other
obligations in the future.


We will need  additional  capital to conduct  our  operations  and  develop  our
products, and our ability to obtain the necessary funding is uncertain.

     Our ongoing  operations  continue to be dependent upon our ability to raise
capital.  Ultimately,  we must achieve  profitable  operations if we are to be a
viable entity.  We intend to proceed as rapidly as possible with the development
of OTC products  that can be sold with a minimum of  regulatory  compliance  and
with the  development  of revenue  sources  through  licensing  of our  existing
intellectual  property  portfolio.  Our  technologies  are in  early  stages  of
development. We do not expect to generate sufficient revenues to enable us to be
profitable  for several  calendar  quarters.  We require  additional  funding to
continue initial production and distribution of OTC products in order to achieve
meaningful  sales volumes.  In addition,  we need to raise  additional  funds in
order to fully implement our integrated  business plan,  including  execution of
the next phases in  clinical  development  of our  pharmaceutical  products  and
resumption of research programs currently suspended.

     We will  require  substantial  capital  resources  in order to conduct  our
operations  and develop our  products.  

     We estimate that our existing capital  resources will be sufficient to fund
our current and planned  operations.  We have based this estimate on assumptions
that may  prove to be  wrong,  and we  cannot  assure  you  that  estimates  and
assumptions will remain unchanged.  For example,  we are currently assuming that
we will continue to operate  without any  significant  staff or other  resources
expansion.  We intend to acquire  additional  funding  through public or private
equity financings or other financing  sources that may be available.  Additional
financing may not be available on acceptable  terms,  or at all. As discussed in
more detail  below,  additional  equity  financing  could result in  significant
dilution  to  shareholders.  Further,  in the event  that  additional  funds are
obtained through licensing or other arrangements, these arrangements may require
us to  relinquish  rights to some of our  technologies,  product  candidates  or
products that we would otherwise seek to develop and commercialize ourselves. If
sufficient  capital is not  available,  we may be required to delay,  reduce the
scope of or eliminate one or more of our product  development  programs,  any of
which could have a material  adverse  effect on our  business and may impair the
value of our patents and other intangible  assets.  We cannot assure you that we
will be able to raise sufficient  capital to sustain  operations before we reach
an acceptable level of revenue generation or that we will be able to achieve, or
maintain, a level of profitability sufficient to meet our operating expenses and
continue as a going concern.

                                       12


Existing shareholders may face dilution from our financing efforts.

     We must raise  additional  capital  from  external  sources to execute  our
business plan. We plan to issue debt securities, capital stock, or a combination
of these securities.  We may not be able to sell these securities,  particularly
under current market conditions. Even if we are successful in finding buyers for
our  securities,  the buyers could demand high  interest  rates or require us to
agree to onerous  operating  covenants,  which could in turn harm our ability to
operate our business by reducing  our cash flow and  restricting  our  operating
activities.  If we were to sell our  capital  stock,  we might be forced to sell
shares at a depressed market price,  which could result in substantial  dilution
to our existing  shareholders.  In addition,  any shares of capital stock we may
issue may have  rights,  privileges,  and  preferences  superior to those of our
common shareholders.

The prescription  drug and medical device products in our internal  pipeline are
at an early stage of development, and they may fail in subsequent development or
commercialization.

     We are  continuing  to pursue  clinical  development  of our most  advanced
pharmaceutical  drug products,  Xantryl and Provecta,  for use as treatments for
specific  conditions.  These products and other  pharmaceutical drug and medical
device  products  that we are  currently  developing  will  require  significant
additional research, formulation and manufacturing development, and pre-clinical
and   extensive   clinical   testing   prior   to   regulatory   licensure   and
commercialization.  Pre-clinical and clinical studies of our pharmaceutical drug
and medical device products under development may not demonstrate the safety and
efficacy   necessary  to  obtain  regulatory   approvals.   Pharmaceutical   and
biotechnology  companies have suffered significant setbacks in advanced clinical
trials,   even  after   experiencing   promising   results  in  earlier  trials.
Pharmaceutical  drug and medical device  products that appear to be promising at
early stages of development may not reach the market or be marketed successfully
for a number of reasons, including the following:

o    a product  may be found to be  ineffective  or have  harmful  side  effects
     during subsequent pre-clinical testing or clinical trials,

o    a product may fail to receive necessary regulatory clearance,

o    a product may be too difficult to manufacture on a large scale,

o    a product may be too expensive to manufacture or market,

o    a product may not achieve broad market acceptance,

o    others may hold  proprietary  rights that will prevent a product from being
     marketed, or

o    others may market equivalent or superior products.

     We do not  expect  any  pharmaceutical  drug  products  or  medical  device
products  that we are  developing  to be  commercially  available  for at  least
several years, if at all. Our research and product  development  efforts may not
be successfully completed and may not result in any successfully  commercialized
products.  Further, after commercial introduction of a new product, discovery of
problems  through  adverse event  reporting  could result in restrictions on the
product,  including  withdrawal from the market and, in certain cases,  civil or
criminal penalties.

Our OTC  products are at an early stage of  introduction,  and we cannot be sure
that  they  will be  widely  accepted  in the  marketplace  or that we will have
adequate  capital to market and distribute these products which are an important
factor in the future success of our business.

     We recently have begun  marketing  Pure-ific,  our first OTC product,  on a
limited  basis.  We did not  recognize any revenue from this product in 2003, as
the sales of this product was not  material.  We  recognized  $18,728 of revenue
from sales of this product  during the 2004 and $2,394  during the first quarter
of 2005. In order for our products to become  commercially  successful,  we must
increase significantly our distribution of them. Increasing  distribution of our
products  requires,  in turn, that we or  distributors  representing us increase
marketing of these products. In view of our limited financial resources,  we may
be unable to afford increases in our marketing of our OTC products sufficient to
improve our  distribution  of our  products.  Even if we can and do increase our
marketing of our OTC  products,  we cannot give you any  assurances  that we can
successfully increase our distribution of our products.

     If we do begin  increasing our  distribution  of our OTC products,  we must
increase  our  production  of these  products in order to fill our  distribution
channels.  Increased production will require additional financial resources that
we do not have at present. Additionally, we may succeed in increasing production
without  succeeding  in  increasing  sales,  which could  leave us with  excess,
possibly unsaleable, inventory.

                                       13


     If we are unable to  successfully  introduce,  market and distribute  these
products,  our business,  financial  condition,  results of operations  and cash
flows could be materially adversely affected.

Competition in the  prescription  drug,  medical device and OTC  pharmaceuticals
markets is intense, and we may be unable to succeed if our competitors have more
funding or better marketing.

     The pharmaceutical and biotechnology  industries are intensely competitive.
Other  pharmaceutical  and  biotechnology  companies and research  organizations
currently  engage in or have in the past engaged in research  efforts related to
treatment of dermatological conditions or cancers of the skin, liver and breast,
which could lead to the  development of products or therapies that could compete
directly with the prescription drug, medical device and OTC products that we are
seeking to develop and market.  Many companies are also  developing  alternative
therapies to treat cancer and dermatological conditions and, in this regard, are
our competitors.  Many of the pharmaceutical  companies developing and marketing
these competing  products have  significantly  greater  financial  resources and
expertise  than  we do in:  o  research  and  development,  o  manufacturing,  o
preclinical  and  clinical  testing,  o obtaining  regulatory  approvals,  and o
marketing.

     Smaller   companies   may  also  prove  to  be   significant   competitors,
particularly  through  collaborative  arrangements  with  large and  established
companies.  Academic  institutions,  government  agencies  and other  public and
private research organizations also may conduct research, seek patent protection
and establish collaborative arrangements for research,  clinical development and
marketing of products similar to ours. These companies and institutions  compete
with  us  in  recruiting  and  retaining  qualified  scientific  and  management
personnel as well as in acquiring technologies complementary to our programs.

     In  addition to the above  factors,  we expect to face  competition  in the
     following areas:

o    product efficacy and safety;

o    the timing and scope of regulatory consents;

o    availability of resources;

o    reimbursement coverage;

o    price; and

o    patent  position,  including the potentially  dominant patent  positions of
     others.

     As a result of the foregoing, our competitors may develop more effective or
more affordable  products or achieve earlier product  commercialization  than we
do.

Product  Competition.  Additionally,  since our currently  marketed products are
generally  established and commonly sold,  they are subject to competition  from
products with similar qualities.

     Our OTC product Pure-ific competes in the market with other hand sanitizing
products, including in particular, the following hand sanitizers:

o    Purell (manufactured by GOJO Industries),

o    Avagard D (manufactured by 3M) and

o    a large  number of generic and  private-label  equivalents  to these market
     leaders.

     Our OTC product  GloveAid  represents  a new product  category  that has no
direct  competitors;  however,  other types of  products,  such as  AloeTouch(R)
disposable gloves  (manufactured by Medline  Industries)  target the same market
niche.
                                       14



     Since our  prescription  products  Provecta  and Xantryl  have not yet been
approved by the FDA or introduced to the  marketplace,  we cannot  estimate what
competition  these products might face when they are finally  introduced,  if at
all.  We  cannot  assure  you that  these  products  will  not face  significant
competition for other prescription drugs and generic equivalents.

