SCHEDULE 13G

Amendment No. 0
ILLUMINA INC
Common Stock
Cusip #452327109

Cusip #452327109
Item 1: 	   	Reporting Person - FMR LLC
Item 4: 	   	Delaware
Item 5: 	   	479,187
Item 6: 	   	0
Item 7: 	   	14,613,789
Item 8: 	   	0
Item 9: 	   	14,618,692
Item 11: 	  	11.684%
Item 12: 	  	HC

Cusip #452327109
Item 1: 	   	Reporting Person - Edward C. Johnson 3d
Item 4: 	   	United States of America
Item 5: 	   	0
Item 6: 	   	0
Item 7: 	   	14,613,789
Item 8: 	   	0
Item 9: 	   	14,618,692
Item 11: 	  	11.684%
Item 12: 	  	IN

SCHEDULE 13G - TO BE INCLUDED IN STATEMENTS
FILED PURSUANT TO RULE 13d-1(b) or 13d-2(b)

Item 1(a). 	    	Name of Issuer:

  	  	          	ILLUMINA INC

Item 1(b). 	    	Name of Issuer's Principal Executive Offices:

  	  	          	9885 Towne Centre Drive
  	  	          	San Diego, CA 92121


Item 2(a). 	     	 Name of Person Filing:

  	   	               	 FMR LLC

Item 2(b). 	     	 Address or Principal Business Office or, if None,
Residence:

  	   	               	 245 Summer Street,Boston,Massachusetts 02210

Item 2(c). 	     	 Citizenship:

  	   	               	 Not applicable

Item 2(d). 	     	 Title of Class of Securities:

  	   	               	 Common Stock

Item 2(e). 	     	 CUSIP Number:

  	   	               	 452327109

Item 3. 	    	This statement is filed pursuant to Rule 13d-1(b) or 13d-2(b)
and the person filing,
FMR LLC, is a parent holding company in accordance with Section 240.13d-
1(b)(ii)(G).   (Note:  See Item 7).

Item 4. 	    	Ownership

  	  	     	(a)    Amount Beneficially Owned: 	14,618,692

  	  	     	(b)    Percent of Class: 	11.684%

  	  	     	(c)    Number of shares as to which such person has:

  	  	     	       (i)    sole power to vote or to direct the vote:
479,187

  	  	     	       (ii)    shared power to vote or to direct the vote: 	0

  	  	     	       (iii)    sole power to dispose or to direct the
disposition of: 	14,613,789

  	  	     	       (iv)    shared power to dispose or to direct the
disposition of: 	0

Item 5. 	    	Ownership of Five Percent or Less of a Class.

  	    	     	Not applicable.

Item 6. 	    	Ownership of More than Five Percent on Behalf of Another
Person.

  	    	     	Various persons have the right to receive or the power to
direct the receipt of dividends from, or the proceeds from the sale of, the
Common Stock of ILLUMINA INC. No one person's interest in the Common Stock
of ILLUMINA INC is more than five percent of the total outstanding Common
Stock.

Item 7. 	    	Identification and Classification of the Subsidiary Which
Acquired the Security Being Reported on By the Parent Holding Company.

  	    	     	See attached Exhibit A.

Item 8. 	    	Identification and Classification of Members of the Group.

  	    	     	Not applicable. See attached Exhibit A.

Item 9. 	    	Notice of Dissolution of Group.

  	    	  	Not applicable.

Item 10. 	    	Certifications.



By signing below I certify that, to the best of my knowledge and belief,
the securities referred to above were acquired in the ordinary course of
business and were not acquired for the purpose of and do not have the
effect of changing or influencing the control of the issuer of such
securities and were not acquired in connection with or as a participant in
any transaction having such purpose or effect. I also certify that, to the
best of my knowledge and belief, FIL Limited and its various non-U.S.
investment management subsidiaries included on this Schedule 13G are
subject to a regulatory scheme substantially comparable to the regulatory
scheme applicable to the functionally equivalent U.S. institutions. I also
undertake to furnish to the Commission staff, upon request, information
that would otherwise be disclosed in a Schedule 13D with respect to FIL
Limited and its various non-U.S. investment management subsidiaries
included on this Schedule 13G.


