PAGE 1
000 B000000 03/31/2016
000 C000000 0001258943
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 6.1
000 J000000 A
001 A000000 PIONEER MUNICIPAL HIGH INCOME ADVANTAGE TRUST
001 B000000 811-21409
001 C000000 6177427825
002 A000000 60 STATE STREET
002 B000000 BOSTON
002 C000000 MA
002 D010000 02109
003 000000 N
004 000000 N
005 000000 N
006 000000 N
007 A000000 N
007 B000000 0
007 C010100 1
007 C010200 2
007 C010300 3
007 C010400 4
007 C010500 5
007 C010600 6
007 C010700 7
007 C010800 8
007 C010900 9
007 C011000 10
008 A000001 PIONEER INVESTMENT MANAGEMENT, INC.
008 B000001 A
008 C000001 801-8255
008 D010001 BOSTON
008 D020001 MA
008 D030001 02109
010 A000001 PIONEER INVESTMENT MANAGEMENT, INC.
010 B000001 801-8255
010 C010001 BOSTON
010 C020001 MA
010 C030001 02109
010 A000002 BROWN BROTHERS HARRIMAN & CO.
010 C010002 BOSTON
010 C020002 MA
010 C030002 02110
011 A000001 PIONEER FUNDS DISTRIBUTOR, INC.
011 B000001 8-41256
011 C010001 BOSTON
011 C020001 MA
PAGE 2
011 C030001 02109
011 C040001 1820
011 A000002 UBS INVESTMENT BANK
011 B000002 8-022651
011 C010002 STAMFORD
011 C020002 CT
011 C030002 06901
011 A000003 RBC CAPITAL MARKETS CORP.
011 B000003 8-045411
011 C010003 MINNEAPOLIS
011 C020003 MN
011 C030003 55402
011 C040003 4422
011 A000004 MERRILL LYNCH & CO.
011 B000004 8-7221
011 C010004 NEW YORK
011 C020004 NY
011 C030004 10281
011 C040004 1201
011 A000005 JANNEY MONTGOMERY SCOTT, LLC
011 B000005 8-462
011 C010005 PHILADELPHIA
011 C020005 PA
011 C030005 19103
011 C040005 1675
011 A000006 WACHOVIA CAPITAL MARKETS, LLC
011 B000006 8-99999
011 C010006 RICHMOND
011 C020006 VA
011 C030006 23219
012 A000001 PIONEER INVEST. MGMT. SHAREHOLDER SERV. INC.
012 B000001 85-01359
012 C010001 BOSTON
012 C020001 MA
012 C030001 02109
012 A000002 AMERICAN STOCK TRANSFER & TRUST CO. (COMMON)
012 B000002 85-00000
012 C010002 BROOKLYN
012 C020002 NY
012 C030002 11219
012 A000003 DEUTSCHE BANK TRUST COMPANY AMERICAS (PREF.)
012 B000003 85-05212
012 C010003 NEW YORK
012 C020003 NY
012 C030003 10005
013 A000001 DELOITTE & TOUCHE LLP
013 B010001 BOSTON
013 B020001 MA
013 B030001 02116
015 A000001 BROWN BROTHERS HARRIMAN & CO.
015 B000001 C
PAGE 3
015 C010001 BOSTON
015 C020001 MA
015 C030001 02110
015 E010001 X
015 A000002 CITIBANK, N.A. BUENOS AIRES BRANCH
015 B000002 S
015 C010002 BUENOS AIRES
015 D010002 ARGENTINA
015 E040002 X
015 A000003 HSBC BANK AUSTRALIA LIMITED
015 B000003 S
015 C010003 SYDNEY
015 D010003 AUSTRALIA
015 E040003 X
015 A000004 UNICREDIT BANK AUSTRIA AG
015 B000004 S
015 C010004 VIENNA
015 D010004 AUSTRIA
015 E040004 X
015 A000005 STANDARD CHARTERED BANK, BANGLADESH BRANCH
015 B000005 S
015 C010005 DHAKA
015 D010005 BANGLADESH
015 E040005 X
015 A000006 DELETE
015 A000007 BNP PARIBAS SECURITIES SERVICES
015 B000007 S
015 C010007 PANTIN
015 D010007 BELGIUM
015 E040007 X
015 A000008 CITIBANK, N.A., SAO PAULO
015 B000008 S
015 C010008 SAO PAULO
015 D010008 BRAZIL
015 E040008 X
015 A000009 CITIBANK EUROPE PLC, BULGARIA BRANCH
015 B000009 S
015 C010009 SOFIA
015 D010009 BULGARIA
015 E040009 X