If we are unable to secure or enforce patent rights,  trademarks,  trade secrets
or other intellectual property our business could be harmed.

     We may not be  successful  in securing or  maintaining  proprietary  patent
protection for our products or products and  technologies we develop or license.
In addition,  our competitors may develop products similar to ours using methods
and  technologies  that  are  beyond  the  scope  of our  intellectual  property
protection, which could reduce our anticipated sales. While some of our products
have proprietary patent protection,  a challenge to these patents can be subject
to  expensive  litigation.   Litigation  concerning  patents,   other  forms  of
intellectual property and proprietary technology is becoming more widespread and
can be protracted and expensive and can distract  management and other personnel
from  performing  their duties for us. We are not currently  aware of any of our
intellectual property that is being infringed upon.

     We also  rely upon  trade  secrets,  unpatented  proprietary  know-how  and
continuing  technological innovation in order to develop a competitive position.
We cannot assure you that others will not  independently  develop  substantially
equivalent proprietary technology and techniques or otherwise gain access to our
trade  secrets  and  technology,  or that we can  adequately  protect  our trade
secrets and technology.

     If we are  unable to secure or enforce  patent  rights,  trademarks,  trade
secrets or other  intellectual  property,  our  business,  financial  condition,
results of operations and cash flows could be materially adversely affected.

If we infringe on the  intellectual  property of others,  our business  could be
harmed.

     We could be sued for infringing patents or other intellectual property that
purportedly cover products and/or methods of using such products held by persons
other than us. Litigation  arising from an alleged  infringement could result in
removal  from the  market,  or a  substantial  delay in, or  prevention  of, the
introduction of our products,  any of which could have a material adverse effect
on our business,  financial condition,  or results of operations and cash flows.
We have not been  notified of any third  party's  belief that we are  infringing
upon their intellectual property.

If we do not update and enhance our technologies, they will become obsolete.

     The pharmaceutical  market is characterized by rapid technological  change,
and our future success will depend on our ability to conduct successful research
in our fields of  expertise,  to discover new  technologies  as a result of that
research,  to develop products based on our  technologies,  and to commercialize
those products. While we believe that our current technology is adequate for our
present needs, if we fail to stay at the forefront of technological development,
we will be unable to compete effectively.  Our competitors are using substantial
resources  to  develop  new  pharmaceutical  technologies  and to  commercialize
products  based on those  technologies.  Accordingly,  our  technologies  may be
rendered  obsolete by advances in existing  technologies  or the  development of
different technologies by one or more of our current or future competitors.

If we lose any of our key personnel,  we may be unable to  successfully  execute
our business plan.

     Our business is presently managed by four key employees:

o    H. Craig Dees, Ph.D., our Chief Executive Officer;

o    Timothy C. Scott, Ph.D., our President;

o    Eric A. Wachter, Ph.D., our Vice President-Pharmaceuticals; and

o    Peter R. Culpepper, CPA, our Chief Financial Officer.

     In  addition  to  their  responsibilities  for  management  of our  overall
business strategy, Drs. Dees, Scott and Wachter are our chief researchers in the
fields in which we are  developing  and planning to develop  prescription  drug,
medical device and OTC products. Also, as of March 31, 2005, we owed $238,078 in
accrued but unpaid  compensation to our employees.  The loss of any of these key
employees  could  have a  material  adverse  effect on our  operations,  and our
ability to execute our business plan might be negatively impacted.  Any of these
key employees may leave their employment with us if they choose to do so, and we
cannot assure you that we would be able to hire similarly  qualified  executives
if any of our key employees should choose to leave.


                                       15


Because  we  have  only  four  employees,   our  management  may  be  unable  to
successfully manage our business.

     In order to  successfully  execute our business plan,  our management  must
succeed in all of the following critical areas:

o    Researching diseases and possible therapies in the areas of dermatology and
     skin care, oncology, and biotechnology;

o    Developing  prescription drug, medical device and OTC products based on our
     research;

o    Marketing and selling developed products;

o    Obtaining additional capital to finance research,  development,  production
     and marketing of our products; and

o    Managing our business as it grows.

     As discussed above, we currently have only four employees,  all of whom are
full-time  employees.  Focusing  on any one of  these  areas  may  divert  their
attention from our other areas of concern and could affect our ability to manage
other aspects of our business.  We cannot assure you that our management will be
able to succeed in all of these  areas or,  even if we do so  succeed,  that our
business  will be  successful  as a result.  We  anticipate  adding a  part-time
regulatory  affairs  officer,  a part-time lab technician and a part-time office
manager within the next year.  While we have not  historically had difficulty in
attracting  employees,  our small size and limited operating history may make it
difficult  for us to attract  and retain  employees  in the future  which  could
further divert managements attention from the operation of our business.

Our common stock price can be volatile because of several  factors,  including a
limited public float.


     During the three month period  ended March 31, 2005,  the sale price of our
common  stock  fluctuated  from  $1.21 to $0.64 per share.  We believe  that our
common stock is subject to wide price  fluctuations  because of several factors,
including:


o    absence of meaningful earnings and external financing;

o    a relatively thin trading market for our common stock,  which causes trades
     of small blocks of stock to have a significant impact on our stock price;

o    general  volatility  of the stock  markets  and the market  prices of other
     publicly traded companies; and

o    investor  sentiment  regarding equity markets  generally,  including public
     perception  of  corporate  ethics  and  governance  and  the  accuracy  and
     transparency of financial reporting.

We have raised substantial amounts of capital in private placements from time to
time,  and if we have  failed to comply  with  applicable  laws and  regulations
applicable  to these  private  placements,  we could be  required  to repay this
capital to investors  and could be subject to legal action by the  investors and
by state and federal securities regulators.

     We have offered and sold securities in private  placements in reliance upon
exemptions  from the  registration  requirements  of the SEC and state agencies.
These exemptions are highly  technical in nature and if we inadvertently  failed
to comply with the  requirements of any of the exemptive  provisions,  investors
might have the right to rescind  their  purchase  of our  securities  or sue for
damages.  If one or more  investors  were to  successfully  seek  rescission  or
prevail  in any  suit,  we  could  face  severe  financial  demands  that  could
materially and adversely  affect our financial  position.  Further,  the SEC and
state  agencies  could take  action  against us that could  divert  management's
attention  from  the  operation  of our  business,  cause  us to pay  fines  and
penalties and cause us to have to repay  investors  their  original  investment,
among other things.

Financings  that  may  be  available  to  us  under  current  market  conditions
frequently  involve  sales at prices  below the prices at which our common stock
trades  on the  Over  the  Counter  Electronic  Bulletin  Board,  as well as the
issuance of warrants or  convertible  debt that require  exercise or  conversion
prices that are  calculated in the future at a discount to the then market price
of our common stock.

     Any  agreement to sell,  or convert debt or equity  securities  into common
stock at a future date and at a price  based on the then  current  market  price
will provide an  incentive  to the investor or third  parties to sell the common
stock short to  decrease  the price and  increase  the number of shares they may
receive in a future purchase,  whether directly from us or in the market.  If we
issue or are deemed to have issued shares of our common stock for  consideration
which is less than $0.75 per share, the  anti-dilutive  provisions  contained in
the secured  convertible  debentures  will become  operative and we will have to
issue  more  

                                       16


shares to the holders of Senior  Convertible  Debentures upon  conversion.  As a
result, the anti-dilutive provisions contained in our agreements with Gryffindor
will become operative.  If these anti-dilutive  provisions become operative,  we
may be  required  to issue a  significant  number of  shares of common  stock to
Gryffindor.  We will not receive any additional proceeds from Gryffindor for the
issuance of these shares of common stock.  Other  financings  that we may obtain
may contain similar provisions, and the existence of anti-dilutive provisions in
some of our  existing  financings  may make it more  difficult  for us to obtain
financing in the future. These types of transactions which cause the issuance of
our common stock in connection with the exercise or conversion of securities may
result in substantial dilution to the remaining holders of our common stock

Financings that may be available to us frequently involve high selling costs.

     Because of our limited operating history, low market  capitalization,  thin
trading volume and other factors,  we have historically had to pay high costs to
obtain financing and expect to continue to be required to pay high costs for any
future  financings in which we may participate.  For example,  our past sales of
shares and our sale of the  convertible  debentures have involved the payment of
finder's  fees or  placement  agent's  fees.  These types of fees are  typically
higher for small  companies  like us.  Payment of fees of this type  reduces the
amount of cash that we receive  from a financing  transaction  and makes it more
difficult for us to obtain the amount of financing  that we need to maintain and
expand our operations.

Future sales by our  stockholders  may adversely  affect our stock price and our
ability to raise funds in new stock offerings.

     Sales of our common  stock in the public  market  following  this  offering
could lower the market  price of our common  stock.  Sales may also make it more
difficult for us to sell equity securities or  equity-related  securities in the
future at a time and price that our management deems acceptable or at all.