Signature



After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete
and correct.

  	November 8, 2013
  	Date

  	/s/ Scott C. Goebel
  	Signature

  	Scott C. Goebel
  	 Duly authorized under Power of Attorney effective as of June 1, 2008,
by and on behalf of FMR LLC and its direct and indirect subsidiaries
SCHEDULE 13G - TO BE INCLUDED IN STATEMENTS
FILED PURSUANT TO RULE 13d-1(b) or 13d-2(b)


                Pursuant to the instructions in Item 7 of Schedule 13G,
Fidelity Management & Research Company ("Fidelity"), 245 Summer Street,
Boston, Massachusetts 02210, a wholly-owned subsidiary of FMR LLC and an
investment adviser registered under Section 203 of the Investment Advisers
Act of 1940, is the beneficial owner of 11,845,495 shares or 9.468% of
the Common Stock outstanding of ILLUMINA INC ("the Company") as a result of
acting as investment adviser to various investment companies registered
under Section 8 of the investment Company Act of 1940.



                Edward C. Johnson 3d and FMR LLC, through its control of
Fidelity, and the funds each has sole power to dispose of the 11,845,495
shares owned by the Funds.

		Fidelity SelectCo, LLC ("SelectCo"), 1225 17th Street,
Suite 1100, Denver, Colorado 80202, a wholly-owned subsidiary of FMR LLC
and an investment adviser registered under Section 203 of the Investment
Advisers Act of 1940, is the beneficial owner of 2,294,310 shares or
1.833% of the outstanding Common Stock outstanding of ILLUMINA INC
("the Company") as a result of acting as investment adviser to various
investment companies registered under Section 8 of the Investment Company
Act of 1940 (the "SelectCo Funds").


                Edward C. Johnson 3d and FMR LLC, through its control
of SelectCo, and the SelectCo Funds each has sole power to dispose of
the 2,294,310 shares owned by the SelectCo Funds.



                Members of the family of Edward C. Johnson 3d, Chairman of
FMR LLC, are the predominant owners, directly or through trusts, of Series
B voting common shares of FMR LLC, representing 49% of the voting power of
FMR LLC. The Johnson family group and all other Series B shareholders have
entered into a shareholders' voting agreement under which all Series B
voting common shares will be voted in accordance with the majority vote of
Series B voting common shares. Accordingly, through their ownership of
voting common shares and the execution of the shareholders' voting
agreement, members of the Johnson family may be deemed, under the
Investment Company Act of 1940, to form a controlling group with respect to
FMR LLC.



                Neither FMR LLC nor Edward C. Johnson 3d, Chairman of FMR
LLC, has the sole power to vote or direct the voting of the shares owned
directly by the Fidelity Funds, which power resides with the Funds' Boards
of Trustees. Fidelity carries out the voting of the shares under written
guidelines established by the Funds' Boards of Trustees.



                Strategic Advisers, Inc., 245 Summer Street, Boston, MA
02210, a wholly- owned subsidiary of FMR LLC and an investment adviser
registered under Section 203 of the Investment Advisers Act of 1940,
provides investment advisory services to individuals.As such, FMR LLC's
beneficial ownership includes 744 shares, or 0.001%, of the Common Stock
outstanding of ILLUMINA INC, beneficially owned through Strategic Advisers,
Inc



                Pyramis Global Advisors, LLC ("PGALLC"), 900 Salem Street,
Smithfield, Rhode Island, 02917, an indirect wholly-owned subsidiary of FMR
LLC and an investment adviser registered under Section 203 of the
Investment Advisers Act of 1940, is the beneficial owner of 138,589 shares
or 0.111% of the outstanding Common Stock of ILLUMINA INC as a result of
its serving as investment adviser to institutional accounts, non-U.S.
mutual funds, or investment companies registered under Section 8 of the
Investment Company Act of 1940 owning such shares.