015 A000010 RBC INVESTOR SERVICES TRUST
015 B000010 S
015 C010010 TORONTO
015 D010010 CANADA
015 E040010 X
015 A000011 BANCO DE CHILE
015 B000011 S
015 C010011 SANTIAGO
015 D010011 CHILE
015 E040011 X
015 A000012 STANDARD CHARTERED BANK (CHINA) LIMITED
PAGE 4
015 B000012 S
015 C010012 SHANGHAI
015 D010012 CHINA
015 E040012 X
015 A000013 CITITRUST COLOMBIA S.A., SOCIEDAD FIDUCIARA
015 B000013 S
015 C010013 BOGOTA
015 D010013 COLOMBIA
015 E040013 X
015 A000014 CITIBANK EUROPE PLC, ORGANIZACNI SLOZKA
015 B000014 S
015 C010014 PRAGUE
015 D010014 CZECH REPUBLIC
015 E040014 X
015 A000015 SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)
015 B000015 S
015 C010015 COPENHAGEN
015 D010015 DENMARK
015 E040015 X
015 A000016 CITIBANK, N.A., CAIRO BRANCH
015 B000016 S
015 C010016 CAIRO
015 D010016 EGYPT
015 E040016 X
015 A000017 NORDEA BANK FINLAND PLC
015 B000017 S
015 C010017 HELSINSKI
015 D010017 FINLAND
015 E040017 X
015 A000018 BNP PARIBAS SECURITIES SERVICES
015 B000018 S
015 C010018 PANTIN
015 D010018 FRANCE
015 E040018 X
015 A000019 BNP PARIBAS SECURITIES SERVICES,FRANKFURT B
015 B000019 S
015 C010019 FRANKFURT
015 D010019 GERMANY
015 E040019 X
015 A000020 STANDARD CHARTERED BANK GHANA LTD.
015 B000020 S
015 C010020 ACCRA
015 D010020 GHANA
015 E040020 X
015 A000021 HSBC BANK PLC, ATHENS BRANCH
015 B000021 S
015 C010021 ATHENS
015 D010021 GREECE
015 E040021 X
015 A000022 STANDARD CHARTERED BANK (HONG KONG) LIMITED
015 B000022 S
PAGE 5
015 C010022 KWUN TONG
015 D010022 HONG KONG
015 E040022 X
015 A000023 CITIBANK EUROPE PLC, HUNGARIAN BRANCH OFFICE
015 B000023 S
015 C010023 BUDAPEST
015 D010023 HUNGARY
015 E040023 X
015 A000024 CITIBANK, N.A., MUMBAI BRANCH
015 B000024 S
015 C010024 MUMBAI
015 D010024 INDIA
015 E040024 X
015 A000025 CITIBANK, N.A., JAKARTA BRANCH
015 B000025 S
015 C010025 JAKARTA
015 D010025 INDONESIA
015 E040025 X
015 A000026 CITIBANK, N.A., LONDON BRANCH
015 B000026 S
015 C010026 LONDON
015 D010026 IRELAND
015 E040026 X
015 A000027 BANK HAPOALIM BM
015 B000027 S
015 C010027 TEL AVIV
015 D010027 ISRAEL
015 E040027 X
015 A000028 BNP PARIBAS SECURITIES SERVICES, MILAN BRANCH
015 B000028 S
015 C010028 MILAN
015 D010028 ITALY
015 E040028 X
015 A000029 SUMITOMO MITSU BANKING CORPORATION
015 B000029 S
015 C010029 TOKYO
015 D010029 JAPAN
015 E040029 X
015 A000030 NORDEA BANK FINLAND PLC
015 B000030 S
015 C010030 HELSINKI
015 D010030 ESTONIA
015 E040030 X
015 A000031 DELETE
015 A000032 HSBC BANK MIDDLE EAST LIMITED, KUWAIT BRANCH
015 B000032 S
015 C010032 SAFAT
015 D010032 KUWAIT
015 E040032 X
015 A000033 KBL EUROPEAN PRIVATE BANKERS SA
015 B000033 S
PAGE 6
015 C010033 LUXEMBOURG
015 D010033 LUXEMBOURG
015 E040033 X
015 A000034 HSBC BANK MALAYSIA BERHAD
015 B000034 S
015 C010034 KUALA LUMPUR
015 D010034 MALAYSIA
015 E040034 X
015 A000035 BANCO NACIONAL DE MEXICO, S.A. (BANAMEX)
015 B000035 S
015 C010035 MEXICO CITY
015 D010035 MEXICO
015 E040035 X
015 A000036 CITIBANK MAGHREB
015 B000036 S
015 C010036 CASABLANCA
015 D010036 MOROCCO
015 E040036 X
015 A000037 BNP PARIBAS SECURITIES SERVICES
015 B000037 S