We have not had  earnings,  but if earnings  were  available,  it is our general
policy to retain any earnings for use in our operation.

     We have never  declared  or paid cash  dividends  on our common  stock.  We
currently  intend to retain all of our future  earnings,  if any, for use in our
business and therefore do not anticipate paying any cash dividends on our common
stock in the foreseeable future.

Our stock price is below $5.00 per share and is treated as a "Penny Stock" which
places restrictions on broker-dealers recommending the stock for purchase.

     Our common stock is defined as "penny stock" under the Securities  Exchange
Act of 1934, which we refer to as the "Exchange Act," and its rules. The SEC has
adopted regulations that define "penny stock" to include common stock that has a
market price of less than $5.00 per share, subject to certain exceptions.  These
rules include the following requirements:

o    broker-dealers  must  deliver,  prior  to  the  transaction,  a  disclosure
     schedule prepared by the SEC relating to the penny stock market;

o    broker-dealers  must disclose the commissions  payable to the broker-dealer
     and its registered representative;

o    broker-dealers must disclose current quotations for the securities;

o    if a  broker-dealer  is  the  sole  market-maker,  the  broker-dealer  must
     disclose this fact and the broker-dealers presumed control over the market;
     and

o    a  broker-dealer   must  furnish  its  customers  with  monthly  statements
     disclosing  recent  price  information  for all  penny  stocks  held in the
     customer's account and information on the limited market in penny stocks.

     Additional sales practice  requirements are imposed on  broker-dealers  who
sell penny stocks to persons other than  established  customers  and  accredited
investors.  For  these  types of  transactions,  the  broker-dealer  must make a
special  suitability  determination for the purchaser and must have received the
purchaser's  written  consent to the  transaction  prior to sale.  If our common
stock remains subject to these penny stock rules these  disclosure  requirements
may have the effect of reducing the level of trading  activity in the  secondary
market for our common stock. As a result, fewer broker-dealers may be willing to
make a market in our stock,  which  could  affect your  ability to re-sell  your
shares.

                                       17



                           Forward-Looking Statements

     Some of the  information  contained in this  prospectus  and the  documents
incorporated   by  reference  into  this  prospectus   include   forward-looking
statements  (as defined in Section 27A of the  Securities Act and Section 21E of
the Exchange Act),  which mean that they relate to events or  transactions  that
have not yet occurred,  our expectations or estimates for our future operations,
our  growth  strategies  or  business  plans or other  facts  that  have not yet
occurred.  These  statements  can be  identified  by the use of  forward-looking
terminology  such as "might," "may," "will,"  "could,"  "expect,"  "anticipate,"
"estimate,"  "likely," "believe," or "continue" or the negative thereof or other
variations  thereon or comparable  terminology.  The above risk factors  contain
discussions  of  important  factors  that should be  considered  by  prospective
investors for their potential impact on forward-looking  statements  included in
this  prospectus  and in the  documents  incorporated  by  reference  into  this
prospectus.  These important factors,  among others, may cause actual results to
differ  materially  and adversely  from the results  expressed or implied by the
forward-looking statements.

                                 Use Of Proceeds

     The selling  shareholders  will receive the net  proceeds  from the sale of
shares.  We will not receive any of the proceeds  from any sale of the shares by
the selling  shareholders.  However,  we will receive the proceeds from any cash
exercise of warrants to purchase some of the shares offered by this  prospectus.
If all warrants are exercised for cash, we would receive proceeds of $9,712,068.
Any proceeds we receive will be used for working  capital  purposes.  Please see
the section of this prospectus  entitled  "Agreements With Purchasers of Secured
Convertible  Debentures",   "Agreements  With  Gryffindor  Capital  Partners  I,
L.L.C.", "Agreements with Financial Advisors and Consultants",  and "Description
of Other Transactions" for more information about the warrants.

          Agreements With Purchasers Of Secured Convertible Debentures

     We are  registering  a  portion  of the  shares  in  order to  satisfy  our
obligations  to DCOFI Master LDC, Asset  Managers  International  Ltd., DC Asset
Management,  LLC,  Alpha  Capital  Aktiengesellschaft,  Whalehaven  Capital Fund
Limited,  Donald Adams, Peter K. Sivaslian and Stephen Ross  (collectively,  the
"Purchasers"). Under a Securities Purchase Agreement dated as of March 30, 2005,
between us and the  Purchasers,  the Purchasers  purchased  secured  convertible
debentures and warrants from us for an aggregate of $3,150,000. We refer to this
agreement in this  prospectus  as the  Securities  Purchase  Agreement.  We have
received all of the proceeds from the sale of the secured convertible debentures
and warrants.

     The Senior  Convertible  Debentures  have a maturity date of March 30, 2007
and are  convertible  into shares of our common stock at a per share  conversion
price of $0.75.  Interest at the greater of (i) the prime rate (adjust monthly),
plus 4% and (ii) 8% is due on a quarterly  basis with the first  installment due
June 30, 2005. At the time the interest is payable, upon certain conditions,  we
have the option to pay all or any portion of accrued  interest in either cash or
shares of our common  stock valued at 85%  multiplied  by the market price as of
the third trading date  immediately  preceding the interest  payment date. Under
the Senior Convertible  Debentures,  for purposes of determining market price as
of any date,  market  price  means:  (i) the average of the last  reported  sale
prices for the shares on the National  Association of Securities  Dealers Inc.'s
Over-the-Counter  Bulletin Board, for the five days  immediately  preceding such
date; (ii) if the OTCBB is not the principal trading market for the shares,  the
average of the last reported sale prices on the principal trading market for the
common stock during the same period as reported by Bloomberg,  L.P., or (iii) if
unable to calculate on any of the foregoing  bases, as reasonable  determined in
good  faith  by the  Board  or an  independent  investment  back  of  nationally
recognized  standing in the valuation  businesses similar to the business of the
Company.

     We may  prepay  the  Senior  Convertible  Debentures  in full by paying the
holders the greater of (i) 125%  multiplied by the sum of the total  outstanding
principal,  plus accrued and unpaid interest,  plus default interest,  if any or
(ii) the highest  number of shares of common stock  issuable upon  conversion of
the total amount  calculated  pursuant to (i)  multiplied by the highest  market
price for the  common  stock  during  the  period  beginning  on the date  until
prepayment.

     On or after any event or series of events which  constitutes  a fundamental
change,  the holder may,  in its sole  discretion,  require us to  purchase  the
debentures, from time to time, in whole or in part, at a purchase price equal to
110% multiplied by the sum of the total outstanding principal,  plus accrued and
unpaid interest,  plus any other obligations  otherwise due under the debenture.
Under the Senior Convertible Debentures, fundamental change means

     (i) any person becomes a beneficial owner of securities representing 50% or
more of the (a)  outstanding  shares of common stock or (b) the combined  voting
power of the then outstanding securities;

                                       18


     (ii) a merger or consolidation  whereby the voting  securities  outstanding
immediately  prior  thereto  fail to continue to  represent  at least 50% of the
combined voting power of the voting securities  immediately after such merger or
consolidation;

     (iii)  the sale or other  disposition  of all or  substantially  all or the
Company's assets;

     (iv) a change in the  composition  of the  Board  within  two  years  which
results in fewer than a majority of  directors  are  directors as of the date of
the debenture;

     (v) the dissolution or liquidation of the Company; or

     (vi) any  transaction or series of  transactions  that has the  substantial
effect of any of the foregoing.

     The Purchasers  also purchased  Class A Warrants and Class B Warrants under
the Securities Purchase Agreement.  Class A and Class B Warrants are exercisable
at any time between March 30, 2005 through and including March 30, 2010. The per
share  exercise  price of a Class A Warrant is $0.935 and the per share exercise
price of the Class B Warrant is $0.8925.

     Pursuant to the Securities  Purchase  Agreement and a  Registration  Rights
Agreement,  we are  obligated  to  register  under the  Securities  Act (i) 150%
multiplied by the number of shares  issuable on conversion of the full aggregate
principal  amount of the convertible  debentures  plus interest  thereon accrued
through the  maturity  date thereof  which,  at our option may be paid either in
cash or shares of common stock; and (ii) 100% multiplied by the number of shares
issuable upon the exercise of the Warrants.

     Under  the  Registration  Rights  Agreement,  we  may be  obligated  to pay
penalties  if the  registration  statement  is not filed by May 9, 2005,  if the
registration  statement is not declared  effective by June 8, 2005,  or if sales
cannot be made pursuant to the  registration  statement (for failure to maintain
effectiveness of registration  statement,  failure to register sufficient number
of common stock, failure to maintain listing or otherwise).  The amount we would
have to pay the  Purchasers,  as partial relief for the damages by reason of any
delay in or  limitation  of their  ability to sell  underlying  shares of common
stock equals 2% of the liquidated value of debentures and warrants.  This amount
is payable the first day of the month after the payment accrues and on the first
day of each month thereafter.

