As filed with the Securities and Exchange Commission on September 26, 2001 Registration No. 333-________ SECURITIES AND EXCHANGE COMMISSION Washington, D. C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 BIOTRANSPLANT INCORPORATED (Exact Name of Registrant as Specified in Its Charter) DELAWARE 04-3119555 (State or Other Jurisdiction of (I.R.S. Employer Incorporation or Organization) Identification Number) CHARLESTOWN NAVY YARD BUILDING 75, THIRD AVENUE CHARLESTOWN, MASSACHUSETTS 02129 (Address of Principal Executive Offices) (Zip Code) 1997 STOCK INCENTIVE PLAN (Full Title of the Plan) ELLIOT LEBOWITZ, PH.D. CHIEF EXECUTIVE OFFICER BIOTRANSPLANT INCORPORATED CHARLESTOWN NAVY YARD BUILDING 75, THIRD AVENUE CHARLESTOWN, MASSACHUSETTS 02129 (Name and Address of Agent for Service) (617) 241-5200 (Telephone Number, Including Area Code, of Agent for Service) CALCULATION OF REGISTRATION FEE -------------------------------------------------------------------------------------------------------------------- TITLE OF SECURITIES PROPOSED MAXIMUM PROPOSED MAXIMUM TO BE AMOUNT OFFERING PRICE AGGREGATE OFFERING AMOUNT OF REGISTERED TO BE REGISTERED PER SHARE PRICE REGISTRATION FEE -------------------------------------------------------------------------------------------------------------------- Common Stock, $.01 par value 2,000,000 $4.34(1) $8,680,000(1) $2,170 shares -------------------------------------------------------------------------------------------------------------------- (1) Estimated solely for the purpose of calculating the registration fee, and based on the average of the high and low prices of the Common Stock on the Nasdaq National Market on September 21, 2001 in accordance with Rules 457(c) and 457(h) under the Securities Act of 1933. Statement of Incorporation by Reference Except as otherwise set forth below, this Registration Statement on Form S-8 incorporates by reference the contents of the Registration Statements on Form S-8, File Nos. 333-29055 and 333-83793, relating to the Registrant's 1997 Stock Incentive Plan. SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Charlestown, Commonwealth of Massachusetts, on this 26th day of September 2001. BIOTRANSPLANT INCORPORATED By:/s/ Elliot Lebowitz ----------------------------------- Elliot Lebowitz Chief Executive Officer POWER OF ATTORNEY We, the undersigned officers and directors of BioTransplant Incorporated hereby severally constitute and appoint Elliot Lebowitz and Richard V. Capasso, and each of them singly, our true and lawful attorneys with full power to them, and each of them singly, to sign for us and in our names in the capacities indicated below, the Registration Statement on Form S-8 filed herewith and any and all subsequent amendments to said Registration Statement, and generally to do all such things in our names and on our behalf and in our capacities as officers and directors to enable BioTransplant Incorporated to comply with the provisions of the Securities Act of 1933, as amended, and all requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by said attorneys, or any of them, to said Registration Statement and any and all amendments thereto. Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated. SIGNATURE TITLE DATE --------- ----- ---- /s/ Elliot Lebowitz Chief Executive Officer and September 26, 2001 ------------------------------------ Director (Principal Executive Elliot Lebowitz Officer) /s/ Walter C. Ogier President, Chief Operating September 26, 2001 ------------------------------------ Officer and Director Walter C. Ogier /s/ Richard V. Capasso Vice President, Finance and September 26, 2001 ------------------------------------ Treasurer (Principal Financial Richard V. Capasso and Accounting Officer) /s/ James C. Foster ------------------------------------ Director September 26, 2001 James C. Foster /s/ Daniel O. Hauser ------------------------------------ Director September 26, 2001 Daniel O. Hauser ------------------------------------ Director Arnold L. Oronsky ------------------------------------ Director Michael S. Perry /s/ Susan Racher ------------------------------------ Director September 26, 2001 Susan Racher EXHIBIT INDEX Exhibit NUMBER DESCRIPTION 4.1(1) Restated Certificate of Incorporation, as amended to date 4.2(2) By-laws, as amended to date 4.3(3) Specimen Certificate of Common Stock, $.01 par value per share, of the Registrant 5 Opinion of Hale and Dorr LLP 23.1 Consent of Hale and Dorr LLP (included in Exhibit 5) 23.2 Consent of Arthur Andersen LLP 23.3 Consent of PricewaterhouseCoopers LLP 24 Power of Attorney (included in the signature pages of this Registration Statement) --------- (1) Incorporated herein by reference to the Registrant's Current Report on Form 8-K dated July 18, 2000 (File No. 000-28324). (2) Incorporated herein by reference to the Registrant's Quarterly Report on Form 10-Q for the quarterly period ending March 31, 1996. (3) Incorporated herein by reference to the Registrant's Registration Statement on Form S-1 (File No. 333-2144).