015 C010037 PANTIN
015 D010037 NETHERLANDS
015 E040037 X
015 A000038 HSBC LIMITED, NEW ZEALAND BRANCH
015 B000038 S
015 C010038 AUCKLAND
015 D010038 NEW ZEALAND
015 E040038 X
015 A000039 STANBIC IBTC BANK PLC
015 B000039 S
015 C010039 LAGOS
015 D010039 NIGERIA
015 E040039 X
015 A000040 NORDEA BANK NORGE ASA
015 B000040 S
015 C010040 OSLO
015 D010040 NORWAY
015 E040040 X
015 A000041 CITIBANK DEL PERU S.A.
015 B000041 S
015 C010041 LIMA
015 D010041 PERU
015 E040041 X
015 A000042 HSBC LIMITED, PHILIPPINE BRANCH
015 B000042 S
015 C010042 TAGUIG CITY
015 D010042 PHILIPPINES
015 E040042 X
015 A000043 BANK HANDLOWY W WARSZAWIE SA
015 B000043 S
015 C010043 WARSAW
PAGE 7
015 D010043 POLAND
015 E040043 X
015 A000044 BNP PARIBAS SECURITIES SERVICES
015 B000044 S
015 C010044 PANTIN
015 D010044 PORTUGAL
015 E040044 X
015 A000045 HSBC BANK MIDDLE EAST LIMITED, QATAR BRANCH
015 B000045 S
015 C010045 ST. HELIER
015 D010045 QATAR
015 E040045 X
015 A000046 CITIBANK EUROPE PLC, DUBLIN-SUCURSALA ROMANIA
015 B000046 S
015 C010046 BUCHAREST
015 D010046 ROMANIA
015 E040046 X
015 A000047 AO CITIBANK FOR CITIBANK, N.A.
015 B000047 S
015 C010047 MOSCOW
015 D010047 RUSSIA
015 E040047 X
015 A000048 DELETE
015 A000049 STANDARD CHARTERED BANK SINGAPORE BRANCH
015 B000049 S
015 C010049 SINGAPORE
015 D010049 SINGAPORE
015 E040049 X
015 A000050 CITIBANK EUROPE PLC, POBOCKA ZAHRANICNEJ BANK
015 B000050 S
015 C010050 BRATISLAVA
015 D010050 SLOVAKIA
015 E040050 X
015 A000051 STANDARD CHARTERED BANK JOHANNESBURG BRANCH
015 B000051 S
015 C010051 JOHANNESBURG
015 D010051 SOUTH AFRICA
015 E040051 X
015 A000052 CITIBANK KOREA INC.
015 B000052 S
015 C010052 SEOUL
015 D010052 SOUTH KOREA
015 E040052 X
015 A000053 BANCO BILBAO VIZCAYA AREGENTARIA SA
015 B000053 S
015 C010053 MADRID
015 D010053 SPAIN
015 E040053 X
015 A000054 HSBC, SRI LANKA BRANCH
015 B000054 S
015 C010054 COLOMBO
PAGE 8
015 D010054 SRI LANKA
015 E040054 X
015 A000055 SKANDINAVISKA ENSKILDA BANKEN AB (PUBL)
015 B000055 S
015 C010055 STOCKHOLM
015 D010055 SWEDEN
015 E040055 X
015 A000056 CREDIT SUISSE AG
015 B000056 S
015 C010056 ZURICH
015 D010056 SWITZERLAND
015 E040056 X
015 A000057 BANK OF TAIWAN
015 B000057 S
015 C010057 TAIPEI
015 D010057 TAIWAN
015 E040057 X
015 A000058 HSBC LIMITED, THAILAND BRANCH
015 B000058 S
015 C010058 BANGKOK
015 D010058 THAILAND
015 E040058 X
015 A000059 CITIBANK ANONIM SIRKETI
015 B000059 S
015 C010059 ISTANBUL
015 D010059 TURKEY
015 E040059 X
015 A000060 HSBC BANK MIDDLE EAST LIMITED
015 B000060 S
015 C010060 DUBAI
015 D010060 UNITED ARAB EMIRATES
015 E040060 X
015 A000061 HSBC BANK PLC
015 B000061 S
015 C010061 LONDON
015 D010061 UNITED KINGDOM
015 E040061 X
015 A000062 CITIBANK, N.A., CARACAS BRANCH
015 B000062 S
015 C010062 CARACAS
015 D010062 VENEZUELA
015 E040062 X
015 A000063 HSBC BANK (VIETNAM) LTD
015 B000063 S
015 C010063 HO CHI MINH CITY
015 D010063 VIETNAM
015 E040063 X
015 A000064 UNICREDIT BANK AUSTRIA AG
015 B000064 S
015 C010064 VIENNA
015 D010064 CROATIA
PAGE 9
015 E040064 X
015 B000065 S
015 A000066 STANDARD CHARTERED BANK KENYA LIMITED