     We refer you to the Securities Purchase Agreement,  the Registration Rights
Agreement,  the  form of  Secured  Convertible  Debentures,  the form of Class A
Warrants  and the form of Class B Warrants  that are filed as  exhibits  to this
registration statement for a more complete description of the complex provisions
that are summarized under this caption.

              Agreements With Gryffindor Capital Partners I, L.L.C.

     We are  registering a portion of shares in order to satisfy our obligations
to  Gryffindor  Capital  Partners  I,  L.L.C.  Under  the  Amendment  No.  1  to
Transaction  Documents  dated  November 26, 2004 between us and  Gryffindor,  we
issued Gryffindor a Second Amended and Restated Senior Secured  Convertible Note
dated November 26, 2004 in the principal amount of $1,185,959 in substitution of
the Senior Secured Convertible Note previously issued to Gryffindor.  The Second
Amended  Note  has a  maturity  date of  November  26,  2005  and  principal  is
convertible  into shares of common  stock at a rate to one share of common stock
for each  $0.73655655  of principal  converted.  Interest is converted at a rate
equal to one share os common  stock for each $0.55  accrued but unpaid  interest
converted.

     The Second Amended Note provides that in the case of a reclassification  of
the common  stock,  recapitalization,  merger,  consolidation,  or other capital
adjustment affecting the common stock prior to the exercise of the warrant, then
Gryffindor  is entitled to receive the number of shares of common  stock,  other
securities  or  property  of the  company,  or  successor  resulting  from  such
consolidation  or merger as the case may be, to which the shares of common stock
deliverable  upon the  exercise of the warrant  would have been  entitled if the
warrant  had  been   exercised   immediately   prior  to  such   reorganization,
reclassification  of  capital  stock,  consolidation,   merger,  sale  or  other
disposition.

     Pursuant to a registration  rights agreement,  we are obligated to register
under the Securities Act the number of shares  issuable upon the full conversion
of the Second  Amended  Note.  We are also  obligated  to keep the  registration
statement of which this prospectus  forms a part effective until the earliest of
the date from which the holders may sell all shares  registered  on their behalf
under Rule 144  promulgated  under the Securities  Act, or the date on which the
holders no longer own any of those  shares.  We refer you to Amendment  No. 1 to
the  Transaction  Documents,  the Second  Amended and  Restated  Senior  Secured
Convertible Note and the form of common stock purchase warrant that are filed as
exhibits to this registration  statement for a more complete  description of the
complex provisions that are summarized under this caption.

                                       19

               Agreements With Financial Advisors And Consultants

     Pursuant  to an  Advisory  Agreement  with us dated  March 1, 2005,  Duncan
Capital Group, LLC served as financial advisor and consultant for the Company in
connection  with  transactions  described  above.  Duncan  received  warrants to
purchase  up to  550,000  shares  of  common  stock of the  Company  as  partial
compensation  for its services.  Half of the warrants have a per share  exercise
price of $0.98  and half of the  warrants  have a per  share  exercise  price of
$1.23. It is Duncan's policy to immediately allocate its warrants and Duncan has
allocated its warrants to the  Irrevocable  Trust dated  December 28, 2004 f/b/o
Olivia  Skriloff,  the  Irrevocable  Trust dated  December 28, 2004 f/b/o Samuel
Skriloff,  David Skriloff,  Richard  Smithline,  and the M.W. Crow Family Trust,
L.P. in such amounts as set forth under the section of this prospectus  entitled
"Offering".

     Pursuant to a Financial Advisory and Investment  Agreement dated August 15,
2004 with Network 1 Financial Solutions, Inc., Damon D. Testaverde and Network 1
received  warrants to purchase up to 280,000 and 70,000  shares of common stock,
respectively,  at a per share exercise price of $1.00.  Testaverde and Network 1
also served as brokers in connection  with the  Securities  Purchase  Agreement.
Pursuant to an  agreement  with  Testaverde  and  Network 1, the Company  issued
Testaverde and Network 1 warrants to purchase up to 360,000 and 40,000 shares of
common  stock,  respectively,  at  a  per  share  exercise  price  of  $0.98  as
compensation for service rendered.


     As compensation for its services as placement agent of the Company's common
stock and warrants,  Venture Catalyst,  LLC received warrants to purchase (a) up
to 57,848 shares of common stock at a per share exercise price of $0.75,  (b) up
to 86,768 shares of common stock at a per share exercise price of $1.00,  (c) up
to 42,411 shares of common stock at a per share exercise price of $0.75, and (d)
up to  63,612  shares of common  stock at a per share  exercise  price of $1.00.
Pursuant  to a  Consulting  Agreement  dated April 1, 2005,  Venture  received a
warrant to purchase up to 149,000 shares of common stock at a per share exercise
price of $1.00.

     As compensation for its services as placement agent of the Company's common
stock and warrants, Trek Properties, LLC received warrants to purchase (a) up to
21,677 shares of common stock at a per share exercise price of $0.75,  (b) up to
32,519 shares of common stock at a per share exercise price of $1.00,  (c) up to
22,339 shares of common stock at a per share exercise price of $0.75, and (d) up
to 33,513 shares of common stock at a per share exercise price of $1.00.

     Pursuant to an agreement  entered  into May 24, 2005,  between us and Kevin
Richardson, as compensation for Richardson's services as a Company spokesperson,
we issued a common stock purchase warrant to Richardson to purchase up to 25,000
shares of common stock at a per share exercise price of $1.00.

     Pursuant  to a Finders  Fee  Agreement  between us and the  Centre  Capital
Advisors,  LLC, we issued  warrants  to  purchase up to 75,000  shares of common
stock at a per share exercise price of $1.00 to William J. Crusoe and Kenneth J.
Spadaford.


                                       20


                        Description Of Other Transactions


     We are also registering  631,833 shares held by other selling  shareholders
and 947,750  shares  issuable  upon  exercise of warrants  held by other selling
shareholders other than the Purchasers, Gryffindor, the persons described in the
section of this  prospectus  entitled  "Agreements  with Financial  Advisors and
Consultants" or affiliates thereof.  These selling  shareholders  acquired their
beneficial  interest in the common stock through various  private  placements of
securities.


     Certain of these  selling  shareholders  are permitted to have their shares
registered  for resale in the  registration  statement  as a result of so-called
"piggy-back"  registration  rights, which means that, because we are required by
the Investor Registration Rights Agreement and the Registration Rights Agreement
to file the registration statement,  holders of "piggy-back" registration rights
must  also be given the  opportunity  to have  their  shares  registered  in the
registration  statement.  Other selling shareholders are permitted to have their
shares  registered  for  resale  in the  registration  statement  pursuant  to a
registration rights agreement.

     We refer you to the  registration  rights  agreements  relating  to some of
these shares that are filed as exhibits to this registration  statement for more
complete description of the provisions of those registration rights agreements.

                              Selling Shareholders



     The following table sets forth the shares  beneficially  owned, as of March
31, 2005, by the selling shareholders prior to the offering contemplated by this
prospectus,  the number of shares each selling  shareholder  is offering by this
prospectus and the number of shares which each would own beneficially if all the
offered shares are sold.  The selling  shareholders  acquired  their  beneficial
interests in the shares being offered hereby in the transactions described under
the headings  "Agreements  with Purchasers of Secured  Convertible  Debentures",
"Agreements  with  Gryffindor  Capital  Partners I,  L.L.C.",  "Agreements  with
Financial  Advisors and Consultants" and in private  placements  described under
the heading "Description of Other Transactions."


     Beneficial  ownership  is  determined  in  accordance  with SEC  rules  and
includes  voting or investment  power with respect to the  securities.  However,
each of the selling  shareholders is subject to limitations on the conversion of
their secured convertible debentures and the exercise of their warrants, if any.
The most  significant of these  limitations is that the selling  shareholder may
not convert its  debentures  or exercise  its  warrants,  if the  conversion  or
exercise  would cause such  holder's  beneficial  ownership  of our common stock
(excluding   shares  underlying  any  of  their  unconverted  to  debentures  or
unexercised warrants) to exceed 4.99% of the outstanding shares of common stock.
Also,  the table below  includes the number of shares which would be issued upon
conversion of a secured convertible debenture in payment of all accrued interest
through  its  maturity  date,  which is more  than 60 days from the date of this
prospectus  and shares which might be issuable on the occurrence of events which
have not yet occurred and may not occur.  Therefore,  although they are included
in the table below, the number of shares of common stock for some listed persons
may include shares that may not be purchased during the 60-day period.

