Ownership Submission
FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  KIRK RANDAL J
2. Date of Event Requiring Statement (Month/Day/Year)
12/29/2010
3. Issuer Name and Ticker or Trading Symbol
TRANSGENOMIC INC [TBIO.OB]
(Last)
(First)
(Middle)
C/O THIRD SECURITY, LLC, 1881 GROVE AVENUE
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

RADFORD, VA 24141
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Series A Convertible Preferred Stock 12/29/2010   (1) Common Stock 4,137,928 (3) $ 0 (4) I By Third Security Senior Staff 2008 LLC (2)
Warrant to Purchase Shares of Series A Convertible Preferred 12/29/2010 12/28/2015 Common Stock 2,068,964 (3) $ 2.32 (5) I By Third Security Senior Staff 2008 LLC (2)
Series A Convertible Preferred Stock 12/29/2010   (1) Common Stock 4,137,928 (3) $ 0 (4) I By Third Security Staff 2010 LLC (2)
Warrant to Purchase Shares of Series A Convertible Preferred 12/29/2010 12/28/2015 Common Stock 2,068,964 (3) $ 2.32 (5) I By Third Security Staff 2010 LLC (2)
Series A Convertible Preferred Stock 12/29/2010   (1) Common Stock 2,068,964 (3) $ 0 (4) I By Third Security Incentive 2010 LLC (2)
Warrant to Purchase Shares of Series A Convertible Preferred 12/29/2010 12/28/2015 Common Stock 1,034,480 (3) $ 2.32 (5) I By Third Security Incentive 2010 LLC (2)

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
KIRK RANDAL J
C/O THIRD SECURITY, LLC
1881 GROVE AVENUE
RADFORD, VA 24141
    X    
Third Security Senior Staff 2008 LLC
C/O THIRD SECURITY, LLC
1881 GROVE AVENUE
RADFORD, VA 24141
    X    
Third Security Staff 2010 LLC
C/O THIRD SECURITY, LLC
1881 GROVE AVENUE
RADFORD, VA 24141
    X    
Third Security Incentive 2010 LLC
C/O THIRD SECURITY, LLC
1881 GROVE AVENUE
RADFORD, VA 24141
    X    

Signatures

/s/ Randal J. Kirk 01/10/2011
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Not applicable
(2) Randal J. Kirk controls each of Third Security Senior Staff 2008 LLC, Third Security Staff 2010 LLC and Third Security Incentive 2010 LLC. Shares held by these entities may be deemed to be indirectly beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk.
(3) Assumes conversion of shares of Series A Convertible Preferred Stock into Common Stock.
(4) Pursuant to its terms, each share of Series A Convertible Preferred Stock is convertible into four shares of Common Stock at a conversion price of $0.58 per share.
(5) Representing the per share price of each share of Series A Preferred Stock issuable upon exercise of the applicable Warrant, which such shares of Series A Preferred Stock are convertible in the manner described in Item 3 above.

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