015 B000066 S
015 C010066 NAIROBI
015 D010066 KENYA
015 E040066 X
018 000000 Y
019 A000000 Y
019 B000000 49
019 C000000 PIONEERFDS
020 C000001 0
020 C000002 0
020 C000003 0
020 C000004 0
020 C000005 0
020 C000006 0
020 C000007 0
020 C000008 0
020 C000009 0
020 C000010 0
021 000000 0
022 A000001 BNY MELLON CAPITAL MARKETS, LLC
022 B000001 23-2384977
022 C000001 24492
022 D000001 23778
022 A000002 J.P. MORGAN SECURITIES LLC
022 B000002 13-3299429
022 C000002 33815
022 D000002 10237
022 A000003 DEUTSCHE BANK SECURITIES INC.
022 B000003 13-2730828
022 C000003 37897
022 D000003 0
022 A000004 SG AMERICAS SECURITIES, LLC
022 B000004 30-0195590
022 C000004 24995
022 D000004 0
022 A000005 CITIGROUP GLOBAL MARKETS INC.
022 B000005 11-2418191
022 C000005 12549
022 D000005 3700
022 A000006 BLACKROCK INVESTMENTS,LLC
022 B000006 13-3806694
022 C000006 10000
022 D000006 3000
022 A000007 GOLDMAN SACHS & CO.
022 B000007 13-5108880
022 C000007 10000
022 D000007 0
022 A000008 MORGAN STANLEY & CO. LLC
PAGE 10
022 B000008 13-2655998
022 C000008 10000
022 D000008 0
022 A000009 UBS SECURITIES LLC
022 B000009 13-3873456
022 C000009 7899
022 D000009 0
022 A000010 BROWN BROTHERS HARRIMAN & CO.
022 B000010 13-4973745
022 C000010 2827
022 D000010 0
023 C000000 177898
023 D000000 41167
024 000000 N
025 D000001 0
025 D000002 0
025 D000003 0
025 D000004 0
025 D000005 0
025 D000006 0
025 D000007 0
025 D000008 0
026 A000000 N
026 B000000 Y
026 C000000 N
026 D000000 Y
026 E000000 N
026 F000000 N
026 G010000 N
026 G020000 N
026 H000000 N
027 000000 N
028 A010000 0
028 A020000 0
028 A030000 0
028 A040000 0
028 B010000 0
028 B020000 0
028 B030000 0
028 B040000 0
028 C010000 0
028 C020000 0
028 C030000 0
028 C040000 0
028 D010000 0
028 D020000 0
028 D030000 0
028 D040000 0
028 E010000 0
028 E020000 0
028 E030000 0
PAGE 11
028 E040000 0
028 F010000 0
028 F020000 0
028 F030000 0
028 F040000 0
028 G010000 0
028 G020000 0
028 G030000 0
028 G040000 0
028 H000000 0
030 A000000 0
030 B000000 0.00
030 C000000 0.00
031 A000000 0
031 B000000 0
032 000000 0
033 000000 0
035 000000 0
036 B000000 0
038 000000 0
042 A000000 0
042 B000000 0
042 C000000 0
042 D000000 0
042 E000000 0
042 F000000 0
042 G000000 0
042 H000000 0
043 000000 0
044 000000 0
045 000000 Y
046 000000 N
047 000000 Y
048 000000 0.600
048 A010000 0
048 A020000 0.000
048 B010000 0
048 B020000 0.000
048 C010000 0
048 C020000 0.000
048 D010000 0
048 D020000 0.000
048 E010000 0
048 E020000 0.000
048 F010000 0
048 F020000 0.000
048 G010000 0
048 G020000 0.000
048 H010000 0
048 H020000 0.000
048 I010000 0
PAGE 12
048 I020000 0.000
048 J010000 0
048 J020000 0.000
048 K010000 0
048 K020000 0.000
049 000000 N
050 000000 N
051 000000 N
052 000000 N
053 A000000 N
054 A000000 Y
054 B000000 Y
054 C000000 Y
054 D000000 N
054 E000000 N
054 F000000 N
054 G000000 N
054 H000000 Y
054 I000000 N
054 J000000 Y
054 K000000 N
054 L000000 N
054 M000000 Y
054 N000000 N
054 O000000 N
055 A000000 N
055 B000000 N
056 000000 N
057 000000 N
058 A000000 N
059 000000 Y
060 A000000 Y
060 B000000 Y
061 000000 0