                                       21






                                                     Beneficial 
Names                                                 Ownership      Shares Registered    Post-Offering             %
------                                               ----------      -----------------    -------------            ---
                                                                                                       
DCOFI Master LDC (1)                                  1,825,112         4,266,666 (3)            0                   0
Asset Managers International Ltd. (1)                 1,825,112         3,700,000 (3)            0                   0
DC Asset Management, LLC  (Class A) (1)                566,666           566,666 (3)             0                   0
Alpha Capital Aktiengesellschaft (1)                  1,825,112         2,133,334 (3)            0                   0
Whalehaven Capital Fund Limited (1)                    640,000           640,000 (3)             0                   0
Donald Adams                                          1,706,666         1,706,666 (3)            0                   0
Peter K. Sivaslian                                     213,334           213,334 (3)             0                   0
Stephen Ross                                           213,334           213,334 (3)             0                   0
Gryffindor Capital Partners I, L.L.C. (1)             1,825,112         1,625,942 (3)      199,170                1.08%
Irrevocable Trust dated December 28, 2004 f/b/o         30,000           30,000 (4)              0                   0
Olivia Skriloff
Irrevocable Trust dated December 28, 2004 f/b/o         30,000           30,000 (4)              0                   0
Samuel Skriloff
David Skriloff                                          77,500           77,500 (4)              0                   0
Richard Smithline                                      112,500           112,500 (4)             0                   0
M.W. Crow Family Trust LP                              300,000           300,000 (4)             0                   0
Damon D. Testaverde (2)                                640,000           640,000 (4)             0                   0
Network 1 Financial Securities, Inc. (2)               110,000           110,000 (4)             0                   0
Kenneth J. Spadaford (2)                                75,000           75,000 (4)              0                   0
William J. Crusoe (2)                                   75,000           75,000 (4)              0                   0
Martin Stern                                            75,000           75,000 (4)              0                   0
Ben F. House                                            75,000           75,000 (4)              0                   0
Robert Johnsen                                          66,668           66,668 (4)              0                   0
Roy L. Paget                                            83,333           83,333 (4)              0                   0
Tom J. Gardiner                                         83,333           83,333 (4)              0                   0
Gene V. Dupreau                                        200,000           200,000 (4)             0                   0
Carmine J. Esposito                                     87,500           87,500 (4)              0                   0
Leon Hertzson                                          175,000           175,000 (4)             0                   0
Samuel Gault                                           125,000           125,000 (4)             0                   0
Edward C. Hacker                                        25,000           25,000 (4)              0                   0
W. Allen Everette                                       75,000           75,000 (4)              0                   0
Gordon Scott Hirsch                                     62,500           62,500 (4)              0                   0
Dale and Margaret Cox                                   33,750           33,750 (4)              0                   0
Belz Broadcasting Company                              337,500           337,500 (4)             0                   0
B. J. Kennedy                                          150,000           150,000 (4)             0                   0
Venture Catalyst, LLC (2)                              399,639           399,639 (4)             0                   0
Trek Properties, LLC (2)                               250,048           250,048 (4)             0                   0
Kevin Richardson                                        25,000            25,000 (4)             0                   0

--------------

                                       22



(1) The selling shareholder advised us that it is not a broker-dealer and is not
affiliated with any broker-dealer and no natural person beneficially owns shares
of common stock or the shares of common stock  issuable  upon  conversion of the
warrants.

(2) The  selling  shareholder  has acted as a  consultant  within the last three
years.

(3) The numbers on the table  reflect an estimate of the number of shares issued
or issuable to the selling shareholder. We are registering the shares underlying
the senior convertible  debentures held by the selling shareholder and a portion
of our common stock which might be issuable to the selling shareholder under the
terms of the agreements  and the selling  shareholder.  We are also  registering
shares the  warrants  held by the selling  shareholder.  See the section of this
prospectus   entitled   "Agreements  with  Purchasers  of  Secured   Convertible
Debentures" for more information regarding our senior convertible debentures and
warrants.

(4) The  numbers  on the table  reflect  the actual  number of shares  issued or
issuable to the selling shareholder. See the section of this prospectus entitled
"Description of Other Transactions."

Relationship Between Provectus and the Selling Shareholders

     None of the  selling  shareholders  are  affiliates  or  controlled  by our
affiliates.  None of the selling shareholders are now or were at any time in the
past  an  officer  or  director  of ours  or any of any of our  predecessors  or
affiliates.  We have separate contractual  obligations to file this registration
with each of the selling shareholders.

                            Description Of Securities

Common Stock

     We are authorized to issue  100,000,000  shares of common stock,  $.001 par
value per share, of which 16,882,275  shares were outstanding and held of record
as of May 31, 2005, by approximately 1,824 shareholders of record. A significant
portion  of our  common  stock is held in either  nominee  name or  street  name
brokerage  accounts.  All outstanding  shares of common stock are fully paid and
non-assessable.  Holders of shares of our common  stock are entitled to one vote
for each  share held of record on all  matters  to be voted on by  shareholders.
Holders of shares of common stock are entitled to receive dividends when, as and
if declared by our board of directors from funds legally available  therefor and
to share  ratably in our  assets  available  upon  liquidation,  dissolution  or
winding  up. The  holders of shares of the common  stock do not have  cumulative
voting  rights for the election of directors  and,  accordingly,  the holders of
more than 50% of the shares of common stock are able to elect all directors. Our
Restated  Articles of Incorporation do not grant preemptive  rights.  The common
stock  may not be  redeemed  except  upon our  consent  and the  consent  of the
shareholders  and the common stock is not subject to liability for further calls
or to assessments by Provectus. This summary does not purport to be complete and
is  qualified  in  its  entirety  by  reference  to  our  Restated  Articles  of
Incorporation and to Nevada law.

Preferred Stock

     We are authorized to issue 25,000,000 shares of preferred stock,  $.001 par
value per share,  of which no shares are issued and  outstanding.  The shares of
preferred  stock may be issued from time to time in one or more  series,  in any
manner  permitted  by law,  as  determined  from  time to time by our  board  of
directors,  and  stated  in the  resolution  or  resolutions  providing  for the
issuance of such shares adopted by our board of directors  pursuant to authority
vested in it. Without  limiting the generality of the foregoing,  shares in such
series shall have voting powers, full or limited, or no voting powers, and shall
have such designations,  preferences and relative,  participating,  optional, or
other special rights, and qualifications,  limitations, or restrictions thereof,
permitted by law, as shall be stated in the resolution or resolutions  providing
for the issuance of such shares adopted by our board of directors. The number of
shares of any such series so set forth in the resolution or  resolutions  may be
increased  (but not above the total  number of  authorized  shares of  preferred
stock)  or  decreased   (but  not  below  the  number  of  shares  thereof  then
outstanding)  by  further  resolution  or  resolutions  adopted  by the board of
directors.

                                       23

Governing Law and Organizational Documents

     Shareholders'  rights and related  matters are  governed by the laws of the
State of Nevada and our Restated Articles of Incorporation  and our Bylaws.  Our
Restated  Articles of  Incorporation  may not be amended without the affirmative
vote of at least a majority  of the shares  entitled  to vote  generally  in the
election  of  directors,  voting as a single  voting  group.  Our  Bylaws may be
amended by either the  affirmative  vote of 75% of all  shares  outstanding  and
entitled to vote  generally in the election of directors,  or by an  affirmative
vote of a majority of our directors then holding office.

Stock Option Plans

     The 2002 Stock  Option  Plan,  as amended,  provides  for the grant of four
types of incentive awards: stock options,  stock appreciation rights,  rights to
purchase restricted stock, and long-term performance awards.

     Our employees and  consultants,  including  officers and directors who also
are employees or  consultants,  and our  directors  who are not employees  whose
present and potential  contributions  are important to our continued success are
eligible to receive awards under the plan. The purpose of a long-term  incentive
plan is to direct the  attention and efforts of  participating  employees to our
long-term  performance by relating incentive  compensation to the achievement of
long-term  corporate economic  objectives.  The plan also is designed to retain,
reward and motivate  participating  employees by  providing an  opportunity  for
investment in the company and the advantages inherent in ownership of our common
stock.

     A total of  5,000,000  shares of our  common  stock may be  subject  to, or
issued pursuant to, awards granted under the plan. If an award under the plan is
forfeited  or  terminated  for any reason,  the shares of common stock that were
subject to the award again become  available for distribution in connection with
awards under the plan. In addition,  shares subject to stock appreciation rights
that  are  exercised  for  cash  again  become  available  for  distribution  in
connection with awards under the plan.

     The plan may be administered by one or more  administrators if the board of
directors  deems division of  administration  necessary or desirable in order to
comply with applicable law. Because the board of directors has not appointed any
committees and because we have so few  employees,  the entire board of directors
currently is acting as the administrator of the plan.

     The  administrator  has the exclusive  discretion to select the  employees,
consultants and non-employee  directors who receive awards under the plan and to
determine  the type,  size,  and  terms of each  award,  to modify  the terms of
awards, to determine when awards will be granted and paid, and to make all other
determinations  which it deems necessary or desirable in the  interpretation and
administration  of the plan.  The plan will  remain in effect  until all  awards
under the plan  either  have been  satisfied  by the  issuance  of shares of our
common stock or the payment of cash or have expired or otherwise  terminated  or
the plan is otherwise  terminated by our board of directors.  However, no awards
may be granted more than ten years after the date of the shareholder's  approval
of the plan. Generally,  a participant's rights and interest under the plan will
not be transferable except by will or by the laws of descent and distribution.