                Edward C. Johnson 3d and FMR LLC, through its control of
PGALLC, each has sole dispositive power over 96,900 shares and sole power
to vote or to direct the voting of 138,589 shares of Common Stock owned by
the institutional accounts or funds advised by PGALLC as reported above.



                Pyramis Global Advisors Trust Company ("PGATC"), 900 Salem
Street, Smithfield, Rhode Island, 02917, an indirect wholly-owned
subsidiary of FMR LLC and a bank as defined in Section 3(a)(6) of the
Securities Exchange Act of 1934, is the beneficial owner of 45,254 shares
or 0.036 % of the outstanding Common Stock of the ILLUMINA INC as a result
of its serving as investment manager of institutional accounts owning such
shares.



                Edward C. Johnson 3d and FMR LLC, through its control of
Pyramis Global Advisors Trust Company, each has sole dispositive power over
40,351 shares and sole power to vote or to direct the voting of 45,254
shares of Common Stock owned by the institutional accounts managed by PGATC
as reported above.



                FIL Limited ("FIL"), Pembroke Hall, 42 Crow Lane, Hamilton,
Bermuda, and various foreign-based subsidiaries provide investment advisory
and management services to a number of non-U.S. investment companies and
certain institutional investors. FIL, which is a qualified institution
under section 240.13d-1(b)(1)(ii), is the beneficial owner of 294,300
shares or 0.235% of the Common Stock outstanding of the Company.



                Partnerships controlled predominantly by members of the
family of Edward C. Johnson 3d, Chairman of FMR LLC and FIL, or trusts for
their benefit, own shares of FIL voting stock. While the percentage of
total voting power represented by these shares may fluctuate as a result of
changes in the total number of shares of FIL voting stock outstanding from
time to time, it normally represents more than 25% and less than 50% of the
total votes which may be cast by all holders of FIL voting stock. FMR LLC
and FIL are separate and independent corporate entities, and their Boards
of Directors are generally composed of different individuals.



                FMR LLC and FIL are of the view that they are not acting as
a "group" for purposes of Section 13(d) under the Securities Exchange Act
of 1934 (the "1934" Act) and that they are not otherwise required to
attribute to each other the "beneficial ownership" of securities
"beneficially owned" by the other corporation within the meaning of Rule
13d-3 promulgated under the 1934 Act. Therefore, they are of the view that
the shares held by the other corporation need not be aggregated for
purposes of Section 13(d). However, FMR LLC is making this filing on a
voluntary basis as if all of the shares are beneficially owned by FMR LLC
and FIL on a joint basis.



SCHEDULE 13G - TO BE INCLUDED IN STATEMENTS
FILED PURSUANT TO RULE 13d-1(b) or 13d-2(b)
RULE 13d-1(f)(1) AGREEMENT


                The undersigned persons, on November 8, 2013, agree and
consent to the joint filing on their behalf of this Schedule 13G in
connection with their beneficial ownership of the Common Stock of ILLUMINA
INC at October 31, 2013.


  	FMR LLC

  	By /s/ Scott C. Goebel
  	Scott C. Goebel
  	Duly authorized under Power of Attorney effective as of June 1, 2008, by
and on behalf of FMR LLC and its direct and indirect subsidiaries

  	Edward C. Johnson 3d

  	By /s/ Scott C. Goebel
  	Scott C. Goebel
  	Duly authorized under Power of Attorney effective as of June 1, 2008, by
and on behalf of Edward C. Johnson 3d

  	Fidelity Management & Research Company

  	By /s/ Scott C. Goebel
  	Scott C. Goebel
  	Senior V.P. and General Counsel