062 A000000 Y
062 B000000 2.7
062 C000000 0.0
062 D000000 0.0
062 E000000 0.0
062 F000000 0.0
062 G000000 0.0
062 H000000 0.0
062 I000000 0.0
062 J000000 0.0
062 K000000 0.0
062 L000000 0.0
062 M000000 0.0
062 N000000 0.0
062 O000000 143.3
062 P000000 0.0
062 Q000000 0.2
PAGE 13
062 R000000 0.0
063 A000000 0
063 B000000 5.7
064 A000000 Y
064 B000000 Y
065 000000 N
066 A000000 N
067 000000 N
068 A000000 N
068 B000000 N
069 000000 N
070 A010000 Y
070 A020000 N
070 B010000 N
070 B020000 N
070 C010000 Y
070 C020000 N
070 D010000 N
070 D020000 N
070 E010000 Y
070 E020000 N
070 F010000 N
070 F020000 N
070 G010000 Y
070 G020000 N
070 H010000 N
070 H020000 N
070 I010000 N
070 I020000 N
070 J010000 Y
070 J020000 Y
070 K010000 Y
070 K020000 N
070 L010000 N
070 L020000 N
070 M010000 N
070 M020000 N
070 N010000 N
070 N020000 N
070 O010000 Y
070 O020000 N
070 P010000 Y
070 P020000 N
070 Q010000 N
070 Q020000 N
070 R010000 N
070 R020000 N
071 A000000 47617
071 B000000 55522
071 C000000 426164
071 D000000 11
PAGE 14
072 A000000 12
072 B000000 23310
072 C000000 0
072 D000000 0
072 E000000 0
072 F000000 2663
072 G000000 241
072 H000000 0
072 I000000 17
072 J000000 6
072 K000000 0
072 L000000 13
072 M000000 16
072 N000000 0
072 O000000 0
072 P000000 0
072 Q000000 0
072 R000000 61
072 S000000 25
072 T000000 0
072 U000000 0
072 V000000 0
072 W000000 523
072 X000000 3565
072 Y000000 0
072 Z000000 19745
072AA000000 463
072BB000000 0
072CC010000 0
072CC020000 192
072DD010000 22682
072DD020000 0
072EE000000 0
073 A010000 0.9550
073 A020000 0.0000
073 B000000 0.0000
073 C000000 0.0000
074 A000000 15062
074 B000000 0
074 C000000 7899
074 D000000 429178
074 E000000 0
074 F000000 0
074 G000000 0
074 H000000 0
074 I000000 0
074 J000000 25
074 K000000 0
074 L000000 6728
074 M000000 108
074 N000000 459000
PAGE 15
074 O000000 9489
074 P000000 218
074 Q000000 0
074 R010000 0
074 R020000 0
074 R030000 0
074 R040000 268
074 S000000 150007
074 T000000 299018
074 U010000 23823
074 U020000 0
074 V010000 12.55
074 V020000 0.00
074 W000000 0.0000
074 X000000 4183
074 Y000000 0
075 A000000 0
075 B000000 294224
076 000000 13.87
077 A000000 Y
077 B000000 Y
077 C000000 N
077 D000000 N
077 E000000 N
077 F000000 N
077 G000000 N
077 H000000 N
077 I000000 N
077 J000000 N
077 K000000 N
077 L000000 N
077 M000000 N
077 N000000 N
077 O000000 N
077 P000000 N
077 Q010000 N
077 Q020000 N
077 Q030000 N
078 000000 N
080 A000000 ICI MUTUAL INSURANCE COMPANY
080 C000000 45000
081 A000000 Y
081 B000000 49
082 A000000 Y
082 B000000 0
083 A000000 N
083 B000000 0
084 A000000 N
084 B000000 0
085 A000000 N
085 B000000 N
PAGE 16
086 A010000 136
086 A020000 1745
086 B010000 0
086 B020000 0
086 C010000 0
086 C020000 0
086 D010000 0
086 D020000 0
086 E010000 0
086 E020000 0
086 F010000 0
086 F020000 0
087 A010000 COMMON STOCK
087 A020000 723762100
087 A030000 MAV
087 B010000 PREFERRED STOCK - SERIES A
087 B020000 723762209
087 C010000 PREFERRED STOCK - SERIES B
087 C020000 723762308
088 A000000 N
088 B000000 N
088 C000000 N
088 D000000 Y
SIGNATURE MARK E. BRADLEY
TITLE TREASURER