Transfer Agent

     We have retained Atlas Stock Transfer Corporation, 5899 South State Street,
Salt Lake City,  UT 84107,  as the transfer  agent for our common  stock.  Atlas
Stock Transfer Corporation's telephone number is (801) 266-7151.

                              Plan Of Distribution

     The selling shareholders and any of their pledgees,  donees,  assignees and
successors-in-interest  may, from time to time,  sell any or all of their shares
of common stock on any stock exchange,  market or trading  facility on which the
shares are traded. These sales may be at fixed or negotiated prices. The selling
shareholders  may use any one or more  of the  following  methods  when  selling
shares:

o    ordinary brokerage transactions and transactions in which the broker-dealer
     solicits purchasers;

o    block trades in which the broker-dealer  will attempt to sell the shares as
     agent but may  position  and resell a portion of the block as  principal to
     facilitate the transaction;

o    purchases by a broker-dealer  as principal and resale by the  broker-dealer
     for its account;

o    an exchange  distribution  in accordance  with the rules of the  applicable
     exchange;

                                       24

o    privately negotiated transactions;

o    short  sales,  but,  if  at  all,  only  after  the  effectiveness  of  the
     registration statement of the shares of common stock offered hereby;

o    broker-dealers may agree with the selling  shareholders to sell a specified
     number of such shares at a stipulated price per share;

o    a combination of any such methods of sale; and

o    any other method permitted pursuant to applicable law.


     The  selling  shareholders  may also sell  shares  under Rule 144 under the
Securities Act, if available, rather than under this prospectus.

     The selling  shareholders  may also engage in short sales  against the box,
puts and calls and other  transactions  in our  securities or derivatives of our
securities and may sell or deliver shares in connection  with these trades.  The
selling  shareholders  may pledge their shares to their brokers under the margin
provisions of customer agreements. If a selling shareholder defaults on a margin
loan, the broker may, from time to time,  offer and sell the pledged shares.  We
believe  that the selling  shareholders  have not entered  into any  agreements,
understandings or arrangements with any underwriters or broker-dealers regarding
the sale of their shares other than ordinary course brokerage arrangements,  nor
is there an underwriter  or  coordinating  broker acting in connection  with the
proposed sale of shares by the selling shareholders.

     Broker-dealers  engaged by the selling  shareholders  may arrange for other
brokers-dealers to participate in sales.  Broker-dealers may receive commissions
or discounts from the selling  shareholders  (or, if any  broker-dealer  acts as
agent  for the  purchaser  of  shares,  from the  purchaser)  in  amounts  to be
negotiated.  The  selling  shareholders  do not  expect  these  commissions  and
discounts to exceed what is customary in the types of transactions involved.

     Selling  shareholders  may be, and any  broker-dealers  or agents  that are
involved  in selling  the shares  are,  deemed to be  "underwriters"  within the
meaning of the Securities Act in connection with such sales. In such event,  any
commissions  received  by such  broker-dealers  or agents  and any profit on the
resale  of the  shares  purchased  by  them  may be  deemed  to be  underwriting
commissions or discounts under the Securities  Act. If the selling  shareholders
are  deemed to be  underwriters,  the  selling  shareholders  may be  subject to
statutory and regulatory liabilities,  including liabilities imposed pursuant to
Sections 11, 12 and 17 of the  Securities  Act and Rule 10b-5 under the Exchange
Act.

     We are required to pay all fees and expenses  incident to the  registration
of the  shares.  Otherwise,  all  discounts,  commissions  or fees  incurred  in
connection  with the sale of the common stock offered hereby will be paid by the
selling shareholders.

     Upon  our  being  notified  by a  selling  shareholder  that  any  material
arrangement  has been entered into with a  broker-dealer  for the sale of shares
through a block trade,  special  offering,  exchange  distribution  or secondary
distribution  or a  purchase  by a  broker  or  dealer,  a  supplement  to  this
prospectus  will be  filed,  if  required,  pursuant  to Rule  424(b)  under the
Securities Act, disclosing

o    the  name  of  each  such  selling  shareholder  and of  the  participating
     broker-dealer(s);

o    the number of shares involved;

o    the price at which such shares were sold;

o    the  commissions   paid  or  discounts  or  concessions   allowed  to  such
     broker-dealer(s), where applicable;

o    that such  broker-dealer(s) did not conduct any investigation to verify the
     information set out or incorporated by reference in this prospectus; and

o    other facts material to the transaction.

     To comply with the securities laws of some states,  the shares will be sold
in those jurisdictions, if required, only through registered or licensed brokers
or dealers.  In  addition,  in some states the shares may not be sold unless the
shares have been  registered  or qualified for sale in the state or an exemption
from registration or qualification is available and complied with.

                                       25


     We advised the selling shareholders that the  anti-manipulative  provisions
of Regulation M  promulgated  under the Exchange Act may apply to their sales of
the shares offered hereby.

                    Indemnification Of Officers And Directors

     Nevada law provides that a Nevada  corporation may indemnify any person who
was or is a party or is threatened to be made a party to any threatened, pending
or completed action, suit or proceeding, whether civil, criminal, administrative
or  investigative,  other  than an action by or in the right of the  corporation
(i.e., a "non-derivative  proceeding"),  by reason of the fact that he or she is
or was a director,  officer, employee or agent of the corporation,  or is or was
serving at the request of the  corporation as a director,  officer,  employee or
agent  of  another  corporation,  partnership,  joint  venture,  trust  or other
enterprise,  against expenses,  including attorneys' fees, judgments,  fines and
amounts paid in settlement actually and reasonably incurred by him in connection
with the action, suit or proceeding if he or she:

o    Is not liable  under  Section  78.138 of the Nevada  Revised  Statutes  for
     breach of his or her fiduciary duties to the corporation; or

o    Acted in good faith and in a manner which he or she reasonably  believed to
     be in or not opposed to the best  interests of the  corporation,  and, with
     respect to any criminal  action or proceeding,  had no reasonable  cause to
     believe his or her conduct was unlawful.

     In addition,  a Nevada corporation may indemnify any person who was or is a
party  or is  threatened  to be  made a  party  to any  threatened,  pending  or
completed  action or suit by or in the  right of the  corporation  to  procure a
judgment in its favor (i.e., a "derivative  proceeding"),  by reason of the fact
that  he or  she  is or  was a  director,  officer,  employee  or  agent  of the
corporation,  or is or was  serving  at the  request  of  the  corporation  as a
director, officer, employee or agent of another corporation,  partnership, joint
venture,  trust or other enterprise against expenses,  including amounts paid in
settlement and attorneys' fees actually and reasonably incurred by him or her in
connection with the defense or settlement of the action or suit if he:

o    Is not liable under Section 78.138 of the Nevada Revised Statute for breach
     of his or her fiduciary duties to the corporation; or

o    Acted in good faith and in a manner which he or she reasonably  believed to
     be in or not opposed to the best interests of the corporation.

     Under Nevada law,  indemnification  may not be made for any claim, issue or
matter  as to which  such a person  has been  adjudged  by a court of  competent
jurisdiction,  after  exhaustion of all appeals  therefrom,  to be liable to the
corporation  or for amounts paid in  settlement to the  corporation,  unless and
only to the  extent  that the court in which the  action or suit was  brought or
other court of competent  jurisdiction  determines upon application that in view
of all the  circumstances  of the case,  the  person is  fairly  and  reasonably
entitled to indemnity for such expenses as the court deems proper.

     To the extent that a director,  officer, employee or agent of a corporation
has been successful on the merits or otherwise in defense of any  non-derivative
proceeding or any derivative  proceeding,  or in defense of any claim,  issue or
matter  therein,  the  corporation  is obligated to indemnify him or her against
expenses,  including  attorneys'  fees,  actually  and  reasonably  incurred  in
connection with the defense.

         Further, Nevada law permits a Nevada corporation to purchase and
maintain insurance or to make other financial arrangements on behalf of any
person who is or was a director, officer, employee or agent of the corporation,
or is or was serving at the request of the corporation as a director, officer,
employee or agent of another corporation, partnership, joint venture, trust or
other enterprise for any liability asserted against him or her and liability and
expenses incurred by him or her in his or her capacity as a director, officer,
employee or agent, or arising out of his or her status as such, whether or not
the corporation has the authority to indemnify him or her against such liability
and expenses.

