FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * Intersouth Associates VI, LLC   2. Issuer Name and Ticker or Trading Symbol ALIMERA SCIENCES INC [ALIM] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) __X__ Other (specify below) May be part of 13(d) group (Last) (First) (Middle) C/O INTERSOUTH PARTNERS, 406 BLACKWELL STREET, SUITE 200 3. Date of Earliest Transaction (Month/Day/Year) 04/27/2010 (Street) DURHAM, NC 27701-3984 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 04/27/2010   C   824,679 A (1) 824,679 I See footnote (2) Common Stock 04/27/2010   C   560,934 A (3) 1,385,613 I See footnote (2) Common Stock 04/27/2010   C   576,859 A (3) 1,962,472 I See footnote (2) Common Stock 04/27/2010   P   90,909 A $ 11 2,053,381 I See footnote (2)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Series A Preferred Stock

(1)

04/27/2010

C

824,679 (4)

(5)

(6)

Common Stock

824,679

(1)

0

I

See footnote (2)

Series B Preferred Stock

(3)

04/27/2010

C

560,934 (4)

(5)

(6)

Common Stock

560,934

(3)

0

I

See footnote (2)

Series C Preferred Stock

(3)

04/27/2010

C

576,859 (4)

(5)

(6)

Common Stock

576,859

(3)

0

I

See footnote (2)

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Intersouth Associates VI, LLC C/O INTERSOUTH PARTNERS 406 BLACKWELL STREET, SUITE 200 DURHAM, NC 27701-3984		X		May be part of 13(d) group
Mumma Mitch C/O INTERSOUTH PARTNERS 406 BLACKWELL STREET, SUITE 200 DURHAM, NC 27701-3984		X		May be part of 13(d) group
Dougherty Dennis C/O INTERSOUTH PARTNERS 406 BLACKWELL STREET, SUITE 200 DURHAM, NC 27701-3984		X		May be part of 13(d) group
INTERSOUTH PARTNERS VI LP C/O INTERSOUTH PARTNERS 406 BLACKWELL STREET, SUITE 200 DURHAM, NC 27701-3984		X		May be part of 13(d) group

Signatures

/s/ Mitch Mumma		04/29/2010
**Signature of Reporting Person		Date
/s/ Dennis Dougherty		04/29/2010
**Signature of Reporting Person		Date
/s/ Mitch Mumma, Intersouth Partners VI, L.P., By: Intersouth Associates VI, LLC, Its General Partner, By: Mitch Mumma, Title: Member Manager		04/29/2010
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	781,092 shares of Series A Preferred Stock automatically converted into 824,679 shares of common stock immediately prior to the closing of the Issuer's initial public offering, for no additional consideration.
(2)	The reportable securities are owned directly by Intersouth Partners VI, L.P. ("IP VI"). Intersouth Associates VI, LLC ("IA VI, LLC") is the general partner of IP VI. IA VI, LLC disclaims beneficial ownership of these securities and this report shall not be deemed an admission that IA VI, LLC is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Mitch Mumma ("Mumma") and Dennis Dougherty ("Dougherty") are the member managers of IA VI, LLC. Each of Mumma and Dougherty disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their pecuniary interest therein.
(3)	Each outstanding share of preferred stock automatically converted into 1 share of common stock immediately prior to the closing of the Issuer's initial public offering, for no additional consideration.
(4)	Reflects a 3.4-for-1 reverse stock split, effective as of immediately prior to the effectiveness of the Registration Statement on Form S-1 (File No. 333-162782).
(5)	Immediately.
(6)	Not applicable.

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