     Under  our  Restated  Articles  of  Incorporation,   we  are  obligated  to
indemnify,  to the  fullest  extent  permitted  by Nevada law,  any  director or
officer  who was or is a party or is  threatened  to be made a party  to,  or is
involved in, any threatened,  pending or completed  action,  suit or proceeding,
whether civil,  criminal,  administrative or investigative (a "proceeding"),  by
reason of the fact that the  director or officer,  or a person of whom he or she
is the legal representative,  is or was a director or officer of Provectus, or a
member of any committee of our board of  directors,  or is or was serving at our
request as a director,  officer,  partner, trustee, employee or agent of another
corporation,  limited liability company,  partnership,  joint venture,  trust or
other  enterprise,  including  service with respect to employee  benefit  plans,
whether the basis of the proceeding is alleged action in an official capacity as
a  director,  officer,  partner,  trustee,  employee  or agent  or in any  other
capacity  while serving as a director  officer,  partner,  trustee,  employee or
agent;  against all expense,  liability  and loss  (including  attorneys'  fees,
judgments,

                                       26



fines,  excise taxes or penalties and amounts paid or to be paid in  settlement)
reasonably  incurred or suffered by the director or officer in  connection  with
the  proceeding.  In addition,  indemnification  is required to continue as to a
person who has ceased to be a director,  officer,  partner, trustee, employee or
agent  and  inures  to  the  benefit  of  his  or  her  heirs,   executors   and
administrators.  However,  subject  to the  exceptions  detailed  below,  we may
indemnify a person seeking  indemnification  in connection with a proceeding (or
part  thereof)  initiated  by the  person  seeking  indemnification  only if the
proceeding  (or part thereof) was  authorized by our board of directors.  We may
indemnify any employee or agent of Provectus to an extent  greater than required
by law only if and to the extent that our directors,  in their  discretion,  may
determine.

     If we do not  pay a  claim  for  indemnification  under  the  our  Restated
Articles of  Incorporation in full within 30 days after a written claim has been
received by us, the claimant may at any time thereafter bring suit against us to
recover the unpaid  amount of the claim and, if  successful in whole or in part,
the claimant  also will be entitled to be paid the expense of  prosecuting  such
claim.  With some  exceptions,  we may defend against an action brought for this
purpose  that the claimant  has not met the  standards of conduct  which make it
permissible  under Chapter 78 of the Nevada Revised Statutes for us to indemnify
the claimant for the amount  claimed,  but the burden of proving such defense is
on us.  Neither our failure  (including  the failure of our board of  directors,
independent  legal  counsel or our  shareholders)  to have made a  determination
prior to the commencement of such action that indemnification of the claimant is
proper in the circumstances because he or she has met the applicable standard of
conduct set forth in Chapter 78 of the Nevada  Revised  Statutes,  nor an actual
determination by us (including our board of directors, independent legal counsel
or our shareholders)  that the claimant has not met such applicable  standard of
conduct is a defense to the action or creates a  presumption  that the  claimant
has not met the applicable standard of conduct.

     Insofar as indemnification for liabilities arising under the Securities Act
may be permitted to  directors,  officers and  controlling  persons of Provectus
pursuant to the foregoing provisions, or otherwise, we have been advised that in
the  opinion  of the SEC  this  indemnification  is  against  public  policy  as
expressed in the Securities Act and is therefore unenforceable.

                  Where You Can Find More Information About Us

     We  file  reports,  proxy  statements,  information  statements  and  other
information with the SEC. You may read and copy this information,  for a copying
fee, at the SEC's Public Reference Room at 450 Fifth Street,  N.W.,  Washington,
D.C. 20549.  Please call the SEC at  1-800-SEC-0330  for more information on its
public  reference  rooms.  Our SEC filings are also available to the public from
commercial  document retrieval  services,  and at the web site maintained by the
SEC at http://www.sec.gov.

     Our  Internet  address  is  http://www.pvct.com.  We have  made  available,
through a link to the SEC's Web site, electronic copies of the materials we file
with the SEC (including our annual reports on Form 10-KSB, our quarterly reports
on Form 10-QSB, our current reports on Form 8-K, the Section 16 reports filed by
our executive  officers,  directors and 10% shareholders and amendments to those
reports).  To receive paper copies of our SEC  materials,  please  contact us by
U.S. mail, telephone, facsimile or electronic mail at the following address:

                   Provectus Pharmaceuticals, Inc.
                   Attention: President
                   7327 Oak Ridge Highway, Suite A
                   Knoxville, TN 37931
                   Telephone: 865/769-4011
                   Facsimile: 865/769-4013
                   Electronic mail: info@pvct.com

     We have filed the  registration  statement  under the Securities  Act, with
respect to the securities  offered pursuant to this prospectus.  This prospectus
does not contain all of the information set forth in the registration statement,
certain parts of which are omitted in accordance  with the rules and regulations
of the SEC.  For  further  information,  reference  is made to the  registration
statement and the exhibits  filed as a part  thereof,  which may be found at the
locations and website referred to above.

                Incorporation Of Certain Information By Reference

     The SEC allows us to  "incorporate  by reference"  into this prospectus the
information  we file with the SEC,  which means that we can  disclose  important
information to you by referring to those documents. The information incorporated
by  reference  is an  important  part  of this  prospectus.  We  incorporate  by
reference the following documents we filed with the SEC:

                                       27



o    Our Annual  Report on Form 10-KSB for the year ended  December 31, 2004, as
     filed with the SEC on March 31, 2005.

o    Our  Quarterly  Report on Form 10-QSB for the quarter ended March 31, 2005,
     as filed with the SEC on May 16, 2005.

o    Our Definitive Proxy Statement to Shareholders, dated April 21, 2005.

o    Our Current Report on Form 8-K dated April 8, 2005

     We are also  incorporating  by reference  additional  documents that we may
file with the SEC under Section  13(a),  13(c),  14 or 15(d) of the Exchange Act
prior to the termination of this offering.

     If you are a  shareholder,  we may  have  sent  you  some of the  documents
incorporated by reference, but you can obtain any of them through the SEC or us.
Documents incorporated by reference are available from us without charge, except
exhibits,  unless we have specifically incorporated by reference an exhibit into
a document that this prospectus incorporates.  Shareholders may obtain documents
incorporated  by reference into this prospectus by requesting them in writing or
by telephone from:

                         Provectus Pharmaceuticals, Inc.
                            ATTN: Investor Relations
                         7327 Oak Ridge Highway, Suite A
                           Knoxville, Tennessee 37931
                                 (865) 769-4011

                                     Experts

     The financial statements  incorporated by reference in this prospectus have
been audited by BDO Seidman, LLP, independent registered public accounting firm,
to the extent and for the periods set forth in their report  incorporated herein
by  reference,  and are  incorporated  herein in reliance upon such report given
upon the authority of said firm as experts in auditing and accounting.

                                  Legal Matters

     The  validity of the shares we are  offering  will be passed upon for us by
Baker, Donelson, Bearman, Caldwell & Berkowitz, P.C., 207 Mockingbird Lane, P.O.
Box 3038, Johnson City, Tennessee 37602.


                                       28


                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14.  Other Expenses of Issuance and Distribution.

     The estimated expenses in connection with this offering are as set forth in
the following table.  All amounts except the Securities and Exchange  Commission
("SEC") registration fee are estimated.



          SEC Registration Fee                         $1,330.85
          Printing and Engraving Expenses               2,500.00
          Accounting Fees and Expenses                  8,000.00
          Legal Fees and Expenses                      50,000.00
          Miscellaneous                                 1,500.00
                                                      ----------
          Total                                       $63,330.85

  
Item 15.  Indemnification of Officers and Directors.

     See "Indemnification Of Officers And Directors" in the prospectus.

Item 16.  Exhibits

     The following exhibits are filed as part of this Registration Statement.

Exhibit No.     Description


4.1* Form of Secured  Convertible  Debenture related to the Securities  Purchase
     Agreement (as defined below)

4.2* Form of Class A Warrant  related to the Securities  Purchase  Agreement (as
     defined below)

4.3* Form of Class B Warrant  related to the Securities  Purchase  Agreement (as
     defined below)

4.4* Registration  Rights  Agreement dated as of March 30, 2005 by and among the
     Company and the initial  investors  named therein related to the Securities
     Purchase Agreement (as defined below)

4.5* Second Amended and Restated Senior Secured  Convertible Note dated November
     26, 2004 related to Gryffindor Capital Partners I, LLC

4.6* Common Stock Purchase  Warrant dated November 26, 2004 issued to Gryffindor
     Capital Partners I,L.L.C.


4.7  Amended and Restated  Convertible  Secured  Promissory  Note of the Company
     dated  January  31,  2003,  issued to  Gryffindor,  incorporated  herein by
     reference to Exhibit 4.3 to the Company's  Quarterly  Report on Form 10-QSB
     dated March 31, 2003, as filed with the SEC on May 9, 2003


4.8* Advisory Agreement with Duncan Capital Group, LLC dated March 1, 2005

4.9* Form of Warrant issued to Duncan Capital Group, LLC designees



                                       29





4.10*Financial  Advisory  and  Investment  Agreement  with  Network 1  Financial
     Securities, Inc. dated August 15, 2004

4.11*Form of  Warrant  issued to Damon D.  Testaverde  and  Network 1  Financial
     Securities, Inc.


4.12 Finders Fee Agreement with Centre Capital Advisors, LLC Incorporated herein
     by reference to Exhibit 4.12 to the Company's  10-QSB for the quarter ended
     March 31, 2005, as filed with the SEC on May 16, 2005

4.13 Form of Warrant issued to Centre Capital Advisors,  LLC incorporated herein
     by reference by Exhibit 4.13 to the Company's  10-QSB for the quarter ended
     March 31, 2005, as filed with the SEC on May 16, 2005

4.14 General Fee Agreement with Venture Catalyst, LLC dated May 3, 2004

4.15 Consulting Agreement with Venture Catalyst, LLC dated December 8, 2004

4.16 Consulting Agreement with Venture Catalyst, LLC dated April 1, 2005

4.17 Form of Warrant issued to Kevin Richardson

4.18 Form  of  Warrant  issued  to  Selling   Securityholders   other  than  the
     Purchasers,  incorporated  herein  by  reference  to  Exhibit  4.2  to  the
     Company's Current Report on Form 8-K dated November 19, 2004, as filed with
     the SEC on November 19, 2004

5.1  Opinion of Baker, Donelson, Bearman, Caldwell & Berkowitz


10.1*Securities  Purchase  Agreement dated as of March 30, 2005 by and among the
     Company and the buyers named therein ("Securities Purchase Agreement")


10.2 Convertible Secured Promissory Note and Warrant Purchase Agreement dated as
     of November 26, 2002 between the Company and Gryffindor Capital Partners I,
     L.L.C.  ("Gryffindor"),  incorporated herein by reference to Exhibit 4.1 to
     the Company's  Current Report on Form 8-K dated November 26, 2002, as filed
     with the SEC on December 10, 2002

10.3 Letter Agreement dated January 31, 2003 between the Company and Gryffindor,
     incorporated  by  reference  to Exhibit  4.2.2 to the  Company's  Quarterly
     Report on Form 10-QSB for the quarter  ended March 31, 2003,  as filed with
     the SEC on May 9, 2003


10.4*Amendment No. 1 to Transaction  Documents with Gryffindor  Capital Partners
     I, L.L.C. dated November 26, 2004



                                       30




10.5 Form of  Securities  Purchase  Agreement  by and  between  the  Company and
     Selling Securityholders, incorporated herein by reference to Exhibit 4.1 to
     the Company's  Current Report on Form 8-K dated November 19, 2004, as filed
     with the SEC on November 19, 2004


13.1 Annual  Report  on Form  10-KSB  for  the  year  ended  December  31,  2004
     incorporated  herein by reference to the Company's Form 10-KSB for the year
     ended December 31, 2004 as filed with the SEC March 31, 2005


13.2 Quarterly  Report on Form  10-QSB for the  quarter  ended  March 31,  2005,
     incorporated  herein by  reference  to the  Company's  Form  10-QSB for the
     quarter ended on March 31, 2005, as filed with the SEC on May 16, 2005.
 
23.1 Consent of Baker,  Donelson,  Bearman,  Caldwell & Berkowitz  (included  in
     Exhibit 5.1)

23.2 Consent of BDO Seidman, LLP

24.1*Power of Attorney 



*  Previously filed with the SEC




















                                       31



Item 17.  Undertakings.

The undersigned Registrant hereby undertakes:

     (1) To file,  during any period in which  offers or sales are being made, a
     post-effective amendment to this Registration Statement:

          (a) To include  any  prospectus  required  by Section  10(a)(3) of the
          Securities Act of 1933 (the "Securities Act"),

          (b) To reflect in the prospectus any facts or events arising after the
          effective  date of the  Registration  Statement  (or the  most  recent
          post-effective  amendment  thereof)  which,  individually  or  in  the
          aggregate, represent a fundamental change in the information set forth
          in the  Registration  Statement.  Notwithstanding  the foregoing,  any
          increase  or decrease  in volume of  securities  offered (if the total
          dollar  value of  securities  offered  would not exceed that which was
          registered)  and  any  deviation  from  the  low  or  high  end of the
          estimated  maximum  offering  range  may be  reflected  in the form of
          prospectus  filed  with the SEC  pursuant  to Rule  424(b)  if, in the
          aggregate, the changes in volume and price represent no more than a 20
          percent  change in the maximum  aggregate  offering price set forth in
          the   "Calculation  of  Registration   Fee"  table  in  the  effective
          Registration Statement,

          (c) To include any  material  information  with respect to the plan of
          distribution not previously disclosed in the Registration Statement or
          any material change to such information in the Registration Statement;
          
     provided, however, that clauses (a) and (b) do not apply if the information
     required to be included in a  post-effective  amendment  by such clauses is
     contained  in periodic  reports  filed with or  furnished to the SEC by the
     Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that
     are incorporated by reference in the Registration Statement.

     (2) That, for the purpose of determining any liability under the Securities
     Act, each such post-effective  amendment shall be deemed a new registration
     statement relating to the securities  offered therein,  and the offering of
     such  securities  at that time shall be deemed to be the initial  bona fide
     offering thereof.

     (3) To remove from registration by means of a post-effective  amendment any
     of the securities  being  registered which remain unsold at the termination
     of the offering.

     (4) That,  for purposes of determining  any liability  under the Securities
     Act,  each filing of the  Registrant's  annual  report  pursuant to Section
     13(a)  or  Section  15(d)  of the  Exchange  Act  that is  incorporated  by
     reference  in this  Registration  Statement  shall  be  deemed  to be a new
     registration  statement relating to the securities offered therein, and the
     offering of such  securities at that time shall be deemed to be the initial
     bona fide offering thereof.

     Insofar as indemnification for liabilities arising under the Securities Act
may  be  permitted  to  directors,  officers  and  controlling  persons  of  the
Registrant  pursuant  to the  provisions  described  under  Item  15  above,  or
otherwise,  the  Registrant has been advised that in the opinion of the SEC such
indemnification  is against public policy as expressed in the Securities Act and
is,  therefore,  unenforceable.  In the event  that a claim for  indemnification
against such  liabilities,  other than the payment by the registrant of expenses
incurred or paid by a director,  officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding, is asserted by such
director,  officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been  settled by  controlling  precedent,  submit to a court of  appropriate
jurisdiction the question whether such  indemnification  by it is against public
policy as  expressed  in the  Securities  Act and will be  governed by the final
adjudication of such issue.

                                       32



The undersigned Registrant hereby undertakes that:

     (1) For purposes of determining any liability under the Securities Act, the
     information  omitted  from  the  form of  prospectus  filed as part of this
     Registration  Statement in reliance  upon Rule 430A and contained in a form
     of prospectus filed by the registrant  pursuant to Rule 424(b)(1) or (4) or
     497(h)  under  the  Securities  Act  shall  be  deemed  to be  part of this
     Registration Statement as of the time it was declared effective.

     (2) For the purpose of determining  any liability under the Securities Act,
     each  post-effective  amendment that contains a form of prospectus shall be
     deemed  to be a new  registration  statement  relating  to  the  securities
     offered therein,  and the offering of such securities at that time shall be
     deemed to be the initial bona fide offering thereof.

     (3) The  undersigned  Registrant  hereby  undertakes  that, for purposes of
     determining  any  liability  under the  Securities  Act, each filing of the
     Registrant's  annual  report  pursuant to Section 13(a) or Section 15(d) of
     the Exchange Act (and, where applicable, each filing of an employee benefit
     plan's annual report pursuant to Section 15(d) of the Exchange Act) that is
     incorporated by reference in the Registration  Statement shall be deemed to
     be a new registration statement relating to the securities offered therein,
     and the offering of such  securities at that time shall be deemed to be the
     initial bona fide offering thereof.


                                       33



                                   SIGNATURES

     Pursuant to the  requirements of the Securities Act of 1933, the Registrant
certifies  that  it  has  reasonable  grounds  to  believe  that  it  meets  all
requirements  for filing on Form S-2 and has duly caused this Amendment No. 1 to
the  Registration  Statement  on Form  S-2 to be  signed  on its  behalf  by the
undersigned,  thereunto  duly  authorized  in the  City of  Knoxville,  State of
Tennessee, on June 14, 2005.

                                   PROVECTUS PHARMACEUTICALS, INC.

                                   By:      /s/ Timothy C. Scott               
                                            -----------------------------------
                                            Timothy C. Scott, Ph.D.
                                            President

                                   By:      /s/ Peter R. Culpepper             
                                            -----------------------------------
                                            Peter R. Culpepper, C.P.A
                                            Chief Financial Officer

                               
     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities indicated on June 14, 2005:

                  Signatures                                           Title



                                                                                
/s/ H. Craig Dees                                                               Chief   Executive   Officer 
---------------------------------------------------------------                 (Principal executive officer)
Director 
H. Craig Dees, Ph.D. 

/s/ Peter R. Culpepper                                                          Chief Financial Officer  (Principal
-----------------------------------------------------------------               accounting  and  financial officer)
 Peter R. Culpepper, C.P.A.                                                     

/s/ Timothy C. Scott                                                            President and Director
-----------------------------------------------------------------
Timothy C. Scott, Ph.D.

/s/ Eric A. Wachter*                                                            Director
-------------------=---------------------------------------------
Eric A. Wachter, Ph.D.

/s/ Stuart Fuchs*                                                                Director
-----------------------------------------------------------------
Stuart Fuchs

* By Timothy C. Scott, Attorney-In-Fact